EMA Verdict Due On Vertex/CRISPR's Gene Editing Therapy & Reata's Omaveloxolone Pink Sheet
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EMA Verdict Due On Vertex/CRISPR's Gene Editing Therapy & Reata's Omaveloxolone - Pink Sheet
Gene Therapy, Innovative Drugs, Surgical Techniques, and the Evolving Landscape of Epilepsy Care: Gregory Krauss ... Neurology Live
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Gene Therapy, Innovative Drugs, Surgical Techniques, and the Evolving Landscape of Epilepsy Care: Gregory Krauss ... - Neurology Live
Reviewed by James Langeland, Professor, Kalamazoo College on 1/30/23
Comprehensivenessrating:4see less
This text does what it claims to do. It provides an introductory overview of a broad swath of genetics.
Content Accuracyrating:4
No glaring errors. One could always nitpick any text book.
Relevance/Longevityrating:3
The text is relevant, but not particularly unique in any sense. One could find virtually the same information in any number of genetics textbooks, presented in largely the same way. A major problem here is that the filed is presented more or less historically with many of the experiments and concepts being described having little to no relevance to genetics today. This is a problem with many texts so I do not single this one out.
Clarityrating:4
As with many open source texts, this one suffers from substandard figures, which directly influences clarity. The words on the age are fine, but the adage is true-a picture can be worth a thousand words. The mainstream publishers spent a lot of money on figures and it shows--they can be really good.
Consistencyrating:4
No comments here.
Modularityrating:4
There seem to be appropriate and logical chapter and section breaks.
Organization/Structure/Flowrating:3
The flow is the same as nearly any other genetics textbook. It suffers from a rigid historical framework. Better than most at Muller's morphs however!
Interfacerating:5
No problems here. I do really like the integrated you tube links. I did not dive into the content of those videos (beyond the scope of my review), but the fact that they are there in abundance is a good use of the open source approach.
Grammatical Errorsrating:5
No problems here.
Cultural Relevancerating:3
No comment.
A very timely section on SARS-Cov-2 at the end! Rich with study questions and answers. Genetics is and should be very problem based, so this is good.I appreciate what is being offered here and I understand the market. There is nothing "wrong" with this textbook. There is also no wow factor that would cause me to adopt it at this time.
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Introduction to Genetics - Open Textbook Library
Clues to preventing Alzheimer's come from patient who, despite genetics, evaded disease Washington University ... Washington University School of Medicine in St. Louis
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Clues to preventing Alzheimer's come from patient who, despite genetics, evaded disease Washington University ... - Washington University School of...
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Environmental stress rather than genetics influenced height differences in early Neolithic people: Study - Phys.org
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What is trisomy 18? Why the fatal genetic disorder is in the news and what it's like to get the diagnosis. - Yahoo Life
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Spanish scientists identify the molecular mechanisms controlling the genes involved in proper formation of the heart ... - EurekAlert
GENEFIT, the First-Ever Fitness Technology to Integrate Personal Genetics with Wearable Tracker Data, Launches to ... Fitt Insider
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GENEFIT, the First-Ever Fitness Technology to Integrate Personal Genetics with Wearable Tracker Data, Launches to ... - Fitt Insider
Genetic 'protection' against depression was no match for pandemic stress, finds study of first-year college students Medical Xpress
Origin and evolution of the triploid cultivated banana genome Nature.com
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Origin and evolution of the triploid cultivated banana genome - Nature.com
CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity Nature.com
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CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity - Nature.com
How do we get our eye color? A genetics expert reveals the fascinating truth Fox News
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How do we get our eye color? A genetics expert reveals the fascinating truth - Fox News
WVU Today | WVU scientists spice up genetic research through habanero peppers and AI WVU Today
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WVU Today | WVU scientists spice up genetic research through habanero peppers and AI - WVU Today
Genetic mutations that promote reproduction tend to shorten human lifespan, study shows Phys.org
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Genetic mutations that promote reproduction tend to shorten human lifespan, study shows - Phys.org
Stanford Scientists Discover Common Genetic Factor That Fends Off Alzheimer's and Parkinson's SciTechDaily
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Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort ... - BMC Medicine
New bill would block American genetic data from access by companies tied to foreign adversaries Homeland Preparedness News
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New bill would block American genetic data from access by companies tied to foreign adversaries - Homeland Preparedness News
Electric Eels Shocking Ability To Alter The Genetics Of Nearby Animals Forbes
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Electric Eels Shocking Ability To Alter The Genetics Of Nearby Animals - Forbes
Most recombinant DNA technology involves the insertion of foreign genes into the plasmids of common laboratory strains of bacteria. Plasmids are small rings of DNA; they are not part of the bacteriums chromosome (the main repository of the organisms genetic information). Nonetheless, they are capable of directing protein synthesis, and, like chromosomal DNA, they are reproduced and passed on to the bacteriums progeny. Thus, by incorporating foreign DNA (for example, a mammalian gene) into a bacterium, researchers can obtain an almost limitless number of copies of the inserted gene. Furthermore, if the inserted gene is operative (i.e., if it directs protein synthesis), the modified bacterium will produce the protein specified by the foreign DNA.
A subsequent generation of genetic engineering techniques that emerged in the early 21st century centred on gene editing. Gene editing, based on a technology known as CRISPR-Cas9, allows researchers to customize a living organisms genetic sequence by making very specific changes to its DNA. Gene editing has a wide array of applications, being used for the genetic modification of crop plants and livestock and of laboratory model organisms (e.g., mice).
The correction of genetic errors associated with disease in animals suggests that gene editing has potential applications in gene therapy for humans. Gene therapy is the introduction of a normal gene into an individuals genome in order to repair a mutation that causes a genetic disease. When a normal gene is inserted into a mutant nucleus, it most likely will integrate into a chromosomal site different from the defective allele; although this may repair the mutation, a new mutation may result if the normal gene integrates into another functional gene. If the normal gene replaces the mutant allele, there is a chance that the transformed cells will proliferate and produce enough normal gene product for the entire body to be restored to the undiseased phenotype.
Genetic engineering has advanced the understanding of many theoretical and practical aspects of gene function and organization. Through recombinant DNA techniques, bacteria have been created that are capable of synthesizing human insulin, human growth hormone, alpha interferon, a hepatitis B vaccine, and other medically useful substances. Plants may be genetically adjusted to enable them to fix nitrogen, and genetic diseases can possibly be corrected by replacing dysfunctional genes with normally functioning genes.
Genes for toxins that kill insects have been introduced in several species of plants, including corn and cotton. Bacterial genes that confer resistance to herbicides also have been introduced into crop plants. Other attempts at the genetic engineering of plants have aimed at improving the nutritional value of the plant.
In 1980 the new microorganisms created by recombinant DNA research were deemed patentable, and in 1986 the U.S. Department of Agriculture approved the sale of the first living genetically altered organisma virus, used as a pseudorabies vaccine, from which a single gene had been cut. Since then several hundred patents have been awarded for genetically altered bacteria and plants. Patents on genetically engineered and genetically modified organisms, particularly crops and other foods, however, were a contentious issue, and they remained so into the first part of the 21st century.
Grains of golden rice, a genetically modified rice (Oryza sativa) that contains beta-carotene.(more)
Special concern has been focused on genetic engineering for fear that it might result in the introduction of unfavourable and possibly dangerous traits into microorganisms that were previously free of theme.g., resistance to antibiotics, production of toxins, or a tendency to cause disease. Indeed, possibilities for misuse of genetic engineering were vast. In particular, there was significant concern about genetically modified organisms, especially modified crops, and their impacts on human and environmental health. For example, genetic manipulation may potentially alter the allergenic properties of crops. In addition, whether some genetically modified crops, such as golden rice, deliver on the promise of improved health benefits was also unclear. The release of genetically modified mosquitoes and other modified organisms into the environment also raised concerns.
In the 21st century, significant progress in the development of gene-editing tools brought new urgency to long-standing discussions about the ethical and social implications surrounding the genetic engineering of humans. The application of gene editing in humans raised significant ethical concerns, particularly regarding its potential use to alter traits such as intelligence and beauty. More practically, some researchers attempted to use gene editing to alter genes in human sperm, which would enable the edited genes to be passed on to subsequent generations, while others sought to alter genes that increase the risk of certain types of cancer, with the aim of reducing cancer risk in offspring. The impacts of gene editing on human genetics, however, were unknown, and regulations to guide its use were largely lacking.
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Genetic engineering - DNA Modification, Cloning, Gene Splicing
Star Trek: Julian Bashir's Tale of Genetic Engineering and the Complexity of Parental Acceptance GameRant
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Star Trek: Julian Bashir's Tale of Genetic Engineering and the Complexity of Parental Acceptance - GameRant