StemCell Therapy

Dentures and implants may now be a thing of the past because scientists have the ability to grow new teeth in a patients mouth.

This is huge for the many adults who end up losing a tooth or multiple teeth during their lifetimes.

As of now, the only options for a missing tooth include implants, or if all teeth are missing, dentures. However, these two methods cause serious dental health problems.

Health issues associated with dental implants include infection at the implant site, injury or damage to the surrounding structures, nerve damage, and sinus problems. Despite being the preferred treatment for missing teeth today, dental implants can fail and have no ability to remodel with surrounding jaw bone, which undergoes necessary and inevitable changes throughout a persons life. (Dentistry iQ)

Dentures can be uncomfortable and make eating difficult. Also, they can cause gum and mouth irritation or infections.

By growing a new tooth in the location where one lost a tooth, all issues associated with implants or dentures are gone. This is a much-needed medical advancement, especially considering that by age 7426% of adults have lost all of their permanent teeth. (Underground Health Reporter)

A new technique pioneered at the Tissue Engineering, and Regenerative Medicine Laboratory of Dr. Jeremy Mao, Edward V. Zegarelli Professor of Dental Medicine, and a professor of biomedical engineering at Columbia University can orchestrate the bodys stem cells to migrate to three-dimensional scaffold that is infused with the growth factor. This can yield an anatomically correct tooth in as soon as nine weeks once implanted in the mouth. (Dentistry iQ)

That is right. Scientists can help the body grow a new tooth in about two months. Gone will be the days of dentures and painful tooth implants.

Key consideration in tooth regeneration is finding a cost-effective approach that can translate into therapies for patients who cannot afford or who are not suitable candidates for dental implants, Dr. Mao said. Cell-homing-based tooth regeneration may provide a distinct pathway toward clinical translation.

In other words, it is may be a less expensive process. However, one thing that is known for sure is that it is far less invasive.

Dental implants usually consist of a cone-shaped titanium screw with a roughened or smooth surface and are placed in the jaw bone. While implant surgery may be performed as outpatient procedure, healing times vary widely, and successful implantation is a result of multiple visits to certified clinicians, including general dentists, oral surgeons, prosthodontists, and periodontists. (Dentistry iQ)

It might just be me, but the thought of a titanium screw anywhere near my mouth gives me the chills.

One more thing, you dont have to wait to get a stem cell treatment with your own stem cells! Stem cells can still help your teeth without a direct stem dental implant. Click HERE to find out how you can receive a stem cell treatment by multiplying your own stem cells.

https://youtu.be/XY85mFnUoi8

Originally posted here:
Stem Cell Dental Implants Grow New Teeth In 2 Months ...

Scanning through the headlines, tuning in to morning television shows, stem cells are repeatedly the topic of discussion a discussion that increasingly includes primary teeth.

The discovery of stem cells in dental pulp has led to much research and predictions about their potential uses. Although the full possibilities of tooth-derived stem cells are not yet known, some researchers believe that they could one day be valuable for regenerating dental tissues and possibly other tissues as well.

Pamela Robey, Ph.D., chief, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, says that because no one knows for certain what the full possibilities are for the cells isolated from dental pulp, nor can they accurately predict if or when they'll be used in clinical settings, patients and professionals need to make informed decisions.

"What we do know," she said, "is the cells from dental pulp in baby or wisdom teeth have the ability to make dentin and pulp and they might have the ability to make bone but right now that's all we really know for sure."

Because "the data for other things is not hard yet, we can't say how useful for the future they'll be," she said.

Dr. Jeremy Mao, a professor of dental medicine and director of the Tissue Engineering and Regenerative Medicine Laboratory at Columbia University, believes that dental stem cells and related bioengineering technologies will transform dentistry in a magnitude that is far greater than amalgam and dental implants.

"Some of the technologies may happen 10 years down the road but others may happen within 10 years," he predicted.

Presently, there are no human trials taking place with the dental postnatal cells and there are no clinical applications available. There also is no central place for dentists or patients to read about the latest in dental stem cell research. Dr. Robey advised anyone hearing claims of new evidence and dental stem cells to consult the Web site http://www.clinicaltrials.gov.

Read the original post:
Dental Stem Cell Potential Explored | Colgate Oral Care

Stem Cell Intro

Ordinary cells in your body replicate to make new cells of the same type blood cells make more blood cells, skin cells make more skins cells and so on. However, there is another type of cell, called a stem cell.

Stem cells are able to repair or replace damaged tissue. This is why scientists and doctors are so excited about the growing role of stem cells to treat disease, injury, and the deterioration of tissue due to aging. Amazingly, after our birth and into adulthood, we keep a store of these stem cells in certain parts of our body.

Different types of stem cells exist in different body tissues, and in varying concentrations. One of the most well-understood and widely researched types of stem cells is the mesenchymal stem cell.

Mesenchymal stem cells can form tissues such as bone, nerve, muscle and blood vessels. They also help body tissue to repair itself, and they play an important role in healing by suppressing inflammation.

Though located in a number of places in the body, mesenchymal stem cells can be found in especially high concentrations in the healthy dental pulp of teeth.

Over time, even stem cells succumb to the environmental insults that age all of our cells. Freezing cells in a youthful state preserves their future ability to generate replacement tissue and heal the body.

All of these attributes make stem cells the cornerstone of the emerging field of treatments and therapies called Regenerative Medicine.

Mesenchymal stem cells have already proven to be a powerful and potent platform for developing treatments. As you are reading this, scientists are studying the role of these amazing cells in treating conditions such as type 1 diabetes, spinal cord injury, stroke, myocardial infarction (heart attack), corneal damage and neurological diseases like Parkinsons, to name just a few.

Hundreds of clinical trials are underway, demonstrating the use of mesenchymal stem cells to treat diseases, to heal injuries, and to grow replacement tissues like bone, nerve, muscle and blood vessels. In fact, mesenchymal stem cells are currently being tested clinically to treat autoimmune diseases like Crohns and GVHD as well as in regenerative applications like bone and cartilage repair and cardiac muscle repair after myocardial infarction.

This exploding field of research, called Regenerative Medicine, holds the promise that your child, utilizing a toolkit of their own stem cells harvested and stored early on, will live a life of unprecedented wellness. Regenerative medical therapies could become common treatments used alongside more traditional ones.

Imagine a future where serious conditions like type 1 diabetes are treated with a combination of drugs and regenerative medicine. Imagine skin and bone grafts created from the patients own cells. Imagine treating age-related conditions like arthritis, dementia, and Alzheimers using cells from the patients teeth that were banked when they were young.

Want to dig deeper into emerging therapies using mesenchymal stem cells?

To learn more, visit http://www.store-a-tooth.com or call (877) 867-5753 to speak with a client educator.

View post:
Dental Stem Cells in Chicago, IL | Harold Krinsky, DDS

*Post also available in: Espaol Romn

Stem cells can multiply (self-renew) and differentiate into every cell within the human body, giving them enormous potential for use in regenerative medicine.

In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult humans, stem and progenitor cells act as a repair system for the body, replenishing specialized cells.

Stem cell research has been going on for over 50 years because stem cells have a unique ability to divide and replicate repeatedly. In addition, their unspecialized nature allows them to become a wide variety of tissue types, which gives them enormous potential for use as living cell therapies.

In this article:

Several broad categories of stem cells exist, including:

Originally, all stem cells were classified as either adult stem cells or embryonic stem cells (ESCs). However, a diverse range of stem cell types has since been identified. When iPS cells were discovered in 2006, the research community had a new stem cell type that possessed most of the characteristics of ESCs without the controversy.

To make things simple, apply these definitions to classify stem cells by when they are collected during the human lifecycle:

To understand the functional potential of each stem cell type, scientists like to describe to what degree each stem cell type can differentiate into other cell types.

When assessing the functional potential of stem cells, use the following definitions:

Human embryonic stem cells (hESCs) are totipotent cells that are derived from embryos that have been createdin vitroat fertility clinics with informed donor consent. Embryonic stem cells are typically collected shortly after fertilization (within 4-5 days). At 5-6 days post-fertilization, embryonic stem cells begin to specialize, at which point they become pluripotent or multipotent cells.

Pluripotent and multipotent stem cells have a more limited differentiation capacity than totipotent stem cells.For example, multipotent blood stem cells can differentiate into red cells, white cells, and platelets in the blood, but they cannot become any cell type.

The precisepointat which a stem cell switches from a totipotent stem cell to a pluripotent or multipotent stem cell is often unclear. Furthermore, iPS cell technology allows us to reverse mature cell types back into a totipotent state. iPS cells are totipotent, so stem cells can now be collected at any point in the human lifecycle.

Today, most clinics that offer stem cell treatments administer mesenchymal stem cells (MSCs), which they source from fat tissue orbone marrow. Mesenchymal stem cells are a type of multipotent stem cell that is being explored for use in the orthopedic repair, pain management, arthritis, asthma, and many other applications. MSCs tend to exert effects on other cells and tissues within the human body, which is called paracrine signaling.

Although risks will exist whenever cell therapies are administered to humans, a large body of scientific evidence suggests that MSCs can be safe for patient use when properly administered and monitored.There is an additional layer of safety that occurs when cells are multipotent (limited in their differentiation capacity). Often, it is safer for them to be self-derived (autologous), rather than from someone else (allogeneic).

Another stem cell type that is commonly used is the hematopoietic stem cell (HSC). HSC transplantation has been used for decades as a means of rebuilding the immune system after a patient undergoes radiation or chemotherapy.

There are many companies working to introduce legitimate stem cell therapies into clinical practice. Unfortunately, there are also unregulated stem cell groups that are offering unverified and unsafe stem cell therapies to patients.

One of the risks of totipotent stem cells (embryonic stem cells and iPS cells) is that they have the potential to produce uncontrolled proliferation. The biggest concern surrounding the clinical application of these cells is their tendency to form tumors. Pluripotent and multipotent stem cells have a lower risk of producing tumor formation, but can potentially create growth of the wrong tissue type for a given location within the human body. Additionally, iPS cells are artificially manipulated in a laboratory process, so there is the possibility that the cells can act in unexpected ways.

Because many of these risks can be mitigated and monitored, stem cells are currently being investigated in hundreds of clinical trials worldwide. The majority of these clinical trials involve the use of mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs). Approximately three-quarters of these stem cell trials worldwide are registered at ClinicalTrials.gov. You can screen that public database to search for trials by condition, disease, location, or sponsor. Additional trials can be found on a country-by-country basis.

To make things more complex, the U.S. FDA regulates stem cell treatments as two different types, commonly called 361 and 351 products:

To share your own knowledge or experience with stem cells, comment below.

Up Next: Advanced Dental Care: Guide To Dental Stem Cell Companies

If you need this information on the go, download your free PDF Fact Sheet below.

Stem Cells Definition | Understanding Stem Cells

Read this article:
Stem Cells Definition | Understanding Stem Cells ...

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek , meaning of the body), they can be found in juvenile as well as adult animals and humans, unlike embryonic stem cells.

Scientific interest in adult stem cells is centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells.[1] Unlike for embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than human embryos designated for scientific research. They have mainly been studied in humans and model organisms such as mice and rats.

A stem cell possesses two properties:

Hematopoietic stem cells are found in the bone marrow and umbilical cord blood and give rise to all the blood cell types.[3]

Mammary stem cells provide the source of cells for growth of the mammary gland during puberty and gestation and play an important role in carcinogenesis of the breast.[4] Mammary stem cells have been isolated from human and mouse tissue as well as from cell lines derived from the mammary gland. Single such cells can give rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice.[4]

Intestinal stem cells divide continuously throughout life and use a complex genetic program to produce the cells lining the surface of the small and large intestines.[5] Intestinal stem cells reside near the base of the stem cell niche, called the crypts of Lieberkuhn. Intestinal stem cells are probably the source of most cancers of the small intestine and colon.[6]

Mesenchymal stem cells (MSCs) are of stromal origin and may differentiate into a variety of tissues. MSCs have been isolated from placenta, adipose tissue, lung, bone marrow and blood, Wharton's jelly from the umbilical cord,[7] and teeth (perivascular niche of dental pulp and periodontal ligament).[8] MSCs are attractive for clinical therapy due to their ability to differentiate, provide trophic support, and modulate innate immune response.[7] These cells have the ability to differentiate into various cell types such as osteoblasts, chondroblasts, adipocytes, neuroectodermal cells, and hepatocytes.[9] Bioactive mediators that favor local cell growth are also secreted by MSCs. Anti-inflammatory effects on the local microenvironment, which promote tissue healing, are also observed. The inflammatory response can be modulated by adipose-derived regenerative cells (ADRC) including mesenchymal stem cells and regulatory T-lymphocytes. The mesenchymal stem cells thus alter the outcome of the immune response by changing the cytokine secretion of dendritic and T-cell subsets. This results in a shift from a pro-inflammatory environment to an anti-inflammatory or tolerant cell environment.[10][11]

Endothelial stem cells are one of the three types of multipotent stem cells found in the bone marrow. They are a rare and controversial group with the ability to differentiate into endothelial cells, the cells that line blood vessels.

The existence of stem cells in the adult brain has been postulated following the discovery that the process of neurogenesis, the birth of new neurons, continues into adulthood in rats.[12] The presence of stem cells in the mature primate brain was first reported in 1967.[13] It has since been shown that new neurons are generated in adult mice, songbirds and primates, including humans. Normally, adult neurogenesis is restricted to two areas of the brain the subventricular zone, which lines the lateral ventricles, and the dentate gyrus of the hippocampal formation.[14] Although the generation of new neurons in the hippocampus is well established, the presence of true self-renewing stem cells there has been debated.[15] Under certain circumstances, such as following tissue damage in ischemia, neurogenesis can be induced in other brain regions, including the neocortex.

Neural stem cells are commonly cultured in vitro as so called neurospheres floating heterogeneous aggregates of cells, containing a large proportion of stem cells.[16] They can be propagated for extended periods of time and differentiated into both neuronal and glia cells, and therefore behave as stem cells. However, some recent studies suggest that this behaviour is induced by the culture conditions in progenitor cells, the progeny of stem cell division that normally undergo a strictly limited number of replication cycles in vivo.[17] Furthermore, neurosphere-derived cells do not behave as stem cells when transplanted back into the brain.[18]

Neural stem cells share many properties with haematopoietic stem cells (HSCs). Remarkably, when injected into the blood, neurosphere-derived cells differentiate into various cell types of the immune system.[19]

Olfactory adult stem cells have been successfully harvested from the human olfactory mucosa cells, which are found in the lining of the nose and are involved in the sense of smell.[20] If they are given the right chemical environment these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold the potential for therapeutic applications and, in contrast to neural stem cells, can be harvested with ease without harm to the patient. This means they can be easily obtained from all individuals, including older patients who might be most in need of stem cell therapies.

Hair follicles contain two types of stem cells, one of which appears to represent a remnant of the stem cells of the embryonic neural crest. Similar cells have been found in the gastrointestinal tract, sciatic nerve, cardiac outflow tract and spinal and sympathetic ganglia. These cells can generate neurons, Schwann cells, myofibroblast, chondrocytes and melanocytes.[21][22]

Multipotent stem cells with a claimed equivalency to embryonic stem cells have been derived from spermatogonial progenitor cells found in the testicles of laboratory mice by scientists in Germany[23][24][25] and the United States,[26][27][28][29] and, a year later, researchers from Germany and the United Kingdom confirmed the same capability using cells from the testicles of humans.[30] The extracted stem cells are known as human adult germline stem cells (GSCs)[31]

Multipotent stem cells have also been derived from germ cells found in human testicles.[32]

To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). Symmetric division gives rise to two identical daughter cells, both endowed with stem cell properties, whereas asymmetric division produces only one stem cell and a progenitor cell with limited self-renewal potential. Progenitors can go through several rounds of cell division before finally differentiating into a mature cell. It is believed that the molecular distinction between symmetric and asymmetric divisions lies in differential segregation of cell membrane proteins (such as receptors) between the daughter cells.

Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. For instance, neural stem cells from the brain, which are derived from ectoderm, can differentiate into ectoderm, mesoderm, and endoderm.[33] Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm.[34] This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell plasticity. More recent findings suggest that pluripotent stem cells may reside in blood and adult tissues in a dormant state.[35] These cells are referred to as "Blastomere Like Stem Cells"[36] and "very small embryonic like" "VSEL" stem cells, and display pluripotency in vitro.[35] As BLSC's and VSEL cells are present in virtually all adult tissues, including lung, brain, kidneys, muscles, and pancreas[37] Co-purification of BLSC's and VSEL cells with other populations of adult stem cells may explain the apparent pluripotency of adult stem cell populations. However, recent studies have shown that both human and murine VSEL cells lack stem cell characteristics and are not pluripotent.[38][39][40][41]

Stem cell function becomes impaired with age, and this contributes to progressive deterioration of tissue maintenance and repair.[42] A likely important cause of increasing stem cell dysfunction is age-dependent accumulation of DNA damage in both stem cells and the cells that comprise the stem cell environment.[42] (See also DNA damage theory of aging.)

Adult stem cells can, however, be artificially reverted to a state where they behave like embryonic stem cells (including the associated DNA repair mechanisms). This was done with mice as early as 2006[43] with future prospects to slow down human aging substantially. Such cells are one of the various classes of induced stem cells.

Adult stem cell research has been focused on uncovering the general molecular mechanisms that control their self-renewal and differentiation.

Adult stem cell treatments have been used for many years to successfully treat leukemia and related bone/blood cancers utilizing bone marrow transplants.[47] The use of adult stem cells in research and therapy is not considered as controversial as the use of embryonic stem cells, because the production of adult stem cells does not require the destruction of an embryo.

Early regenerative applications of adult stem cells has focused on intravenous delivery of blood progenitors known as Hematopetic Stem Cells (HSC's). CD34+ hematopoietic Stem Cells have been clinically applied to treat various diseases including spinal cord injury,[48] liver cirrhosis [49] and Peripheral Vascular disease.[50] Research has shown that CD34+ hematopoietic Stem Cells are relatively more numerous in men than in women of reproductive age group among spinal cord Injury victims.[51] Other early commercial applications have focused on Mesenchymal Stem Cells (MSCs). For both cell lines, direct injection or placement of cells into a site in need of repair may be the preferred method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenous injected cells are sequestered in the lungs.[52] Clinical case reports in orthopedic applications have been published. Wakitani has published a small case series of nine defects in five knees involving surgical transplantation of mesenchymal stem cells with coverage of the treated chondral defects.[53] Centeno et al. have reported high field MRI evidence of increased cartilage and meniscus volume in individual human clinical subjects as well as a large n=227 safety study.[54][55][56][57] Many other stem cell based treatments are operating outside the US, with much controversy being reported regarding these treatments as some feel more regulation is needed as clinics tend to exaggerate claims of success and minimize or omit risks.[58]

The therapeutic potential of adult stem cells is the focus of much scientific research, due to their ability to be harvested from the parent body that is females during the delivery.[59][60][61] In common with embryonic stem cells, adult stem cells have the ability to differentiate into more than one cell type, but unlike the former they are often restricted to certain types or "lineages". The ability of a differentiated stem cell of one lineage to produce cells of a different lineage is called transdifferentiation. Some types of adult stem cells are more capable of transdifferentiation than others, but for many there is no evidence that such a transformation is possible. Consequently, adult stem therapies require a stem cell source of the specific lineage needed, and harvesting and/or culturing them up to the numbers required is a challenge.[62][63] Additionally, cues from the immediate environment (including how stiff or porous the surrounding structure/extracellular matrix is) can alter or enhance the fate and differentiation of the stem cells.[64]

Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in a number of tissues, including umbilical cord blood.[65] Using genetic reprogramming, pluripotent stem cells equivalent to embryonic stem cells have been derived from human adult skin tissue.[66][67][68][69][70] Other adult stem cells are multipotent, meaning they are restricted in the types of cell they can become, and are generally referred to by their tissue origin (such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.).[71][72] A great deal of adult stem cell research has focused on investigating their capacity to divide or self-renew indefinitely, and their potential for differentiation.[73] In mice, pluripotent stem cells can be directly generated from adult fibroblast cultures.[74]

In recent years, acceptance of the concept of adult stem cells has increased. There is now a hypothesis that stem cells reside in many adult tissues and that these unique reservoirs of cells not only are responsible for the normal reparative and regenerative processes but are also considered to be a prime target for genetic and epigenetic changes, culminating in many abnormal conditions including cancer.[75][76] (See cancer stem cell for more details.)

Adult stem cells express transporters of the ATP-binding cassette family that actively pump a diversity of organic molecules out of the cell.[77] Many pharmaceuticals are exported by these transporters conferring multidrug resistance onto the cell. This complicates the design of drugs, for instance neural stem cell targeted therapies for the treatment of clinical depression.

Read more:
Adult stem cell - Wikipedia

Dental stem cell companies are companies that preserve the valuable cells contained with dental structures.While stem cells from teeth have not yet been approved for therapeutic use in humans, there is great potential for their future use within regenerative medicine applications.

In this article:

Simply put, dental stem cell companies collect and preserve cells from teeth.Dental pulp is the soft living tissue inside a tooth that contains adult stem cells. The ideal time to harvest dental stem cells is when children lose their baby teeth through natural loss or extraction by a dentist.

Although dental pulp gets the most attention, there are stem cell and progenitor cells present in other oral structures as well.

Five different types of dental stem cells have been discovered, which include:

The following are the companies offeringdentalstem cells storage as part of a diversified stem cell storage approach. Each of these companies was created as a cord blood bank to collect and store the blood present in a newborns umbilical cord, because this blood contains a rich population of stem cells.

Similar to cord blood banking, dental stem cell banking involves stem cell collection, processing, and long-term storage. Therefore, it is an excellent service addition for many cord blood banks, including:

In addition, specialty companies also exist that focus exclusively on dentalstem cell storage.

The major players in this area include:

While there are many other small providers of tooth stem cell storage, the companies listed above account formore than 80% of the total market share, according to estimates by BioInformant.

Below, five leading dental stem cell companies are profiled and their storage services explained.

BioEden began offering tooth stem cell storage as early as 2006[1], making it one of the earliest known providers of dental stem cell storage. Read our interview withTony Veverka, Chief Group Executive of BioEden.

Precious Cells Group (PCG) got into dental stem cell banking by entering into a strategic alliance to provide processing, laboratory and regulatory undertakings on behalf of Bioeden in the U.K.

Unfortunately, PCG went out of businessin March 2018 and no longer offers dental stem cell storage services.

The National Dental Pulp Laboratory launched in 2007[2].

Originally, the company was formed in the early 1970s as a cryogenic laboratory specializing in fertility work. In the mid 1990]s, it began preserving stem cells from umbilical cord blood, and today, it also offers storage for the stem cells found in teeth.

According to Stemade, it is thefirst and largest private dental stem cell storage company in India.[3] The company has also served areas of Asia since 2013 [4].Stemade licenses their dental storage technology fromInstitut Clinident Biopharma, which it describes as offering a technical solution to the collection and preservation of the dental pulp, rich in adult stem cells[5]. TheInstitut Clinident Biopharma also licenses its technology to European companies as well.

There is also ReeLabs[6], a major enterprise forstem cell storage in India,banking cells from over ten human sources. To learn more about ReeLabs, read our interview withDr. Abhijit Bopardikar, Director.

Clearly, the regions that are currentlymost active in offering dental stem cell storage are the United States, India, and the United Kingdom, respectively.

If you found this blog valuable, subscribe to BioInformants stem cell industry updates.

What other questions do you have regarding tooth stem cells and dental stem cell companies? Mention them in the comments below.

Footnotes[1] Us.bioeden.com, (1963). About BioEden Inc | Stem cells | Tooth stem cell storage bank. [online] Available at: http://us.bioeden.com/about/ [Accessed 4 Nov. 2014].[2] Ndpl.net,. National Dental Pulp Laboratory | Preserving Dental Stem Cells. N.p., 2015. Web. 19 Sept. 2015.[3] Stemade.com,. Stemade Indias First & Largest Dental Stem Cell Bank. N.p., 2015. Web. 01 Dec. 2015.[4] Biospectrumasia.com,. Asias First Dental Stem Cell Bank Is Here. N.p., 2015. Web. 02 Dec. 2015.[5] Stemade.com/about/partners,. Stemade Partner. N.p., 2015. Web. 01 Dec. 2015.[6] Reelabs.com,. Stem Cell Banking & Therapy In India | Reelabs. N.p., 2015. Web. 18 Dec. 2015.

Guide To Dental Stem Cell Companies | Tooth Stem Cells

Read more here:
Guide To Dental Stem Cell Companies | Tooth Stem Cells

NIDCR-Supported Researchers Explore Basic Biology & Therapeutic Potential

More than 15 years ago, NIDCR researcher Pamela Robey, PhD, and colleagues made the surprising discovery that humanbaby teeth and wisdom teeth contain adaptable cells known as stem cells, which can transform into other cell types. These readily accessible cells raised early hopes that they might revolutionize repair of teeth and oral tissues, and possibly lead to new therapies for diabetes, heart disease, and neural conditions.

But scientists soon realized that the complex biology of dental stem cells made it challenging to move from animal models to human patients. The US FDA has yet to approve the use of dental stem cells in medical procedures, Robey says.

Based on current evidence, clinical use of dental stem cells may be closest to fruition for root canal therapy or repair of bone defects caused by gum disease. However, the possibility of regenerating whole teeth and other uses may be many more decades down the road.

To fully explore the potential of these versatile cells, NIDCR supports a range of scientists who are working to better understand dental stem cells and their therapeutic promise.

Basic Questions

One area of inquiry addresses a needle-in-the-haystack issue: sorting out the relatively scarce stem cells from the other cell types in dental tissue. To be used in experiments or in the clinic, dental stem cells must first be identified, isolated through a process called enrichment, then assessed to ensure theyre at the right stage of development.

In order to identify and enrich stem cells, NIDCR-supported researchers are looking for proteins or genes specifically expressed by dental stem cells that can serve as identifiers, or markers, to distinguish them from other cells. We have pretty good markers for the mature progeny of dental stem cells, Robeysays. But more and better markers are needed to isolate highly enriched stem cell populations that will enable high-quality experiments.

Nadya Lumelsky, PhD, director of NIDCRs Tissue Engineering and Regenerative Medicine Program, notes that highly enriched dental stem cell populations will also be key to developing potential therapies. Separating the irrelevant cells from a population means that a higher fraction are true stem cells, which means the replacement tissue is higher quality and can more reliably repair defects, Lumelsky says. Better methods of enriching and expanding dental stem cells will also be important for generating sufficient numbers of cells to be used at the scale needed for clinical studies.

More reliable markers for dental stem cells will help scientists trace the process of stem cell development and differentiation as it naturally occurs in the body during normal growth or after tissue injury or damage. Much research has been done on dental stem cell behavior in culture. But stem cells in a dish behave differently from stem cells in their natural environment, Robey notes. Some insights into the natural behavior of dental stem cells have been gleaned through studies of mice and their continuously renewing incisors. Yet the differences between mouse and human dental stem cells remain unclear.

Identifying the cellular and molecular signals that guide stem cell repair processes in the body will help researchers develop strategies for recreating these processes in stem cell therapies. It could also help scientists learn how to reliably prompt cells to differentiate into one cell type and not anotherin the case of dental stem cells, how to produce the hard tissue called dentin instead of pulp, for instance.

Instead of removing and re-implanting stem cells, alternative approaches called autotherapies employ small molecules or other minimally invasive methods to trigger stem cells healing properties inside the body. For example, some NIDCR-supported scientists are exploring ways to repair teeth by recruiting dental stem cells to the site of damage or decay and prompting them to regenerate pulp and dentin.

A Path to the Clinic

Beyond the basic investigations of dental stem cell biology, some NIDCR-supported scientists are exploring how the cells might be used in the clinic to help to repair bone and teeth. A major area of research involves the potential usedental stem cells in root canal therapy. Dental specialists perform root canal procedureswhen pulp becomes inflamed or infected. A clinician removes the dental pulp, cleans the inside of the tooth, then fills and seals the space. However, repaired teeth that lack pulp may become brittle and more likely to break. To improve root canal outcomes, several NIDCR-supported researchers are exploring the use of dental stem cells to replace inflamed tissue and regenerate healthy pulp.

Jacques Nr, DDS, PhD,at the University of Michigan, is one of these scientists. Several years ago, Nrs group loaded dental stem cells into a human tooth slice that contained a physical support structure, or scaffold, for the cells.

Transplanting these constructs into mice resulted in dental pulp tissue approximating normal dental pulp, Nr says. His group is now addressing a common barrier to much of the regenerative medicine field: providing a blood supply to regenerated tissue. Integrating blood vessels is vital for effective tissue regeneration, and dental pulp is no exception.

Nrs group has directed dental pulp stem cells to generate structures resembling blood vessels that integrate with the mouses own vasculature. How this happens is still unclear, though, and his group continues to explore the question. Understanding the molecular signals that guide this process will allow us to develop a successful pulp regeneration strategy for eventual clinical use, Nr says. The findings from this research may also apply to the use of dental stem cells in other therapeutic contexts, such as potential bone regeneration.

Other researchers are looking for markers to identify and isolate bone-forming dental stem cells. These studies also entail finding the precise molecular recipe to prompt the cells to form bone.

Once dental stem cells are implanted in a defect, whether tooth or bone, the proper physical and chemical atmospherecalled a microenvironmentis necessary to keep the cells growing and alive. NIDCR-supported scientists are working to optimize stem cell microenvironments for given therapies. One important facet is optimizing scaffolds for the cells. Regenerative therapies cant work without the proper structure to corral and guide cell growth, and different tissues require different scaffolds.

While much work remains to be done before dental stem cells enter the clinic, Nr remains optimistic that the cells easy accessibility and regenerative properties make them a valuable asset.

These unique cells may translate into helping patients in the not-too-distant future, Nr says. Its important to strike the right balance between caution and hope.

References

Sipp D, Robey PG, Turner L. Clear up this stem-cell mess. Nature. 2018 Sep;561(7724):455-457. doi: 10.1038/d41586-018-06756-9.

Zhang Z, Nor F, Oh M, Cucco C, Shi S, Nr JE. 36. Wnt/-Catenin Signaling Determines the Vasculogenic Fate of Postnatal Mesenchymal Stem Cells. Stem Cells. 2016 Jun;34(6):1576-87. doi: 10.1002/stem.2334.

Bento LW, Zhang Z, Imai A, Nr F, Dong Z, Shi S, Araujo FB, Nr JE. Endothelial differentiation of SHED requires MEK1/ERK signaling. J Dent Res. 2013 Jan;92(1):51-7. doi: 10.1177/0022034512466263. Epub 2012 Oct 31.

Sakai VT, Zhang Z, Dong Z, Neiva KG, Machado MA, Shi S, Santos CF, Nr JE. SHED differentiate into functional odontoblasts and endothelium. J Dent Res. 2010 Aug;89(8):791-6. doi: 10.1177/0022034510368647. Epub 2010 Apr 15.

Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, Smith AJ, Nr JE. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008 Aug;34(8):962-9. doi: 10.1016/j.joen.2008.04.009.

Miura M, Gronthos S. Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA. May 13;100(10):5807-12. Epub 2003 Apr 25.

Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30.

Original post:
The Quest to Understand Dental Stem Cells | National ...

Tooth stem cells (also called dental stem cells) are cells collected from the teeth and supporting oral structures.Dental pulp is the soft living tissue inside a tooth that contains a type of adult stem cell called a mesenchymal stem cell (MSC). The ideal time to harvest dental stem cells is when children lose their baby teeth through natural loss or extraction by a dentist.

In this article:

Tooth stem cells are defined as stem cells collected from the dental structures, including components of the developing tooth, as well as structures within the mature tooth and periodontal ligaments. Tooth stem cells are multipotent, meaning they can become a variety of cell types that could potentially be used for therapeutic applications.

The type of stem cell found within the dental pulp is called a mesenchymal stem cell (MSC). MSCs from a range of sources are being explored in more than 800 clinical trials worldwide, making teeth an interesting source of these cells.

While MSCs from teeth have not yet been approved for clinical use in humans, there is interesting potential for their use within regenerative medicine applications.

Tooth Stem Cell Cost

The cost of tooth stem cell storage has two parts, the Processing Fee and the Storage Fee. The Processing Fee is a one-time fee, while the Storage Fee is a reoccurring fee.

The Processing Fee covers the steps that the dental stem cell bank must take to prepare the valuable cells within a tooth for long-term storage. The Storage Fee covers the cost of preserving the tooth stem cells in frozen (cryogenic) conditions with proper backup systems and data protection.

For BioEden, the market leader in the U.S. and worldwide, its Processing Fee is$1,250. Its annual Storage Cost is $120 per year or $17.95 per month.

Alternatively, BioEden offers the option for a family to pay a lump sum fee to cover One Off Processing and 21 Years of Storage for $2930. Over a 21 year period, this options offers over $840 in savings as compared to paying annually at $120/year.

Click here to see BioEdens full pricing schedule for tooth stem cell storage.

Should I Store Tooth Stem Cells?

Whether or not to store tooth stem cells is a personal decisions, but stem cells from dental pulp do have differences in comparison to other types of stem cells. First, they are not limited to the quantity extracted from a tooth, because the cells can be expanded in number within a laboratory.

Second, they have the ability todifferentiate into range of other cell types, and in this regard, have a diverse range of potentialapplications.

Cellsharvested from baby teeth are also advantageous in that they have been harvested while the cells are young, healthy, and full offunctionality.

Finally, harvesting tooth stem cells is a non-invasive method of collecting stem cells. No medical or dental intervention is required, because a tooth can be exfoliatednaturally. In the case of tooth extraction, these procedures are necessary for other dental reasons and the ability to preserve tooth stem cells is a valuable byproduct.

Stem cells from teeth are of growing interest among parents, because these stem cells can be collected without the need for invasive procedures.

While tooth stem cell storageis a relatively new service, new competitors are entering the market on a global basis. The United States, UK, and India currently host the greatest number of dental stem cell storage companies.

The largest competitor within the tooth stem cell storage market is BioEden.BioEden became the worlds first company to collect, assess, and cryogenically store living stem cells from teeth when it began offering services in 2006.

BioEden now operates in 25 countries and has members in over 60 countries. It also has laboratories in the US (Texas), Europe (UK), and Asia (Thailand).

It is also one of the few tooth stem cell companies that storesallsamples in duplicate inseparate locations for thepurpose of creating additional security and safety. This can preserve the cells in the event of natural disaster or other emergency.

With this wide global reach and early entry into the field, BioEden is estimated to control morethan 50% of the dental stem cell storage market worldwide.To learn more, view our interview with Tony Veverka, the CEO of BioEden.

Interview with Tony Veverka, Chief Group Executive of BioEden How Dental Stem Cells Will Impact Our Future https://t.co/ubbG3TFa1M

BioInformant (@StemCellMarket) June 19, 2016

Types of Tooth Stem Cells

Five different types of tooth stem cells have been discovered, which are:

While the future is unknown, it is possible that tooth stem cells could be used in the future to restore tooth structure lost to decay or injury, as well astreat a range of acute and chronic diseases.

Up Next:Do You Know the 5 Types of Dental Stem Cells?

What are Tooth Stem Cells? | Dental Stem Cells

Read more:
What are Tooth Stem Cells? | Dental Stem Cells | BioInformant

Stem cell therapies have great potential to cure currently untreatable diseases and to even extend lifespans. Due to their differentiating qualities, they have been used for novel regenerative protocols. Ongoing progress towards the clinical use of dental pulp stem cells has recently expanded the possibilities for clinical applications based on pulp and periodontal tissue regeneration. Dental stem cells are a kind of mesenchymal cell that reside within the dental pulp and are classified as postnatal stem cell populations.

At present, there are two approved clinical trials and one clinical trial protocol related to dental stem cells that have not yet started recruiting. Nevertheless, these trials are still in an early phase that are testing the feasibility of the stem cells and the tolerance of the stem cell implantation, but have not applied the cells on patients for accruing diseases.

One trial in China is using stem cells from human exfoliated deciduous teeth (SHED) as the main target for investigation. Investigators from China are aiming to explore and clarify if autologous (cells or tissues obtained from the same individual) SHED stem cell transplantation can efficiently regenerate pulp (the center part of a tooth) and periodontal (connective tissue known as gum) tissue in immature permanent teeth and necrotic pulp of teeth in humans.

Millions of teeth are accidentally and forcibly detached each year, especially causing losses of immature permanent teeth in children. This clinical trial is starting to recruit patients with immature permanent teeth and pulp necrosis. SHED will be used as the cell source for regenerating pulp and periodontal tissue in immature teeth.

One of the main limitations in bone regeneration is lack of vascularization of newly sharp tissue. A new trial starting in France is aiming to use the dental stem cells of a simple and non-invasive tissue source such as dental pulp to develop a brand new pre-vascularized tissue-engineered bone construct. The dental pulp stem cells were isolated from the dental tissue of patients wisdom teeth and then used to assess their endothelial and osteoblastic differentiation to obtain pre-vascularized tissue engineered bone construct. Furthermore, one commercial differentiation medium is also used to evaluate its effect on the cell differentiation and production of a prevascularized bone construct.

TOOTH (The Open study Of dental pulp stem cell Therapy in Humans), a clinical trial protocol, is an open study, phase 1, single-blind clinical trial being conducted by Australian researchers. The protocol is investigating the use of dental pulp stem cell therapy for stroke survivors with chronic disability, with the aims of determining the maximum tolerable dose of the cell therapy, and the safety and feasibility for patients with chronic stroke.

Taken together with those trials, on going or just a start, the regenerating methods are still emphasized on the early phase clinical study of improving human diseases. Although clinical trials using dental pulp stem cells for treating human diseases are not very common, preclinical research has broadened the extent of potential clinical applications. Dental stem cells can differentiate into several cell types, such as neurons, adipocytes, and chondrocytes. From that, their therapeutic potential has been identified for various conditions, including neurological disorders, angiogenesis and vasculogenesis, liver disease, diabetes mellitus, and for regenerative ocular therapy, bone tissue engineering, and, of course, therapeutic applications in dentistry such as regenerative endodontic therapy, dentin regeneration, regenerative periodontal therapy, and bioengineered teeth.

Stem cell therapies have been a hot topic of research for years, but progress toward clinical trials for applications to humans has been slow due to ethical concerns and source obtained for transplantation. Dental pulp stem cells could resolve both these issues, by using human exfoliated deciduous teeth instead of invasive source such as embryonic stem cells. Pending successful completion of ongoing clinical trials, we can hope to see further work towards applying regenerative therapies based on dental stem cells for other organs, ultimately generating novel therapies to cure currently untreatable diseases.

Please note: PreScouter provides secondary research and is not associated with the experiments or getting volunteers for clinical trials.

Stay current on your favorite topics

Tina is a dedicated, enthusiastic and innovative Pre-Clinical Researcher and Medical Writer who has a strong academic background encompassing a PhD in Clinical Science, a Masters in General Physiology and a Bachelors in Clinical Psychology. She has always been passionate about delivering exciting medical information. Tina is a technically-proficient researcher with exposure to multiple fields including urology, reproductive health, immunology, endocrinology and rheumatology gained across healthcare, clinical trials and pharmaceutical organizations. She joined PreScouter as a Global Scholar recently. Besides her medical research, she also starts up a commercial business with her favorite thing FOOD.

See original here:
A review of dental stem cells where are we now in ...

Sometimes kids trip and fall, and their teeth take the hit. Nearly half of children suffer some injury to a tooth during childhood. When that trauma affects an immature permanent tooth, it can hinder blood supply and root development, resulting in what is essentially a dead tooth.

Until now, the standard of care has entailed a procedure called apexification that encourages further root development, but it does not replace the lost tissue from the injury and, even in a best-case scenario, causes root development to proceed abnormally.

New results of a clinical trial, jointly led by Songtao Shi of the University of Pennsylvania and Yan Jin, Kun Xuan, and Bei Li of the Fourth Military Medicine University in Xian, China, suggest that there is a more promising path for children with these types of injuries: using stem cells extracted from the patients baby teeth. The work was published in the journal Science Translational Medicine.

This treatment gives patients sensation back in their teeth. If you give them a warm or cold stimulation, they can feel it; they have living teeth again, says Shi, professor and chair in the Department of Anatomy and Cell Biology in Penns School of Dental Medicine. So far we have follow-up data for two, two and a half, even three years, and have shown its a safe and effective therapy.

Shi has been working for a decade to test the possibilities of dental stem cells after discovering them in his daughters baby tooth. He and colleagues have learned more about how these dental stem cells, officially called human deciduous pulp stem cells (hDPSC), work, and how they could be safely employed to regrow dental tissue, known as pulp.

The Phase 1trial was conducted in China, which has a research track for clinical trials.The 40 children enrolled had each injured one of their permanent incisors, and still had baby teeth. Thirty were assigned to hDPSC treatment and 10 to the control treatment, apexification.

Those whoreceived hDPSC treatment had tissue extracted from a healthy baby tooth. The stem cells from this pulp were allowed to reproduce in a laboratory culture, and the resulting cells were implanted into the injured tooth.

Upon follow-up, the researchers found that patients who received hDPSCs had more signs than the control group of healthy root development and thicker dentin, the hard part of a tooth beneath the enamel, as well as increased blood flow.

At the time the patients were initially seen, all had little sensation in the tissue of their injured teeth. A year following the procedure, only those who received hDPSCs had regained some sensation. Examining a variety of immune-system components, the team found no evidence of safety concerns.

As further support of the treatments efficacy, the researchers had the opportunity to directly examine the tissue of a treated tooth when the patient re-injured it, and had to have it extracted. They found that the implanted stem cells regenerated different components of dental pulp, including the cells that produce dentin, connective tissue, and blood vessels.

For me, the results are very exciting, Shi says. To see something we discovered take a step forward to potentially become a routine therapy in the clinic is gratifying.

It is, however, just a first step. While using a patients own stem cells reduces the chances of immune rejection, its not possible in adult patients who have lost all of their baby teeth. Shi and colleagues are beginning to test the use of allogenic stem cells, or cells donated from another person, to regenerate dental tissue in adults. They are also hoping to secure FDA approval to conduct clinical trials using hDPSCs in the United States.

Eventually, they see even broader applications of hDPSCs for treating systemic disease, such as lupus, which Shi has worked on before.

Were really eager to see what we can do in the dental field, Shi says, and then building on that to open up channels for systemic disease therapy.

The research was supported by the National Key Research and Development Program of China, the NaturalScience Foundation of China and a pilot grant from Penn Dental Medicine.

See the original post here:
Regrowing dental tissue with stem cells from baby teeth ...

You may have heard about stem cell research on the nightly news, but did you know that your extracted wisdom teeth could help make a medical breakthrough? Dental stem cells are being investigated for multiple applications to help solve some of the biggest health issues we face today. Amazingly, these uses are not limited to the oral cavity.

What Exactly Are Stem Cells?

Stem cells are different from most other cells in a human body because they are not specialized, explains the National Institutes of Health. Unlike a red blood cell or a skin cell, a stem cell has the unique ability to develop into many different cell types to heal the body and replenish damaged tissue. When a stem cell multiplies, it can either form additional stem cells or grow into cells that have a more specific function, such as liver cells or muscle cells in the heart. Under experimental conditions, a stem cell can even form organ- or tissue-specific cells with specialized functions.

Unfortunately, some controversy surrounds the use of stem cells for research. Stem cells can come from multiple sources: embryonic tissue and postnatal tissue. When embryonic cells are used, they are isolated from developing fetal tissue. When postnatal cells are used, they are typically referred to as adult stem cells and come from a fully developed animal or human child or adult. Stems cells from oral tissues are always adult stem cells and are often donated by living adults for their own use from their own extracted teeth or oral tissue.

What Is So Unique About Dental Stem Cells?

According to the Journal of Natural Science, Biology and Medicine, the stem cells that come from oral tissues are ideal for use in research since they are readily accessible and can be harvested noninvasively. These cells have the potential to be used in multiple clinical applications, such as regenerative dentistry.

As explained in the Journal of Tissue Engineering, dental stem cells can be obtained from a number of oral tissues, including the craniofacial bones, periodontal ligament, dental pulp, tooth germ, dental follicle, oral mucosa, apical papilla, gingiva and periosteum. The easiest sources from which to obtain these cells are the pulp of exfoliated deciduous teeth and extracted wisdom teeth. Your patients may be excited to learn that if they lose a tooth and it is donated to research, it may potentially help with the development of treatments for others with debilitating diseases.

Potential Uses for Dental Stem Cells

One of the most impressive qualities of dental stem cells is their wide variety of potential applications. In in vitro studies, these cells were found to create dentin-like structures and to differentiate into osteoblast-like cells that built bone, leading to research surrounding regeneration of dental tissues.

Additionally, stem cells' versatility makes them promising for treating degenerative conditions, such as stroke, Alzheimer's disease, multiple sclerosis, Parkinson's disease, cirrhosis, arthritis, cardiac defects and spinal cord injuries. Stem cell-grown pancreatic cells may even be able to produce insulin and reverse hyperglycemia in patient who have diabetes. All of this potentially from a tooth!

Takeaways

Why It's Important

Keeping up with research on dental innovations and research can help you stay informed and be a source of knowledge for your patients. Someday, you may even help them contribute to science and medicine by donating a lost tooth.

See more here:
Colgate Oral Health Advisor - Dental Stem Cells: A ...

StemSave is a collaboration of Dentists and stem cell researchers who want to give families a convenient and reliable way to benefit from emerging new healthcare treatments.

By enrolling in our program, you and your Dentist can preserve your familys vital stem cells in the event of future disease or injury.

Like "biological insurance," storing Dental Stem Cells gives you and your family the option to choose the most advanced medical treatments available in the years ahead, when you may need them most.

Best of all, StemSave makes this option simple and affordable in two easy steps.

When your child's baby tooth becomes loose, or when a dental professional recommends that you or a family member has a tooth or wisdom teeth removed, this is your opportunity to secure stem cells through StemSave.

Enroll in StemSave. Your personalized StemSave recovery and transport kit, along with an email notification, will be sent directly to your Dentist. If your Dentist is not already enrolled as StemSave Dental Professional, we will contact him or her directly to introduce ourselves and navigate them through our easy Dental Professional enrollment page. Contact us to see if your Dentist is a StemSave provider.

Make an appointment with your Dentist for the planned procedure and the convenient recovery of your stem cells.

Securing your stem cells is easy - How your dentist does it:

For more information on this process, click here to go StemSave FAQs.

View post:
Storing Your Dental Stem Cells in 2 Easy Steps

Of all of the possible techniques and strategies that can lead us as a species to find a way to increase our size, the advent of stem cells is one of the most promising ideas.In this post, I wanted to give a very general and brief introduction to our journey into the subject of stem cells to search for a solution to our height increase endeavor. This first post will definitely wont be the last post on this subject since there is so much research currently being done in this subject to look for solutions to some of our biggest medical and cosmetic problems we face in our modern era.

If we remember from our high school or college biology classes, we might remember that we all came from the zygotic formation brought by the male gamete the sperm coming into fusion with the female gamete the egg. From this initial single organism zygote we are slowly developed into something resembling a human baby in our mothers uterus. The curous person would be asking the question Just how exactly does the zygote figure out how to grow and develop into the product of a human baby? That comes from the instructions in the cell called DNA. DNA stand for deoxyribonucleic acid, which is a double helix structure which has at its most basic level only 4 types of nucleotides bases being repeated and sorted in a certain order. From the way the nucleotide bases are set up, we get our codons, which organize themselves to form genes. the genes are really just segments of biological instruction ,or information. The information is what really tells the cells what to do. That is where almost all of genetics and the study of stem cells begins.

The stem cell is a type of cell which can differentiate itself and transform into another type of cell which has a specialized function as well as self generate more of itself. The ability of the stem cell to turn into so many different types of cells allows its application into the medical sciences to be nearly endless. If we can get certain stem cells to regrow into the tyep fo tissues and even organs that we wnat, we can essentially treat our body like a car, where if a specific part is damaged or not functioning, we can go into out body and replace the damaged tissue from the stem cell derived results.

If we look at the diagram to our left we can see just what types of diseases and pathologies stem cells therapy can potentially treat. Some of the possibilities can seem to come from science fiction.

Stroke, Baldness, Blindness, Learning Defects, Deafness Alzheimers disease, Parkinsons Disease, Missing Teeth, Teeth cavitations, Wond healing, Brain Injuries, Amyotrophic lateral sclerosis, Myocardial Infarction, Muscular Dystrophy, Diabetes, Bone marrow transplantation, Spinal cord injury, Multiple types of cancer, Osteoarthiritis, Crohns Disease.

It would seem from this list that our desire to use stem cells to increase our height seems almost insignificant when we consider what other applications stem cell therapies can be used for. It is a real shame the the US government and scientific community has been slow or even against the research of stem cell therapy. What often has to happen is that if a person suffering from a specific pathology wanted to use stem cell therapy as treatment, they have to leave the US and get it somewhere else.I dont have a Ph. D so I dont feel like I am qualified to explain to you all the most important aspects of stem cells so I will leave most of the instructioning to Wikiepdia.

From the Wikipedia Article on Stem Cells found HERE, I wanted to post a few of the main points about the unique cells.

Stem cellsarebiological cellsfound in all multicellularorganisms, that candivide(throughmitosis) anddifferentiateinto diverse specialized cell types and can self-renew to produce more stem cells. In mammals, there are two broad types of stem cells:embryonic stem cells, which are isolated from theinner cell massofblastocysts, andadult stem cells, which are found in various tissues. Inadultorganisms, stem cells andprogenitor cellsact as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells (these are called pluripotent cells), but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.

There are three accessible sources ofautologousadult stem cells in humans:

Stem cells can also be taken fromumbilical cord bloodjust after birth. Of all stem cell types, autologous harvesting involves the least risk. By definition, autologous cells are obtained from ones own body, just as one may bank his or her own blood for elective surgical procedures.

Highly plastic adult stem cells are routinely used in medical therapies, for example inbone marrow transplantation. Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves throughcell culture. Embryoniccell linesandautologousembryonic stem cells generated throughtherapeutic cloninghave also been proposed as promising candidates for futuretherapies.

The classical definition of a stem cell requires that it possess two properties:

Two mechanisms to ensure that a stem cell population is maintained exist:

Pluripotent, embryonic stem cells originate as inner cell mass (ICM) cells within a blastocyst. These stem cells can become any tissue in the body, excluding a placenta. Only cells from an earlier stage of the embryo, known as themorula, are totipotent, able to become all tissues in the body and the extraembryonic placenta.

Humanembryonicstem cellsA: Cell colonies that are not yet differentiated.B:Nervecell

Main article:Cell potency

Potencyspecifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell.

The practical definition of a stem cell is the functional definitiona cell that has the potential to regenerate tissue over a lifetime. For example, the defining test for a bone marrow or hematopoietic stem cell (HSC) is the ability to transplant one cell and save an individual without HSCs. In this case, a stem cell must be able to produce new blood cells and immune cells over a long term, demonstrating potency. It should also be possible to isolate stem cells from the transplanted individual, which can themselves be transplanted into another individual without HSCs, demonstrating that the stem cell was able to self-renew.

Properties of stem cells can be illustratedin vitro, using methods such asclonogenic assays, in which single cells are assessed for their ability to differentiate and self-renew.Stem cells can also be isolated by their possession of a distinctive set of cell surface markers. However,in vitroculture conditions can alter the behavior of cells, making it unclear whether the cells will behave in a similar mannerin vivo. There is considerable debate as to whether some proposed adult cell populations are truly stem cells.

Embryonic stem (ES) cell lines are cultures of cells derived from theepiblasttissue of theinner cell mass(ICM) of ablastocystor earliermorulastage embryos.[9]A blastocyst is an early stageembryoapproximately four to five days old in humans and consisting of 50150 cells. ES cells arepluripotentand give rise during development to all derivatives of the three primarygerm layers: ectoderm, endoderm and mesoderm. In other words, they can develop into each of the more than 200 cell types of the adultbodywhen given sufficient and necessary stimulation for a specific cell type. They do not contribute to the extra-embryonic membranes or theplacenta. The endoderm is composed of the entire gut tube and the lungs, the ectoderm gives rise to the nervous system and skin, and the mesoderm gives rise to muscle, bone, bloodin essence, everything else that connects the endoderm to the ectoderm.

Stem cell division and differentiation. A: stem cell; B: progenitor cell; C: differentiated cell; 1: symmetric stem cell division; 2: asymmetric stem cell division; 3: progenitor division; 4: terminal differentiation

Also known assomatic(from Greek , of the body) stem cells and germline (giving rise to gametes) stem cells, they can be found in children, as well as adults.

Pluripotent adult stem cells are rare and generally small in number but can be found in a number of tissues including umbilical cord blood.A great deal of adult stem cell research to date has had the aim of characterizing the capacity of the cells to divide or self-renew indefinitely and their differentiation potential.In mice, pluripotent stem cells are directly generated from adult fibroblast cultures. Unfortunately, many mice do not live long with stem cell organs.

Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin (mesenchymal stem cell, adipose-derived stem cell,endothelial stem cell,dental pulp stem cell, etc.).

Adult stem cell treatments have been successfully used for many years to treat leukemia and related bone/blood cancers through bone marrow transplants.

Multipotent stem cells are also found inamniotic fluid. These stem cells are very active, expand extensively without feeders and are not tumorigenic.Amniotic stem cellsare multipotent and can differentiate in cells of adipogenic, osteogenic, myogenic, endothelial, hepatic and also neuronal lines.[29]All over the world, universities and research institutes are studyingamniotic fluidto discover all the qualities of amniotic stem cells

These are not adult stem cells, but rather adult cells (e.g. epithelial cells) reprogrammed to give rise to pluripotent capabilities. Using genetic reprogramming with proteintranscription factors, pluripotent stem cells equivalent toembryonic stem cellshave been derived from human adult skin tissue

To ensure self-renewal, stem cells undergo two types of cell division (seeStem cell division and differentiationdiagram). Symmetric division gives rise to two identical daughter cells both endowed with stem cell properties. Asymmetric division, on the other hand, produces only one stem cell and aprogenitor cellwith limited self-renewal potential. Progenitors can go through several rounds of cell division before terminallydifferentiatinginto a mature cell. It is possible that the molecular distinction between symmetric and asymmetric divisions lies in differential segregation of cell membrane proteins (such asreceptors) between the daughter cells.

Stem cell treatmentsare a type of intervention strategy that introduces new adult stem cells into damaged tissue in order to treat disease or injury. Manymedical researchersbelieve that stem cell treatments have the potential to change the face of human disease and alleviate suffering.The ability ofstem cellsto self-renew and give rise to subsequent generations with variable degrees of differentiation capacities,offers significant potential for generation of tissues that can potentially replace diseased and damaged areas in the body, with minimal risk of rejection and side effects

Me: I wanted to add for this last part that the list of pathologies that stem cell therapy can be used to treat for is really long and amazing. If you wanted to read up on all the types of things stem cells can be use to be treated for, click on the Wikipedia article on Stem Cell Treatments located HERE.

Original post:
Grow Taller Using Stem Cells , Part I - Natural Height Growth

By: Ian Murnaghan BSc (hons), MSc - Updated: 13 Feb 2018| *Discuss

The concept of stem cells can seem a complicated one and you may have seen foreign words such as 'pluripotent' written in magazines or discussed on television. Stem cells describe all of the cells that can give rise to the different cells found in tissues. There are however, different types of stem cells. One such type is a pluripotent stem cell.

Approximately four days after fertilisation, the totipotent cells start to specialise and form a cluster of cells known as a blastocyst. The blastocyst has yet another smaller group of cells known as the inner cell mass and it is these inner pluripotent stem cells that will go on to create most of the cells and tissues in the human body. These pluripotent stem cells are therefore different than totipotent stem cells because they don't develop into a complete organism. As such, a pluripotent cell won't give rise to the placenta or other tissues that are vital for foetal development. It will still develop into the other specialised cell types in the human body, such as nerve or heart cells.

You may have also heard the term 'stem cell line.' Stem cells from embryos can be used to create these pluripotent stem cell 'lines,' which are grown in the laboratory or cultured from foetal tissue.

Pluripotent stem cells have a vast potential for the treatment of disease, namely because they give rise to the majority of cell types in the human body. These include muscle, blood, heart and nerve cells. Another potential use for pluripotent stem cells involves the generation of cells and tissues for use in transplantation.

Pluripotent stem cells can evolve into specialised cells that ultimately can replace diseased cells and tissues. Drug research is another area that pluripotent stem cells may benefit. Animals are a commonly used model to assess the safety and use of drugs. Instead of initially testing drugs on animals, they can be evaluated through testing on cells grown from pluripotent stem cells. Those drugs that appear tolerated and safe can then progress to testing on animals and finally, humans.

The positive uses of pluripotent stem cells are enormous but new research and ethical challenges must be taken into account before the public can reap the full benefits. For those who suffer from the many diseases that may be treated by pluripotent stem cells, additional knowledge and research will hopefully come sooner rather than later.

You might also like...

Share Your Story, Join the Discussion or Seek Advice..

ME - 13-Feb-18 @ 5:40 PM

Dr anas - 20-Mar-17 @ 5:37 PM

Aftab ahmad siddiqi - 25-Jan-17 @ 5:07 AM

Ricky - 12-Feb-16 @ 12:22 PM

dev - 16-Sep-15 @ 10:41 PM

Elaine - 14-Aug-15 @ 8:16 AM

ExploreStemCells - 5-Aug-15 @ 11:38 AM

rippa77 - 2-Aug-15 @ 5:02 PM

massawe - 22-May-15 @ 8:46 AM

SAN - 4-Feb-15 @ 2:32 PM

Stemcellgirl1234 - 1-Feb-15 @ 3:08 AM

sri85 - 18-Jun-14 @ 9:26 AM

Micki - 11-May-14 @ 8:20 PM

JDC - 24-Apr-14 @ 6:57 PM

sasha - 28-Mar-14 @ 11:37 AM

Elsheihk - 16-Jul-13 @ 1:14 AM

http://beyouthful.ne - 6-May-13 @ 5:14 AM

NOTPABLO - 2-May-13 @ 6:23 PM

raj - 30-Dec-12 @ 4:51 PM

Jan - 25-Nov-12 @ 11:57 PM

benjie - 7-Sep-12 @ 10:01 PM

djvc - 29-Dec-11 @ 3:26 AM

Title:

(never shown)

Continued here:
Pluripotent Stem Cells

Dental Implants have been used to correct missing or damaged teeth for quite some time. However, in the past, most dental implant procedures have relied on man-made materials to create the replacement teeth. New research may just change all that. Imagine if you could essentially grow your own teeth in as little as 9 weeks. Well, new studies are doing just that.

According to the Hearty Soul:

Researchers at the University of Nottingham and Harvard University have developed a new biomaterial that they say allows damaged pulp in the tooth to regenerate itself and form a protective layer of dentin. This is a major step forward for long-term fillings and helping the tooth prevent infections which could lead to a root canal.

A root canal is given when an injury or large cavitydamages a tooth down to the core, causing infection or inflammation. The dentist numbs the tooth and drills into the infected area. They clean it from the inside then fill the canals with apermanent material known as gutta-percha before capping the crown of the tooth. Its about as fun as it sounds.

Wow, imagine being able to grow your own teeth. Not only does that seem more realistic, the procedure seems pretty straight forward and the result is your own body tissues creating what you need. So how does this work? According to the Health is Wealth of Heart, it is pretty straight forward:

Dr Jeremy Mao, the Edward V. Zegarellu Professor of Dental Medicine at Columbia University Medical Center, explains that a three-dimensional scaffold with growth factor has the potential to regenerate and regrow anatomically correct teeth within just nine weeks after the implantation.

The procedure was developed in the Tissue Engineering and Regenerative Medicine Laboratory at the university. In the process, the bodys own stem cells go toward the scaffold, which consists of completely natural materials. Once the scaffold is colonized with stem cells, the tooth starts growing in the socket, and later merges with the surrounding tissue.

In this way teeth do not grow in a Petri dish, and anatomically correct teeth regenerate by using the bodys own material. This dental treatment offers a faster recovery time and, unlike implantation, a completely natural regrowth process.

While this seems pretty cool, it is not always well received by the general populous. Some do not believe in stem cell manipulation. However, it is believed that this can be a very effective and efficient way of regenerating teeth in the future. This treatment is not currently available but we do think it is something to watch in the future.

Traditional methods of using dental implants for tooth replacement or repair are still your best option. Learn more about it here.

The rest is here:
Dental Implants Using Stem Cells for Natural Growth

For many, a toothache may bring up their deepest and darkest fears. The reality for many is that the dentist can send you through a wave of emotions, to the point that you may end up trying to avoid your appointment entirely.

Problems with your teeth only get worse if left unattended. Thats why the large proportion of people who suffer dental anxiety end up leaving a problem unchecked until its too late. In such cases, you may eventually face the need to replace a lost tooth.

Common diseases like tooth decay and gum disease can lead to tooth loss. Traditionally, dentists have used dental bridges and dentures to replace diseased teeth. Dental implants were one of the late 20th centurys largest innovations in dental treatment. The replacement of teeth with space-age metal seems like weve reached an incredible level of technology.

Butrecent advances in stem cell research have revealed a future where dental implants could become old technology.

You might say that being a human makes us unlucky regarding how many teeth we get in our life. Over your lifetime, you have just two sets of teeth. Deciduous or baby teeth are lost by the time youre 12 or 13 years old. That means your adult teeth have to last you for the rest of your life.

Some other species, meanwhile, have unlimited teeth during their lifetimes. A shark is so fantastically unique at this they can replace teeth in just a few weeks. The idea of a shark's mouth probably leaves you cringing about the one thing more terrifying than the dentist. But sharks are proof of nature's ability to grow new teeth into adulthood.

Scientists have taken this lead and looked into the way that stem cells can be used to grow new teeth in an adult human. Nature may have significant advantages over dental implants. Dental implants, due to cost and complexity, are not a common dental procedure. A procedure involving stem cells may provide a far more accessible and affordable tooth replacement option.

Dental implants, for instance, cant be placed in people with certain conditions. Additionally, many people are fearful of the dental implant process. It requires oral surgery, which has advanced remarkably recently, but despite the rise in technology, dental implants arent without their pitfalls. Some of the potential drawbacks include the following:

So, with sharks in mind, are stem cells the future of replacing teeth?

The body contains many different types of cells. From birth, as a tiny speck, you arent equipped with all the different types of cells required in the body. Stem cells are what help you to create all the different organs and systems that make youyou. They are an undifferentiated cell capable of changing to every cell in your body.

Stem cellscan be found in most tissues of the body and help to create and replenish your body. They are usually buried deep, in difficult to find places. They are often sparse and hidden amongst cells with a similar appearance.

Scientists have found that even teeth hold a reservoir of stem cells, which are found in baby teeth and also adult teeth. These cells have the full ability to replicate themselves.

Dental stem cells may have applications in many fields of medical science due to the compatibility with the bodys immune system. One problem with inserting stem cells is the body may reject them through an immune response. But apart from having potential roles in other medical procedures, the obvious application is actually to replace teeth. Studies are beginning to show tangible pathways to tooth implantation with dental stem cells.

There has been significant progress in the use of stem cells in animal studies. Teeth have successfully grown at Kings College in London. Their research team combined human gum tissue and stem cells from mice teeth that undergo tooth formation. The cells themselves can seek out a blood supply from surrounding tissue to make a live tooth.

Other studies have had teeth successfully implanted into rats. At Harvard's Whys Institute, a research team has found success in re-growing rat teeth. They used a technique using a low-power laser to activate stem cells to regrow tooth structure.

Over at Columbia University, one study has taken it to the next step. Here, researchers were able to guide stem cells to create a three-dimensional scaffold. The results showed that an anatomically complete tooth could grow in about 9 weeks.

The big question with all of these studies is to reproduce the results in humans. Of course, performing dentistry on rats was not without its challenges. While the dentin was incredibly similar to that which grows naturally, it isn't exactly the same as humans.

The biggest challenges facing dental stem cells are reproducing reliable human clinical outcomes. Instead of replacing entire teeth, stem cells may help to heal teeth as an interim step in the dental chair.

For example, teeth are known to contain cells that can heal the dentin layers themselves. There could be some intermediate steps for stem cells to heal teeth. In tooth decay, stem cells may be able to heal a cavity before a tooth requires root canal therapy. Stem cells may be able to repair dental pulp and direct the immune system to remove tooth decay-causing bacteria.

One thing for certain is that we all contain stem cells in our teeth. Instead of simply throwing a tooth in the bin after an extraction, we may be able to extract cells for a future when they can be used to replenish a tooth.

With many people moving to cryopreserve their own cells, it may become standard to store the stem cells held in our teeth. At the moment, baby teeth and wisdom teeth are the best candidates, and these are often the ones that we are losing the most. Healthy teeth contain these fascinating cells and may perform miracles in the dental chair in the future.

Read the original here:
Will Stem Cells Replace Dental Implants? - verywellhealth.com

The restorative properties of stem cells:

Stem cells are unique because they drive the natural healing process throughout your life. Stem cells are different from other cells in the body because they regenerate and produce specialized cell types. They heal and restore skin, bones, cartilage, muscles, nerves and other tissues when injured.

As a result, amazing new medical treatments are being developed to treat a range of diseases contemporary medicine currently deems difficult or impossible to treat. Among them are:

While stem cells can be found in most tissues of the body, they are usually buried deep, are few in number and are similar in appearance to surrounding cells. With the discovery of stem cells in teeth, an accessible and available source of stem cells has been identified. The tooth is natures safe for these valuable stem cells, and there is an abundance of these cells in baby teeth, wisdom teeth and permanent teeth. The stem cells contained within teeth are capable of replicating themselves and can be readily recovered at the time of a planned dental procedure. Living stem cells found within extracted teeth were routinely discarded every day, but now, with the knowledge from recent medical research, Dr. Hershkin provides you the opportunity to save these cells for future use in developing medical treatments for your family.

Aside from being the most convenient stem cells to access, dental stem cells have significant medical benefits in the development of new medical therapies. Using ones own stem cells for medical treatment means a much lower risk of rejection by the body and decreases the need for powerful drugs that weaken the immune system, both of which are negative but typical realities that come into play when tissues or cells from a donor are used to treat patients.

Further, the stem cells from teeth have been observed in research studies to be among the most powerful stem cells in the human body. Stem cells from teeth replicate at a faster rate and for a longer period of time than do stem cells harvested from other tissues of the body.

Stem cells in the human body age over time and their regenerative abilities slow down later in life. The earlier in life that your familys stem cells are secured, the more valuable they will be when they are needed most.

Accessible The stem cells contained within teeth are recovered at the time of a planned procedure: Extraction of wisdom teeth, baby teeth or other healthy permanent teeth.

Affordable when compared with other methods of acquiring and preserving life saving stem cells: Peripheral blood, Bone Marrow, Cord blood etc, recovering Stem Cells from teeth is the most affordable and least invasive.

Convenience the recovery of stem cells from teeth can be performed in the doctors office anytime when a healthy tooth is being extracted.

Ease of Use The recovery of stem cells from teeth does not add any additional time on to a planned procedure.

Why should someone recover and cryopreserve their own stem cells from teeth?Healthy dental pulp contains stem cells that are among the most powerful stem cells in the body and replicate at a faster rate and for a longer period of time than other types of stem cells. Stem cells from teeth show great promise for future regenerative medical treatments of neuro-degenerative diseases, heart disease, diabetes, bone diseases and brain and nerve injuries.

Which teeth are candidates for stem cell recovery and cryopreservation?Any extracted tooth with a healthy pulp contains stem cells. Wisdom teeth, baby teeth and other permanent teeth i.e. healthy teeth that are fractured and teeth recommended for extraction for orthodontic purposes are all candidates for stem cell recovery and cryopreservation.

At what age am I no longer eligible to recover and preserve stem cells from teeth?Age does not seem to play a major factor. All extracted healthy teeth contain stem cells. The younger you are then the younger the cells and these may be more beneficial in future regenerative therapies.

Is one tooth enough or should I try to bank as many teeth as I can as the opportunities arise. I banked deciduous teeth, should I bank third molars?Diseases of different severity or tissue defects of different size will undoubtedly require different amounts of stem cells to heal. Conceptually, the more teeth are banked, the greater the potential for sufficient stem cells to treat various diseases.

Read the original post:
Stem Cells New York | Stem Cell Recovery | Oral Surgery

In a first, scientists, including one of Indian-origin, have used light to coax stem cells to regrow parts of teeth.

The study, led by David Mooney, a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard, is the first to demonstrate the ability to use low-power light to trigger stem cells inside the body to regenerate tissue.

The researchers used a low-power laser to trigger human dental stem cells to form dentin, the hard tissue that is similar to bone and makes up the bulk of teeth ()

A number of biologically active molecules, such as regulatory proteins called growth factors, can trigger stem cells to differentiate into different cell types.

Current regeneration efforts require scientists to isolate stem cells from the body, manipulate them in a laboratory, and return them to the body efforts that face a host of regulatory and technical hurdles to their clinical translation ()

Lead author and dentist Praveen Arany, an Assistant Clinical Investigator at the National Institutes of Health (NIH), took rodents to the laboratory version of a dentists office to drill holes in their molars.

He treated the tooth pulp that contains adult dental stem cells with low-dose laser treatments, applied temporary caps, and kept the animals comfortable and healthy ()

read more:goo.gl/TldVzf

Read the original post:
Dental stem cells to regrow and repair teeth

Stem cell therapies have great potential to cure currently untreatable diseases and to even extend lifespans. Due to their differentiating qualities, they have been used for novel regenerative protocols. Ongoing progress towards the clinical use of dental pulp stem cells has recently expanded the possibilities for clinical applications based on pulp and periodontal tissue regeneration. Dental stem cells are a kind of mesenchymal cell that reside within the dental pulp and are classified as postnatal stem cell populations.

At present, there are two approved clinical trials and one clinical trial protocol related to dental stem cells that have not yet started recruiting. Nevertheless, these trials are still in an early phase that are testing the feasibility of the stem cells and the tolerance of the stem cell implantation, but have not applied the cells on patients for accruing diseases.

One trial in China is using stem cells from human exfoliated deciduous teeth (SHED) as the main target for investigation. Investigators from China are aiming to explore and clarify if autologous (cells or tissues obtained from the same individual) SHED stem cell transplantation can efficiently regenerate pulp (the center part of a tooth) and periodontal (connective tissue known as gum) tissue in immature permanent teeth and necrotic pulp of teeth in humans.

Millions of teeth are accidentally and forcibly detached each year, especially causing losses of immature permanent teeth in children. This clinical trial is starting to recruit patients with immature permanent teeth and pulp necrosis. SHED will be used as the cell source for regenerating pulp and periodontal tissue in immature teeth.

One of the main limitations in bone regeneration is lack of vascularization of newly sharp tissue. A new trial starting in France is aiming to use the dental stem cells of a simple and non-invasive tissue source such as dental pulp to develop a brand new pre-vascularized tissue-engineered bone construct. The dental pulp stem cells were isolated from the dental tissue of patients wisdom teeth and then used to assess their endothelial and osteoblastic differentiation to obtain pre-vascularized tissue engineered bone construct. Furthermore, one commercial differentiation medium is also used to evaluate its effect on the cell differentiation and production of a prevascularized bone construct.

TOOTH (The Open study Of dental pulp stem cell Therapy in Humans), a clinical trial protocol, is an open study, phase 1, single-blind clinical trial being conducted by Australian researchers. The protocol is investigating the use of dental pulp stem cell therapy for stroke survivors with chronic disability, with the aims of determining the maximum tolerable dose of the cell therapy, and the safety and feasibility for patients with chronic stroke.

Taken together with those trials, on going or just a start, the regenerating methods are still emphasized on the early phase clinical study of improving human diseases. Although clinical trials using dental pulp stem cells for treating human diseases are not very common, preclinical research has broadened the extent of potential clinical applications. Dental stem cells can differentiate into several cell types, such as neurons, adipocytes, and chondrocytes. From that, their therapeutic potential has been identified for various conditions, including neurological disorders, angiogenesis and vasculogenesis, liver disease, diabetes mellitus, and for regenerative ocular therapy, bone tissue engineering, and, of course, therapeutic applications in dentistry such as regenerative endodontic therapy, dentin regeneration, regenerative periodontal therapy, and bioengineered teeth.

Stem cell therapies have been a hot topic of research for years, but progress toward clinical trials for applications to humans has been slow due to ethical concerns and source obtained for transplantation. Dental pulp stem cells could resolve both these issues, by using human exfoliated deciduous teeth instead of invasive source such as embryonic stem cells. Pending successful completion of ongoing clinical trials, we can hope to see further work towards applying regenerative therapies based on dental stem cells for other organs, ultimately generating novel therapies to cure currently untreatable diseases.

Please note: PreScouter provides secondary research and is not associated with the experiments or getting volunteers for clinical trials.

If you have any questions or would like to know if we can help your business with its innovation challenge, please contact our Life Sciences lead, Jeremy Schmerer atjschmerer@prescouter.com.

Stay current on your favorite topics

Tina is a dedicated, enthusiastic and innovative Pre-Clinical Researcher and Medical Writer who has a strong academic background encompassing a PhD in Clinical Science, a Masters in General Physiology and a Bachelors in Clinical Psychology. She has always been passionate about delivering exciting medical information. Tina is a technically-proficient researcher with exposure to multiple fields including urology, reproductive health, immunology, endocrinology and rheumatology gained across healthcare, clinical trials and pharmaceutical organizations. She joined PreScouter as a Global Scholar recently. Besides her medical research, she also starts up a commercial business with her favorite thing FOOD.

Go here to see the original:
A review of dental stem cells - PreScouter

To use this resource, simply select the condition you are interested in from the categories displayed in the menu. For example, if you are interested in trials for Macular Degeneration, then select 'Vision loss' and 'Macular Degeneration' from the drop down menu.If the condition you are interested in is not listed, please use the search function on the Australian Clinical Trials website.

It is important to remember that just because a treatment is being evaluated as part of a clinical trial, that does not make it a proven safe and effective therapy. These trials are experimental. All clinical trials, however, must gain full ethical approval from a registered regulatory body. When searching for clinical trials, ensure you check it has ethical approval before registering. Visit What are clinical trials? to learn more.Please use this listing for your research, but continue to speak to your treating Australiandoctors for independent advice on what is best for you.

View post:
Stem Cell Clinical Trials - Stem Cells Australia