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Arthritis – NHS

Thursday, August 30th, 2018

Arthritis is a common condition that causes pain and inflammation in ajoint.

In the UK, around 10 million people have arthritis. It affects peopleof all ages, including children.

The two most common types of arthritis are:

Osteoarthritis is the most common type of arthritis in the UK, affecting around 8 million people.

It most often develops inadults who are in their late 40s or older. It's also more common in women andpeople with a family history ofthe condition.However, it can occur at any age as a result of an injury or be associated with otherjoint-related conditions, such as gout or rheumatoid arthritis.

Osteoarthritis initially affects the smooth cartilage lining of the joint. This makes movement more difficult than usual, leading to pain and stiffness.

Once the cartilage lining starts to roughen and thin out, the tendons and ligaments have to work harder. This can cause swelling and the formation of bony spurs, called osteophytes.

Severe loss of cartilage can lead to bone rubbing on bone, altering the shape of the joint and forcing the bones out of their normal position.

The most commonly affected jointsare those in the:

In the UK, rheumatoid arthritis affects more than 400,000 people. It often starts when a person is between 40 and 50 years old. Women are three times more likely to be affected than men.

Rheumatoid and osteoarthritis are two different conditions. Rheumatoid arthritis occurs when the body's immune system targets affected joints, which leads to pain and swelling.

The outer covering (synovium) of the joint is the first place affected. This can then spread across the joint, leading to further swelling and a change in the joint's shape. Thismay cause thebone and cartilage to break down.

People with rheumatoid arthritis can also develop problems with other tissues and organs in their body.

Thesymptoms of arthritis you experience will vary depending on the type you have.

This is why it's important to have an accurate diagnosis if you have:

Arthritis is often associated with older people, butit can alsoaffect children. In the UK, about 15,000 children and young people are affected by arthritis.

Most types of childhood arthritis are known as juvenile idiopathic arthritis (JIA). JIA causes pain andinflammation in one or more joints for at least six weeks.

Although the exact cause of JIA isunknown, the symptoms often improve as a child gets older, meaning they can lead a normal life.

The main types of JIA are discussed below. Arthritis Research UK has more information about the different types of juvenile idiopathic arthritis.

Oligo-articular JIA is the most common type of JIA. It affects fewer than five joints in the bodymost commonly in the knees, ankles and wrists.

Oligo-articular JIA has good recovery rates and long-term effects are rare. However, there's a risk that childrenwith the condition may develop eye problems, so regulareyetests with an ophthalmologist (eye care specialist) are recommended.

Polyarticular JIA, or polyarthritis, affects five or more joints. It can develop at any age during childhood.

The symptoms of polyarticular JIA are similar to the symptoms of adult rheumatoid arthritis. The condition is often accompanied by a rash and a high temperature of 38C (100.4F) or above.

Systemic onset JIA begins with symptoms such as a fever, rash, lethargy (a lack of energy) and enlarged glands. Later on, joints canbecome swollen and inflamed.

Like polyarticular JIA, systemic onset JIA can affect children of any age.

Enthesitis-related arthritis is a type of juvenile arthritis that affects older boys or teenagers. It can cause pain in the soles of the feet and around the knee and hip joints, where the ligaments attach to the bone.

There's no cure for arthritis, but there are many treatments that can help slow down the condition.

For osteoarthritis, medications are often prescribed, including:

In severe cases, the following surgical procedures may be recommended:

Read moreabouthow osteoarthritis is treated.

Treatment forrheumatoid arthritis aimsto slow down the condition's progress and minimise joint inflammation or swelling. This isto try and prevent damage to the joints. Recommended treatments include:

Read moreabouthow rheumatoid arthritisis treated.

Read more about:

You can also use the NHS post code search tofind arthritis services in your area.

Page last reviewed: 19/01/2016Next review due: 01/11/2018

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Alternative Medicine, Holistic Doctors,Naturopathic …

Wednesday, August 29th, 2018

Acupuncture ParkDr. Insung Park732-754-0392

3 Locations:Acupuncture Park30 Montgomery St. Suite 230Jersey City, NJ 07302

45 East Main St. #105Freehold, NJ 07728

402 Main St. #207Metuchen, NJ 08840

239 Mather Ave.Princeton, NJ 08540``````````````````````````````````````````````````````````````````````````````````Advanced Orthopedics and Sports Medicine InstituteNeil Paulvin, D.O.301 Professional View DriveFreehold,NJ732-720-2555Integrative and sports medicine. Services include acupuncture, biopuncture, PRP, prolotherapy, craniosacral therapy, neurotransmitter evaluations, biopuncture,food allergy testing. Also treat fibromyalgia, fatigue & irritable bowel syndrome.```````````````````````````````````````````````````````````````````````````````

Dr. Nicole Rivera, D.CDr. Nick Carruthers, D.C.Dr.Kyle Kim, D.C.Broke Scheller,M.S. , C.N.S.

Integrative Wellness Group provides a solution for you to get well and stay well by integrating physical medicine, functional medicine, and energy medicine. Our practitioners address chronic pain and infections such as Lyme, autoimmune conditions, mold illness, digestive troubles, and other chronic conditions with a 'whole-istic approach and treatment programs designed for your specific need. Our programs include autonomic response testing, chiropractic, sound wave therapy, functional medicine, nutritional counseling, cold laser, a state-of-the-art detox spa and more!``````````````````````````````````````````````````````````````````````````````````MD Wellness&MD SkinMichael E. Rothman, MD *1325 Warren Ave, Suite 6Spring Lake, NJ 07762Phone - 732-268-7663

Nutritional & metabolic medicine, Hormonalimbalances, weight loss, chronic degenerative diseases, high blood pressure & diabetes. Medical grade skin and body care is available at the MD Skin site.`````````````````````````````````````````````````````````````````````````````````NJ Spine and Wellness210 Mounts Corner DriveFreehold, NJ 07728(732) 414-2700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,

Inna Lukyanovsky, RPh,Functional Medicine PractitionerRealHealthExpert1-800-557-803945 N Main Rd Suite 2BMarlboro, NJSpecializing in BioIdentical Hormones, Wellness, Immune System Support, Gastrointestinal Health, Integrative Medicine and Much More.

```````````````````````````````````````````````````````````````````````````````NUCCA Upper Cervical ChiropracticMolland Spinal Care124 State Rte. 35Red Bank, NJ 07701(908) 601-5600

This special form of Upper Cervical Chiropractic focuses on gently and specifically correcting your body and spine to allow health and healing to build from within.````````````````````````````````````````````````````````````````````````````````Red Bank Acupuncture CenterTinton Fall, NJ````````````````````````````````````````````````````````````````````````````````Ted Block AcupunctureFreehold, NJ

````````````````````````````````````````````````````````````````````````````````````Wholetrition Wellness Center265 New Jersey 34Colts Neck, NJ732-858-1548

Chiropractic, Acupuncture, Feldenkrais, hypnotherapyIntegrated Energy Therapy, Reiki, nutrition and more.

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AARP’s Health Tools

Tuesday, August 28th, 2018

Blindness is the inability to see anything, even light. Ifyoure partially blind, you have limited vision. For example, you may haveblurry vision or the inability to distinguish the shapes of objects. Completeblindness means that you cant see at all and are in total darkness. Legalblindness refers to vision thats highly compromised. What a person withhealthy eyes can see from 200 feet away a legally blind person can see onlyfrom 20 feet away.

Seek medical attention right away if you suddenly lose theability to see. Have someone bring you to the emergency room for treatment. Dontwait for your vision to return. Depending on the cause of your blindness,immediate treatment may increase your chances of restoring your vision.Treatment may involve surgery or medication.

If youre completely blind, you can see nothing. If yourepartially blind, you might experience the following symptoms:

Your childs visual system begins to develop in the womb,but it wont be fully formed until about 2 years of age. By 6 to 8 weeks ofage, your baby should be able to fix their gaze on an object and follow itsmovement. By 4 months of age, their eyes should be properly aligned and notturned inward or outward.

The symptoms of visual impairment in young children can include:

The following eye diseases and conditions can causeblindness:

Blindness is a potential complication if you have diabetesor have a stroke. Birth defects, eye injuries, and complications from eyesurgery are other common causes of blindness.

The following conditions can impair vision or cause blindnessin infants:

The following categories of people are at risk of blindness:

A thorough eye exam by an optometrist will help to determinethe cause of your blindness or partial loss of vision. Your eye doctor willadminister a series of tests that measure the clarity of your vision, thefunction of your eye muscles, and how your pupils react to light. Theyllexamine the general health of your eyes using a slit lamp, which is a low-powermicroscope paired with a high-intensity light.

A pediatrician will screen your baby for eye problemsshortly after birth. At 6 months of age, you should have an eye doctor orpediatrician check your child again for visual acuity, focus, and eyealignment. The doctor will look at your babys eye structures and see whetherthey can follow a light or colorful object with their eyes.

Your child should be able to pay attention to visual stimuliby 6 to 8 weeks of age. If your child doesnt react to light shining in theireyes or focus on colorful objects by 2 to 3 months of age, have their eyesexamined right away. You should have their eyes examined if you notice crossedeyes or any other symptoms of impaired vision.

In some cases of vision impairment, one or more of thefollowing may help to restore your vision:

If you experience partial blindness that cant be corrected,your doctor will provide guidance on how to function with limited vision. Forexample, you can use a magnifying glass to read, increase the text size on yourcomputer, and use audio clocks and audiobooks.

Complete blindness requires approaching life in a new wayand learning new skills. For example, you may need to learn how to:

You may also need to have handrails installed in yourbathroom.

The long-term outlook for restoring vision and slowingvision loss is better when treatment is preventive and sought immediately.Cataracts can be treated effectively with surgery and dont necessarily resultin blindness. Early diagnosis and treatment are also important in cases ofglaucoma and macular degeneration to help slow down or stop your vision loss.

To detect eye diseases and help prevent vision loss, getregular eye examinations. If youre diagnosed with certain eye conditions, suchas glaucoma, treatment with medication can help prevent blindness.

Have your childs eyes examined at 6 months of age, 3 yearsof age, and every two years between the ages of 6 and 18 years old to helpprevent vision loss. If you notice symptoms of vision loss between routinevisits, make an appointment with their eye doctor immediately.

Written by: Chitra Badii and Marijane LeonardMedically reviewed on: Mar 09, 2016: Mark R. Laflamme, MD

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Seattle Stem Cell Therapy Clinic – Regenerative Medicine

Saturday, August 25th, 2018

Regenerative Medicine at Seattle Sports & Regenerative Medicine includes the collection and use of therapeutic stem cells to regrow, repair, or replace damaged or diseased tissue within the musculoskeletal system, including: shoulders, elbows, wrists, hips, knees, and ankles.

As your physician, Dr. Wagner is committed to providing the highest level of care, priding himself on staying connected to the ever-changing medical community and the most advanced medical technology available. It is his promise, as your physician, to responsibly provide the most progressive treatments, as long as he is completely confident that they are safe and beneficial for his patients.

Stem cell therapy and Platelet Rich Plasma (PRP) injections are both offered to alleviate pain and repair injury in the bodys tendons and joints, proving to be very effective in such conditions as osteoarthritis, tendon injuries, meniscus and labrum tears. Over 5 million stem cell procedures for osteoarthritis have been performed in the United States with no significant adverse effects reported.

We understand that the use of stem cells may sound complex, however, stem cell therapy is just the opposite. It is a simple procedure, performed in our office during a visit lasting approximately 90 minutes. If you have questions or would like a consultation with Dr. Wagner to learn if you are a candidate for stem cell therapy, please contact Seattle Sports and Regenerative Medicine.

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Genetics | Definition of Genetics by Merriam-Webster

Saturday, August 25th, 2018

Suddenly, Soo-Kyung, 42, and her husband Jae Lee, 57, another genetics specialist at O.H.S.U., had to transform from dispassionate scientists into parents of a patient, desperate for answers.

Among the brightest of those homegrown stars is Zhao Bowen, a Chinese science prodigy who dropped out of high school to start running a genetics lab.

Among the brightest of those homegrown stars is Zhao Bowen, a Chinese science prodigy who dropped out of high school to start running a genetics lab.

Krainer, a molecular genetics professor at Cold Spring Harbor Laboratory on Long Island, N.Y., had worked on the scientific underpinnings of the medicine for more than 15 years.

Since these discoveries, the field of genetics has expanded even furtherall the way to our own front doors, in fact, thanks to at-home genetic tests such as 23andMe.

Coral genetics is a field of increasing interest to scientists.

Krainer, a molecular genetics professor at Cold Spring Harbor Laboratory on Long Island, N.Y., had worked on the scientific underpinnings of the medicine for more than 15 years.

His father retired as a genetics professor at Northern Illinois University, also in DeKalb.

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Genetic Engineering – MSPCA-Angell

Saturday, August 25th, 2018

The MSPCAbelieves scientists ability to clone animals, to alter the genetic makeup of an animal, and to transfer pieces of genetic material from one species to another raises serious concerns for animals and humans alike.

This pagewill explore issues related to genetic engineering, transgenic animals, and cloned animals. It will examine the implications of genetic engineering on human and animal welfare and will touch on some related moral and ethical concerns that our society has so far failed to completely address.

Definitions

Problems related to the physical and psychological well-being of cloned and transgenic animals, significant ethical concerns about the direct manipulation of genetic material, and questions about the value of life itself must all be carefully weighed against the potential benefits of genetic engineering for disease research, agricultural purposes, vaccine development, pharmaceutical products, and organ transplants.

Genetic engineering is, as yet, an imperfect science that yields imperfect results.

Changes in animal growth and development brought about by genetic engineering and cloning are less predictable, more rapid, and often more debilitating than changes brought about through the traditional process of selective breeding.

This is especially apparent with cloning. Success rates are incredibly low; on average, less than 5% of cloned embryos are born and survive.

Clones are created at a great cost to animals. The clones that are successful, as well as those that do not survive and the surrogates who carry them, suffer greatly.Many of the cloned animals that do survive are plagued by severe health problems.

Offspring suffer from severe birth defects such as Large Offspring Syndrome (LOS), in which the cloned offspring are significantly larger than normal fetuses; hydrops, a typically fatal condition in which the mother or the fetus swells with fluid; respiratory distress; developmental problems; malformed organs; musculoskeletal deformities; or weakened immune systems, to name only a few.

Additionally, surrogates are subjected to repeated invasive procedures to harvest their eggs, implant embryos, or due to the offsprings birth defects surgical intervention to deliver their offspring. All of these problems occur at much higher rates than for offspring produced via traditional breeding methods.

Cloning increases existing animal welfare and environmental concerns related to animal agriculture.

In 1996, the birth of the ewe, Dolly, marked the first successful cloning of a mammal from adult cells. At the time of her birth, the researchers who created Dolly acknowledged the inefficiency of the new technology: it took 277 attempts to create this one sheep, and of these, only 29 early embryos developed, and an even smaller number of these developed into live fetuses. In the end, Dolly was the sole surviving clone. She was euthanized in 2003 at just 6 years of age, about half as old as sheep are expected to live, and with health problems more common in older sheep.

Since Dollys creation, the process of cloning has not demonstrated great improvement in efficiency or rates of success. A 2003 review of cloning in cattle found that less than 5% of cloned embryos transferred into surrogate cows survived; a 2016 study showedno noticeable increase in efficiency, with the success rate being about 1%.

Currently, research is focused on cloning for agricultural purposes. Used alone, or in concert with genetic engineering, the objective is to clone the best stock to reproduce whole herds or flocks with desired uniform characteristics of a specific trait, such as fast growth, leaner meat, or higher milk production. Cloning is often pursued to produce animals that grow faster so they can be slaughtered sooner and to raise more animals in a smaller space.

For example, transgenic fish are engineered to grow larger at a faster rate and cows injected with genetically engineered products to increase their productivity. Another example of this is the use of the genetically engineered drug, bovine growth hormone (BGH or BST) to increase milk production in dairy cows. This has also been associated with increased cases of udder disease, spontaneous abortion, lameness, and shortened lifespan. The use of BGH is controversial; many countries (such as Canada, Japan, Australia, and countries in the EU) do not allow it, and many consumers try to avoid it.A rise in transgenic animals used for agriculture will only exacerbate current animal welfare and environmental concerns with existing intensive farming operations.(For more information on farming and animal welfare, visit the MSPCAs Farm Animal Welfare page.)

Much remains unknown about thepotential environmental impacts of widespread cloning of animals. The creation of genetically identical animals leads to concerns about limited agricultural animal gene pools. The effects of creating uniform herds of animals and the resulting loss of biodiversity, have significant implications for the environment and for the ability of cloned herds to withstand diseases. This could make an impact on the entireagriculture industry and human food chain.

These issues became especiallyconcerning when, in 2008, the Federal Drug Administration not only approved the sale of meat from the offspring of cloned animals, but also did not require that it be labeled as such. There have been few published studies that examine the composition of milk, meat, or eggs from cloned animals or their progeny, including the safety of eating those products. The health problems associated with cloned animals, particularly those that appear healthy but have concealed illnesses or problems that appear unexpectedly later in life, could potentially pose risks to the safety of the food products derived from those animals.

Genetically Engineered Pets

Companion animals have also been cloned. The first cloned cat, CC, was created in 2001. CCs creation marked the beginning of the pet cloning industry, in which pet owners could pay to bank DNA from their companion dogs and cats to be cloned in the future. In 2005, the first cloned dog was created; later, the first commercially cloned dog followed at a cost of $50,000. Many consumers assume that cloning will produce a carbon copy of their beloved pet, but this is not the case. Even though the animals are genetically identical, they often do not resemble each other physically or behaviorally.

To date, the pet cloning industry has not been largely successful. However, efforts to make cloning a successful commercial venture are still being put forth.RBio (formerly RNL Bio), a Korean biotechnology company, planned to create a research center that would produce 1,000 cloned dogs annually by 2013. However, RBio, considered a black market cloner, failed to make any significant strides in itscloning endeavors and seems to have been replaced by other companies, such as South Korean-based Sooam Biotech, now the worlds leader in commercial pet cloning. Since 2006, Sooam has cloned over 800 dogs, in addition to other animals, such as cattle and pigs, for breed preservation and medical research.

While South Korean animal cloning expands, the interest in companion animal cloning in the United States continues to remain low. In 2009, the American company BioArts ceased its dog cloning services and ended its partnership with Sooam, stating in a press release that cloning procedures were still underdeveloped and that the cloning market itself was weak and unethical. However, in September 2016, ViaGen Petscreated the first American-born cloned puppy. ViaGen, an American company that has been cloning horses and livestock for over a decade, not only offers cloning services, but also offers to cyropreserve a pets DNA in case owners want to clone their pets in the future.

Of course, ViaGens process is more complicated than it sounds cloning and preservation costs pet owners up to tens of thousands of dollars, and the cloned animals are not necessarily behaviorally identical to their original counterparts. Furthermore, companion animal cloning causes concern not only because of the welfare issues inherent in the cloning process, but also because of its potential to contribute to pet overpopulation problem in the US, as millions of animals in shelters wait for homes.

Cloning and Medical Research

Cloning is also used to produce copies of transgenic animals that have been created to mimic certain human diseases. The transgenic animals are created, then cloned, producing a supply of animals for biomedical testing.

A 1980 U.S. Supreme Court decision to permit the patenting of a microorganism that could digest crude oil had a great impact on animal welfare and genetic engineering. Until that time, the U.S. Patent Office had prohibited the patenting of living organisms. However, following the Supreme Court decision, the Patent Office interpreted this ruling to extend to the patenting of all higher life forms, paving the way for a tremendous explosion of corporate investment in genetic engineering research.

In 1988, the first animal patent was issued to Harvard University for the Oncomouse, a transgenic mouse genetically modified to be more prone to develop cancers mimicking human disease. Since then, millions of transgenic mice have been produced. Transgenic rats, rabbits, monkeys, fish, chickens, pigs, sheep, goats, cows, horses, cats, dogs, and other animals have also been created.

Both expected and unexpected results occur in the process of inserting new genetic material into an egg cell. Defective offspring can suffer from chromosomal abnormalities that can cause cancer, fatal bleeding disorders, inability to reproduce, early uterine death, lack of ability to nurse, and such diseases as arthritis, diabetes, liver disease, and kidney disease.

The production of transgenic animals is of concern because genetic engineering is often used to create animals with diseases that cause intense suffering. Among the diseases that can be produced in genetically engineered research mice are diabetes, cancer, cystic fibrosis, sickle-cell anemia, Huntingtons disease, Alzheimers disease, and a rare but severe neurological condition called Lesch-Nyhansyndromethat causes the sufferer to self-mutilate. Animals carrying the genes for these diseases can suffer for long periods of time, both in the laboratory and while they are kept on the shelf by laboratory animal suppliers.

Another reason for the production of transgenic animals is pharming, in which sheep and goats are modified to produce pharmaceuticals in their milk. In 2009, the first drug produced by genetically engineered animals was approved by the FDA. The drug ATryn, used to prevent fatal blood clots in humans, is derived from goats into which a segment of human DNA has been inserted, causing them to produce an anticoagulant protein in their milk. This marks the first time a drug has been manufactured from a herd of animals created specifically to produce a pharmaceutical.

A company has also manufactured a drug produced in the milk of transgenic rabbits to treat a dangerous tissue swelling caused by a human protein deficiency. Yet another pharmaceutical manufacturer, PharmAnthene, was funded by the US Department of Defense to develop genetically engineered goats whose milk produces proteins used in a drug to treat nerve gas poisoning. The FDA also approved a drug whose primary proteins are also found in the milk of genetically engineered goats, who are kept at a farm in Framingham, Massachusetts. Additionally, a herd of cattle was recently developed that produces milk containing proteins that help to treat human emphysema. These animals are essentially used as pharmaceutical-production machines to manufacture only those substances they were genetically modified to produce; they are not used as part of the normal food supply chain for items such as meat or milk.

The transfer of animal tissues from one species to another raises potentially serious health issues for animals and humans alike.

Some animals are also genetically modified to produce tissues and organs to be used for human transplant purposes (xenotransplantation). Much effort is being focused in this area as the demand for human organs for transplantation far exceeds the supply, with pigs the current focus of this research.

While efforts to date have been hampered by a pig protein (porcine endogenous retroviruses- PERVs) that can cause organ rejection by the recipients immune system, efforts are underway to develop genetically modified swine with a human protein that would mitigate the chance of organ rejection. A Cambridge-based company, eGenesis, is using CRISPR to make organs grown in pigs more human-compatible. PERVs are often passed down from the surrogate mothers into the fetuses, which can then cause tumors, leukemia, and neuronal degeneration in the humans that receive the organs. eGenesis was able to remove 62 PERV genes when growing organs in petri dishes. Further, eGenesis has been working on inserting 12 human genes into the pig ovum to make the grown organs more human-like. Even in the early stages, genetic manipulation has impacts on both the mother pig and the genetically-modified piglets. One batch of embryos all died, and another batch resulted in a lot of miscarriages. Read more about the research here.

Little is known about the ways in which diseases can be spread from one species to another, raising concerns for both animals and people, and calling into question the safety of using transgenic pigs to supply organs for human transplant purposes. Scientists have identified various viruses common in the heart, spleen, and kidneys of pigs that could infect human cells. In addition, new research is shedding light on particles called prions that, along with viruses and bacteria, may transmit fatal diseases between animals and from animals to humans.

Acknowledging the potential for transmission of viruses from animals to humans, the National Institutes of Health, a part of the U.S. Department of Health and Human Services,issued a moratorium in 2015 onxenotransplantation until the risks are better understood, ceasing funding until more research has been carried out. With the science of genetic engineering, the possibilities are endless, but so too are the risks and concerns.

Genetic engineering research has broad ethical and moral ramifications with few established societal guidelines.

While biotechnology has been quietly revolutionizing the science for decades, public debate in the United Statesover the moral, ethical, and physical effects of this research has been insufficient. To quote Colorado State University Philosopher Bernard Rollin, We cannot control technology if we do not understand it, and we cannot understand it without a careful discussion of the moral questions to which it gives rise.

Research into non-animal methods of achieving some of the same goals looks promising.

Researchers in the U.S. and elsewhere have found ways togenetically engineer cereal grains to produce human proteins. One example of this, developed in the early 2000s, is a strain of rice that can produce a human protein used to treat cystic fibrosis. Wheat, corn, and barley may also be able to be used in similar ways at dramatically lower financial and ethical costs than genetically engineering animals for this purpose.

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Timeline of major events in stem cell research policy …

Saturday, August 25th, 2018

Stem cells have been used in medicine since the 1950s when bone marrow transplants were first used to treat leukemia. Congressional involvement in stem cell policy started as early as 1974.The first major amendment related to the use of federal funds for research involving embryonic stem (ES) cells occurred in 1996.From this point onward, this timeline provides policy landmarks affecting the course of stem cell research in the U.S.For information prior to 1996,click here (link is external).

Congress bans federal funding for research on embryos through the Dickey-Wicker Amendment, named after Reps. Jay Dickey (R-AR) and Roger Wicker (R-MS). The amendment prohibits the use of federal funds for the creation of a human embryo or embryos for research purposes, or research in which a human embryo or embryos are destroyed, discarded or knowingly subjected to risk of injury or death greater than that allowed for research on fetuses in utero.

The National Institutes of Health (NIH), interpreting the Dickey-Wicker Amendment, releases guidelines for research on ES cells.

The guidelines stipulate that:

President George W. Bush prohibits the federal funding of any research using ES cell lines derived after August 9, 2001, but his policy does not affect research in the private sector or research conducted with state funding. The President claims that more than 60 stem cell lines are still available for funding. Research on adult stem cells is not affected by this executive order.

H.R. 810, which would have expanded federal funding for stem cell research to include stem cells derived from embryos created for, but subsequently not used in, the in vitro fertilization process, passes both the House and the Senate in the 109th Congress, attracting bipartisan support. However, the bill is quickly vetoed by President Bush. The House votes 235-193 in favor of the bill, but the two-thirds majority needed to override the veto is not reached.

In the 110th Congress, the Senate passes their version of The Stem Cell Research Enhancement Act (S. 5) with strong bipartisan support, 63-34. The House also passes the Senate's version of the bill 247-176. Again, the bill is vetoed by President Bush, and again Congress cannot override the veto.

President Barack Obama issues an executive order,titled "Removing Barriers to Responsible Scientific Research Involving Human Stem Cells."See the full text here (link is external).

A group of plaintiffs led by adult stem cell scientists James Sherley, M.D., Ph.D., and Theresa Deisher, Ph.D., file a lawsuit against the National Institutes of Health (NIH) and the Department of Health and Human Services, arguing that federal funding of ES cell research is in violation of the Dickey-Wicker amendment. The case was brought up against Kathleen Sebelius, the U.S. Secretary of Health and Human Services at that time.

"Therefore this Court, following the [U.S. Court of Appeals for the D.C. Circuit] reasoning and conclusions, must find that defendants reasonably interpreted the Dickey-Wicker Amendment to permit funding for human embryonic stem cell research because such research is not 'research in which a human embryo or embryos are destroyed' ...The NIH reasonably concluded, as expressed in the notice of proposed rulemaking, that the fundamental policy question of whether to provide federal funds for embryonic stem cell research wasnt a question for it to decide. That policy question is not answered by any congressional law, and it has fallen on three presidential administrations to provide an answer. For all three such administrations, Democratic and Republican, the answer has been to permit federal funding. They have differed only as to the path forward." Royce C. Lamberth, Chief Judge. See the full text of the ruling here.

Researchers at Cedars-Sinai Medical Center and Johns Hopkins University publish results from a clinical trial in which adult stem cells were extracted from patients following a heart attack. The stem cells were grown in a petri dish and were then returned to the patients heart. In the first demonstrated case of therapeutic regeneration, the treatment decreases scarring and leads to regrowth of heart tissue.

In a decision favorable to proponents of ES cell research, the U.S. Court of Appeals for the D.C. Circuit upholds a lower court ruling that dismisses a lawsuit challenging the Obama administrations expansion of federal funding for stem cell research.

The Supreme Court announces that it will not hearSherley v. Sebelius, thereby upholding the previous ruling of the D.C. Circuit Court's ruling. This is a major victory for scientifically and ethically responsible innovative research, Bernard Siegel, spokesperson for the Stem Cell Action Coalition and executive director of the Genetics Policy Institute, says in a statement.

Researchers at the Oregon Health and Science University successfully reprogram human skin cells into ES cells, using a technique called somatic cell nuclear transfer (SCNT). By removing the DNA from an egg cell and replacing it with genetic material from a skin cell, scientists create stem cells that can be programmed into becoming many different cell types, including the contracting cardiomyocytes that make up our heart muscle. Nuclear transfer (NT)-ES cells hold great promise for regenerative medicine because the resulting stem cells are a genetic match to the skin cell donor.

An FDA-approved clinical trial finds that treatment with ES cells improves sight in over half of 18 patients suffering from macular degeneration. The study, published in The Lancet, shows that transplantation of ES cells is safe in the long-term.

The 21stCentury Cures Act includes provisions intended to assure timely regulatory review of regenerative therapies, including cell therapies enabled by stem cell therapy research.

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What is Nanomedicine? : Center for Nanomedicine

Friday, August 24th, 2018

Nanomedicine is defined as the medical application of nanotechnology. Nanomedicine can include a wide range of applications, including biosensors, tissue engineering, diagnostic devices, and many others. In the Center for Nanomedicine at Johns Hopkins, we focus on harnessing nanotechnology to more effectively diagnose, treat, and prevent various diseases. Our entire bodies are exposed to the medicines that we take, which can lead to unpleasant side effects and minimize the amount of medicine that reaches the places where it is needed. Medications can be more efficiently delivered to the site of action using nanotechnology, resulting in improved outcomes with less medication.

For example, treating cancer with current chemotherapy delivery techniques is like spraying an entire rose garden with poison in order to kill a single weed. It would be far more effective to spray a small amount of poison, directly on the weed, and save the roses. In this analogy, a cancer patients hair follicles, immune cells, and epithelia are the roses being poisoned by the chemotherapy. Using nanotechnology, we can direct the chemotherapy to the tumor and minimize exposure to the rest of the body. In addition, our nanotechnologies are more capable of bypassing internal barriers (see Technologies), further improving upon conventional nanotechnologies. Not only is our approach more effective at eradicating tumors (see Cancer under Research), but it also results in much higher quality of life for the patient.

Nanotechnology can also reduce the frequency with which we have to take our medications. Typically, the human body can very quickly and effectively remove medications, reducing the duration of action. For example, the current treatment for age-related macular degeneration (AMD) requires monthly injections into the eye in a clinical setting. However, if the medication is slowly released from the inside of a nanoparticle, the frequency of injection can be reduced to once every 6 months (see Eye under Research). The nanoparticle itself also slowly biodegrades into components that naturally occur in the body, which are also removed from the body after the medication has done its job. This exciting technology is currently being commercialized and moved toward clinical trials (see Commercialization).

Nanomedicine will lead to many more exciting medical breakthroughs. Please explore our various nanotechnology platforms and the numerous areas in which we are pursuing nanomedicine-based medical solutions.

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What is Nanomedicine? : Center for Nanomedicine

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Global catastrophic risk – Wikipedia

Friday, August 24th, 2018

Hypothetical future event that has the potential to damage human well-being on a global scale

A global catastrophic risk is a hypothetical future event which could damage human well-being on a global scale,[2] even crippling or destroying modern civilization.[3] An event that could cause human extinction or permanently and drastically curtail humanity's potential is known as an existential risk.[4]

Potential global catastrophic risks include anthropogenic risks (technology, governance, climate change) and natural or external risks.[3] Examples of technology risks are hostile artificial intelligence and destructive biotechnology or nanotechnology. Insufficient or malign global governance creates risks in the social and political domain, such as a global war, including nuclear holocaust, bioterrorism using genetically modified organisms, cyberterrorism destroying critical infrastructure like the electrical grid; or the failure to manage a natural pandemic. Problems and risks in the domain of earth system governance include global warming, environmental degradation, including extinction of species, famine as a result of non-equitable resource distribution, human overpopulation, crop failures and non-sustainable agriculture. Examples of non-anthropogenic risks are an asteroid impact event, a supervolcanic eruption, a lethal gamma-ray burst, a geomagnetic storm destroying electronic equipment, natural long-term climate change, or hostile extraterrestrial life.

Philosopher Nick Bostrom classifies risks according to their scope and intensity.[5] A "global catastrophic risk" is any risk that is at least "global" in scope, and is not subjectively "imperceptible" in intensity. Those that are at least "trans-generational" (affecting all future generations) in scope and "terminal"[clarification needed] in intensity are classified as existential risks. While a global catastrophic risk may kill the vast majority of life on earth, humanity could still potentially recover. An existential risk, on the other hand, is one that either destroys humanity (and, presumably, all but the most rudimentary species of non-human lifeforms and/or plant life) entirely or at least prevents any chance of civilization recovering. Bostrom considers existential risks to be far more significant.[6]

Similarly, in Catastrophe: Risk and Response, Richard Posner singles out and groups together events that bring about "utter overthrow or ruin" on a global, rather than a "local or regional" scale. Posner singles out such events as worthy of special attention on cost-benefit grounds because they could directly or indirectly jeopardize the survival of the human race as a whole.[7] Posner's events include meteor impacts, runaway global warming, grey goo, bioterrorism, and particle accelerator accidents.

Researchers experience difficulty in studying near human extinction directly, since humanity has never been destroyed before.[8] While this does not mean that it will not be in the future, it does make modelling existential risks difficult, due in part to survivorship bias.

Bostrom identifies four types of existential risk. "Bangs" are sudden catastrophes, which may be accidental or deliberate. He thinks the most likely sources of bangs are malicious use of nanotechnology, nuclear war, and the possibility that the universe is a simulation that will end. "Crunches" are scenarios in which humanity survives but civilization is irreversibly destroyed. The most likely causes of this, he believes, are exhaustion of natural resources, a stable global government that prevents technological progress, or dysgenic pressures that lower average intelligence. "Shrieks" are undesirable futures. For example, if a single mind enhances its powers by merging with a computer, it could dominate human civilization. Bostrom believes that this scenario is most likely, followed by flawed superintelligence and a repressive totalitarian regime. "Whimpers" are the gradual decline of human civilization or current values. He thinks the most likely cause would be evolution changing moral preference, followed by extraterrestrial invasion.[4]

Some risks, such as that from asteroid impact, with a one-in-a-million chance of causing humanity's extinction in the next century,[9] have had their probabilities predicted using straightforward, well-understood, and (in principle) precise methods (although even in cases like these, the exact rate of large impacts is contested).[10] Similarly, the frequency of volcanic eruptions of sufficient magnitude to cause catastrophic climate change, similar to the Toba Eruption, which may have almost caused the extinction of the human race,[11] has been estimated at about 1 in every 50,000 years.[12]

The relative danger posed by other threats is much more difficult to calculate. In 2008, an informal survey of small but illustrious group of experts on different global catastrophic risks at the Global Catastrophic Risk Conference at the University of Oxford suggested a 19% chance of human extinction by the year 2100. The conference report cautions that the results should be taken "with a grain of salt".[13] In November 2017, a statement by 15,364 scientists from 184 countries indicated that increasing levels of greenhouse gases from use of fossil fuels, human population growth, deforestation, and overuse of land for agricultural production, particularly by farming ruminants for meat consumption, are trending in ways that forecast an increase in human misery over coming decades.[3]

The 2016 annual report by the Global Challenges Foundation estimates that an average American is more than five times more likely to die during a human-extinction event than in a car crash.[14][15]

There are significant methodological challenges in estimating these risks with precision. Most attention has been given to risks to human civilization over the next 100 years, but forecasting for this length of time is difficult. The types of threats posed by nature may prove relatively constant, though new risks could be discovered. Anthropogenic threats, however, are likely to change dramatically with the development of new technology; while volcanoes have been a threat throughout history, nuclear weapons have only been an issue since the 20th century. Historically, the ability of experts to predict the future over these timescales has proved very limited. Man-made threats such as nuclear war or nanotechnology are harder to predict than natural threats, due to the inherent methodological difficulties in the social sciences. In general, it is hard to estimate the magnitude of the risk from this or other dangers, especially as both international relations and technology can change rapidly.

Existential risks pose unique challenges to prediction, even more than other long-term events, because of observation selection effects. Unlike with most events, the failure of a complete extinction event to occur in the past is not evidence against their likelihood in the future, because every world that has experienced such an extinction event has no observers, so regardless of their frequency, no civilization observes existential risks in its history.[8] These anthropic issues can be avoided by looking at evidence that does not have such selection effects, such as asteroid impact craters on the Moon, or directly evaluating the likely impact of new technology.[5]

Some scholars have strongly favored reducing existential risk on the grounds that it greatly benefits future generations. Derek Parfit argues that extinction would be a great loss because our descendants could potentially survive for four billion years before the expansion of the Sun makes the Earth uninhabitable.[16][17] Nick Bostrom argues that there is even greater potential in colonizing space. If future humans colonize space, they may be able to support a very large number of people on other planets, potentially lasting for trillions of years.[6] Therefore, reducing existential risk by even a small amount would have a very significant impact on the expected number of people who will exist in the future.

Exponential discounting might make these future benefits much less significant. However, Gaverick Matheny has argued that such discounting is inappropriate when assessing the value of existential risk reduction.[9]

Some economists have discussed the importance of global catastrophic risks, though not existential risks. Martin Weitzman argues that most of the expected economic damage from climate change may come from the small chance that warming greatly exceeds the mid-range expectations, resulting in catastrophic damage.[18] Richard Posner has argued that we are doing far too little, in general, about small, hard-to-estimate risks of large-scale catastrophes.[19]

Numerous cognitive biases can influence people's judgment of the importance of existential risks, including scope insensitivity, hyperbolic discounting, availability heuristic, the conjunction fallacy, the affect heuristic, and the overconfidence effect.[20]

Scope insensitivity influences how bad people consider the extinction of the human race to be. For example, when people are motivated to donate money to altruistic causes, the quantity they are willing to give does not increase linearly with the magnitude of the issue: people are roughly as concerned about 200,000 birds getting stuck in oil as they are about 2,000.[21] Similarly, people are often more concerned about threats to individuals than to larger groups.[20]

There are economic reasons that can explain why so little effort is going into existential risk reduction. It is a global good, so even if a large nation decreases it, that nation will only enjoy a small fraction of the benefit of doing so. Furthermore, the vast majority of the benefits may be enjoyed by far future generations, and though these quadrillions of future people would in theory perhaps be willing to pay massive sums for existential risk reduction, no mechanism for such a transaction exists.[5]

Some sources of catastrophic risk are natural, such as meteor impacts or supervolcanoes. Some of these have caused mass extinctions in the past.

On the other hand, some risks are man-made, such as global warming,[22] environmental degradation, engineered pandemics and nuclear war. According to the Future of Humanity Institute, human extinction is more likely to result from anthropogenic causes than natural causes.[5][23]

In 2012, Cambridge University created The Cambridge Project for Existential Risk which examines threats to humankind caused by developing technologies.[24] The stated aim is to establish within the University a multidisciplinary research centre, Centre for the Study of Existential Risk, dedicated to the scientific study and mitigation of existential risks of this kind.[24]

The Cambridge Project states that the "greatest threats" to the human species are man-made; they are artificial intelligence, global warming, nuclear war, and rogue biotechnology.[25]

It has been suggested that learning computers that rapidly become superintelligent may take unforeseen actions or that robots would out-compete humanity (one technological singularity scenario).[26] Because of its exceptional scheduling and organizational capability and the range of novel technologies it could develop, it is possible that the first Earth superintelligence to emerge could rapidly become matchless and unrivaled: conceivably it would be able to bring about almost any possible outcome, and be able to foil virtually any attempt that threatened to prevent it achieving its objectives.[27] It could eliminate, wiping out if it chose, any other challenging rival intellects; alternatively it might manipulate or persuade them to change their behavior towards its own interests, or it may merely obstruct their attempts at interference.[27] In Bostrom's book, Superintelligence: Paths, Dangers, Strategies, he defines this as the control problem.[28]

Vernor Vinge has suggested that a moment may come when computers and robots are smarter than humans. He calls this "the Singularity."[29] He suggests that it may be somewhat or possibly very dangerous for humans.[30] This is discussed by a philosophy called Singularitarianism.

Physicist Stephen Hawking, Microsoft founder Bill Gates and SpaceX founder Elon Musk have expressed concerns about the possibility that AI could evolve to the point that humans could not control it, with Hawking theorizing that this could "spell the end of the human race".[31] In 2009, experts attended a conference hosted by the Association for the Advancement of Artificial Intelligence (AAAI) to discuss whether computers and robots might be able to acquire any sort of autonomy, and how much these abilities might pose a threat or hazard. They noted that some robots have acquired various forms of semi-autonomy, including being able to find power sources on their own and being able to independently choose targets to attack with weapons. They also noted that some computer viruses can evade elimination and have achieved "cockroach intelligence." They noted that self-awareness as depicted in science-fiction is probably unlikely, but that there were other potential hazards and pitfalls.[29] Various media sources and scientific groups have noted separate trends in differing areas which might together result in greater robotic functionalities and autonomy, and which pose some inherent concerns.[32][33] Eliezer Yudkowsky believes that risks from artificial intelligence are harder to predict than any other known risks. He also argues that research into artificial intelligence is biased by anthropomorphism. Since people base their judgments of artificial intelligence on their own experience, he claims that they underestimate the potential power of AI. He distinguishes between risks due to technical failure of AI, which means that flawed algorithms prevent the AI from carrying out its intended goals, and philosophical failure, which means that the AI is programmed to realize a flawed ideology.[34]

Biotechnology can pose a global catastrophic risk in the form of bioengineered organisms (viruses, bacteria, fungi, plants or animals). In many cases the organism will be a pathogen of humans, livestock, crops or other organisms we depend upon (e.g. pollinators or gut bacteria). However, any organism able to catastrophically disrupt ecosystem functions, e.g. highly competitive weeds, outcompeting essential crops, poses a biotechnology risk.

A biotechnology catastrophe may be caused by accidentally releasing a genetically engineered organism escaping from controlled environments, by the planned release of such an organism which then turns out to have unforeseen and catastrophic interactions with essential natural or agro-ecosystems, or by intentional usage of biological agents in biological warfare, bioterrorism attacks.[35] Terrorist applications of biotechnology have historically been infrequent.[35] To what extent this is due to a lack of capabilities or motivation is not resolved.[35]

Exponential growth has been observed in the biotechnology sector and Noun and Chyba predict that this will lead to major increases in biotechnological capabilities in the coming decades.[35] They argue that risks from biological warfare and bioterrorism are distinct from nuclear and chemical threats because biological pathogens are easier to mass-produce and their production is hard to control (especially as the technological capabilities are becoming available even to individual users).[35]

Given current development, more risk from novel, engineered pathogens is to be expected in the future.[35] Pathogens may be intentionally or unintentionally genetically modified to change virulence and other characteristics.[35] For example, a group of Australian researchers unintentionally changed characteristics of the mousepox virus while trying to develop a virus to sterilize rodents.[35] The modified virus became highly lethal even in vaccinated and naturally resistant mice.[36][37] The technological means to genetically modify virus characteristics are likely to become more widely available in the future if not properly regulated.[35]

Noun and Chyba propose three categories of measures to reduce risks from biotechnology and natural pandemics: Regulation or prevention of potentially dangerous research, improved recognition of outbreaks and developing facilities to mitigate disease outbreaks (e.g. better and/or more widely distributed vaccines).[35]

(See also Natural pathogens below.)

Cyberattacks have the potential to destroy everything from personal data to electric grids. Christine Peterson, co-founder and past president of the Foresight Institute, believes a cyberattack on electric grids has the potential to be a catastrophic risk.[38] Peterson also identifies attacks on Internet of Things devices as potentially catastrophic.

Global warming refers to the warming caused by human technology since the 19th century or earlier. Global warming reflects abnormal variations to the expected climate within the Earth's atmosphere and subsequent effects on other parts of the Earth. Projections of future climate change suggest further global warming, sea level rise, and an increase in the frequency and severity of some extreme weather events and weather-related disasters. Effects of global warming include loss of biodiversity, stresses to existing food-producing systems, increased spread of known infectious diseases such as malaria, and rapid mutation of microorganisms.

It has been suggested that runaway global warming (runaway climate change) might cause Earth to become searingly hot like Venus. In less extreme scenarios, it could cause the end of civilization as we know it.[39]

An environmental or ecological disaster, such as world crop failure and collapse of ecosystem services, could be induced by the present trends of overpopulation, economic development,[40] and non-sustainable agriculture. An October 2017 report published in The Lancet stated that toxic air, water, soils, and workplaces were collectively responsible for 9 million deaths worldwide in 2015, particularly from air pollution which was linked to deaths by increasing susceptibility to non-infectious diseases, such as heart disease, stroke, and lung cancer.[41] The report warned that the pollution crisis was exceeding "the envelope on the amount of pollution the Earth can carry" and threatens the continuing survival of human societies.[41]

Most environmental scenarios involve one or more of the following: Holocene extinction event,[42] scarcity of water that could lead to approximately one half of the Earth's population being without safe drinking water, pollinator decline, overfishing, massive deforestation, desertification, climate change, or massive water pollution episodes. Detected in the early 21st century, a threat in this direction is colony collapse disorder,[43] a phenomenon that might foreshadow the imminent extinction[44] of the Western honeybee. As the bee plays a vital role in pollination, its extinction would severely disrupt the food chain.

Romanian American economist Nicholas Georgescu-Roegen, a progenitor in economics and the paradigm founder of ecological economics, has argued that the carrying capacity of Earth that is, Earth's capacity to sustain human populations and consumption levels is bound to decrease sometime in the future as Earth's finite stock of mineral resources is presently being extracted and put to use; and consequently, that the world economy as a whole is heading towards an inevitable future collapse, leading to the demise of human civilization itself.[45]:303f Ecological economist and steady-state theorist Herman Daly, a student of Georgescu-Roegen, has propounded the same argument by asserting that "... all we can do is to avoid wasting the limited capacity of creation to support present and future life [on Earth]."[46]:370

Ever since Georgescu-Roegen and Daly published these views, various scholars in the field have been discussing the existential impossibility of distributing Earth's finite stock of mineral resources evenly among an unknown number of present and future generations. This number of generations is likely to remain unknown to us, as there is little way of knowing in advance if or when mankind will eventually face extinction. In effect, any conceivable intertemporal distribution of the stock will inevitably end up with universal economic decline at some future point.[47]:253256 [48]:165 [49]:168171 [50]:150153 [51]:106109 [52]:546549 [53]:142145

Nick Bostrom suggested that in the pursuit of knowledge, humanity might inadvertently create a device that could destroy Earth and the Solar System.[54] Investigations in nuclear and high-energy physics could create unusual conditions with catastrophic consequences. For example, scientists worried that the first nuclear test might ignite the atmosphere.[55][56] More recently, others worried that the RHIC[57] or the Large Hadron Collider might start a chain-reaction global disaster involving black holes, strangelets, or false vacuum states. These particular concerns have been refuted,[58][59][60][61] but the general concern remains.

Biotechnology could lead to the creation of a pandemic, chemical warfare could be taken to an extreme, nanotechnology could lead to grey goo in which out-of-control self-replicating robots consume all living matter on earth while building more of themselvesin both cases, either deliberately or by accident.[62]

Many nanoscale technologies are in development or currently in use.[63] The only one that appears to pose a significant global catastrophic risk is molecular manufacturing, a technique that would make it possible to build complex structures at atomic precision.[64] Molecular manufacturing requires significant advances in nanotechnology, but once achieved could produce highly advanced products at low costs and in large quantities in nanofactories of desktop proportions.[63][64] When nanofactories gain the ability to produce other nanofactories, production may only be limited by relatively abundant factors such as input materials, energy and software.[63]

Molecular manufacturing could be used to cheaply produce, among many other products, highly advanced, durable weapons.[63] Being equipped with compact computers and motors these could be increasingly autonomous and have a large range of capabilities.[63]

Phoenix and Treder classify catastrophic risks posed by nanotechnology into three categories:

At the same time, nanotechnology may be used to alleviate several other global catastrophic risks.[63]

Several researchers state that the bulk of risk from nanotechnology comes from the potential to lead to war, arms races and destructive global government.[36][63][65] Several reasons have been suggested why the availability of nanotech weaponry may with significant likelihood lead to unstable arms races (compared to e.g. nuclear arms races):

Since self-regulation by all state and non-state actors seems hard to achieve,[67] measures to mitigate war-related risks have mainly been proposed in the area of international cooperation.[63][68] International infrastructure may be expanded giving more sovereignty to the international level. This could help coordinate efforts for arms control. International institutions dedicated specifically to nanotechnology (perhaps analogously to the International Atomic Energy Agency IAEA) or general arms control may also be designed.[68] One may also jointly make differential technological progress on defensive technologies, a policy that players should usually favour.[63] The Center for Responsible Nanotechnology also suggests some technical restrictions.[69] Improved transparency regarding technological capabilities may be another important facilitator for arms-control.

A grey goo is another catastrophic scenario, which was proposed by Eric Drexler in his 1986 book Engines of Creation[70] and has been a theme in mainstream media and fiction.[71][72] This scenario involves tiny self-replicating robots that consume the entire biosphere using it as a source of energy and building blocks. Nowadays, however, nanotech expertsincluding Drexlerdiscredit the scenario. According to Chris Phoenix a "so-called grey goo could only be the product of a deliberate and difficult engineering process, not an accident".[73]

The scenarios that have been explored most frequently are nuclear warfare and doomsday devices. Although the probability of a nuclear war per year is slim, Professor Martin Hellman has described it as inevitable in the long run; unless the probability approaches zero, inevitably there will come a day when civilization's luck runs out.[74] During the Cuban missile crisis, U.S. president John F. Kennedy estimated the odds of nuclear war at "somewhere between one out of three and even".[75] The United States and Russia have a combined arsenal of 14,700 nuclear weapons,[76] and there is an estimated total of 15,700 nuclear weapons in existence worldwide.[76]

While popular perception sometimes takes nuclear war as "the end of the world", experts assign low probability to human extinction from nuclear war.[77][78] In 1982, Brian Martin estimated that a USSoviet nuclear exchange might kill 400450 million directly, mostly in the United States, Europe and Russia, and maybe several hundred million more through follow-up consequences in those same areas.[77]

Nuclear war could yield unprecedented human death tolls and habitat destruction. Detonating large numbers of nuclear weapons would have an immediate, short term and long-term effects on the climate, causing cold weather and reduced sunlight and photosynthesis[79] that may generate significant upheaval in advanced civilizations.[80]

Beyond nuclear, other threats to humanity include biological warfare (BW) and bioterrorism. By contrast, chemical warfare, while able to create multiple local catastrophes, is unlikely to create a global one.

The 20th century saw a rapid increase in human population due to medical developments and massive increases in agricultural productivity[81] such as the Green Revolution.[82] Between 1950 and 1984, as the Green Revolution transformed agriculture around the globe, world grain production increased by 250%. The Green Revolution in agriculture helped food production to keep pace with worldwide population growth or actually enabled population growth. The energy for the Green Revolution was provided by fossil fuels in the form of fertilizers (natural gas), pesticides (oil), and hydrocarbon-fueled irrigation.[83] David Pimentel, professor of ecology and agriculture at Cornell University, and Mario Giampietro, senior researcher at the National Research Institute on Food and Nutrition (INRAN), place in their 1994 study Food, Land, Population and the U.S. Economy the maximum U.S. population for a sustainable economy at 200 million. To achieve a sustainable economy and avert disaster, the United States must reduce its population by at least one-third, and world population will have to be reduced by two-thirds, says the study.[84]

The authors of this study believe that the mentioned agricultural crisis will begin to have an effect on the world after 2020, and will become critical after 2050. Geologist Dale Allen Pfeiffer claims that coming decades could see spiraling food prices without relief and massive starvation on a global level such as never experienced before.[85][86]

Wheat is humanity's third-most-produced cereal. Extant fungal infections such as Ug99[87] (a kind of stem rust) can cause 100% crop losses in most modern varieties. Little or no treatment is possible and infection spreads on the wind. Should the world's large grain-producing areas become infected, the ensuing crisis in wheat availability would lead to price spikes and shortages in other food products.[88]

Several asteroids have collided with earth in recent geological history. The Chicxulub asteroid, for example, is theorized to have caused the extinction of the non-avian dinosaurs 66 million years ago at the end of the Cretaceous. No sufficiently large asteroid currently exists in an Earth-crossing orbit; however, a comet of sufficient size to cause human extinction could impact the Earth, though the annual probability may be less than 108.[89] Geoscientist Brian Toon estimates that a 60-mile meteorite would be large enough to "incinerate everybody".[90] Asteroids with around a 1km diameter have impacted the Earth on average once every 500,000 years; these are probably too small to pose an extinction risk, but might kill billions of people.[89][91] Larger asteroids are less common. Small near-Earth asteroids are regularly observed. As of 2013, Spaceguard estimates it has identified 95% of all NEOs over 1km in size.[92]

In 1.4 million years, the star Gliese 710 is expected to start causing an increase in the number of meteoroids in the vicinity of Earth when it passes within 1.1 light-years of the Sun, perturbing the Oort cloud. Dynamic models by Garca-Snchez predict a 5% increase in the rate of impact.[93] Objects perturbed from the Oort cloud take millions of years to reach the inner Solar System.

In April 2018, the B612 Foundation reported "It's a 100 per cent certain we'll be hit [by a devastating asteroid], but we're not 100 per cent sure when."[94][95] In June 2018, the US National Science and Technology Council warned that America is unprepared for an asteroid impact event, and has developed and released the "National Near-Earth Object Preparedness Strategy Action Plan" to better prepare.[96][97][98][99][100]

Extraterrestrial life could invade Earth[101] either to exterminate and supplant human life, enslave it under a colonial system, steal the planet's resources, or destroy the planet altogether.

Although evidence of alien life has never been documented, scientists such as Carl Sagan have postulated that the existence of extraterrestrial life is very likely. In 1969, the "Extra-Terrestrial Exposure Law" was added to the United States Code of Federal Regulations (Title 14, Section 1211) in response to the possibility of biological contamination resulting from the U.S. Apollo Space Program. It was removed in 1991.[102] Scientists consider such a scenario technically possible, but unlikely.[103]

An article in The New York Times discussed the possible threats for humanity of intentionally sending messages aimed at extraterrestrial life into the cosmos in the context of the SETI efforts. Several renowned public figures such as Stephen Hawking and Elon Musk have argued against sending such messages on the grounds that extraterrestrial civilizations with technology are probably far more advanced than humanity and could pose an existential threat to humanity.[104]

Climate change refers to a lasting change in the Earth's climate. The climate has ranged from ice ages to warmer periods when palm trees grew in Antarctica. It has been hypothesized that there was also a period called "snowball Earth" when all the oceans were covered in a layer of ice. These global climatic changes occurred slowly, prior to the rise of human civilization about 10 thousand years ago near the end of the last Major Ice Age when the climate became more stable. However, abrupt climate change on the decade time scale has occurred regionally. Since civilization originated during a period of stable climate, a natural variation into a new climate regime (colder or hotter) could pose a threat to civilization.

In the history of the Earth, many ice ages are known to have occurred. More ice ages will be possible at an interval of 40,000100,000 years. An ice age would have a serious impact on civilization because vast areas of land (mainly in North America, Europe, and Asia) could become uninhabitable. It would still be possible to live in the tropical regions, but with possible loss of humidity and water. Currently, the world is in an interglacial period within a much older glacial event. The last glacial expansion ended about 10,000 years ago, and all civilizations evolved later than this. Scientists do not predict that a natural ice age will occur anytime soon. This may be due to manmade emissions potentially delaying the possible onset or another ice age for at least another 50,000 years.

A number of astronomical threats have been identified. Massive objects, e.g. a star, large planet or black hole, could be catastrophic if a close encounter occurred in the Solar System. In April 2008, it was announced that two simulations of long-term planetary movement, one at the Paris Observatory and the other at the University of California, Santa Cruz, indicate a 1% chance that Mercury's orbit could be made unstable by Jupiter's gravitational pull sometime during the lifespan of the Sun. Were this to happen, the simulations suggest a collision with Earth could be one of four possible outcomes (the others being Mercury colliding with the Sun, colliding with Venus, or being ejected from the Solar System altogether). If Mercury were to collide with Earth, all life on Earth could be obliterated entirely: an asteroid 15km wide is believed to have caused the extinction of the non-avian dinosaurs, whereas Mercury is 4,879km in diameter.[105]

Another cosmic threat is a gamma-ray burst, typically produced by a supernova when a star collapses inward on itself and then "bounces" outward in a massive explosion. Under certain circumstances, these events are thought to produce massive bursts of gamma radiation emanating outward from the axis of rotation of the star. If such an event were to occur oriented towards the Earth, the massive amounts of gamma radiation could significantly affect the Earth's atmosphere and pose an existential threat to all life. Such a gamma-ray burst may have been the cause of the OrdovicianSilurian extinction events. Neither this scenario nor the destabilization of Mercury's orbit are likely in the foreseeable future.[106]

If the Solar System were to pass through a dark nebula, a cloud of cosmic dust, severe global climate change would occur.[107]

A powerful solar flare or solar superstorm, which is a drastic and unusual decrease or increase in the Sun's power output, could have severe consequences for life on Earth.

If our universe lies within a false vacuum, a bubble of lower-energy vacuum could come to exist by chance or otherwise in our universe, and catalyze the conversion of our universe to a lower energy state in a volume expanding at nearly the speed of light, destroying all that we know without forewarning.[108][further explanation needed] Such an occurrence is called vacuum decay.

The magnetic poles of the Earth shifted many times in geologic history. The duration of such a shift is still debated. Theories exist that during such times, the Earth's magnetic field would be substantially weakened, threatening civilization by allowing radiation from the Sun, especially solar wind, solar flares or cosmic radiation, to reach the surface. These theories have been somewhat discredited, as statistical analysis shows no evidence for a correlation between past reversals and past extinctions.[109][110]

Numerous historical examples of pandemics[111] had a devastating effect on a large number of people. The present, unprecedented scale and speed of human movement make it more difficult than ever to contain an epidemic through local quarantines. A global pandemic has become a realistic threat to human civilization.

Naturally evolving pathogens will ultimately develop an upper limit to their virulence.[112] Pathogens with the highest virulence, quickly killing their hosts reduce their chances of spread the infection to new hosts or carriers.[113] This simple model predicts that - if virulence and transmission are not genetically linked - pathogens will evolve towards low virulence and rapid transmission. However, this is not necessarily a safeguard against a global catastrophe, for the following reasons:

1. The fitness advantage of limited virulence is primarily a function of a limited number of hosts. Any pathogen with a high virulence, high transmission rate and long incubation time may have already caused a catastrophic pandemic before ultimately virulence is limited through natural selection.2. In models where virulence level and rate of transmission are related, high levels of virulence can evolve.[114] Virulence is instead limited by the existence of complex populations of hosts with different susceptibilities to infection, or by some hosts being geographically isolated.[112] The size of the host population and competition between different strains of pathogens can also alter virulence.[115] 3. A pathogen that infects humans as a secondary host and primarily infects another species (a zoonosis) has no constraints on its virulence in people, since the accidental secondary infections do not affect its evolution.[116]

Naturally evolving organisms, like the products of biotechnology, can disrupt essential ecosystem functions.

An example of a pathogen able to threaten global food security is the wheat rust Ug99.

Other examples are neobiota (invasive species), i.e. organisms that become disruptive to ecosystems once transportedoften as a result of human activityto a new geographical region. Normally the risk is a local disruption. If it becomes coupled with serious crop failures and a global famine it may, however, pose a global catastrophic risk.

A remote possibility is a megatsunami. It has been suggested that a megatsunami caused by the collapse of a volcanic island could, for example, destroy the entire East Coast of the United States, but such predictions are based on incorrect assumptions and the likelihood of this happening has been greatly exaggerated in the media.[117] While none of these scenarios are likely to destroy humanity completely, they could regionally threaten civilization. There have been two recent high-fatality tsunamisafter the 2011 Thoku earthquake and the 2004 Indian Ocean earthquake. A megatsunami could have astronomical origins as well, such as an asteroid impact in an ocean.[118]

A geological event such as massive flood basalt, volcanism, or the eruption of a supervolcano[119] could lead to a so-called volcanic winter, similar to a nuclear winter. One such event, the Toba eruption,[120] occurred in Indonesia about 71,500 years ago. According to the Toba catastrophe theory,[121] the event may have reduced human populations to only a few tens of thousands of individuals. Yellowstone Caldera is another such supervolcano, having undergone 142 or more caldera-forming eruptions in the past 17 million years.[122]A massive volcano eruption would eject extraordinary volumes of volcanic dust, toxic and greenhouse gases into the atmosphere with serious effects on global climate (towards extreme global cooling: volcanic winter if short-term, and ice age if long-term) or global warming (if greenhouse gases were to prevail).

When the supervolcano at Yellowstone last erupted 640,000 years ago, the thinnest layers of the ash ejected from the caldera spread over most of the United States west of the Mississippi River and part of northeastern Mexico. The magma covered much of what is now Yellowstone National Park and extended beyond, covering much of the ground from Yellowstone River in the east to the Idaho falls in the west, with some of the flows extending north beyond Mammoth Springs.[123]

According to a recent study, if the Yellowstone caldera erupted again as a supervolcano, an ash layer one to three millimeters thick could be deposited as far away as New York, enough to "reduce traction on roads and runways, short out electrical transformers and cause respiratory problems". There would be centimeters of thickness over much of the U.S. Midwest, enough to disrupt crops and livestock, especially if it happened at a critical time in the growing season. The worst-affected city would likely be Billings, Montana, population 109,000, which the model predicted would be covered with ash estimated as 1.03 to 1.8 meters thick.[124]

The main long-term effect is through global climate change, which reduces the temperature globally by about 515 degrees C for a decade, together with the direct effects of the deposits of ash on their crops. A large supervolcano like Toba would deposit one or two meters thickness of ash over an area of several million square kilometers.(1000 cubic kilometers is equivalent to a one-meter thickness of ash spread over a million square kilometers). If that happened in some densely populated agricultural area, such as India, it could destroy one or two seasons of crops for two billion people.[125]

However, Yellowstone shows no signs of a supereruption at present, and it is not certain that a future supereruption will occur there.[126][127]

Research published in 2011 finds evidence that massive volcanic eruptions caused massive coal combustion, supporting models for significant generation of greenhouse gases. Researchers have suggested that massive volcanic eruptions through coal beds in Siberia would generate significant greenhouse gases and cause a runaway greenhouse effect.[128] Massive eruptions can also throw enough pyroclastic debris and other material into the atmosphere to partially block out the sun and cause a volcanic winter, as happened on a smaller scale in 1816 following the eruption of Mount Tambora, the so-called Year Without a Summer. Such an eruption might cause the immediate deaths of millions of people several hundred miles from the eruption, and perhaps billions of deaths[129] worldwide, due to the failure of the monsoon[citation needed], resulting in major crop failures causing starvation on a profound scale.[129]

A much more speculative concept is the verneshot: a hypothetical volcanic eruption caused by the buildup of gas deep underneath a craton. Such an event may be forceful enough to launch an extreme amount of material from the crust and mantle into a sub-orbital trajectory.

Planetary management and respecting planetary boundaries have been proposed as approaches to preventing ecological catastrophes. Within the scope of these approaches, the field of geoengineering encompasses the deliberate large-scale engineering and manipulation of the planetary environment to combat or counteract anthropogenic changes in atmospheric chemistry. Space colonization is a proposed alternative to improve the odds of surviving an extinction scenario.[130] Solutions of this scope may require megascale engineering.Food storage has been proposed globally, but the monetary cost would be high. Furthermore, it would likely contribute to the current millions of deaths per year due to malnutrition.[citation needed]

Some survivalists stock survival retreats with multiple-year food supplies.

The Svalbard Global Seed Vault is buried 400 feet (120m) inside a mountain on an island in the Arctic. It is designed to hold 2.5 billion seeds from more than 100 countries as a precaution to preserve the world's crops. The surrounding rock is 6C (21F) (as of 2015) but the vault is kept at 18C (0F) by refrigerators powered by locally sourced coal.[131][132]

More speculatively, if society continues to function and if the biosphere remains habitable, calorie needs for the present human population might in theory be met during an extended absence of sunlight, given sufficient advance planning. Conjectured solutions include growing mushrooms on the dead plant biomass left in the wake of the catastrophe, converting cellulose to sugar, or feeding natural gas to methane-digesting bacteria.[133][134]

Insufficient global governance creates risks in the social and political domain, but the governance mechanisms develop more slowly than technological and social change. There are concerns from governments, the private sector, as well as the general public about the lack of governance mechanisms to efficiently deal with risks, negotiate and adjudicate between diverse and conflicting interests. This is further underlined by an understanding of the interconnectedness of global systemic risks.[135]

The Bulletin of the Atomic Scientists (est. 1945) is one of the oldest global risk organizations, founded after the public became alarmed by the potential of atomic warfare in the aftermath of WWII. It studies risks associated with nuclear war and energy and famously maintains the Doomsday Clock established in 1947. The Foresight Institute (est. 1986) examines the risks of nanotechnology and its benefits. It was one of the earliest organizations to study the unintended consequences of otherwise harmless technology gone haywire at a global scale. It was founded by K. Eric Drexler who postulated "grey goo".[136][137]

Beginning after 2000, a growing number of scientists, philosophers and tech billionaires created organizations devoted to studying global risks both inside and outside of academia.[138]

Independent non-governmental organizations (NGOs) include the Machine Intelligence Research Institute (est. 2000) which aims to reduce the risk of a catastrophe caused by artificial intelligence and the Singularity.[139] The top donors include Peter Thiel and Jed McCaleb.[140] The Lifeboat Foundation (est. 2009) funds research into preventing a technological catastrophe.[141] Most of the research money funds projects at universities.[142] The Global Catastrophic Risk Institute (est. 2011) is a think tank for all things catastrophic risk. It is funded by the NGO Social and Environmental Entrepreneurs. The Global Challenges Foundation (est. 2012), based in Stockholm and founded by Laszlo Szombatfalvy, releases a yearly report on the state of global risks.[14][15] The Future of Life Institute (est. 2014) aims to support research and initiatives for safeguarding life considering new technologies and challenges facing humanity.[143] Elon Musk is one of its biggest donors.[144] The Nuclear Threat Initiative seeks to reduce global threats from nuclear, biological and chemical threats, and containment of damage after an event.[145] It maintains a nuclear material security index.[146]

University-based organizations include the Future of Humanity Institute (est. 2005) which researches the questions of humanity's long-term future, particularly existential risk. It was founded by Nick Bostrom and is based at Oxford University. The Centre for the Study of Existential Risk (est. 2012) is a Cambridge-based organization which studies four major technological risks: artificial intelligence, biotechnology, global warming and warfare. All are man-made risks, as Huw Price explained to the AFP news agency, "It seems a reasonable prediction that some time in this or the next century intelligence will escape from the constraints of biology". He added that when this happens "we're no longer the smartest things around," and will risk being at the mercy of "machines that are not malicious, but machines whose interests don't include us."[147] Stephen Hawking was an acting adviser. The Millennium Alliance for Humanity and the Biosphere is a Stanford University-based organization focusing on many issues related to global catastrophe by bringing together members of academic in the humanities.[148][149] It was founded by Paul Ehrlich among others.[150] Stanford University also has the Center for International Security and Cooperation focusing on political cooperation to reduce global catastrophic risk.[151]

Other risk assessment groups are based in or are part of governmental organizations. The World Health Organization (WHO) includes a division called the Global Alert and Response (GAR) which monitors and responds to global epidemic crisis.[152] GAR helps member states with training and coordination of response to epidemics.[153] The United States Agency for International Development (USAID) has its Emerging Pandemic Threats Program which aims to prevent and contain naturally generated pandemics at their source.[154] The Lawrence Livermore National Laboratory has a division called the Global Security Principal Directorate which researches on behalf of the government issues such as bio-security, counter-terrorism, etc.[155]

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Myths and Misconceptions About Stem Cell Research …

Wednesday, August 22nd, 2018

En Espaol

There is no shortage of myths and misconceptions when it comes to stem cell research and regenerative medicine. Here we address the most common concerns.

If you have more questions that aren't addressed here, please visit our other Stem Cell FAQ pages.

Is CIRM-funded stem cell research carried out ethically?Where do the embryos come from to create stem cell lines?I'm opposed to abortion. Can embryonic stem cell lines come from aborted fetuses?Does creating stem cell lines destroy the embryo?Are adult stem cells as goodor betterthan embryonic stem cells?Don't iPS cells eliminate the need to use embryos in stem cell research?Can't stem cell research lead to human cloning?

Stem cell research, like any fieldwithin biomedicine, poses social and ethical concerns. CIRM, as well as the broader research community, takes these seriously.

As a state funding body, CIRM has comprehensive policies to govern research, similar to our national counterpart, the National Institutes of Health. CIRM-funded researchers must comply with a comprehensive set of regulations that have been carefully developed and are in accordance with national and international standards.

These regulations were among the first formal policies governing the conduct of stem cell research and are in accordance with recommendations from the National Academies and from the International Society for Stem Cell Research. CIRMs Standards Working Group meets regularly to consider new ethical challenges as the science progresses and to revise standards to reflect the current state of the research.

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CIRM regulationsNational Academies of Science guidelinesInternational Society for Stem Cell Research guidelinesNational Academies of Science podcast about guidelines for embryonic stem cell research More about CIRM-grantee ethics training (4:03)

All the human embryonic stem cell lines currently in use come from four to five day-old embryos left over from in vitro fertilization (IVF) procedures. In IVF, researchers mix a man's sperm and a woman's eggs together in a lab dish. Some of those eggs will become fertilized. At about five days the egg has divided to become a hollow ball of roughly 100 cells called a blastocyst which is smaller than the size of the dot over an i. It is these very early embryos that are implanted into the woman in the hopes that she becomes pregnant.

Each cycle of IVF can produce many blastocysts, some of which are implanted into the woman. The rest are stored in the IVF clinic freezer. After a successful implantation, they must decide what to do with any remaining embryos. There are a few options:

Some embryonic stem cell lines also come from embryos that a couple has chosen not to implant because they carry harmful genetic mutations like the ones that cause cystic fibrosis or Tay Sachs disease. These are discovered through routine genetic testing prior to implantation. Still other embryos might be malformed in some way that causes them to be rejected for implantation into the mother. Embryos with genetic defects of malformations would have been discarded if the couple had not chosen to donate them to stem cell research.

People who donate leftover embryos for research go through an extensive consent process to ensure that they understand embryonic stem cell research. Under state, national and international regulations, no human embryonic stem cell lines can be created without explicit consent from the donor.

Policies vary as to whether women may be paid or otherwise compensated to donate eggs. Most jurisdictions allow donors to be reimbursed for direct costs such as travel to the clinic or lodging. Some also allow payments or IVF services to be provided to egg donors.

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How do scientists create stem cell lines from left over IVF embryos? (4:11)

No. Emybronic stem cells only come from four to five day old blastocysts or younger embryos.

In most cases, yes. The hollow blastocystwhich is where embryonic stem cells come fromcontains a cluster of 20-30 cells called the inner cell mass. These are the cells that become embryonic stem cells in a lab dish. The process of extracting these cells destroys the embryo.

Dont forget that the embryos were donated from IVF clinics. They had either been rejected for implantation and were going to be destroyed, or the couple had decided to stop storing the embryos for future use. The embryos used to create embryonic stem cell lines were already destined to be destroyed.

There is, however, a second method that creates embryonic stem cell lines without destroying the embryo. Instead, scientists take a single cell from a very early stage IVF embryo and can use that one cell to develop a new line. The process of removing one cell from an early stage embryo has been done for many years as a way of testing the embryo for genetic predisposition to diseases such as Tay Sachs. This process is called preimplantation genetic testing.

Adult stem cells are extremely valuable and have great potential for future therapies. However, these cells are very restricted in what they can do. Unlike embryonic stem cells, which can grow into virtually any cell type in the body, adult stem cells can only follow certain paths.

For example, Blood-forming stem cells can grow into mature blood cells, and brain stem cells may be able to grow into mature neurons, but a blood-forming stem cell cant grow into a neuron, and vice versa. Whats more, adult stem cells dont grow indefinitely in the lab, unlike embryonic stem cells, and they arent as flexible in the types of diseases they can treat.

And, while the news is full of stories about people who had great results from adult stem cell therapies, few of these therapies are part of big trials that can test whether a potential therapy is safe and effective. Until some of these large trials take place with both adult and embryonic stem cells we won't know which type of stem cell is superior. Even researchers who study adult stem cells advocate working with embryonic cells as well.

CIRM is excited about their potential for treating some diseases. However, our goal is to accelerate new treatments for diseases in need. At this time the most effective way of doing that is by exploring all types of stem cells. That's why CIRM has funded researchers pursuing a wide range of approaches to finding cures for diseases.

See how much of CIRM's funding has gone to different types of stem cells here: Overview of CIRM Stem Cell Research Funding.

Filter our list of all funded CIRM grants to see awards using different cell types.

How are adult stem cell different from embryonic stem cells? (3:29)

Induced pluripotent stem cells, or iPS cells, represent another type of cell that could be used for stem cell research. . iPS cells are adult cellsusually skin cellsthat scientists genetically reprogram to appear like embryonic stem cells. The technology used to generate human iPS cells, pioneered by Shinya Yamanaka in 2007, is very promising, which is why CIRM has funded many grants that create and use these cells to study or treat disease. However, iPS cell technology is very new and scientists are looking into whether those cells have the same potential as human embryonic stem cells and whether the cells are safe for transplantation.Many CIRM-funded researchers are working to find better ways of creating iPS cells that are both safe and effective.

Experts agree that research on all types of stem cells is critical. In September 2008, a panel of experts convened by the U.S. National Academy of Sciences stated that the use of human embryonic stem cells is still necessary. As panel chair Richard Hynes of the Massachusetts Institute of Technology stated:

It is far from clear at this point which types of cell types will prove to be the most useful for regenerative medicine, and it is likely that each will have some utility.

See a video about creating iPS cells (3:40)

No. Every significant regulatory and advisory body has restrictions on reproductive cloning. The National Academy of Sciences has issued guidelines banning the technique as has the International Society for Stem Cell Research. The California constitution and CIRM regulations specifically prohibit reproductive cloning with its funding.

Updated 2/16

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Longevity FAQ Laura Deming

Wednesday, August 22nd, 2018

Senescent cell removal135%2016Does not affect rotarod performance, object discrimination. Slight delay in wound closure.1Rapamycin110%2009Late-life rapamyicn treatment extends lifespan (pooled females from multiple-site NIA study)2NR105%2016Claim an increase in running distance3Catalase117%2005Mitochondrially-targeted catalase expression extended mouse lifespan compared to control4Sirt6 overexpression115%2012Sirt6-overexpression increases male mouse lifespan5Metformin106%2013In males, small but significant lifespan extension after metformin application6DN-IB110%2013Dominant negative to downregulate IKK-beta activity, delivered to hypothalamus of middle-aged mice7Klotho120%2005Overexpression under human elongation factor 1 promoter increases lifespan, slight fertility loss8S6K1118%2009KO of S6K1 extends lifspan compared to wildtype mice9p66128%1999Mutation of a p66shc, member of proto-oncogene locus SHC, extends lifespan. May be just due to cancer effect.10Lowering protein:carbohydrate ratio128%2014Varied protein, carbohydrate, and total energy levels.11Fat-specific insulin receptor knockout mice111%2003Fat-specific insulin receptor knockout mice show a significant increase in lifespan12C57BL/6 mice with NZB/OlaHsd mitochondrial mutations120%2016Same nuclear, different mitochondrial DNA.13Fasting mimicking diet112%2015FMD followed by 10 days of normal, then repeat14Rapamycin127%2014Rapamycin from 9 months of age, weight decreased ~30% at highest dose15Brain-specific Sirt1 expression116%2013Brain-specific Sirt1 expression in female mice increases lifespan over wildtype16SRT1720104%2014Start diet at 28 weeks of age, very small increase on lifespan17Spermidine111%2016Polyamine, administered in drinking water18Atg5 overexpression117%2013Transgenic mice ubiquitously expressing Atg5 (crucial for autophagasome confirmation) live longer.19Telomerase124%2012Paper showing telomerase therapy increasing life20Insulin receptor substrate null132%2008Insulin receptor substrate 1 null mouse lifespan extension in females21Snell Dwarf Mice142%2001Snell dwarf mouse paper showing life extension22Ames Dwarf Mice168%1996Original Ames dwarf mouse paper showing life extension23s-Arf/p53113%2007An extra copy of p53 and upstream regulator Arf/p16Ink4a increases lifespan24Slow growth during lactation106%2004Male mice suckled by dams fed a low-protein diet lived longer than their control cohort25Methionine restriction111%2005Methionine restriction increases mouse lifespan, here median lifespan increase in mice that survived at least 1 yr.26Rapamycin (3 months)114%2016Lifespan given from time of treatment which was 23-24 mo, used 24 mo to get percentage so this is an estimate27GHR-BP138%2000Mice deficient in growth hormone receptor / binding protein live longer (female mean, not median, lifespan shown here)28mTOR116%2013mTOR depletion extends lifespan29PTEN overexpression112%2012Overexpression of PTEN, a tumor suppressor which counteracts PI3K, extends mouse lifespan30Myc (+/-)121%2015Claim no correlation between weight and lifespan31FGF-21139%2012Hepatic-specific expression of FGF-21 (which suppresses growth hormone and reduces the production of IGF) increases lifespan, female lifespan shown here32BubR1 overexpression114%2012Kinase which localizes to kinetochore, overexpression increases lifespan33AC5 KO132%2007AC5 knockount mice lived longer than control, potentially linked to effects on cAMP production and beta-adrenergic receptor signaling.3417-alpha-estradiol112%201317-alpha-estradiol extended lifespan in males, but not females (as expected)35Acarbose122%2013Acarbose extended male more than female lifespan36TRPV1 -/-114%2014Resting exchange ratio similar at 16 mo to 3 mo37SRT2104106%2014Start diet at 28 weeks of age, very small increase if there38Hcrt-UCP2128%2006UCP2 under hypocretin promoter lowers core body temp, increases lifespan39G6PD overexpression114%2016Reduces NADP+40IGF-1 Receptor Brain KO (+/-)109%2008Brain-specific IGF-1 Receptor +/- mice live longer than WT41SURF-1 KO121%2007Mutations in SURF1, a cytochrome c oxidase assembly factor, extend lifespan. Mitochondrial.42Litter enlargemnet (CR)118%200950% enlargement of litter in first 20 days, to induce caloric restriction43mclk-1 heterozygous115%2005A heterozygous knockout of mclk1 (important in mitochondrial respiration) results in mouse lifespan extension compared to wildtype44Nordihydroguairaitic acid112%2008NDGA and aspirin extend lifespan by a little bit. Small molecule.45Aspirin108%2008NDGA and aspirin extend lifespan by a little bit. Small molecule.46SOD mimetic carboxyfullerene115%2008Carboxyfullerene, described as an SOD mimetic, increased the lifespan of treated mice compared to wildtype control47Removal of visceral fat tissue108%2008Removal of visceral fat tissue increases lifespan over control48Low glycotoxin diet112%2007Low glycotoxin (low levels of AGE's) shown to extend lifespan49Per2 (-/-)118%2016Lifespan study incomplete50Neonatal metformin120%2015Animals recieved on 3, 5, 7th day after birth - bad for females, good for males.51GHRH KO146%2013GHRH (Growth-Hormone Releasing Hormone) disruption extends lifespan, presumably through the insulin/IGF pathway axis52Sod-2 overexpresion104%2007Overexpression of SOD-2 targeted to the mitochondrion increases mouse lifespan relative to wildtype53Metallothionein cardiac-specific expression114%2006Cardiac-specific expression of antioxidant metallothionein extended the lifespan of wildtype mice compared to WT FVB control.54IGF1R(+/-)121%2013Tyrosine kinase receptor activated by IGF1/255Ink4a/Arf/Ink4b116%2009Encodes 2 CDKs (p16 and p15), and Arf (upstream of p53)56Adult-onset Ghr (-/-)100%2016Male mice have >2x higher insulin than female mice57Ovary Transplantation117%2003Original paper showing that transplantation of young ovaries into old animals could result in lifespan increase58UCP-1 transgenic111%2007Transgenic mice with skeletal muscle-specific UCP1 had increased longevity. Small increase if there.59PAPP131%2010Knockout of PAPP-A (which enhances IGF-1 activity by degrading the inhibitory IGF-binding protein) increases lifespan over wildtype, female lifespan shown here60CR diet with lard132%201540% decrease starting at 4 months61loss of function of Riib (PKA subunit)114%2009Knockout of RIIbeta, a subunit of PKA, increased lifespan in mice compared to wildtype62Myostatin (+/-)109%2015Knockout induces double-muscle mice63Akt1 +/-113%2013Haploinsufficiency of Akt1 increases mouse lifespan relative to wildtype. Insulin/IGF-1 pathway.64miR-17117%2014Not clear if there is a main function for miR-1765NDGA111%2015Makes up ~12.5% of the dry weight of leaves66FAT10ko119%2014Ubiquitin-like protein which can signal for protein to go to proteasome.67Intranasal Hsp70116%2015Seemed to extend lifespan when started at 17 months68RasGRF1(-/-)120%2011Ras-guanine nucleotide exchange factor (Ras-GRF1) -/- mice displayed increased lifespan compared to wildtype.69Lmna-Lcs (Lamin C alone)113%2014Body weight and tumor incidence increase in mice expressing only Lamin-C70Cisd2 overexpression119%2011Cisd2 transgenic mice (expressing more of it) lived longer than wildtype. Cisd2 is a transmembrane protein expressed on the mitochondrial outer membrane and associated with a human longevity locus.71metoprolol110%2013Administration of the beta-adrenerginc receptor blocker metoprolol to mice increased lifespan compared to wildtype72nebivolol106%2013Administration of the beta-adrenerginc receptor blocker nebivolol to mice increased lifespan compared to wildtype73uPA (in ocular lens/CNS nerve cells)118%1997uPA expression under alpha-crystallin promoter increases lifespan, small/eat less74MIF-1 KO116%2010MIF-1 knockout mutant (T-cell derived cytokine) extends lifespan75mGsta4-null113%2009Enzyme protects against lipid peroxidation, weird that less of its activity might increase lifespan76Muscle-specific GHRKO109%2015Knockout under muscle creatinine kinase promoter77CAM-(1A)AR mice110%2011Mice with a constitutively active mutant form of the alpha1-adrenergic receptor (CAM-alpha1aAR) lived longer than wildtype control78Cardiac-specific catalase overexpression113%2007Overexpression of catalase specifically in the heart in mice79Icariin108%2015Flavonoid80miR-29 brain-specific KO112%2016miR-29 highly expresed in brain during development81Bi-maternal mice128%2010Mice prepared to be bi-maternal were found longer-lived than their normal cohort82RNase-L(-/-)127%2007Knockout of RNase-L, which accelerates cell senescence when expressed, increases lifespan in mice compared to wildtype83hMTH1-Tg116%2013Express high levels of hMTH1 hydrolase, thought to degrade 8-oxodGTP and 8-oxoGTP. Oxidative stress.84DGAT-1 -/-126%2012Knockout of DGAT1, which catalyzes triglyceride synthesis, extends mouse lifespan relative to wildtype85IGFBP-2 overexpression105%2016Proteins bind IGF1/2, degraded during pregnancy, delay in sexual maturity86PAPP-A on high-fat diet105%2015Males chosen so no adverse developmental effect on fat depots87clk-1(-/-) with clk-1 transgene128%2014clk-1 functions in ubiquinone synthesis, but levels weren't very affected.88AgRP -/-110%2006Neuropeptide that is appetite stimulator, overexpression leads to hyperphagia and obesity.89Bone marrow transplantation106%2013Bone marrow transplantation from young to old mice was claimed to extend lifespan90Young blood injections94%2014Resulted in decreased lifespan91Nas(-/-) mice125%2011Hyposulfatemic NaS1 null mice (Nas1 -/-) had an increased lifespan compared to wildtype control.92Cyclophilin D (+/-)119%2017Decrease in maximum lifespan93PAPP-A in adults120%2017Tamoxifen-induced knockdown94Mtbp (+/-)120%2016Rotarod, open field, blood glucose, insulin, IGF-1 were the same.95

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Longevity FAQ Laura Deming

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Blindness (Harvest Book): Jose Saramago, Giovanni Pontiero …

Wednesday, August 22nd, 2018

This is a shattering work by a literary master.The Boston Globe

This is an important book, one that is unafraid to face all of the horrors of the century.The Washington Post

Symphonic . . . [There is] a clear-eyed and compassionate acknowledgment of things as they are, a quality that can only honestly be termed wisdom. We should be grateful when it is handed to us in such generous measure.The New York Times Book Review

Saramago's surreal allegory explores the ability of the human spirit to prevail in even the most absurdly unjust of conditions, yet he reinvents this familiar struggle with the stylistic eccentricity of a master.The New Yorker

Extraordinarily nuanced and evocative . . . This year's most propulsive, and most profound, thriller.The Village Voice

Like Jonathan Swift, Saramago uses airily matter-of-fact detail to frame a bitter parable; unlike Swift he pierces the parable with a dart of steely tenderness . . . out of leisurely prose, the ferocity and tenderness shoot suddenly: arrows set alight. . . . Enchanting, sinuous dialogue.TheLos Angeles Times

Blindness may be as revolutionary in its own way and time as were, say, The Trial and The Plague in theirs. Another masterpiece.Kirkus Reviews (starred review)

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Biotechnology – NCEA Biology

Wednesday, August 22nd, 2018

91607Demonstrate understanding of human manipulations of genetic transfer and its biological implicationsIntroduction to the standard and key words listA super amazing (it really is) place to start.This assessment could be run as a research task by your teachers so the content will only be provided to understand the concepts around the standard. The main idea is that you will be looking at two biological manipulations (that's something that us humans have done directly to a genome of an animal or plant) and linking this to multiple implications for THAT organism. Remember this standard is not about the human implications and only how it affects the organism or populations. Make sure you build a good understanding as whatever you do will have to be from your own perspective/ words. The big idea for 91607 is on how humans are potentially impacting on and changing the rate and direction of the evolution of populations so make sure you focus on this during your research/ classroom learning.You will need to know about the following topics before doing your assessment. Down the bottom of the page many of these are covered.

As biological knowledge and techniques have developed the actual processes used change. When you are researching you have to try to sort out what techniques have been used in the past and what are being used now. Usually the longer a process has been used the more automated it becomes. Another change, for example, is that when the sequence of a gene becomes known the gene can be produced rather than isolated from the genes in an organism.

When researching on the internet it is important to look at the age of the info you are reading.....one way is to use the dates of any material being referenced and a second is to look at the last date the info was updated. eg look at this site which contains good basic info about how the processes used to be carried out Transgenic cropsLook at the dates of referenced material - 1997, 1998, 1999, and last updated says "March 11, 2004"(from studyit.org ST5)

term

Link to information covering this

annealing

How PCR Works

An animation of the process.

blunt ends

cloning

Animation

Early experiments

Animation

DNA profiling

DNA Applications Choose "Recovering the Romanovs" from the bottom of this page

Fish http://www.thefishsite.com/articles/336/fish-fingerprints-dna-screening-tracks-and-monitors-offenders

DNA sequencing

gel electrophoresis

Link to interactive gel - awesome, unplug your headphones!

gene cloning

Animation

genetic engineering

Genetic engineering, also calledgenetic modification, is the direct manipulation of an organism's genome using biotechnology

GMO

A good online interactive quiz

ligase enzyme

microsatellite

Interesting powerpoint

plasmid

PCR

Another one

The purpose of PCR is to amplify a small amount of DNA into a huge amount of DNA so it can be used in techniques such as gel electrophoresis.

primer

Work through this

recognition site

recombinant DNA

restriction enzyme

extracting DNA

Workshop

Marker assisted selection

A good website.There is a growing arsenal of molecular markers (polymorphisms) that aid in identifying QTL and selecting them for crop and animal enhancement. The process of using such markers is called marker-assisted selection (MAS), which differs from genetic modification because the genes being selected for crop or animal improvement are not altered in any way.

Once you have worked out the manipulation your animals go through for your 2 topics you will have to research the effect of these changed on the gene pools and evolution of the organisms. Remember that with natural selection it happens on POPULATIONS and not individuals. Individuals need to reproduce and then survive in theirhabitatto reproduce or else their alleles will be removed from the population. What implications with this in mind has the genetic manipulation caused? The term 'biological implications' means the biological consequences or changes that are caused or could be caused by the manipulation you are studying. The list of implications you are given is written in broad terms that are often linked together but the terms give you a good starting point for your research. Each different manipulation and species studied has different implications. Remember to look for both positive and negative implications.(From Studyit.org.nz)

All the examples below may not be isolated case but be linked. Forexample (in brief), Bt cotton has been genetically engineered to include a genethat is toxic to bollworm, a parasite that kills the cotton plant. This removes the need for chemical sprays onBt cotton crops. This modificationincreases the survival of individualsand the population in relation to bollworm, so crop size increases but,because it is a monoculture, Bt cotton has reduced genetic biodiversity and a limited gene pool. This means that if the organism issusceptible to another disease or parasite, the whole population is susceptibleso affects the survival of thepopulation as a whole where other risks are concerned. The absence of chemical sprays increases theoccurrence of other non-target pests, which in turn not only damage cotton butalso other crops, affecting the ecosystem.

eg plant species with low genetic diversity (eg wheat) are more likely to all suffer from the same disease. eg populations a transgenic plant species such as Bt-corn have increased survival due to resistance to certain pest insects. (From Studyit.org.nz)

PowerPoint looking at how populations survive.

Plant species with low genetic diversity (eg wheat) are less likely to under go evolution because the population has more fixed alleles so when the environment changes the population has less opportunity to change allele frequency.

Some excellent places to start your research

http://www.biotechlearn.org.nz/ The Biotechnology Learning Hub provides teaching resources for primary and secondary schools.

https://blogs.otago.ac.nz/ouassa/category/resources/biology-resources/ Another great website run by the University of Otago.

The three principal methods used for the creation of transgenic animals are DNA microinjection, embryonic stem cell-mediated gene transfer and retrovirus-mediated gene transfer.a) DNA microinjection.

This method involves the direct microinjection of a chosen gene construct (a single gene or a combination of genes) from another member of the same species or from a different species, into the pronucleus of a fertilized ovum. It is one of the first methods that proved to be effective in mammals (Gordon and Ruddle, 1981). The introduced DNA may lead to the over- or under-expression of certain genes or to the expression of genes entirely new to the animal species. The insertion of DNA is, however, a random process, and there is a high probability that the introduced gene will not insert itself into a site on the host DNA that will permit its expression. The manipulated fertilized ovum is transferred into the oviduct of a recipient female, or foster mother that has been induced to act as a recipient by mating with a vasectomized male.

A major advantage of this method is its applicability to a wide variety of species.b) Embryonic stem cell-mediated gene transfer.

This method involves prior insertion of the desired DNA sequence by homologous recombination into an in vitro culture of embryonic stem (ES) cells. Stem cells are undifferentiated cells that have the potential to differentiate into any type of cell (somatic and germ cells) and therefore to give rise to a complete organism. These cells are then incorporated into an embryo at the blastocyst stage of development. The result is a chimeric animal. ES cell-mediated gene transfer is the method of choice for gene inactivation, the so-called knock-out method.

This technique is of particular importance for the study of the genetic control of developmental processes. This technique works particularly well in mice. It has the advantage of allowing precise targeting of defined mutations in the gene via homologous recombination.c) Retrovirus-mediated gene transfer.

To increase the probability of expression, gene transfer is mediated by means of a carrier or vector, generally a virus or a plasmid. Retroviruses are commonly used as vectors to transfer genetic material into the cell, taking advantage of their ability to infect host cells in this way. Offspring derived from this method are chimeric, i.e., not all cells carry the retrovirus. Transmission of the transgene is possible only if the retrovirus integrates into some of the germ cells.

For any of these techniques the success rate in terms of live birth of animals containing the transgene is extremely low. Providing that the genetic manipulation does not lead to abortion, the result is a first generation (F1) of animals that need to be tested for the expression of the transgene. Depending on the technique used, the F1 generation may result in chimeras. When the transgene has integrated into the germ cells, the so-called germ line chimeras are then inbred for 10 to 20 generations until homozygous transgenic animals are obtained and the transgene is present in every cell. At this stage embryos carrying the transgene can be frozen and stored for subsequent implantation.

Biological implications may involve the impact on: For this part look at Animal and Plant/ Evolution sections

ecosystems

genetic biodiversity

health or survival of individuals

survival of populations

evolution of populations.

And finally the PCR SONG!! Should be a number 1 download on itunes... or not.

Some examples that may be used - there are many more and some have much more usable information than others.

Selective Breeding

Transgenesis

Horses

Golden rice

Corn

Whiffy wheat

Dogs

Daisys modified milk

Apples

GLO fish

Sheep

"Fish tomato"

Achievement

Merit

Excellence

Demonstrate understanding by using biological ideas to describe:

two human manipulations of genetic transfer

two biological implications for each human manipulation of genetic transfer.

As for Achieved and,

Demonstrate in-depth understanding by using biological ideas to explain how or why:

genetic transfer is manipulated for each human manipulation context

and

explain two biological implications within or between the two human manipulation contexts of genetic transfer.

As for Merit and,

Demonstrate comprehensive understanding by:

linking biological ideas within or between human manipulations of genetic transfer

and

two biological implications

The linking of ideas may involve justifying, relating, evaluating, comparing and contrasting, and analysing.

it could be linking 'one implication with another'. Forming links means putting ideas together to explain something eg how whole organism cloning, of an animal used for food, could result in a specific problem (eg reduced genetic diversity) for humans in the future and what the implication of this problem could be (eg reduced survival leading to reduced food supply).

For your Biotech project a possible format could be (please note this may or may not berelevantto the way your teacher has runyour internal) - please talk to them first..

Intro - Introduction to what genetic manipulation is including a brief description of focus manipulations of manupulation 1 and 2.

P1 - Introduce case study for 1.

P2 - Biological processes of 1 in relation to your case study (e.g. selection, inbreeding and marker assisted selection for selective breeding though your topic may be different)

P3 - Biological implications of selective breeding of your case study (e.g. at least 2 of; ecosystems, genetic biodiversity, health or survival of individuals, survival of populations or evolution of populations)

P4 - Introduce case study for 2.

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Biotechnology - NCEA Biology

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Biotechnology | University of Canterbury

Wednesday, August 22nd, 2018

Qualifications Overview

Biotechnology is of national and international importance. It considers and develops knowledge about biochemical, molecular, ecological, and evolutionary processes. Biotechnology tools are applied in research underpinning biodiversity and biosecurity throughout Aotearoa NewZealand.

Biotechnology research is directed towards developing technology with both economic and environmental outcomes. The OECD has predicted that, by 2030, biotechnology will assume a major role in the global economy with the advances from research in the tertiary sector.

The School of Biological Sciences | Te Kura Ptaiao Koiora offers the Bachelor of Science endorsed in Biotechnology to students majoring in Biological Sciences. Students follow one of two pathways:

Year 13 biology, statistics, and chemistry is strongly recommended.

For certain disciplines, some knowledge of physics is helpful.

All students should have adequate English skills.

As an emerging field with both national and international importance, biotechnology provides many career opportunities in universities, business, government agencies, Crown Research Institutes, and in ministries concerned with the environment, agriculture, and forestry.

Find out more about what you can do with a degree in Biotechnology.

'Biology at Canterbury is great, and Biotechnology is a very employable, fast-growing and lucrative ...

Anish Shah

Biological Sciences, Biotechnology

'My dream is to be involved in as many ventures as I can, specialising in clean energies...'

Steve Rowe

Biotechnology, Strategy and Entrepreneurship

School of Biological Sciences | Te Kura Ptaiao Koiora

Phone +64 3 369 5200 Email biological-sciences@canterbury.ac.nz

Location See the School's website for up-to-date location details.

Postal address College of Science | Te Rngai PtaiaoUniversity of Canterbury | Te Whare Wnanga o Waitaha Private Bag 4800 Christchurch 8140 New Zealand

Choose an area that you are interested in and learn how UC's extensive range of study options can let you study what you want to.

Biology means the study of living things. Biologists investigate animals, plants, and microbes in many different ways and on a huge range of scales from ...

Chemistry is the central science. It deals with the composition, structure, and behaviour of the atoms and molecules that make up all forms of matter. ...

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Biotechnology | University of Canterbury

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Biotechnology and biological sciences | University of Canterbury

Wednesday, August 22nd, 2018

UC's School of Biological Sciences is a vibrant research environment, which receives more than $3 million of external research income every year.

Research is fascinating and conducted across three main fields - biotechnology, biodiversity and biosecurity, all of which are exciting and rapidly developing subjects worldwide.

Our students mix and match, according to their needs and interests, from the diverse range of courses including Antarctic ecosystems, marine ecology and climate change. There are opportunities to use gene technologies, electron microscopes and satellite images, and the research can take you to field stations throughout New Zealand's South Island, to Antarctica and the other side of the world.

Areas of current research biomolecular interactionsinclude:

Biomolecular Interaction Centre

Staff actively working in these areas are:

Areas of current research in biosafety include:

Areas of current research in biomedicine include:

Staff actively working in these areas are:

Areas of current research in bioengineering include:

Staff actively working in these areas are:

Areas of current research in Antarctic studies include:

Staff actively working in these areas are:

Areas of current research in atmospheric processes include:

Staff actively working in these areas are:

Areas of current research in aquaculture and marine ecology include:

Staff actively working in these areas are:

Areas of current research in climate change include:

Staff actively working in these areas are:

Areas of current research in free radical biochemistry include:

Staff actively working in these areas are:

Areas of current research in freshwater ecology and management include:

Staff actively working in these areas are:

Areas of current research in plant processes include:

Staff actively working in these areas are:

Continued here:
Biotechnology and biological sciences | University of Canterbury

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NZTech and NZBio combine tech forces – BIOTechNZ

Wednesday, August 22nd, 2018

04Jul

New Zealand is beginning to witness unprecedented opportunities in areas of technology convergence as cutting-edge and world-first technology continues to accelerate and merge.

NZTech chief executive Graeme Muller says New Zealand has a history of innovation in the biotech and biosciences areas, often driven by strong Kiwi foundations in the primary sectors.

So, it is no surprise NZBio is merging with the NZTech Alliance of 18 tech sector areas.

We have seen biotech companies like Comvita merging their knowledge of a natural product like honey with biotech to create world-leading honey-based medicinal products, Muller says.

We have also seen New Zealand-founded carbon recycling company Lanzatech merging biotech with manufacturing.

As biotechnology, high-tech manufacturing and ICT such as artificial intelligence begin to cross over, the New Zealand tech ecosystem is now well placed to identify and support future growth companies through this coming together of NZBio and NZTech.

At the heart of this amazing period in human history is the convergence of atoms, bits and genes, the ability to use technology to do amazing things like New Zealands Revolution Fibres which is using electrospinning to produce collagen nanofibres and create artificial skin.

NZBio chief executive Dr Zahra Champion says merging with NZTech was a natural fit.

In todays world, the importance of biotech is increased in many fields, from medicines to agriculture, from animal husbandry to textiles, from defenceless to energetic, Dr Champion says.

New Zealand is fragmented across all sectors with large number of industry bodies across all sectors. We are seeing the blurring of the lines between bioscience and technology.

Biotech is everything bio-based such as bioscience, biochemistry, biotechnology, biomanufacturing and life sciences within the agritech, health diagnostics and therapeutics, industrial, environmental and foodtech sectors.

Dr Champion says the industry brings with it high-paying jobs and innovative ideas in an industry that encompasses a huge diversity of applications and being part of the NZTech Alliance, will enable us to maximise New Zealands bio-base technology capability to create a strong and prosperous New Zealand bio economy.

More than 70 percent of New Zealands export earnings are derived from biology-based industries spanning human and animal health, agriculture, horticulture and other natural products. Exports include finished products and ingredients destined for the food, cosmetics, nutraceutical and pharmaceutical industries.

The OECD has estimated the potential contribution of the bio-economy to New Zealands GDPWill climb to $NZ182 billion by 2030.

For further information contact Make Lemonade editor-in-chief Kip Brook on 0275 030188.

Photo: Zahra Champion

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NZTech and NZBio combine tech forces - BIOTechNZ

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Biotech, life sciences & pharmaceuticals – AJ Park

Wednesday, August 22nd, 2018

Biotech, life science and pharmaceutical innovations are at the cutting edge of technology and research and development. The risks and challenges are huge, but so are the potential rewards.

The complexity of biotechnology, life sciences and pharmaceutical patents means that you need access to a team of highly specialised advisors. And when you need to protect and exploit your biotech, life sciences and pharmaceutical innovations, its essential you are advised by a team that has a thorough understanding of the technology as well as the business issues facing the international industry.

AJ Park has a dedicated team of experts who specialise in biotechnology, life sciences and pharmaceuticals. Our specialist team of patent attorneys includes many with dual science and law qualifications, and several with PhDs. Some have benefited from industry experience or research tenures at universities throughout the world, and others have trained as intellectual property office examiners.

Our team works with a range of entities involved in biotech, life sciences and pharmaceuticals. Our clients include start-up companies, food technology companies, life sciences companies, multi-national pharmaceutical companies, Crown Research Institutes and universities.

We are a committed sponsor of the New Zealand biotechnology industry body NZBio, and a member of the Australian equivalent AusBiotech, which gives us the opportunity to work with many of Australasias most innovative biotech companies.

Our investment in keeping up-to-date with international developments in biotech, life sciences and pharmaceuticals means you can be confident that the advice we give you is world-class.

Although the technology and processes can be complex, we will communicate clearly and make sure you understand what you need to know.

For plain English advice on biotech, life sciences and pharmaceutical inventions, get in touch with one of our experts below.

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Biotech, life sciences & pharmaceuticals - AJ Park

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Kotsanis Institute – Integrative Medicine and Natural Pain …

Wednesday, August 22nd, 2018

Need help financing your cancer care?

Designed for cancer patients and other individuals with a life limiting illness

Or click HERE to see if your policy may qualify.

Click HEREfor Go Fund Me for Medical Fundraising

Do you offer financial assistance or financing?

YES! We Participate in Care Credit (Recommended for treating your child or any non-life-threatening condition)

CLICK HEREto see CareCredit website & info

CLICK HERE to Other Financial Considerations

Kotsanis Institute offers a patient-centered approach to health that combines the best of traditional andcomplementary medicine with nutrition called integrative medicine.We welcome you to stop by our clinic for a free tour and brief consultation with a staff member to learn about what we do here at the Kotsanis Institute. We listen to your goals, draw a roadmap to achieve your goals, and guide you every step to a symphony of health.

Dr. Kotsanis practice integrates elements of both mainstream and complementary medicine. This practice, known as integrative medicine, embraces principals and treatment methods which may or may not be accepted or embraced by conventional medicine providers, individual physicians or other health care institutions.

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Kotsanis Institute - Integrative Medicine and Natural Pain ...

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Molecular Genetics – The Ohio State University

Tuesday, August 21st, 2018

Molecular geneticists with a BS degree often work as laboratory technicians. They are in demand to work on research projects in universities. Federal and state government agencies such as the National Institutes of Health, the Department of Energy, the Department of Agriculture and the Environmental Protection Agency hire molecular geneticists to work on a variety of applied research problems. In the private sector, agricultural and pharmaceutical companies are increasingly hiring molecular geneticists to apply their skillsto genetic engineering as well as classical breeding programs. The newand growing biotechnology industry is largely based on the expertise of molecular geneticists.

Many molecular genetics majors go to medical or other professional schools. The major program is rigorous, and molecular genetics is an important area in modern medicine. Also, well-qualified majors are encouraged to participate in the facultys research programs. As a result, molecular genetics majors have been successful in gaining entrance to professional schools.

Many molecular genetics graduates go on to graduate school. A few of these get an MS degree, which qualifies them for higher-paying laboratory technician jobs. Most go directly to the PhD program. Molecular geneticists with a PhD are widely employed by government and industry to design and supervise research and development projects. Nearly all colleges and universities have molecular geneticists on their faculties, teaching and doing research. Molecular geneticists with a PhD plus postdoctoral research training are eligible for faculty positions at research-oriented universities like Ohio State.

An undergraduate major in molecular genetics does not limit ones options to careers in medicine or biological research. Because this major provides the academic preparation and strong science background appropriate for students who plan careers in marketing, business or management in high technology industries, some molecular genetics students choose to use their science background to pursue a professional degree in business or law. A few students choose to put their molecular genetics training to use by obtaining a masters degree in education and becoming science teachers.

Link:
Molecular Genetics - The Ohio State University

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Stem Cell Therapy dangers and risks – Magaziner Center for …

Sunday, August 19th, 2018

Stem Cell Therapy dangers and risks December 13, 2013 December 13, 2013

I received a disturbing call from a woman in Texas recently. She was having some complications from the stem cell treatment that she received in her hometown.

In what is becoming a more common email or call from people not our patients, she revealed that she believed that her doctor was inexperienced in the Stem Cell procedure and did not know how to address her complications.

Even though I did not have the luxury of examining her, I tried to ask some questions to help her with her situation.

It seems, that she had received placental cells.They were injected into her knee and it caused a severe inflammatory response that left her with a great deal of pain. I did wish her the best and try to offer some advice, but also let her know that it is not legal nor recommended to inject placental cells into a patient.

While we have found the use of stem cells for the symptomatic treatment of arthritis and pain to be very helpful in our practice, one must be very cautious as to know what they are receiving.

As I mentioned, placental cells are not only illegal, but are immature cells that can have mutagenic properties. That is, they have the ability to turn into cancer cells and furthermore it is uncertain if the body can reject them since they are not harvested from the person who is receiving the treatment. These cells, also differentiate to form both blood cells and tissue cells so there is a great deal of insufficiency if you are looking to heal damaged tissue.

Bone marrow derived stem cells also have this same property of containing cell lines that turn into blood cells. There are certain areas, like the tibia, where the bone marrow contains many more blood cells then areas such as the hip, which contain more mesenchymal cells. Certain doctors have recommended tibial bone marrow draws for the use of bone marrow prolotherapy from the tibia, but this has very little scientific backing to be included as a stem cell source. There is also no research whatsoever showing its efficacy.

Many other doctors use bone marrow from the hip in their stem cell procedure. While this is a richer source of mesenchymal cells when compared to the tibia it is still a very poor source of stem cells.

Results from stem cell procedures not only depend on the cell type and where they are injected, but also the diagnostic skill and approach of the physician. While stem cells may have amazing properties, they are not so magical where we can just inject stem cells into a joint and hope for good results. As a physician, it is our job to evaluate and treat any problem surrounding, above and below the joint using a very careful physical examination. A comprehensive approach, not a single sided approach, will yield the best results for the patient.

Growth hormone has also been touted by one physician as useful in a stem cell mixture. That physician is conducting a study on this, but it still remains unproven. We had used this in power injection solution well over 10 years ago and stopped because it did not produce any significant clinical benefit. Furthermore, stem cells do need to be combined with a variety of growth factors in order to further their differentiation into new tissue. This can be achieved by using specialized forms of PRP along with the stem cell mixture. Both ourselves with our partners at Kensey and Dr. Centeno from Regenexx has done laboratory tests to look at the importance of this. There is a large variation in how stem cells perform based upon the environment that they are given with the PRP.

In summary, while these procedures have tremendous potential, we need to follow in the best of our knowledge base and follow our outcomes. Eventually, our technology will expand, and in the future we will have the capability to harvest stem cells in less than a half hour But this will take several years of development.

Scott Greenberg MD

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Stem Cell Therapy dangers and risks - Magaziner Center for ...

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