HIGH POINT, N.C., Dec. 15, 2020 (GLOBE NEWSWIRE) -- vTv Therapeutics Inc.(Nasdaq: VTVT) today announced that the Phase 2 Elevage study of azeliragon in people with mild Alzheimers disease and type 2 diabetes did not meet its primary objective of demonstrating an improvement in cognition as assessed by the 14-item Alzheimers Disease Assessment Scale Cognitive Subscale (ADAS-cog14) relative to placebo. The 6-month trial investigated the efficacy and safety of 5 mg azeliragon administered orally once daily compared to placebo in 43 people with mild probable Alzheimers disease and type 2 diabetes. The azeliragon treated group (n=21) had a 1.8 point decline from baseline in ADAS-cog14 compared to a placebo (n=22) decline of 0.35. These differences were not statistically significant. Consistent with previous studies, azeliragon was generally well-tolerated with similar incidences of treatment-emergent adverse events overall and by system organ class in both treatment groups.
We will continue to analyze the data to determine if there are potential benefits or future applications for azeliragon in Alzheimers, dementia or related indications that we or other interested parties may seek to pursue, said Steve Holcombe, chief executive officer, vTv Therapeutics. On behalf of vTv Therapeutics, we would like to extend our most sincere and heartfelt gratitude to study participants, their families, physicians and caregivers for their commitment to this important study despite the challenging circumstances created by the COVID-19 pandemic.
AboutvTv TherapeuticsvTv Therapeutics Inc.is a clinical-stage biopharmaceutical company focused on developing oral small molecule drug candidates. vTv has a pipeline of clinical drug candidates led by programs for the treatment of type 1 diabetes, Alzheimers and related dementia, and inflammatory disorders. vTvs development partners are pursuing additional indications in type 2 diabetes, chronic obstructive pulmonary disease (COPD), genetic mitochondrial diseases, and chronic kidney disease. For more information, please visitwww.vtvtherapeutics.comor follow us on Twitter: @vTvTherapeutics.
Forward-Looking StatementsThis release contains forward-looking statements, which involve risks and uncertainties. These forward-looking statements can be identified by the use of forward-looking terminology, including the terms anticipate, believe, could, estimate, expect, intend, may, plan, potential, predict, project, should, target, will, would and, in each case, their negative or other various or comparable terminology. All statements other than statements of historical facts contained in this release, including statements regarding the timing of our clinical trials, our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans, objectives of management and expected market growth are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Important factors that could cause our results to vary from expectations include those described under the heading Risk Factors in our Annual Report on Form 10-K and our other filings with theSEC. These forward-looking statements reflect our views with respect to future events as of the date of this release and are based on assumptions and subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. These forward-looking statements represent our estimates and assumptions only as of the date of this release and, except as required by law, we undertake no obligation to update or review publicly any forward-looking statements, whether as a result of new information, future events or otherwise after the date of this release. We anticipate that subsequent events and developments will cause our views to change. Our forward-looking statements do not reflect the potential impact of any future acquisitions, merger, dispositions, joint ventures or investments we may undertake. We qualify all of our forward-looking statements by these cautionary statements.
Contacts
Investors:
Corey DavisLifeSci AdvisorsCDavis@LifeSciAdvisors.com
or
Media:Glenn SilverLazar FINN Partners646-871-8485gsilver@lazarpartners.com
Source: vTv Therapeutics Inc.
- 001 Diabetes treated with Stem Cell Therapy [Last Updated On: June 25th, 2010] [Originally Added On: June 25th, 2010]
- 002 Diabetes - Video [Last Updated On: November 7th, 2011] [Originally Added On: November 7th, 2011]
- 003 Stem Cell Treatment vs Diet For Diabetes - Video [Last Updated On: January 11th, 2012] [Originally Added On: January 11th, 2012]
- 004 Orgenesis' Sarah Ferber, Ph.D on Using a Diabetes Patient's Own Liver Cells as a Novel Source of Insulin [Last Updated On: June 15th, 2012] [Originally Added On: June 15th, 2012]
- 005 Diabetes reversed in mice using stem cells [Last Updated On: June 27th, 2012] [Originally Added On: June 27th, 2012]
- 006 Differences between type 1 and 2 diabetes [Last Updated On: June 27th, 2012] [Originally Added On: June 27th, 2012]
- 007 Diabetes Reversed In Mice Thanks To Stem Cell Transplant [Last Updated On: June 28th, 2012] [Originally Added On: June 28th, 2012]
- 008 Diabetes Reversal In Mice Via Stem Cells [Last Updated On: June 29th, 2012] [Originally Added On: June 29th, 2012]
- 009 Diabetes drug makes brain cells grow [Last Updated On: July 6th, 2012] [Originally Added On: July 6th, 2012]
- 010 Diabetes drug helps brain growth, makes mice smarter [Last Updated On: July 6th, 2012] [Originally Added On: July 6th, 2012]
- 011 Diabetes study hit by lack of funds [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- 012 Targeted Nanoparticle Probes for Embryonic Stem Cell Derived Progenitor Cells - Video [Last Updated On: November 17th, 2012] [Originally Added On: November 17th, 2012]
- 013 Diabetes Stem Cell Patient Testimonials - Video [Last Updated On: December 19th, 2012] [Originally Added On: December 19th, 2012]
- 014 Diabetes Precations - Tooth decay Treatment - Video [Last Updated On: February 5th, 2013] [Originally Added On: February 5th, 2013]
- 015 Potential Diabetes Breakthrough - Video [Last Updated On: April 29th, 2013] [Originally Added On: April 29th, 2013]
- 016 APDF: Stem cells in diabetes -Dr Kumaravel - Video [Last Updated On: October 4th, 2013] [Originally Added On: October 4th, 2013]
- 017 Diabetes: Progress toward stem cell therapies - Video [Last Updated On: January 25th, 2014] [Originally Added On: January 25th, 2014]
- 018 Diabetes 22 years - Video [Last Updated On: February 3rd, 2014] [Originally Added On: February 3rd, 2014]
- 019 Treatment for Diabetes - with Stem cells - Video [Last Updated On: April 28th, 2014] [Originally Added On: April 28th, 2014]
- 020 Diabetes cure? Cloned human stem cells could provide the answer - Video [Last Updated On: May 1st, 2014] [Originally Added On: May 1st, 2014]
- 021 Stem Cell Research Diabetes - Video [Last Updated On: May 26th, 2014] [Originally Added On: May 26th, 2014]
- 022 CIRM Movie on Diabetes for Viacyte - Video [Last Updated On: May 27th, 2014] [Originally Added On: May 27th, 2014]
- 023 James Shapiro: "Cutting Edge Islet and Stem Cell Transplant Therapies in the Clinic for Diabetes" - Video [Last Updated On: August 4th, 2014] [Originally Added On: August 4th, 2014]
- 024 Step 1 - lupus / diabetes / alzheimers syrum - Take 5ml blood - Video [Last Updated On: October 6th, 2014] [Originally Added On: October 6th, 2014]
- 025 Major step toward diabetes cure - Video [Last Updated On: October 11th, 2014] [Originally Added On: October 11th, 2014]
- 026 Stem Cells Could Produce Insulin - Video [Last Updated On: October 14th, 2014] [Originally Added On: October 14th, 2014]
- 027 Diabetes Breakthrough! Human Stem Cells Altered to Make Insulin! - Video [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- 028 Did Scientists Just Cure Type 1 Diabetes? - Video [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- 029 Breakthrough in diabetes stem cell research - Video [Last Updated On: October 16th, 2014] [Originally Added On: October 16th, 2014]
- 030 TESTIMONI LAMININE - Ginjal Diabetes dan Komplikasi - Video [Last Updated On: December 1st, 2014] [Originally Added On: December 1st, 2014]
- 031 Laminine - Seminar Diabetes - Video [Last Updated On: December 4th, 2014] [Originally Added On: December 4th, 2014]
- 032 stemtech testimonial diabetes www afastemcell com - Video [Last Updated On: April 29th, 2015] [Originally Added On: April 29th, 2015]
- 033 Afastemcell - testimoni penderita diabetes - Video [Last Updated On: April 29th, 2015] [Originally Added On: April 29th, 2015]
- 034 Stress: American Diabetes Association [Last Updated On: May 19th, 2015] [Originally Added On: May 19th, 2015]
- 035 Diabetes.net Welcome to the Original Diabetes Network [Last Updated On: May 19th, 2015] [Originally Added On: May 19th, 2015]
- 036 Diabetes mellitus - Wikipedia, the free encyclopedia [Last Updated On: May 19th, 2015] [Originally Added On: May 19th, 2015]
- 037 Diabetes Warrior - Diabetes Management from a Paleolithic ... [Last Updated On: May 20th, 2015] [Originally Added On: May 20th, 2015]
- 038 children with DIABETES Online Community [Last Updated On: May 27th, 2015] [Originally Added On: May 27th, 2015]
- 039 Diabetes mellitus [Last Updated On: May 30th, 2015] [Originally Added On: May 30th, 2015]
- 040 Diabetes - Type 1 Diabetes, Type 2 Diabetes, Gestational ... [Last Updated On: June 2nd, 2015] [Originally Added On: June 2nd, 2015]
- 041 Diabetes: Causes, Symptoms and Treatments [Last Updated On: July 12th, 2015] [Originally Added On: July 12th, 2015]
- 042 Diabetes mellitus type 1 - Wikipedia, the free encyclopedia [Last Updated On: July 14th, 2015] [Originally Added On: July 14th, 2015]
- 043 Type 2 Diabetes: Everything You Need to Know [Last Updated On: July 23rd, 2015] [Originally Added On: July 23rd, 2015]
- 044 Washington, DC - American Diabetes Association [Last Updated On: August 21st, 2015] [Originally Added On: August 21st, 2015]
- 045 Type 1 Diabetes: Causes, Tests, Symptoms and Treatments [Last Updated On: August 23rd, 2015] [Originally Added On: August 23rd, 2015]
- 046 Diabetes management - Wikipedia, the free encyclopedia [Last Updated On: August 24th, 2015] [Originally Added On: August 24th, 2015]
- 047 Type 2 Diabetes: Causes, Symptoms, Prevention, and More [Last Updated On: August 27th, 2015] [Originally Added On: August 27th, 2015]
- 048 Diabetes Diet and Food Tips: Eating to Prevent, Control ... [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 049 Questions & Answers about Diabetes in the Workplace and ... [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 050 Diabetes Symptoms: Common Symptoms of Diabetes [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 051 Diabetes mellitus type 2 - Wikipedia, the free encyclopedia [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 052 Diabetes center - US News [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 053 About Diabetes - American Heart Association [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 054 Diabetes, Type 2 Medication | Drugs.com [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 055 Diabetes mellitus - Lab Tests Online [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 056 Diabetes | Overview [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 057 Diabetes | Nutrition.gov [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 058 NJDOH - Family Health services [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 059 Bridgewater New Jersey Office of the American Diabetes ... [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- 060 Type 2 Diabetes Condition Center - Health.com [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- 061 NIHSeniorHealth: Diabetes - What is Diabetes? [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- 062 Diabetes [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- 063 Diabetes - Symptoms, Diagnosis, Treatment of Diabetes - NY ... [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- 064 Raleigh North Carolina Office of the American Diabetes ... [Last Updated On: September 13th, 2015] [Originally Added On: September 13th, 2015]
- 065 Louisiana Office of the American Diabetes Association [Last Updated On: September 21st, 2015] [Originally Added On: September 21st, 2015]
- 066 Home - Palm Beach Diabetes [Last Updated On: September 29th, 2015] [Originally Added On: September 29th, 2015]
- 067 Diabetes Basics - What is Diabetes? - Lifeclinic [Last Updated On: October 3rd, 2015] [Originally Added On: October 3rd, 2015]
- 068 Diabetes Center | Jefferson University Hospitals | Serving ... [Last Updated On: October 3rd, 2015] [Originally Added On: October 3rd, 2015]
- 069 Kentucky: Cabinet for Health and Family Services - Diabetes [Last Updated On: October 3rd, 2015] [Originally Added On: October 3rd, 2015]
- 070 Virginia Diabetes and Endocrinology [Last Updated On: October 9th, 2015] [Originally Added On: October 9th, 2015]
- 071 Chicago Illinois Office of the American Diabetes Association [Last Updated On: October 17th, 2015] [Originally Added On: October 17th, 2015]
- 072 Diabetes Facts & Information | Joslin Diabetes Center [Last Updated On: November 2nd, 2015] [Originally Added On: November 2nd, 2015]
- 073 Michigan: American Diabetes Association [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 074 Diabetes - MidMichigan Health [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 075 WHO | Diabetes programme [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 076 Were creating a world without T1D. - JDRF [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 077 Chicago Diabetes Project | Researching to Cure Diabetes [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 078 Bridgewater, New Jersey - American Diabetes Association [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 079 Philadelphia Pennsylvania Office of the American Diabetes ... [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]
- 080 DPH Disease Information: Diabetes Info - Delaware [Last Updated On: August 4th, 2016] [Originally Added On: August 4th, 2016]