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Archive for the ‘Arthritis’ Category

Shoulder Arthritis: Non-Surgical Alternatives To Help Your Body Heal – Video

Saturday, February 1st, 2014


Shoulder Arthritis: Non-Surgical Alternatives To Help Your Body Heal
Shoulder pain either from osteoarthritis or rotator cuff injury can be extremely painful and debilitating. Dr. Robert Wagner discusses the latest course of treatment using your body #39;s own ability...

By: StemCell ARTS

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Rejection… is it a problem with stem cell arthritis treatment? – Video

Monday, December 16th, 2013


Rejection... is it a problem with stem cell arthritis treatment?
http://www.stemcellsarthritistreatment.com Stem cells may not be rejected... here #39;s why it #39;s important for arthritis treatment... Ryan and colleagues in an a...

By: Nathan Wei

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Ankle arthritis treatment… what are thre options? – Video

Thursday, October 17th, 2013


Ankle arthritis treatment... what are thre options?
http://www.stemcellsarthritistreatment.com Ankle arthritis is increasing in prevalence. The most common causes are trauma and ligamentous laxity. Conservativ...

By: Nathan Wei

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Ankle arthritis treatment... what are thre options? - Video

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What are sources of stem cells in the adult … implications for arthritis treatment – Video

Sunday, October 13th, 2013


What are sources of stem cells in the adult ... implications for arthritis treatment
http://www.stemcellsarthritistreatment.com There a number of different sources of SCs in the adult. Usually, adult SCs tend to differentiate into the tissue ...

By: Nathan Wei

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Malibu gets stem cell treatment to help his arthritis – Video

Tuesday, September 24th, 2013


Malibu gets stem cell treatment to help his arthritis

By: AZpetvet

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Malibu gets stem cell treatment to help his arthritis - Video

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Blood vessels and stem cells for arthritis treatment – Video

Sunday, May 12th, 2013


Blood vessels and stem cells for arthritis treatment
http://www.stemcellsarthritistreatment.com Researchers at the Cornell University School of Medicine have discovered that endothelial cells, cells that line b...

By: Nathan Wei

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Stem cell arthritis treatment and cartilage repair using Sox… Huh? – Video

Friday, May 10th, 2013


Stem cell arthritis treatment and cartilage repair using Sox... Huh?
http://www.stemcellsarthritistreatment.com We #39;ve talked about the role of different biologics that aid stem cells in cartilage repair. Another class of biolo...

By: Nathan Wei

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Alternative to knee replacement: The guinea pig arthritis model! – Video

Sunday, April 21st, 2013


Alternative to knee replacement: The guinea pig arthritis model!
http://www.stemcellsarthritistreatment.com Guinea pig science models... how are they going to help us with stem cell repair of cartilage? Sato and colleagues...

By: Nathan Wei

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Alternative to knee replacement: The guinea pig arthritis model! - Video

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BMP needed for cartilage repair and growth in arthritis – Video

Sunday, February 24th, 2013


BMP needed for cartilage repair and growth in arthritis
http://www.stemcellsarthritistreatment.com Bone morphogenic protein or BMP is an essential ingredient needed for normal cartilage development, growth, and repair. Mouse models deficient in this protein show significant deformities as do humans deficient in the gene responsible for BMP. BMP has been shown to stimulate cartilage growth from mesenchymal stem cells and enhance the production of collagen. However, it has also been shown that when implanted in areas away from where cartilage would normally grow, BMP led to the formation of ectopic bone, meaning bone growing in areas it shouldn #39;t. http

By: Nathan Wei

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Knee arthritis repair… Is it just injecting stem cells into the knee…No! – Video

Saturday, February 23rd, 2013


Knee arthritis repair... Is it just injecting stem cells into the knee...No!
http://www.stemcellsarthritistreatment.com Many people are under the illusion that all it takes to treat an osteoarthritic joint is to shoot some stem cells into the joint. Nothing could be further from the truth. Here #39;s why... The success of a stem cell procedure rests on a four-legged stool. The first of course is the stem cell preparation. The second are growth factors that are needed to stimulate stem cell growth and proliferation. The third is a scaffold for the stem cells to adhere to. And the fourth is injury induction in the area that needs to be healed. Without all four critical factors, the procedure is not going to work. http

By: Nathan Wei

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Knee arthritis repair... Is it just injecting stem cells into the knee...No! - Video

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Adapts to any job: sugar for stem cell arthritis treatment.mp4 – Video

Monday, February 11th, 2013


Adapts to any job: sugar for stem cell arthritis treatment.mp4
http://www.stemcellsarthritistreatment.com Polysaccharides are sugars that play an important role in the structure of matrix material- the stuff that holds cells together. These materials are being investigated as possible stem cell scaffolds. These polysaccharides can be turned into gels rapidly and therefore can be injected into a damaged joint easily. Among these are agarose and alginate which are derived from algae. Hyaluronic acid is already being used as a palliative osteoarthritis treatment but is also considered a possible scaffold. The last polysaccharide is chitosan which has shown excellent results when used in a sheep model of osteoarthritis. http

By: Nathan Wei

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What Areas of Arthritis Do Autologous Stem Cells Work Best For? – Video

Thursday, November 15th, 2012


What Areas of Arthritis Do Autologous Stem Cells Work Best For?
What types of conditions and what types of arthritis are most amenable to autologous stem cell treatment. Some joints do better than others. Why that is is still a matter of conjecture. It #39;s important to realize stem cells don #39;t work for every condition.From:Nathan WeiViews:0 0ratingsTime:02:00More inScience Technology

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Stem Cells Rheumatoid Arthritis Treatment: A New Discovery… Will It Work? – Video

Sunday, November 4th, 2012


Stem Cells Rheumatoid Arthritis Treatment: A New Discovery... Will It Work?
Today #39;s episode is about adult mesenchymal stem cells and their use in rheumatoid arthritis. So far, I #39;ve discussed the use of stem cells in rebuilding cartilage in patients suffering from osteoarthritis. Interestingly, there has been some recent data regarding the use of adult mesenchymal stem cells in rheumatoid arthritis. Adult mesenchymal stem cells were recently found to suppress effector T cell and inflammatory responses and have emerged as attractive therapeutic candidates for immune disorders. MSCs have profound inhibiting effects on what are called fibroblast-like synoviocytes and T cells from RA patients. They could suppress cell multiplication and thus reduce the invasive behavior and inflammatory responses of multiple villains involved in the immunologic problems that cause rheumatoid arthritis. This could also explain why they have benefits above and beyond cartilage regeneration in osteoarthritis. For more information copy and past this link into your browser. http://www.stemcellsarthritistreatment.comFrom:Nathan WeiViews:0 0ratingsTime:03:58More inScience Technology

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Innocent Intrigue : Hans S. Keirstead at TEDxOrangeCoast – Video

Sunday, November 4th, 2012


Innocent Intrigue : Hans S. Keirstead at TEDxOrangeCoast
Stem cells will fundamentally change the course of human disease and longevity, says Hans Keirstead. An internationally known stem cell expert, Hans Keirstead has pioneered stem cell programs at UC Irvine and California Stem Cell. He led his teams to develop a stem cell-based treatment for paralysis, that marked the first such stem cell-based clinical trial ever approved by a regulatory body, worldwide, with positive interim data in a Phase 1 clinical trial. Dr. Keirstead also helped develop a therapy for the treatment of ulcerative collitis and rheumatoid arthritis, that has successfully met primary endpoints in Phase II clinical trials. He developed a stem cell-based therapy for the motor neuron diseases ALS and spinal muscular atrophy that will soon enter clinical testing, and made headlines for creating a 3D retina from stem cells for the treatment of retinal diseases. More recently, is developing a stem cell-based treatment for late stage cancers, a technology that has met primary endpoints in Phase II clinical trials. AboutTEDx. TEDx was created in the spirit of TED #39;s mission, "ideas worth spreading." The program is designed to give communities, organizations and individuals the opportunity to stimulate dialogue through TED-like experiences at the local level. At TEDx events, a screening of TEDTalks videos -- or a combination of live presenters and TEDTalks videos -- sparks deep conversation and connections. TEDx events are fully planned and coordinated ...From:TEDxTalksViews:25 1ratingsTime:10:48More inScience Technology

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'Humanized' mice may enable discovery of better medicines for rheumatoid arthritis

Friday, October 5th, 2012

Washington, October 5 (ANI): By developing the first animal model that duplicates the human response in rheumatoid arthritis (RA), researchers at Northwestern University Feinberg School of Medicine have made a breakthrough in their search for better therapies to combat the disease.

This is the first time human stem cells have been transplanted into mice in order to find RA treatments, said corresponding and senior author Harris Perlman, associate professor of rheumatology at Feinberg.

"We believe this will improve drug discovery because the reactions we observed were authentic human reactions," he stated.

Until now, scientists have relied on the common scientific method of using specially bred mice to find drugs to control RA. However, human and mouse immune systems differ dramatically, so studying RA in these mice does not give an accurate representation of how the disease functions in humans. In some cases, RA drugs that seemed promising based on results in mice failed in human clinical trials.

Mice implanted with human stem cells have been used before mainly to study infectious disease.

The Northwestern team injected day-old mice with human stem cells from umbilical cord blood, including white blood cells, which regulate immunity. Then, RA was introduced in the mice and suppressed with Enbrel, a common first-line drug for joint inflammation in humans. This offered evidence that their immune systems were indeed replicating human defences.

Scientists seek mouse models that mimic RA in humans in order to learn how the complex disease operates. In the last decade, researchers and physicians have found many subtypes of RA that originate on the molecular level and are each produced by different pathways in the body.

A debilitating disease, rheumatoid arthritis is a chronic autoimmune disorder characterized by persistent inflammation around joint areas, predominantly in the wrist and fingers. The disease causes pain, swelling, stiffness and loss of function and can result in tissue destruction. Approximately 1.3 million people have the disease.

Onset of RA usually begins between ages 25 to 55, but recent studies reveal that the disease actually begins several years before symptoms appear. This has broadened the focus to create drugs that prevent RA or at least enable early diagnosis instead of trying to reduce symptoms once it is further along and difficult to control.

This is the second mouse model Perlman has developed to help discover better rheumatoid arthritis therapies. Earlier this year, he introduced a mouse model that develops RA and is predisposed to atherosclerosis, or hardening of the arteries, a common RA complication in humans.

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'Humanized' mice may enable discovery of better medicines for rheumatoid arthritis

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'Humanized' mice advance study of rheumatoid arthritis

Thursday, October 4th, 2012

Public release date: 3-Oct-2012 [ | E-mail | Share ]

Contact: Marla Paul Marla-Paul@northwestern.edu 312-503-8928 Northwestern University

Researchers at Northwestern University Feinberg School of Medicine have developed the first animal model that duplicates the human response in rheumatoid arthritis (RA), an important step that may enable scientists to discover better medicines to treat the disease.

Corresponding and senior author Harris Perlman, associate professor of rheumatology at Feinberg, introduced his team's new prototype mouse model in a recent online issue of the Journal of Translational Medicine.

"This is the first time human stem cells have been transplanted into mice in order to find RA treatments," Perlman said. "We believe this will improve drug discovery because the reactions we observed were authentic human reactions."

Until now, scientists have relied on the common scientific method of using specially bred mice to find drugs to control RA. However, human and mouse immune systems differ dramatically, so studying RA in these mice does not give an accurate representation of how the disease functions in humans. In some cases, RA drugs that seemed promising based on results in mice failed in human clinical trials.

Mice implanted with human stem cells have been used before mainly to study infectious disease.

The Northwestern team injected day-old mice with human stem cells from umbilical cord blood, including white blood cells, which regulate immunity. Then, RA was introduced in the mice and suppressed with Enbrel, a common first-line drug for joint inflammation in humans. This offered evidence that their immune systems were indeed replicating human defenses.

Scientists seek mouse models that mimic RA in humans in order to learn how the complex disease operates. In the last decade, researchers and physicians have found many subtypes of RA that originate on the molecular level and are each produced by different pathways in the body.

A debilitating disease, rheumatoid arthritis is a chronic autoimmune disorder characterized by persistent inflammation around joint areas, predominantly in the wrist and fingers. The disease causes pain, swelling, stiffness and loss of function and can result in tissue destruction. Approximately 1.3 million people have the disease.

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'Humanized' mice advance study of rheumatoid arthritis

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Stem cells may prevent post-injury arthritis

Saturday, August 11th, 2012

Public release date: 10-Aug-2012 [ | E-mail | Share ]

Contact: Mary Jane Gore mary.gore@duke.edu 919-660-1309 Duke University Medical Center

DURHAM, N.C.-- Duke researchers may have found a promising stem cell therapy for preventing osteoarthritis after a joint injury.

Injuring a joint greatly raises the odds of getting a form of osteoarthritis called post-traumatic arthritis, or PTA. There are no therapies yet that modify or slow the progression of arthritis after injury.

Researchers at Duke University Health System have found a very promising therapeutic approach to PTA using a type of stem cell, called mesenchymal stem cells (MSCs), in mice with fractures that typically would lead to them developing arthritis. Their findings could lead to a therapy that would be used after joint injury and before signs of significant osteoarthritis.

The scientists thought the stem cells would work to prevent PTA by altering the balance of inflammation and regeneration in knee joints, because these stem cells have beneficial properties in other regions of the body.

"The stem cells were able to prevent post-traumatic arthritis," said Farshid Guilak, Ph.D., director of orthopaedic research at Duke and senior author of the study.

The study was published on August 10 in Cell Transplantation.

The researchers also thought that a type of mice bred for their super-healing properties would probably fare better than typical mice, but they were wrong.

"We decided to investigate two therapies for the study, said lead author Brian Diekman, Ph.D., a postdoctoral researcher in the Guilak lab. "We thought that stem cells from so-called superhealer mice would be superior at providing protection, and instead, we found that they were no better than stem cells from typical mice. We thought that maybe it would take stem cells from superhealers to gain an effect as strong as preventing arthritis after a fracture, but we were surprised and excited to learn that regular stem cells work just as well."

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TiGenix : completes patient enrollment in Phase IIa rheumatoid arthritis study

Wednesday, August 8th, 2012

Regulated information August 8, 2012

TiGenix completes patient enrollment in Phase IIa rheumatoid arthritis study

Leuven (BELGIUM), Madrid (SPAIN) - August 8, 2012 - TiGenix (NYSE Euronext: TIG), the European leader in cell therapy, announced today the completion of patient enrollment in the Company`s Phase IIa study of Cx611, a suspension of expanded allogeneic adult stem cells, in rheumatoid arthritis. The Phase IIa clinical trial is a 53-subject, multicenter, placebo-controlled study in 3 cohorts with different dosing regimens, designed to assess safety, feasibility, tolerance, and optimal dosing. The study is being conducted at 23 centers. The Company believes that this clinical trial can set the stage not only for the further development of Cx611 in RA, but also in a wide range of other autoimmune disorders.

"In addition to the primary endpoints of safety and optimal dosing, we expect this trial to yield a first indication of the duration of the efficacy of Cx611 in this very difficult patient population: the enrolled patients have previously failed to respond to at least two biologicals," said Eduardo Bravo, CEO of TiGenix. "In the trial patients are treated with three injections of Cx611. The six-month follow-up without further dosing should provide us with a truly meaningful result. This is the most advanced stem cell therapy trial in RA in the world, and completing the enrollment on time confirms our leadership position in the field. We anticipate reporting the results of the study no later than April 2013."

About Cx611 for rheumatoid arthritis Cx611 is a suspension of expanded allogeneic adult stem cells derived from human adipose (fat) tissue (expanded Adipose derived Stem Cells or `eASCs`) that is delivered through intra-venous injection for the treatment of rheumatoid arthritis. The objective of the Phase IIa trial is to determine safety, feasibility, tolerance, and optimal dosing. This multicentre, placebo-controlled study has enrolled 53 patients, divided in 3 cohorts with different dosing regimens. There are 23 centers open and the company expects the final results to be available in the first half of 2013.

For more information: Eduardo Bravo Chief Executive Officer eduardo.bravo@tigenix.com

Claudia D`Augusta Chief Financial Officer claudia.daugusta@tigenix.com Hans Herklots Director Investor & Media Relations hans.herklots@tigenix.com +32 16 39 60 97

About TiGenix

TiGenix NV (NYSE Euronext Brussels: TIG)is a leading European cell therapy companywith a marketed product for cartilage repair, ChondroCelect, and a strongpipeline with clinical stage allogeneic adult stem cell programsfor the treatment ofautoimmune and inflammatory diseases.TiGenixis based out of Leuven (Belgium) and has operations in Madrid (Spain), and Sittard-Geleen (theNetherlands). For more information please visitwww.tigenix.com.

Forward-looking information

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San Rafael dog gets arthritis relief from stem cell treatment

Monday, August 6th, 2012

Emma, a snow-white German shepherd, has been plagued with arthritis for two years, limping and sometimes crying out in pain. But an innovative new procedure using her own stem cells has helped, her veterinarian and owner say.

"Her joint mobility has improved. I can move her elbows into a flexed position now," said Kristina Hansson, a veterinarian with San Rafael's Northbay Animal Hospital. Hansson injected Emma's own stem cells into 10 of her joints three months ago in a yet-unproven procedure that cost about $2,000, promoted by MediVet America, a Kentucky company.

"We're very pleased," said Arthur Latno of San Rafael, owner of the 9-year-old, 80-pound dog. "She doesn't limp any more and she doesn't cry."

Latno

He is apparently one of the first Marin pet owners to do so. Though there are some practitioners in Marin who use stem cell therapy, it is not yet widespread, according to Andrew Lie, a veterinarian at the East San Rafael Veterinary Clinic and president of the Marin County Veterinary Medical Association.

Lie himself doesn't use the therapy. "Personally, I think I would wait to see more research and studies come out. I think it's a little early

"This (the stem cell procedure) is incredibly promising, but on the other hand there is a lot of homework that needs to be done to determine whether these are valid therapeutic measures," said John Peroni, an associate professor at the University of Georgia College of Veterinary Medicine.

Peroni also chairs the North American Veterinary Regenerative Medicine Association. Peroni himself, along with colleagues at other universities including the University of California at Davis, is engaged in controlled clinical trials involving stem cells and animals. When such trials, peer-reviewed work and long-term studies are published, the effectiveness of the procedures will be easier to determine.

Dogs aren't the only mammals getting stem cell therapy for arthritis. The treatment is being used on humans as well. One example is the Centeno-Schultz Clinic in Broomfield, Colo, which offers a treatment called Regenexx that has received a good deal of media coverage. As with the animal procedure, it involves using a patient's own stem cells.

When the term "stem cells" is used, it brings to mind controversial procedures involving human embryos. In the MediVet procedure, however, the stem cells come from the animal's own body.

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San Rafael dog gets arthritis relief from stem cell treatment

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Tulsa Arthritis walk set for Saturday

Thursday, May 17th, 2012

About 67 million people are expected to have the disease by 2030, he said.

"This is a crisis that's going to get worse," he said.

The local chapter of the Arthritis Foundation will host the 2012 Arthritis Walk on Saturday at the University of Tulsa.

Klippel said prevention is a key part of the foundation's message.

People need walkable cities, parks and biking and jogging lanes available to them if they are going to stay healthy and avoid chronic diseases such as arthritis.

Maintaining a healthy weight is also important to avoiding the disease, he said.

Research into inherited forms of arthritis is ongoing, and researchers also are looking at the use of stem cells to treat the disease, Klippel said.

"The biotech industry is going to be really, really important as we move forward," he said.

The Arthritis Foundation continues to raise awareness of the disease and some of the health access problems that keep people, particularly those in minority populations, from treating it properly, Klippel said.

"There are a lot of people in this country, like Native Americans, that aren't getting the care they need for their arthritis," he said.

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Tulsa Arthritis walk set for Saturday

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