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Russia – Wikipedia, the free encyclopedia

October 17th, 2016 4:44 pm

Coordinates: 60N 90E / 60N 90E / 60; 90

Rossijskaja Federacija

26 December 1991

Russia (i; Russian: , tr. Rossija; IPA:[rsij]; from the Greek: Rus'), also officially known as the Russian Federation[12] (Russian: , tr. Rossijskaja Federacija; IPA:[rsijskj fdratsj]), is a transcontinental country in Eurasia.[13] At 17,075,200 square kilometres (6,592,800sqmi),[14] Russia is the largest country in the world, covering more than one eighth of Earth's inhabited land area,[15][16][17] and the ninth most populous, with over 146.6million people at the end of March 2016.[6][7] Extending across the entirety of northern Asia and much of Eastern Europe, Russia spans eleven time zones and incorporates a wide range of environments and landforms. From northwest to southeast, Russia shares land borders with Norway, Finland, Estonia, Latvia, Lithuania and Poland (both with Kaliningrad Oblast), Belarus, Ukraine, Georgia, Azerbaijan, Kazakhstan, China, Mongolia, and North Korea. It shares maritime borders with Japan by the Sea of Okhotsk and the U.S. state of Alaska across the Bering Strait.

The nation's history began with that of the East Slavs, who emerged as a recognizable group in Europe between the 3rd and 8th centuries AD.[18] Founded and ruled by a Varangian warrior elite and their descendants, the medieval state of Rus arose in the 9th century. In 988 it adopted Orthodox Christianity from the Byzantine Empire,[19] beginning the synthesis of Byzantine and Slavic cultures that defined Russian culture for the next millennium.[19] Rus' ultimately disintegrated into a number of smaller states; most of the Rus' lands were overrun by the Mongol invasion and became tributaries of the nomadic Golden Horde in the 13th century.[20] The Grand Duchy of Moscow gradually reunified the surrounding Russian principalities, achieved independence from the Golden Horde, and came to dominate the cultural and political legacy of Kievan Rus'. By the 18th century, the nation had greatly expanded through conquest, annexation, and exploration to become the Russian Empire, which was the third largest empire in history, stretching from Poland on the west to Alaska on the east.[21][22]

Following the Russian Revolution, the Russian Soviet Federative Socialist Republic became the largest and leading constituent of the Union of Soviet Socialist Republics, the world's first constitutionally socialist state.[23] The Soviet Union played a decisive role in the Allied victory in World WarII,[24][25] and emerged as a recognized superpower and rival to the United States during the Cold War. The Soviet era saw some of the most significant technological achievements of the 20th century, including the world's first human-made satellite and the launching of the first humans in space. By the end of 1990, the Soviet Union had the world's second largest economy, largest standing military in the world and the largest stockpile of weapons of mass destruction.[26][27][28] Following the partition of the Soviet Union in 1991, fourteen independent republics emerged from the USSR; as the largest, most populous, and most economically developed republic, the Russian SFSR reconstituted itself as the Russian Federation and is recognized as the continuing legal personality and sole successor state of the Soviet Union.[29] It is governed as a federal semi-presidential republic.

The Russian economy ranks as the twelfth largest by nominal GDP and sixth largest by purchasing power parity in 2015.[30] Russia's extensive mineral and energy resources are the largest such reserves in the world,[31] making it one of the leading producers of oil and natural gas globally.[32][33] The country is one of the five recognized nuclear weapons states and possesses the largest stockpile of weapons of mass destruction.[34] Russia is a great power and a permanent member of the United Nations Security Council, as well as a member of the G20, the Council of Europe, the Asia-Pacific Economic Cooperation (APEC), the Shanghai Cooperation Organisation (SCO), the Organization for Security and Co-operation in Europe (OSCE), and the World Trade Organization (WTO), as well as being the leading member of the Commonwealth of Independent States (CIS), the Collective Security Treaty Organization (CSTO) and one of the five members of the Eurasian Economic Union (EEU), along with Armenia, Belarus, Kazakhstan, and Kyrgyzstan.

The name Russia is derived from Rus, a medieval state populated mostly by the East Slavs. However, this proper name became more prominent in the later history, and the country typically was called by its inhabitants " " (russkaja zemlja), which can be translated as "Russian Land" or "Land of Rus'". In order to distinguish this state from other states derived from it, it is denoted as Kievan Rus' by modern historiography. The name Rus itself comes from Rus people, a group of Varangians (possibly Swedish Vikings)[35][36] who founded the state of Rus ().

An old Latin version of the name Rus' was Ruthenia, mostly applied to the western and southern regions of Rus' that were adjacent to Catholic Europe. The current name of the country, (Rossija), comes from the Byzantine Greek designation of the Kievan Rus', Rossaspelt (Rosa pronounced[rosia]) in Modern Greek.[37]

The standard way to refer to citizens of Russia is "Russians".[38]

Nomadic pastoralism developed in the Pontic-Caspian steppe beginning in the Chalcolithic.[39]

In classical antiquity, the Pontic Steppe was known as Scythia. Beginning in the 8th century BC, Ancient Greek traders brought their civilization to the trade emporiums in Tanais and Phanagoria. The Romans settled on the western part of the Caspian Sea, where their empire stretched towards the east.[dubious discuss][40] In the 3rd to 4th centuries AD a semi-legendary Gothic kingdom of Oium existed in Southern Russia until it was overrun by Huns. Between the 3rd and 6th centuries AD, the Bosporan Kingdom, a Hellenistic polity which succeeded the Greek colonies,[41] was also overwhelmed by nomadic invasions led by warlike tribes, such as the Huns and Eurasian Avars.[42] A Turkic people, the Khazars, ruled the lower Volga basin steppes between the Caspian and Black Seas until the 10th century.[43]

The ancestors of modern Russians are the Slavic tribes, whose original home is thought by some scholars to have been the wooded areas of the Pinsk Marshes.[44] The East Slavs gradually settled Western Russia in two waves: one moving from Kiev toward present-day Suzdal and Murom and another from Polotsk toward Novgorod and Rostov. From the 7th century onwards, the East Slavs constituted the bulk of the population in Western Russia[45] and assimilated the native Finno-Ugric peoples, including the Merya, the Muromians, and the Meshchera.

The establishment of the first East Slavic states in the 9th century coincided with the arrival of Varangians, the traders, warriors and settlers from the Baltic Sea region. Primarily they were Vikings of Scandinavian origin, who ventured along the waterways extending from the eastern Baltic to the Black and Caspian Seas.[46] According to the Primary Chronicle, a Varangian from Rus' people, named Rurik, was elected ruler of Novgorod in 862. In 882 his successor Oleg ventured south and conquered Kiev,[47] which had been previously paying tribute to the Khazars, founding Kievan Rus'. Oleg, Rurik's son Igor and Igor's son Sviatoslav subsequently subdued all local East Slavic tribes to Kievan rule, destroyed the Khazar khaganate and launched several military expeditions to Byzantium and Persia.

In the 10th to 11th centuries Kievan Rus' became one of the largest and most prosperous states in Europe.[48] The reigns of Vladimir the Great (9801015) and his son Yaroslav the Wise (10191054) constitute the Golden Age of Kiev, which saw the acceptance of Orthodox Christianity from Byzantium and the creation of the first East Slavic written legal code, the Russkaya Pravda.

In the 11th and 12th centuries, constant incursions by nomadic Turkic tribes, such as the Kipchaks and the Pechenegs, caused a massive migration of Slavic populations to the safer, heavily forested regions of the north, particularly to the area known as Zalesye.[49]

The age of feudalism and decentralization was marked by constant in-fighting between members of the Rurik Dynasty that ruled Kievan Rus' collectively. Kiev's dominance waned, to the benefit of Vladimir-Suzdal in the north-east, Novgorod Republic in the north-west and Galicia-Volhynia in the south-west.

Ultimately Kievan Rus' disintegrated, with the final blow being the Mongol invasion of 123740[50] that resulted in the destruction of Kiev[51] and the death of about half the population of Rus'.[52] The invading Mongol elite, together with their conquered Turkic subjects (Cumans, Kipchaks, Bulgars), became known as Tatars, forming the state of the Golden Horde, which pillaged the Russian principalities; the Mongols ruled the Cuman-Kipchak confederation and Volga Bulgaria (modern-day southern and central expanses of Russia) for over two centuries.[53]

Galicia-Volhynia was eventually assimilated by the Kingdom of Poland, while the Mongol-dominated Vladimir-Suzdal and Novgorod Republic, two regions on the periphery of Kiev, established the basis for the modern Russian nation.[19] The Novgorod together with Pskov retained some degree of autonomy during the time of the Mongol yoke and were largely spared the atrocities that affected the rest of the country. Led by Prince Alexander Nevsky, Novgorodians repelled the invading Swedes in the Battle of the Neva in 1240, as well as the Germanic crusaders in the Battle of the Ice in 1242, breaking their attempts to colonize the Northern Rus'.

The most powerful state to eventually arise after the destruction of Kievan Rus' was the Grand Duchy of Moscow ("Muscovy" in the Western chronicles), initially a part of Vladimir-Suzdal. While still under the domain of the Mongol-Tatars and with their connivance, Moscow began to assert its influence in the Central Rus' in the early 14th century, gradually becoming the leading force in the process of the Rus' lands' reunification and expansion of Russia.[citation needed] Moscow's last rival, the Novgorod Republic, prospered as the chief fur trade center and the easternmost port of the Hanseatic League.

Times remained difficult, with frequent Mongol-Tatar raids. Agriculture suffered from the beginning of the Little Ice Age. As in the rest of Europe, plague was a frequent occurrence between 1350 and 1490.[54] However, because of the lower population density and better hygienewidespread practicing of banya, a wet steam baththe death rate from plague was not as severe as in Western Europe,[55] and population numbers recovered by 1500.[54]

Led by Prince Dmitry Donskoy of Moscow and helped by the Russian Orthodox Church, the united army of Russian principalities inflicted a milestone defeat on the Mongol-Tatars in the Battle of Kulikovo in 1380. Moscow gradually absorbed the surrounding principalities, including formerly strong rivals such as Tver and Novgorod.

IvanIII ("the Great") finally threw off the control of the Golden Horde and consolidated the whole of Central and Northern Rus' under Moscow's dominion. He was also the first to take the title "Grand Duke of all the Russias".[56] After the fall of Constantinople in 1453, Moscow claimed succession to the legacy of the Eastern Roman Empire. IvanIII married Sophia Palaiologina, the niece of the last Byzantine emperor ConstantineXI, and made the Byzantine double-headed eagle his own, and eventually Russia's, coat-of-arms.

In development of the Third Rome ideas, the Grand Duke IvanIV (the "Terrible")[57] was officially crowned the first Tsar ("Caesar") of Russia in 1547. The Tsar promulgated a new code of laws (Sudebnik of 1550), established the first Russian feudal representative body (Zemsky Sobor) and introduced local self-management into the rural regions.[58][59]

During his long reign, Ivan the Terrible nearly doubled the already large Russian territory by annexing the three Tatar khanates (parts of the disintegrated Golden Horde): Kazan and Astrakhan along the Volga River, and the Siberian Khanate in southwestern Siberia. Thus, by the end of the 16th century Russia was transformed into a multiethnic, multidenominational and transcontinental state.

However, the Tsardom was weakened by the long and unsuccessful Livonian War against the coalition of Poland, Lithuania, and Sweden for access to the Baltic coast and sea trade.[60] At the same time, the Tatars of the Crimean Khanate, the only remaining successor to the Golden Horde, continued to raid Southern Russia.[61] In an effort to restore the Volga khanates, Crimeans and their Ottoman allies invaded central Russia and were even able to burn down parts of Moscow in 1571.[62] But in the next year the large invading army was thoroughly defeated by Russians in the Battle of Molodi, forever eliminating the threat of an OttomanCrimean expansion into Russia. The slave raids of Crimeans, however, did not cease until the late 17th century though the construction of new fortification lines across Southern Russia, such as the Great Abatis Line, constantly narrowed the area accessible to incursions.[63]

The death of Ivan's sons marked the end of the ancient Rurik Dynasty in 1598, and in combination with the famine of 160103[64] led to civil war, the rule of pretenders, and foreign intervention during the Time of Troubles in the early 17th century.[65] The Polish-Lithuanian Commonwealth occupied parts of Russia, including Moscow. In 1612, the Poles were forced to retreat by the Russian volunteer corps, led by two national heroes, merchant Kuzma Minin and Prince Dmitry Pozharsky. The Romanov Dynasty acceded to the throne in 1613 by the decision of Zemsky Sobor, and the country started its gradual recovery from the crisis.

Russia continued its territorial growth through the 17th century, which was the age of Cossacks. Cossacks were warriors organized into military communities, resembling pirates and pioneers of the New World. In 1648, the peasants of Ukraine joined the Zaporozhian Cossacks in rebellion against Poland-Lithuania during the Khmelnytsky Uprising in reaction to the social and religious oppression they had been suffering under Polish rule. In 1654, the Ukrainian leader, Bohdan Khmelnytsky, offered to place Ukraine under the protection of the Russian Tsar, AlekseyI. Aleksey's acceptance of this offer led to another Russo-Polish War. Finally, Ukraine was split along the Dnieper River, leaving the western part, right-bank Ukraine, under Polish rule and the eastern part (Left-bank Ukraine and Kiev) under Russian rule. Later, in 167071, the Don Cossacks led by Stenka Razin initiated a major uprising in the Volga Region, but the Tsar's troops were successful in defeating the rebels.

In the east, the rapid Russian exploration and colonisation of the huge territories of Siberia was led mostly by Cossacks hunting for valuable furs and ivory. Russian explorers pushed eastward primarily along the Siberian River Routes, and by the mid-17th century there were Russian settlements in Eastern Siberia, on the Chukchi Peninsula, along the Amur River, and on the Pacific coast. In 1648, the Bering Strait between Asia and North America was passed for the first time by Fedot Popov and Semyon Dezhnyov.

Under Peter the Great, Russia was proclaimed an Empire in 1721 and became recognized as a world power. Ruling from 1682 to 1725, Peter defeated Sweden in the Great Northern War, forcing it to cede West Karelia and Ingria (two regions lost by Russia in the Time of Troubles),[66] as well as Estland and Livland, securing Russia's access to the sea and sea trade.[67] On the Baltic Sea Peter founded a new capital called Saint Petersburg, later known as Russia's "Window to Europe". Peter the Great's reforms brought considerable Western European cultural influences to Russia.

The reign of PeterI's daughter Elizabeth in 174162 saw Russia's participation in the Seven Years' War (175663). During this conflict Russia annexed East Prussia for a while and even took Berlin. However, upon Elisabeth's death, all these conquests were returned to the Kingdom of Prussia by pro-Prussian PeterIII of Russia.

CatherineII ("the Great"), who ruled in 176296, presided over the Age of Russian Enlightenment. She extended Russian political control over the Polish-Lithuanian Commonwealth and incorporated most of its territories into Russia during the Partitions of Poland, pushing the Russian frontier westward into Central Europe. In the south, after successful Russo-Turkish Wars against Ottoman Turkey, Catherine advanced Russia's boundary to the Black Sea, defeating the Crimean Khanate. As a result of victories over Qajar Iran through the Russo-Persian Wars, by the first half of the 19th century Russia also made significant territorial gains in Transcaucasia and the North Caucasus, forcing the former to irrevocably cede what is nowadays Georgia, Dagestan, Azerbaijan and Armenia to Russia.[68][69] This continued with AlexanderI's (180125) wresting of Finland from the weakened kingdom of Sweden in 1809 and of Bessarabia from the Ottomans in 1812. At the same time, Russians colonized Alaska and even founded settlements in California, such as Fort Ross.

In 18031806, the first Russian circumnavigation was made, later followed by other notable Russian sea exploration voyages. In 1820, a Russian expedition discovered the continent of Antarctica.

In alliances with various European countries, Russia fought against Napoleon's France. The French invasion of Russia at the height of Napoleon's power in 1812 failed miserably as the obstinate resistance in combination with the bitterly cold Russian winter led to a disastrous defeat of invaders, in which more than 95% of the pan-European Grande Arme perished.[70] Led by Mikhail Kutuzov and Barclay de Tolly, the Russian army ousted Napoleon from the country and drove through Europe in the war of the Sixth Coalition, finally entering Paris. AlexanderI headed Russia's delegation at the Congress of Vienna that defined the map of post-Napoleonic Europe.

The officers of the Napoleonic Wars brought ideas of liberalism back to Russia with them and attempted to curtail the tsar's powers during the abortive Decembrist revolt of 1825. At the end of the conservative reign of NicolasI (182555), a zenith period of Russia's power and influence in Europe was disrupted by defeat in the Crimean War. Between 1847 and 1851, about one million people died of Asiatic cholera.[71]

Nicholas's successor AlexanderII (185581) enacted significant changes in the country, including the emancipation reform of 1861. These Great Reforms spurred industrialization and modernized the Russian army, which had successfully liberated Bulgaria from Ottoman rule in the 187778 Russo-Turkish War.

The late 19th century saw the rise of various socialist movements in Russia. AlexanderII was killed in 1881 by revolutionary terrorists, and the reign of his son AlexanderIII (188194) was less liberal but more peaceful. The last Russian Emperor, NicholasII (18941917), was unable to prevent the events of the Russian Revolution of 1905, triggered by the unsuccessful Russo-Japanese War and the demonstration incident known as Bloody Sunday. The uprising was put down, but the government was forced to concede major reforms, including granting the freedoms of speech and assembly, the legalization of political parties, and the creation of an elected legislative body, the State Duma of the Russian Empire. The Stolypin agrarian reform led to a massive peasant migration and settlement into Siberia. More than four million settlers arrived in that region between 1906 and 1914.[72]

In 1914, Russia entered World WarI in response to Austria-Hungary's declaration of war on Russia's ally Serbia, and fought across multiple fronts while isolated from its Triple Entente allies. In 1916, the Brusilov Offensive of the Russian Army almost completely destroyed the military of Austria-Hungary. However, the already-existing public distrust of the regime was deepened by the rising costs of war, high casualties, and rumors of corruption and treason. All this formed the climate for the Russian Revolution of 1917, carried out in two major acts.

The February Revolution forced Nicholas II to abdicate; he and his family were imprisoned and later executed in Yekaterinburg during the Russian Civil War. The monarchy was replaced by a shaky coalition of political parties that declared itself the Provisional Government. An alternative socialist establishment existed alongside, the Petrograd Soviet, wielding power through the democratically elected councils of workers and peasants, called Soviets. The rule of the new authorities only aggravated the crisis in the country, instead of resolving it. Eventually, the October Revolution, led by Bolshevik leader Vladimir Lenin, overthrew the Provisional Government and gave full governing power to the Soviets, leading to the creation of the world's first socialist state.

Following the October Revolution, a civil war broke out between the anti-Communist White movement and the new Soviet regime with its Red Army. Bolshevist Russia lost its Ukrainian, Polish, Baltic, and Finnish territories by signing the Treaty of Brest-Litovsk that concluded hostilities with the Central Powers of World WarI. The Allied powers launched an unsuccessful military intervention in support of anti-Communist forces. In the meantime both the Bolsheviks and White movement carried out campaigns of deportations and executions against each other, known respectively as the Red Terror and White Terror. By the end of the civil war, Russia's economy and infrastructure were heavily damaged. Millions became White migrs,[73] and the Povolzhye famine of 1921 claimed up to 5million victims.[74]

The Russian Soviet Federative Socialist Republic (called Russian Socialist Federative Soviet Republic at the time), together with the Ukrainian, Byelorussian, and Transcaucasian Soviet Socialist Republics, formed the Union of Soviet Socialist Republics (USSR), or Soviet Union, on 30 December 1922. Out of the 15 republics that would make up the USSR, the largest in size and over half of the total USSR population was the Russian SFSR, which came to dominate the union for its entire 69-year history.

Following Lenin's death in 1924, a troika was designated to govern the Soviet Union. However, Joseph Stalin, an elected General Secretary of the Communist Party, managed to suppress all opposition groups within the party and consolidate power in his hands. Leon Trotsky, the main proponent of world revolution, was exiled from the Soviet Union in 1929, and Stalin's idea of Socialism in One Country became the primary line. The continued internal struggle in the Bolshevik party culminated in the Great Purge, a period of mass repressions in 193738, during which hundreds of thousands of people were executed, including original party members and military leaders accused of coup d'tat plots.[75]

Under Stalin's leadership, the government launched a planned economy, industrialisation of the largely rural country, and collectivization of its agriculture. During this period of rapid economic and social change, millions of people were sent to penal labor camps,[76] including many political convicts for their opposition to Stalin's rule; millions were deported and exiled to remote areas of the Soviet Union.[76] The transitional disorganisation of the country's agriculture, combined with the harsh state policies and a drought, led to the Soviet famine of 19321933.[77] The Soviet Union, though with a heavy price, was transformed from a largely agrarian economy to a major industrial powerhouse in a short span of time.

The Appeasement policy of Great Britain and France towards Adolf Hitler's annexation of Austria and Czechoslovakia did not stem an increase in the power of Nazi Germany and initiated a threat of war to the Soviet Union.[citation needed] Around the same time, the Third Reich allied with the Empire of Japan, a rival of the USSR in the Far East and an open enemy of the USSR in the SovietJapanese Border Wars in 193839.

In August 1939, after another failure of attempts to establish an anti-Nazi alliance with Britain and France,[citation needed] the Soviet government decided to improve relations with Germany by concluding the Molotov-Ribbentrop Pact, pledging non-aggression between the two countries and dividing Eastern Europe into their respective spheres of influence. While Hitler conquered Poland and France and other countries acted on a single front at the start of World WarII, the USSR was able to build up its military and claim some of the former territories of the Russian Empire, Western Ukraine, Hertza region and Northern Bukovina as a result of the Soviet invasion of Poland, Winter War, occupation of the Baltic states and Soviet occupation of Bessarabia and Northern Bukovina.

On 22 June 1941, Nazi Germany broke the non-aggression treaty and invaded the Soviet Union with the largest and most powerful invasion force in human history,[78] opening the largest theater of World WarII. Although the German army had considerable early success, their attack was halted in the Battle of Moscow. Subsequently, the Germans were dealt major defeats first at the Battle of Stalingrad in the winter of 194243,[79] and then in the Battle of Kursk in the summer of 1943. Another German failure was the Siege of Leningrad, in which the city was fully blockaded on land between 1941 and 1944 by German and Finnish forces, and suffered starvation and more than a million deaths, but never surrendered.[80] Under Stalin's administration and the leadership of such commanders as Georgy Zhukov and Konstantin Rokossovsky, Soviet forces took Eastern Europe in 194445 and captured Berlin in May 1945. In August 1945 the Soviet Army ousted the Japanese from China's Manchukuo and North Korea, contributing to the allied victory over Japan.

The 194145 period of World WarII is known in Russia as the "Great Patriotic War". The Soviet Union together with the United States, the United Kingdom and China were considered as the Big Four of Allied powers in World War II [81] and later became the Four Policemen which was the foundation of the United Nations Security Council.[82] During this war, which included many of the most lethal battle operations in human history, Soviet military and civilian deaths were 10.6million and 15.9million respectively,[83] accounting for about a third of all World WarII casualties. The full demographic loss to the Soviet peoples was even greater.[84] The Soviet economy and infrastructure suffered massive devastation which caused the Soviet famine of 194647[85] but the Soviet Union emerged as an acknowledged military superpower on the continent.

After the war, Eastern and Central Europe including East Germany and part of Austria was occupied by Red Army according to the Potsdam Conference. Dependent socialist governments were installed in the Eastern Bloc satellite states. Becoming the world's second nuclear weapons power, the USSR established the Warsaw Pact alliance and entered into a struggle for global dominance, known as the Cold War, with the United States and NATO. The Soviet Union supported revolutionary movements across the world, including the newly formed People's Republic of China, the Democratic People's Republic of Korea and, later on, the Republic of Cuba. Significant amounts of Soviet resources were allocated in aid to the other socialist states.[86]

After Stalin's death and a short period of collective rule, the new leader Nikita Khrushchev denounced the cult of personality of Stalin and launched the policy of de-Stalinization. The penal labor system was reformed and many prisoners were released and rehabilitated (many of them posthumously).[87] The general easement of repressive policies became known later as the Khrushchev Thaw. At the same time, tensions with the United States heightened when the two rivals clashed over the deployment of the United States Jupiter missiles in Turkey and Soviet missiles in Cuba.

In 1957, the Soviet Union launched the world's first artificial satellite, Sputnik1, thus starting the Space Age. Russia's cosmonaut Yuri Gagarin became the first human to orbit the Earth, aboard the Vostok1 manned spacecraft on 12 April 1961.

Following the ousting of Khrushchev in 1964, another period of collective rule ensued, until Leonid Brezhnev became the leader. The era of the 1970s and the early 1980s was designated later as the Era of Stagnation, a period when economic growth slowed and social policies became static. The 1965 Kosygin reform aimed for partial decentralization of the Soviet economy and shifted the emphasis from heavy industry and weapons to light industry and consumer goods but was stifled by the conservative Communist leadership.

In 1979, after a Communist-led revolution in Afghanistan, Soviet forces entered that country at the request of the new regime. The occupation drained economic resources and dragged on without achieving meaningful political results. Ultimately, the Soviet Army was withdrawn from Afghanistan in 1989 due to international opposition, persistent anti-Soviet guerilla warfare, and a lack of support by Soviet citizens.

From 1985 onwards, the last Soviet leader Mikhail Gorbachev, who sought to enact liberal reforms in the Soviet system, introduced the policies of glasnost (openness) and perestroika (restructuring) in an attempt to end the period of economic stagnation and to democratise the government. This, however, led to the rise of strong nationalist and separatist movements. Prior to 1991, the Soviet economy was the second largest in the world,[88] but during its last years it was afflicted by shortages of goods in grocery stores, huge budget deficits, and explosive growth in the money supply leading to inflation.[89]

By 1991, economic and political turmoil began to boil over, as the Baltic republics chose to secede from the Soviet Union. On 17 March, a referendum was held, in which the vast majority of participating citizens voted in favour of changing the Soviet Union into a renewed federation. In August 1991, a coup d'tat attempt by members of Gorbachev's government, directed against Gorbachev and aimed at preserving the Soviet Union, instead led to the end of the Communist Party of the Soviet Union. On 25 December 1991, the USSR was dissolved into 15 post-Soviet states.

In June 1991, Boris Yeltsin became the first directly elected President in Russian history when he was elected President of the Russian Soviet Federative Socialist Republic, which became the independent Russian Federation in December of that year. During and after the disintegration of the Soviet Union, wide-ranging reforms including privatization and market and trade liberalization were undertaken,[90] including radical changes along the lines of "shock therapy" as recommended by the United States and the International Monetary Fund.[91] All this resulted in a major economic crisis, characterized by a 50% decline in both GDP and industrial output between 1990 and 1995.[90][92]

The privatization largely shifted control of enterprises from state agencies to individuals with inside connections in the government. Many of the newly rich moved billions in cash and assets outside of the country in an enormous capital flight.[93] The depression of the economy led to the collapse of social services; the birth rate plummeted while the death rate skyrocketed.[94] Millions plunged into poverty, from a level of 1.5% in the late Soviet era to 3949% by mid-1993.[95] The 1990s saw extreme corruption and lawlessness, the rise of criminal gangs and violent crime.[96]

The 1990s were plagued by armed conflicts in the North Caucasus, both local ethnic skirmishes and separatist Islamist insurrections. From the time Chechen separatists declared independence in the early 1990s, an intermittent guerrilla war has been fought between the rebel groups and the Russian military. Terrorist attacks against civilians carried out by separatists, most notably the Moscow theater hostage crisis and Beslan school siege, caused hundreds of deaths and drew worldwide attention.

Russia took up the responsibility for settling the USSR's external debts, even though its population made up just half of the population of the USSR at the time of its dissolution.[97] High budget deficits caused the 1998 Russian financial crisis[98] and resulted in a further GDP decline.[90]

On 31 December 1999, President Yeltsin unexpectedly resigned, handing the post to the recently appointed Prime Minister, Vladimir Putin, who then won the 2000 presidential election. Putin suppressed the Chechen insurgency although sporadic violence still occurs throughout the Northern Caucasus. High oil prices and the initially weak currency followed by increasing domestic demand, consumption, and investments has helped the economy grow for nine straight years, improving the standard of living and increasing Russia's influence on the world stage.[99] However, since the World economic crisis of 2008 and a subsequent drop in oil prices, Russia's economy has stagnated and poverty has again started to rise.[100] While many reforms made during the Putin presidency have been generally criticized by Western nations as undemocratic,[101] Putin's leadership over the return of order, stability, and progress has won him widespread admiration in Russia.[102]

On 2 March 2008, Dmitry Medvedev was elected President of Russia while Putin became Prime Minister. Putin returned to the presidency following the 2012 presidential elections, and Medvedev was appointed Prime Minister.

In 2014, after President Viktor Yanukovych of Ukraine fled as a result of a revolution, Putin requested and received authorization from the Russian Parliament to deploy Russian troops to Ukraine.[103][104][105][106][107] Following a Crimean referendum in which separation was favored by a large majority of voters, but not accepted internationally,[108][109][110][111][112][113] the Russian leadership announced the accession of Crimea into the Russian Federation. On 27 March the United Nations General Assembly voted in favor of a non-binding resolution opposing the Russian annexation of Crimea by a vote of 100 in favour, 11 against and 58 abstentions.[114]

In September 2015, Russia started military intervention in the Syrian Civil War, consisting of air strikes against militant groups of the Islamic State, al-Nusra Front (al-Qaeda in the Levant), and the Army of Conquest.

It could face charges for attacking Syrian City Aleppo. It has also been accused of being behind the Hillary Clinton e-mail hack.

According to the Constitution of Russia, the country is a federation and semi-presidential republic, wherein the President is the head of state[115] and the Prime Minister is the head of government. The Russian Federation is fundamentally structured as a multi-party representative democracy, with the federal government composed of three branches:

The president is elected by popular vote for a six-year term (eligible for a second term, but not for a third consecutive term).[116] Ministries of the government are composed of the Premier and his deputies, ministers, and selected other individuals; all are appointed by the President on the recommendation of the Prime Minister (whereas the appointment of the latter requires the consent of the State Duma). Leading political parties in Russia include United Russia, the Communist Party, the Liberal Democratic Party, and A Just Russia. In 2013, Russia was ranked as 122nd of 167 countries in the Democracy Index, compiled by The Economist Intelligence Unit,[117] while the World Justice Project currently ranks Russia 80th of 99 countries surveyed in terms of rule of law.[118]

The Russian Federation is recognized in international law as a successor state of the former Soviet Union.[29] Russia continues to implement the international commitments of the USSR, and has assumed the USSR's permanent seat in the UN Security Council, membership in other international organisations, the rights and obligations under international treaties, and property and debts. Russia has a multifaceted foreign policy. As of 2009[update], it maintains diplomatic relations with 191 countries and has 144 embassies. The foreign policy is determined by the President and implemented by the Ministry of Foreign Affairs of Russia.[119]

As the successor to a former superpower, Russia's geopolitical status has often been debated, particularly in relation to unipolar and multipolar views on the global political system. While Russia is commonly accepted to be a great power, in recent years it has been characterized by a number of world leaders,[120][121] scholars,[122] commentators and politicians[123] as a currently reinstating or potential superpower.[124][125][126]

As one of five permanent members of the UN Security Council, Russia plays a major role in maintaining international peace and security. The country participates in the Quartet on the Middle East and the Six-party talks with North Korea. Russia is a member of the G8 industrialized nations, the Council of Europe, OSCE, and APEC. Russia usually takes a leading role in regional organisations such as the CIS, EurAsEC, CSTO, and the SCO.[127] Russia became the 39th member state of the Council of Europe in 1996.[128] In 1998, Russia ratified the European Convention on Human Rights. The legal basis for EU relations with Russia is the Partnership and Cooperation Agreement, which came into force in 1997. The Agreement recalls the parties' shared respect for democracy and human rights, political and economic freedom and commitment to international peace and security.[129] In May 2003, the EU and Russia agreed to reinforce their cooperation on the basis of common values and shared interests.[130] Former President Vladimir Putin had advocated a strategic partnership with close integration in various dimensions including establishment of EU-Russia Common Spaces.[131] Since the dissolution of the Soviet Union, Russia has developed a friendlier relationship with the United States and NATO. The NATO-Russia Council was established in 2002 to allow the United States, Russia and the 27 allies in NATO to work together as equal partners to pursue opportunities for joint collaboration.[132]

Russia maintains strong and positive relations with other BRIC countries. India is the largest customer of Russian military equipment and the two countries share extensive defense and strategic relations.[133] In recent years, the country has strengthened bilateral ties especially with the People's Republic of China by signing the Treaty of Friendship as well as building the Trans-Siberian oil pipeline and gas pipeline from Siberia to China.[134][135]

An important aspect of Russia's relations with the West is the criticism of Russia's political system and human rights management (including LGBT rights, media freedom, and reports about killed journalists) by Western governments, the mass media and the leading democracy and human rights watchdogs. In particular, such organisations as the Amnesty International and Human Rights Watch consider Russia to have not enough democratic attributes and to allow few political rights and civil liberties to its citizens.[136][137]Freedom House, an international organisation funded by the United States, ranks Russia as "not free", citing "carefully engineered elections" and "absence" of debate.[138] Russian authorities dismiss these claims and especially criticise Freedom House. The Russian Ministry of Foreign Affairs has called the 2006 Freedom in the World report "prefabricated", stating that the human rights issues have been turned into a political weapon in particular by the United States. The ministry also claims that such organisations as Freedom House and Human Rights Watch use the same scheme of voluntary extrapolation of "isolated facts that of course can be found in any country" into dominant tendencies.[139]

The Russian military is divided into the Ground Forces, Navy, and Air Force. There are also three independent arms of service: Strategic Missile Troops, Aerospace Defence Forces, and the Airborne Troops. In 2006, the military had 1.037million personnel on active duty.[140] It is mandatory for all male citizens aged 1827 to be drafted for a year of service in Armed Forces.[99]

Russia has the largest stockpile of nuclear weapons in the world. It has the second largest fleet of ballistic missile submarines and is the only country apart from the United States with a modern strategic bomber force.[34][141] Russia's tank force is the largest in the world, its surface navy and air force are among the largest ones.

The country has a large and fully indigenous arms industry, producing most of its own military equipment with only few types of weapons imported. Russia is one of the world's top supplier of arms, a spot it has held since 2001, accounting for around 30% of worldwide weapons sales[142] and exporting weapons to about 80 countries.[143] The Stockholm International Peace Research Institute, SIPRI, found that Russia was the second biggest exporter of arms in 2010-14, increasing their exports by 37 per cent from the period 2005-2009. In 2010-14, Russia delivered weapons to 56 states and to rebel forces in eastern Ukraine.[144]

The Russian government's published 2014 military budget is about 2.49 trillion rubles (approximately US$69.3 billion), the third largest in the world behind the US and China. The official budget is set to rise to 3.03 trillion rubles (approximately US$83.7 billion) in 2015, and 3.36 trillion rubles (approximately US$93.9 billion) in 2016.[145] However, unofficial estimates put the budget significantly higher, for example the Stockholm International Peace Research Institute (SIPRI) 2013 Military Expenditure Database estimated Russia's military expenditure in 2012 at US$90.749 billion.[146] This estimate is an increase of more than US$18 billion on SIPRI's estimate of the Russian military budget for 2011 (US$71.9 billion).[147] As of 2014[update], Russia's military budget is higher than any other European nation.

According to 2012 Global Peace Index, Russia is the sixth least peaceful out of 162 countries in the world, principally because of its defense industry. Russia has historically ranked low on the index since its inception in 2007.[148]

According to the Constitution, the country comprises eighty-five federal subjects,[149] including the Republic of Crimea and the federal city of Sevastopol, whose recent establishment is internationally disputed and criticized as illegal annexation.[150] In 1993, when the Constitution was adopted, there were eighty-nine federal subjects listed, but later some of them were merged. These subjects have equal representationtwo delegates eachin the Federation Council.[151] However, they differ in the degree of autonomy they enjoy.

Federal subjects are grouped into eight federal districts, each administered by an envoy appointed by the President of Russia.[154] Unlike the federal subjects, the federal districts are not a subnational level of government, but are a level of administration of the federal government. Federal districts' envoys serve as liaisons between the federal subjects and the federal government and are primarily responsible for overseeing the compliance of the federal subjects with the federal laws.

Russia is the largest country in the world; its total area is 17,125,200 square kilometres (6,612,100sqmi).[155][156] There are 23 UNESCO World Heritage Sites in Russia, 40 UNESCO biosphere reserves,[157] 41 national parks and 101 nature reserves. It lies between latitudes 41 and 82 N, and longitudes 19 E and 169 W.

Russia's territorial expansion was achieved largely in the late 16th century under the Cossack Yermak Timofeyevich during the reign of Ivan the Terrible, at a time when competing city-states in the western regions of Russia had banded together to form one country. Yermak mustered an army and pushed eastward where he conquered nearly all the lands once belonging to the Mongols, defeating their ruler, Khan Kuchum.[158]

Russia has a wide natural resource base, including major deposits of timber, petroleum, natural gas, coal, ores and other mineral resources.

The two most widely separated points in Russia are about 8,000km (4,971mi) apart along a geodesic line. These points are: a 60km (37mi) long Vistula Spit the boundary with Poland separating the Gdask Bay from the Vistula Lagoon and the most southeastern point of the Kuril Islands. The points which are farthest separated in longitude are 6,600km (4,101mi) apart along a geodesic line. These points are: in the west, the same spit on the boundary with Poland, and in the east, the Big Diomede Island. The Russian Federation spans nine time zones.

Most of Russia consists of vast stretches of plains that are predominantly steppe to the south and heavily forested to the north, with tundra along the northern coast. Russia possesses 10% of the world's arable land.[159] Mountain ranges are found along the southern borders, such as the Caucasus (containing Mount Elbrus, which at 5,642m (18,510ft) is the highest point in both Russia and Europe) and the Altai (containing Mount Belukha, which at the 4,506m (14,783ft) is the highest point of Siberia outside of the Russian Far East); and in the eastern parts, such as the Verkhoyansk Range or the volcanoes of Kamchatka Peninsula (containing Klyuchevskaya Sopka, which at the 4,750m (15,584ft) is the highest active volcano in Eurasia as well as the highest point of Asian Russia). The Ural Mountains, rich in mineral resources, form a north-south range that divides Europe and Asia.

Russia has an extensive coastline of over 37,000km (22,991mi) along the Arctic and Pacific Oceans, as well as along the Baltic Sea, Sea of Azov, Black Sea and Caspian Sea.[99] The Barents Sea, White Sea, Kara Sea, Laptev Sea, East Siberian Sea, Chukchi Sea, Bering Sea, Sea of Okhotsk, and the Sea of Japan are linked to Russia via the Arctic and Pacific. Russia's major islands and archipelagos include Novaya Zemlya, the Franz Josef Land, the Severnaya Zemlya, the New Siberian Islands, Wrangel Island, the Kuril Islands, and Sakhalin. The Diomede Islands (one controlled by Russia, the other by the United States) are just 3km (1.9mi) apart, and Kunashir Island is about 20km (12.4mi) from Hokkaido, Japan.

Russia has thousands of rivers and inland bodies of water, providing it with one of the world's largest surface water resources. Its lakes contain approximately one-quarter of the world's liquid fresh water.[160] The largest and most prominent of Russia's bodies of fresh water is Lake Baikal, the world's deepest, purest, oldest and most capacious fresh water lake.[161] Baikal alone contains over one-fifth of the world's fresh surface water.[160] Other major lakes include Ladoga and Onega, two of the largest lakes in Europe. Russia is second only to Brazil in volume of the total renewable water resources. Of the country's 100,000 rivers,[162] the Volga is the most famous, not only because it is the longest river in Europe, but also because of its major role in Russian history.[99] The Siberian rivers Ob, Yenisey, Lena and Amur are among the longest rivers in the world.

The enormous size of Russia and the remoteness of many areas from the sea result in the dominance of the humid continental climate, which is prevalent in all parts of the country except for the tundra and the extreme southeast. Mountains in the south obstruct the flow of warm air masses from the Indian Ocean, while the plain of the west and north makes the country open to Arctic and Atlantic influences.[163]

Most of Northern European Russia and Siberia has a subarctic climate, with extremely severe winters in the inner regions of Northeast Siberia (mostly the Sakha Republic, where the Northern Pole of Cold is located with the record low temperature of 71.2C or 96.2F), and more moderate winters elsewhere. Both the strip of land along the shore of the Arctic Ocean and the Russian Arctic islands have a polar climate.

The coastal part of Krasnodar Krai on the Black Sea, most notably in Sochi, possesses a humid subtropical climate with mild and wet winters. In many regions of East Siberia and the Far East, winter is dry compared to summer; other parts of the country experience more even precipitation across seasons. Winter precipitation in most parts of the country usually falls as snow. The region along the Lower Volga and Caspian Sea coast, as well as some areas of southernmost Siberia, possesses a semi-arid climate.

Throughout much of the territory there are only two distinct seasonswinter and summeras spring and autumn are usually brief periods of change between extremely low and extremely high temperatures.[163] The coldest month is January (February on the coastline); the warmest is usually July. Great ranges of temperature are typical. In winter, temperatures get colder both from south to north and from west to east. Summers can be quite hot, even in Siberia.[165] The continental interiors are the driest areas.

From north to south the East European Plain, also known as Russian Plain, is clad sequentially in Arctic tundra, coniferous forest (taiga), mixed and broad-leaf forests, grassland (steppe), and semi-desert (fringing the Caspian Sea), as the changes in vegetation reflect the changes in climate. Siberia supports a similar sequence but is largely taiga. Russia has the world's largest forest reserves,[166] known as "the lungs of Europe",[167] second only to the Amazon Rainforest in the amount of carbon dioxide it absorbs.

There are 266 mammal species and 780 bird species in Russia. A total of 415 animal species have been included in the Red Data Book of the Russian Federation as of 1997 and are now protected.[168]

Russia has a developed, high-income market economy with enormous natural resources, particularly oil and natural gas. It has the 15th largest economy in the world by nominal GDP and the 6th largest by purchasing power parity (PPP). Since the turn of the 21st century, higher domestic consumption and greater political stability have bolstered economic growth in Russia. The country ended 2008 with its ninth straight year of growth, but growth has slowed with the decline in the price of oil and gas. Real GDP per capita, PPP (current international) was 19,840 in 2010.[169] Growth was primarily driven by non-traded services and goods for the domestic market, as opposed to oil or mineral extraction and exports.[99] The average nominal salary in Russia was $967 per month in early 2013, up from $80 in 2000.[170][171] In March 2014 the average nominal monthly wages reached 30,000 RUR (or US$980),[172][173] while tax on the income of individuals is payable at the rate of 13% on most incomes.[174] Approximately 12.8% of Russians lived below the national poverty line in 2011,[175] significantly down from 40% in 1998 at the worst point of the post-Soviet collapse.[95] Unemployment in Russia was 5.4% in 2014, down from about 12.4% in 1999.[176] The middle class has grown from just 8million persons in 2000 to 104million persons in 2013.[177][178] However, after United States-led sanctions since 2014 and a collapse in oil prices, the proportion of middle-class could halve to 20%.[179] Sugar imports reportedly dropped 82% between 2012 and 2013 as a result of the increase in domestic output.[180]

Oil, natural gas, metals, and timber account for more than 80% of Russian exports abroad.[99] Since 2003, the exports of natural resources started decreasing in economic importance as the internal market strengthened considerably. Despite higher energy prices, oil and gas only contribute to 5.7% of Russia's GDP and the government predicts this will be 3.7% by 2011.[181] Oil export earnings allowed Russia to increase its foreign reserves from $12billion in 1999 to $597.3billion on 1 August 2008, the third largest foreign exchange reserves in the world.[182] The macroeconomic policy under Finance Minister Alexei Kudrin was prudent and sound, with excess income being stored in the Stabilization Fund of Russia.[183] In 2006, Russia repaid most of its formerly massive debts,[184] leaving it with one of the lowest foreign debts among major economies.[185] The Stabilization Fund helped Russia to come out of the global financial crisis in a much better state than many experts had expected.[183]

A simpler, more streamlined tax code adopted in 2001 reduced the tax burden on people and dramatically increased state revenue.[186] Russia has a flat tax rate of 13%. This ranks it as the country with the second most attractive personal tax system for single managers in the world after the United Arab Emirates.[187] According to Bloomberg, Russia is considered well ahead of most other resource-rich countries in its economic development, with a long tradition of education, science, and industry.[188] The country has a higher proportion of higher education graduates than any other country in Eurasia.[189]

The economic development of the country has been uneven geographically with the Moscow region contributing a very large share of the country's GDP.[190] Inequality of household income and wealth has also been noted, with Credit Suisse finding Russian wealth distribution so much more extreme than other countries studied it "deserves to be placed in a separate category."[191][192] Another problem is modernisation of infrastructure, ageing and inadequate after years of being neglected in the 1990s; the government has said $1trillion will be invested in development of infrastructure by 2020.[193] In December 2011, Russia finally[clarification needed] joined the World Trade Organisation, allowing it a greater access to overseas markets. Some analysts estimate that WTO membership could bring the Russian economy a bounce of up to 3% annually.[194] Russia ranks as the second-most corrupt country in Europe (after Ukraine), according to the Corruption Perceptions Index. The Norwegian-Russian Chamber of Commerce also states that "[c]orruption is one of the biggest problems both Russian and international companies have to deal with".[195] The high rate of corruption acts as a hidden tax as businesses and individuals often have to pay money that is not part of the official tax rate. It is estimated that corruption is costing the Russian economy an estimated $2 billion (80 billion rubles) per year.[196] In 2014, a book-length study by Professor Karen Dawisha was published concerning corruption in Russian under Putin's government.[197]

The Russian central bank announced plans in 2013 to free float the Russian ruble in 2015. According to a stress test conducted by the central bank Russian financial system would be able to handle a currency decline of 25%30% without major central bank interference. However, Russian economy began stagnating in late 2013 and in combination with the War in Donbass is in danger of entering stagflation, slow growth and high inflation. The Russian ruble collapsed by 24% from October 2013 to October 2014 entering the level where the central bank may need to intervene to strengthen the currency. Moreover, after bringing inflation down to 3.6% in 2012, the lowest rate since gaining independence from the Soviet Union, inflation in Russia jumped to nearly 7.5% in 2014, causing the central bank to increase its lending rate to 8% from 5.5% in 2013.[198][199][200] In an October 2014 article in Bloomberg Business Week, it was reported that Russia had significantly started shifting its economy towards China in response to increasing financial tensions following its annexation of Crimea and subsequent Western economic sanctions.[201]

Russia's total area of cultivated land is estimated at 1,237,294 square kilometres (477,722sqmi), the fourth largest in the world.[202] From 1999 to 2009, Russia's agriculture grew steadily,[203] and the country turned from a grain importer to the third largest grain exporter after the EU and the United States.[204] The production of meat has grown from 6,813,000 tonnes in 1999 to 9,331,000 tonnes in 2008, and continues to grow.[205]

This restoration of agriculture was supported by a credit policy of the government, helping both individual farmers and large privatized corporate farms that once were Soviet kolkhozes and which still own the significant share of agricultural land.[206] While large farms concentrate mainly on grain production and husbandry products, small private household plots produce most of the country's potatoes, vegetables and fruits.[207]

Since Russia borders three oceans (the Atlantic, Arctic, and Pacific), Russian fishing fleets are a major world fish supplier. Russia captured 3,191,068 tons of fish in 2005.[208] Both exports and imports of fish and sea products grew significantly in recent years, reaching $2,415 and $2,036 million, respectively, in 2008.[209]

Sprawling from the Baltic Sea to the Pacific Ocean, Russia has more than a fifth of the world's forests, which makes it the largest forest country in the world.[166][210] However, according to a 2012 study by the Food and Agriculture Organization of the United Nations and the Government of the Russian Federation,[211] the considerable potential of Russian forests is underutilized and Russia's share of the global trade in forest products is less than four percent.[212]

In recent years, Russia has frequently been described in the media as an energy superpower.[213][214] The country has the world's largest natural gas reserves,[215] the 8th largest oil reserves,[216] and the second largest coal reserves.[217] Russia is the world's leading natural gas exporter[218] and second largest natural gas producer,[33] while also the largest oil exporter and the largest oil producer.[32]

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Molecular Genetics – DNA, RNA, & Protein

October 17th, 2016 4:42 pm

MOLECULAR GENETICS You Are Here* molecular basis of inheritance Genes ---> Enzymes ---> Metabolism (phenotype) Central Dogma of Molecular Biology* DNA -transcription-->RNA-translation--> Protein Concept Activity -17.1 Overview of Protein Synthesis - INFORMATION FLOW

What is a GENE = ? DNA is the genetic material... [ but what about, retroviruses, as HIV & TMV, contain RNA ] - a discrete piece of deoxyribonucleic acid - linear polymer of repeating nucleotide monomers nucleotides* --> A adenine,C cytosine T thymidine,G guanine --> polynucleotide*

Technology with a Twist - Understanding Genetics

INFORMATION PROCESSING & the CENTRAL DOGMA - the letters of the genetic alphabet... are the nucleotides A, T, G, & C of DNA - the unit of information is CODON = genetic 'word' a triplet sequence of nucleotides 'CAT' in a polynucleotide 3 nucleotides = 1 codon (word) = 1 amino acid in a polypeptide - the definition of (codon) word = amino acid - Size of Human Genome: 3,000,000,000 base pairs or 1.5b in single strand of DNA genes 500,000,000 possible codons (words or amino acids) - average page your textbook = approx 850 words thus, human genome is equal to 588,000 pages or 470 copies of bio text book reading at 3 bases/sec it would take you about 47.6 years @ 8h/d - 7d/w WOW... extreme nanotechnology Mice & humans (indeed, most or all mammals including dogs, cats, rabbits, monkeys, & apes) have roughly the same number of nucleotides in their genomes -- about 3 billion bp. It is estimated that 99.9% of the 3billion n's of human genome is same person to person.

Experimental Proof of DNA as Genetic Material...

1. Transformation Experiments of Fred Griffith... (1920's) Streptococcus pneumoniae -pathogenic S strain & benign R transforming 'principle'* (converting R to S cells) is the genetic element 2. Oswald Avery, Colin MacLeod, & Maclyn McCarty... (1940's) suggest the transforming substance* is DNAmolecules, but... 3. Alfred Hershey & Martha Chase's* 1952 bacteriophage experiments*... VIRAL REPLICATION*[ phage infection & & lytic/lysogenic* ] a genetically controlled biological activity (viral reproduction) they did novel experiment... 1st real use radioisotopes in biology* CONCLUSION - DNA is genetic material because (32P) nucleic acid not (35S) protein guides* viral replication Sumanas, Inc. animation - Lifecycle of HIV virus

Structure of DNA ..... Discovery of Double Helix... Watson's book Nobel prize* -JD Watson, Francis Crick,Maurice Wilkins, but [ Erwin Chargaff & RosyFranklin]... Race for the Double Helix "Life Story" - a BBC dramatization of the discovery of DNA. used two approaches to decipher structure: 1. model building - figure* (are the bases in/out; are the sugar-P's in/out?) 2. x-ray diffraction*pattern* favor a DNA helix of constant diameter* we know now: DNA is a double stranded, helical, polynucleotide chains, made of... 4 nucleotides - A, T, G, C (purine & pyrimidines) in 2 polynucleotide strands (polymer chains) head-tail polarity [5'-----3'] - strands run antiparallel held together via weak H-Bonds & complimentary pairing - Chargaff's rule*..... A:T G:C A + G / T + C = 1.0 Fig's:sugar-P backbone*,base*pairing, dimensions*, models of DNA structure* john kyrk's animation of DNA & Quicktime movie of DNA structure literature references & myDNAi timeline*

Replication of DNA... (Arthur Kornberg - 1959 Nobel - died 10/26/07) copying of DNA into DNA is structurally obvious??? [figure*] Patterns of Replication* = conservative, semi-conservative, & dispersive Matt Meselson & Frank Stahl1958 - experimental design* can we separate 15N-DNA from 14N-DNA - (OLD DNA from NEW DNA)? sedimentation of DNA's (sucrose gradients --> CsCl gradients* & picture*) we can predict results... figure* & overview& all possible results Sumanas, Inc. animation - Meselson-Stahl DNA Replications*

Model of Replication is bacterial with DNA polymerase III... several enzymes* form a Replication Complex (Replisome) & include: helicase - untwists DNA topoisomerase [DNA gyrase] - removes supercoils, single strand binding proteins - stabilize replication fork, Primase - makes RNA primer POL III - synthesizes new DNA strands DNA polymerase I - removes RNA primer 1 base at a time, adds DNA bases DNA ligase repairs Okazaki fragments (seals lagging strand 3' open holes) Concept Activity - DNA Replication Review Structure of DNA polymerase III* copies both strands simultaneously, as DNA is Threaded Through a Replisome* a "replication machine", which may be stationary by anchoring in nuclear matrix Continuous & Discontinuous replication occur simultaneously in both strands

EVENTS: 1. DNA pol III binds at the origin of replication site in the template strand 2. DNA is unwound by replisome complex using helicase & topoisomerase 3. all polymerases require a preexisting DNA strand (PRIMER) to start replication, thus Primase adds a single short primer to the LEADING strand and adds many primers to the LAGGING strand 4. DNA pol III is a dimer adding new nucleotides to both strands primers direction of reading is 3' ---> 5' on template direction of synthesis of new strand is 5" ---> 3' rate of synthesis is substantial 400 nucleotide/sec 5. DNA pol I removes primer at 5' end replacing with DNA bases, leaves 3' hole 6. DNA ligase seals 3' holes of Okazaki fragments on lagging strand the sequence of events in detail* and DNA Repair* Rates of DNA synthesis: myDNAi movie of replication* native polymerase: 400 bases/sec with 1 error per 109 bases artificial: phophoramidite method (Marvin Caruthers, U.Colorado); ssDNA synthesis on polystyrene bead @ 1 base/300 sec with error rate of 1/100b

GENE Expression the Central Dogma of Molecular Biology depicts flow of genetic information Transcription - copying of DNA sequence into RNA Translation- copying of RNA sequence into protein DNA sequence -------> RNA sequence -----> amino acid sequence TAC AUG MET triplet sequence in DNA --> codon in mRNA ---->amino acid in protein Information : triplet sequence in DNA is the genetic word [codon] Compare Events: Procaryotes* vs. Eucaryotes* = Separation of labor Differences DNA vs. RNA (bases & sugars) and its single stranded Flow of Gene Information (FIG*) - One Gene - One enzyme (Beadle & Tatum) 18.3-Overview: Control of Gene Expression

Transcription - RNA polymerase Concept Activity 17.2 - Transcription RNA*polymerase - in bacteria Sigma factor* binds promoter & initiates* copying* [pnpase] transcription factors* are needed to recognize specific DNA sequence [motif*], binds to promoter DNA region [ activators & transcription factors*]* makes a complimentary copy* of one of the two DNA strands[sense strand] Quicktime movie of transcription*myDNAi Roger Kornberg's movie of transcription (2006 Nobel)* Kinds of RNA [table*] tRNA - small, 80n, anticodon sequence, single strand with 2ndary structure* function = picks up aa & transports it to ribosome rRNA - 3 individual pieces of RNA - make up the organelle = RIBOSOME primary transcript is processed into the 3 pieces of rRNA pieces(picture*) & recall structure of ribosome

Other classes of RNA: small nuclear RNA (snRNP's)- plays a structural and catalytic role in spliceosome* there are 5 snRNP's making a spliceosome [U1, U2, U4, U5, & U6]; they and participate in several RNA-RNA and RNA-protein interactions

SRP (signal recognition particle) - srpRNA is a component of the protein-RNA complex that recognizes the signal sequence of polypeptides targeted to the ER - figure*

small nucleolar RNA (snoRNA) - aids in processing of pre-rRNA transcripts for ribosome subunit formation in the nucleolus

micro RNA's (micro-RNA)- also called antisense RNA & interfereing RNA; c7-fig 19.9 short (20-24 nucleotide) RNAs that bind to mRNA inhibiting it. figure* present in MODEL eukaryotic organisms as:roundworms, fruit flies, mice, humans, & plants (arabidopsis); seems to help regulate gene expression by controlling the timing of developmental events via mRNA action also inhibits translation of target mRNAs. ex: siRNA --> [BARR Body*]

TRANSLATION - Making a Protein process of making a protein in a specific amino acid sequence from a unique mRNA sequence...[ E.M. picture* ] polypeptides are built on the ribosome (pic) on a polysome [ animation*] Sequence of 4 Steps in Translation... [glossary] 1. add an amino acid to tRNA -- > aa-tRNA - ACTIVATION* 2. assemble players [ribosome*, mRNA, aa-tRNA] - INITIATION* 3. adding new aa's via peptidyl transferase - ELONGATION* 4. stopping the process - TERMINATION* Concept CD Activity - 17.4 Events in Translation Review the processes - initiation, elongation, & termination myDNAi real-time movie of translation*& Quicktime movie of translation Review figures & parts: Summary fig* [ components, locations, AA-site, & advanced animation ] [ Nobel Committee static animations of Central Dogma ]

GENETIC CODE... ...is the sequence of nucleotides in DNA, but routinely shown as a mRNA code* ...specifies sequence of amino acids to be linked into the protein coding ratio* - # of n's... how many nucleotides specify 1 aa 1n = 4 singlets, 2n= 16 doublets, 3n = 64 triplets Student CD Activity - 11.2 - Triplet Coding S. Ochoa (1959 Nobel) - polynucleotide phosphorylase can make SYNTHETIC mRNA Np-Np-Np-Np <----> Np-Np-Np + Np Marshall Nirenberg (1968 Nobel)- synthetic mRNA's used in an in vitro system 5'-UUU-3' = pheU + C --> UUU, UUC, UCC, CCC UCU, CUC, CCU, CUU the Genetic CODE* - 64 triplet codons [61 = aa & 3 stop codons] universal (but some anomalies), 1 initiator codon (AUG), redundant but non-ambiguous, and exhibits "wobble*".

GENETIC CHANGE - a change in DNA nucleotide sequence (= change in mRNA) - 2 significant waysmutation & recombination [glossary] 1. MUTATION - a permanent change in an organism's DNA*that results in a different codon = different amino acid sequence Point mutation* - a single to few nucleotides change... - deletions, insertions, frame-shift mutations* [CAT] - single nucleotide base substitutions* : non-sense = change to no amino acid (a STOP codon) UCA --> UAA ser to non mis-sense = different amino acid UCA --> UUA ser to leu Sickle Cell Anemia* - a mis-sense mutation... (SCA-pleiotropy) another point mutation blood disease - thalassemia - Effects = no effect, detrimental (lethal), +/- functionality, beneficial

2. Recombination (Recombinant DNA)newly combined DNA's that [glossary]* can change genotype via insertion of NEW (foreign) DNA molecules into recipient cell 1. fertilization*- sperm inserted into recipient egg cell* --> zygote [n + n = 2n] 2. exchange of homologous chromatids via crossing over* = new gene combo's 3. transformation* - absorption of 'foreign' DNA by recipient cells changes cell 4. BACTERIAL CONJUGATION* - involves DNA plasmidsg* (F+ & R = resistance) conjugation may be a primitive sex-like reproduction in bacteria[Hfr*] 5. VIRAL TRANSDUCTION - insertion via a viral vector(lysogeny* &TRANSDUCTION*) general transduction - pieces of bacterial DNA are packaged w viral DNA during viral replication restricted transduction - a temperate phage goes lytic carrying adjacent bacterial DNA into virus particle 6. DESIGNER GENES - man-made recombinant DNA molecules

Designer Genes - Genetic Engineering - Biotechnology

RECOMBINANT DNA TECHNOLOGY... a collection of experimental techniques, which allow for isolation, copying, & insertion of new DNA sequences into host-recipientcells by A NUMBER OF laboratory protocols & methodologies

Restriction Endonucleases-[glossary]*... diplotomic cuts (unequal) at uniqueDNA sequences Eco-R1-figure* @ mostly palindromes... [never odd or even] 5' GAATTC 3' 5' G. . . . . + AATTC 3' 3' CTTAAG 5' 3' CTTAA .. .. G 5' campbell 7/e movie* DNA's cut this way have STICKY (complimentary) ENDS & can be reannealed or spliced* w other DNA molecules to produce new genes combosand sealed via DNA ligase. myDNAi movie of restriction enzyme action*

Procedures of Biotechnology? [Genome Biology Research] A. Technology involved in Cloning a Gene...[animation* & the tools of genetic analysis] making copies of gene DNA 1. via a plasmid*[ A.E. fig& human shotgun plasmid cloning & My DNAi movie*] 2. Librariesg... [ library figure* & BAC's* &Sumanas animation - DNA fingerprint library] 3. Probesg... [ cDNAg & reverse transcriptaseg & DNA Probe Hybridizationg... cDNA figure*& cDNA library* & a probe for a gene of interest* finding a gene with a probe among a library*] 4. Polymerase Chain Reactiong & figure 20.7* & animation*+Sumanas, Inc. animation* the PCR song PCR reaction protocol & Xeroxing DNA & Taq polymerase

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Molecular Genetics - DNA, RNA, & Protein

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MCW: Microbiology and Molecular Genetics Department

October 17th, 2016 4:42 pm

The mission of our faculty is to conduct innovative and impactful research in Microbiology, Immunology, and Molecular Genetics and to train students and postdoctoral fellows for careers as biomedical scientists. Our faculty also instruct in the Graduate School of Biomedical Sciences and the Medical School and often collaborate with clinical scientists to facilitate the translation of bench to bedside therapies to treat human diseases. Our students acquire professional training while carrying out independent research projects in microbial pathogenesis and physiology, the immune response, and host interactions with microbial pathogens. Our administrative and research staff strive to support the research, teaching and service activities of our students and faculty.

Contact information for faculty members in the department, including email addresses and room numbers, can be found on the faculty pages.

Medical College of Wisconsin Department of Microbiology and Molecular Genetics BSB - 2nd Floor - Room 273 8701 Watertown Plank Road Milwaukee, WI 53226

(414) 955-8253 | (414) 955-6535 (fax)

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Stem-cell therapy – Wikipedia

October 17th, 2016 4:40 pm

This article is about the medical therapy. For the cell type, see Stem cell.

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.

Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions.

Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.

For over 30 years, bone marrow has been used to treat cancer patients with conditions such as leukaemia and lymphoma; this is the only form of stem-cell therapy that is widely practiced.[1][2][3] During chemotherapy, most growing cells are killed by the cytotoxic agents. These agents, however, cannot discriminate between the leukaemia or neoplastic cells, and the hematopoietic stem cells within the bone marrow. It is this side effect of conventional chemotherapy strategies that the stem-cell transplant attempts to reverse; a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. The transplanted cells also generate an immune response that helps to kill off the cancer cells; this process can go too far, however, leading to graft vs host disease, the most serious side effect of this treatment.[4]

Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids.[5] It is an allogenic stem therapy based on mesenchymal stem cells (MSCs) derived from the bone marrow of adult donors. MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. The doses are stored frozen until needed.[6]

The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and immunological diseases.[7]

In 2014, the European Medicines Agency recommended approval of Holoclar, a treatment involving stem cells, for use in the European Union. Holoclar is used for people with severe limbal stem cell deficiency due to burns in the eye.[8]

In March 2016 GlaxoSmithKline's Strimvelis (GSK2696273) therapy for the treatment ADA-SCID was recommended for EU approval.[9]

Stem cells are being studied for a number of reasons. The molecules and exosomes released from stem cells are also being studied in an effort to make medications.[10]

Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease.[11][12][13] There have been preliminary studies related to multiple sclerosis.[14][15]

Healthy adult brains contain neural stem cells which divide to maintain general stem-cell numbers, or become progenitor cells. In healthy adult laboratory animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder.[16][17][18]

Stroke and traumatic brain injury lead to cell death, characterized by a loss of neurons and oligodendrocytes within the brain. A small clinical trial was underway in Scotland in 2013, in which stem cells were injected into the brains of stroke patients.[19]

Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury.[20][21][22]

The pioneering work[23] by Bodo-Eckehard Strauer has now been discredited by the identification of hundreds of factual contradictions.[24] Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, but this has covered old[25] and recent[26] infarcts as well as heart failure not arising from myocardial infarction.[27] While initial animal studies demonstrated remarkable therapeutic effects,[28][29] later clinical trials achieved only modest, though statistically significant, improvements.[30][31] Possible reasons for this discrepancy are patient age,[32] timing of treatment[33] and the recent occurrence of a myocardial infarction.[34] It appears that these obstacles may be overcome by additional treatments which increase the effectiveness of the treatment[35] or by optimizing the methodology although these too can be controversial. Current studies vary greatly in cell-procuring techniques, cell types, cell-administration timing and procedures, and studied parameters, making it very difficult to make comparisons. Comparative studies are therefore currently needed.

Stem-cell therapy for treatment of myocardial infarction usually makes use of autologous bone-marrow stem cells (a specific type or all), however other types of adult stem cells may be used, such as adipose-derived stem cells.[36] Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007.[citation needed]

Possible mechanisms of recovery include:[11]

It may be possible to have adult bone-marrow cells differentiate into heart muscle cells.[11]

The first successful integration of human embryonic stem cell derived cardiomyocytes in guinea pigs (mouse hearts beat too fast) was reported in August 2012. The contraction strength was measured four weeks after the guinea pigs underwent simulated heart attacks and cell treatment. The cells contracted synchronously with the existing cells, but it is unknown if the positive results were produced mainly from paracrine as opposed to direct electromechanical effects from the human cells. Future work will focus on how to get the cells to engraft more strongly around the scar tissue. Whether treatments from embryonic or adult bone marrow stem cells will prove more effective remains to be seen.[37]

In 2013 the pioneering reports of powerful beneficial effects of autologous bone marrow stem cells on ventricular function were found to contain "hundreds" of discrepancies.[38] Critics report that of 48 reports there seemed to be just five underlying trials, and that in many cases whether they were randomized or merely observational accepter-versus-rejecter, was contradictory between reports of the same trial. One pair of reports of identical baseline characteristics and final results, was presented in two publications as, respectively, a 578 patient randomized trial and as a 391 patient observational study. Other reports required (impossible) negative standard deviations in subsets of patients, or contained fractional patients, negative NYHA classes. Overall there were many more patients published as having receiving stem cells in trials, than the number of stem cells processed in the hospital's laboratory during that time. A university investigation, closed in 2012 without reporting, was reopened in July 2013.[39]

One of the most promising benefits of stem cell therapy is the potential for cardiac tissue regeneration to reverse the tissue loss underlying the development of heart failure after cardiac injury.[40]

Initially, the observed improvements were attributed to a transdifferentiation of BM-MSCs into cardiomyocyte-like cells.[28] Given the apparent inadequacy of unmodified stem cells for heart tissue regeneration, a more promising modern technique involves treating these cells to create cardiac progenitor cells before implantation to the injured area.[41]

The specificity of the human immune-cell repertoire is what allows the human body to defend itself from rapidly adapting antigens. However, the immune system is vulnerable to degradation upon the pathogenesis of disease, and because of the critical role that it plays in overall defense, its degradation is often fatal to the organism as a whole. Diseases of hematopoietic cells are diagnosed and classified via a subspecialty of pathology known as hematopathology. The specificity of the immune cells is what allows recognition of foreign antigens, causing further challenges in the treatment of immune disease. Identical matches between donor and recipient must be made for successful transplantation treatments, but matches are uncommon, even between first-degree relatives. Research using both hematopoietic adult stem cells and embryonic stem cells has provided insight into the possible mechanisms and methods of treatment for many of these ailments.[citation needed]

Fully mature human red blood cells may be generated ex vivo by hematopoietic stem cells (HSCs), which are precursors of red blood cells. In this process, HSCs are grown together with stromal cells, creating an environment that mimics the conditions of bone marrow, the natural site of red-blood-cell growth. Erythropoietin, a growth factor, is added, coaxing the stem cells to complete terminal differentiation into red blood cells.[42] Further research into this technique should have potential benefits to gene therapy, blood transfusion, and topical medicine.

In 2004, scientists at King's College London discovered a way to cultivate a complete tooth in mice[43] and were able to grow bioengineered teeth stand-alone in the laboratory. Researchers are confident that the tooth regeneration technology can be used to grow live teeth in human patients.

In theory, stem cells taken from the patient could be coaxed in the lab turning into a tooth bud which, when implanted in the gums, will give rise to a new tooth, and would be expected to be grown in a time over three weeks.[44] It will fuse with the jawbone and release chemicals that encourage nerves and blood vessels to connect with it. The process is similar to what happens when humans grow their original adult teeth. Many challenges remain, however, before stem cells could be a choice for the replacement of missing teeth in the future.[45][46]

Research is ongoing in different fields, alligators which are polyphyodonts grow up to 50 times a successional tooth (a small replacement tooth) under each mature functional tooth for replacement once a year.[47]

Heller has reported success in re-growing cochlea hair cells with the use of embryonic stem cells.[48]

Since 2003, researchers have successfully transplanted corneal stem cells into damaged eyes to restore vision. "Sheets of retinal cells used by the team are harvested from aborted fetuses, which some people find objectionable." When these sheets are transplanted over the damaged cornea, the stem cells stimulate renewed repair, eventually restore vision.[49] The latest such development was in June 2005, when researchers at the Queen Victoria Hospital of Sussex, England were able to restore the sight of forty patients using the same technique. The group, led by Sheraz Daya, was able to successfully use adult stem cells obtained from the patient, a relative, or even a cadaver. Further rounds of trials are ongoing.[50]

In April 2005, doctors in the UK transplanted corneal stem cells from an organ donor to the cornea of Deborah Catlyn, a woman who was blinded in one eye when acid was thrown in her eye at a nightclub. The cornea, which is the transparent window of the eye, is a particularly suitable site for transplants. In fact, the first successful human transplant was a cornea transplant. The absence of blood vessels within the cornea makes this area a relatively easy target for transplantation. The majority of corneal transplants carried out today are due to a degenerative disease called keratoconus.

The University Hospital of New Jersey reports that the success rate for growth of new cells from transplanted stem cells varies from 25 percent to 70 percent.[51]

In 2014, researchers demonstrated that stem cells collected as biopsies from donor human corneas can prevent scar formation without provoking a rejection response in mice with corneal damage.[52]

In January 2012, The Lancet published a paper by Steven Schwartz, at UCLA's Jules Stein Eye Institute, reporting two women who had gone legally blind from macular degeneration had dramatic improvements in their vision after retinal injections of human embryonic stem cells.[53]

In June 2015, the Stem Cell Ophthalmology Treatment Study (SCOTS), the largest adult stem cell study in ophthalmology ( http://www.clinicaltrials.gov NCT # 01920867) published initial results on a patient with optic nerve disease who improved from 20/2000 to 20/40 following treatment with bone marrow derived stem cells.[54]

Diabetes patients lose the function of insulin-producing beta cells within the pancreas.[55] In recent experiments, scientists have been able to coax embryonic stem cell to turn into beta cells in the lab. In theory if the beta cell is transplanted successfully, they will be able to replace malfunctioning ones in a diabetic patient.[56]

Human embryonic stem cells may be grown in cell culture and stimulated to form insulin-producing cells that can be transplanted into the patient.

However, clinical success is highly dependent on the development of the following procedures:[11]

Clinical case reports in the treatment orthopaedic conditions have been reported. To date, the focus in the literature for musculoskeletal care appears to be on mesenchymal stem cells. Centeno et al. have published MRI evidence of increased cartilage and meniscus volume in individual human subjects.[57][58] The results of trials that include a large number of subjects, are yet to be published. However, a published safety study conducted in a group of 227 patients over a 3-4-year period shows adequate safety and minimal complications associated with mesenchymal cell transplantation.[59]

Wakitani has also published a small case series of nine defects in five knees involving surgical transplantation of mesenchymal stem cells with coverage of the treated chondral defects.[60]

Stem cells can also be used to stimulate the growth of human tissues. In an adult, wounded tissue is most often replaced by scar tissue, which is characterized in the skin by disorganized collagen structure, loss of hair follicles and irregular vascular structure. In the case of wounded fetal tissue, however, wounded tissue is replaced with normal tissue through the activity of stem cells.[61] A possible method for tissue regeneration in adults is to place adult stem cell "seeds" inside a tissue bed "soil" in a wound bed and allow the stem cells to stimulate differentiation in the tissue bed cells. This method elicits a regenerative response more similar to fetal wound-healing than adult scar tissue formation.[61] Researchers are still investigating different aspects of the "soil" tissue that are conducive to regeneration.[61]

Culture of human embryonic stem cells in mitotically inactivated porcine ovarian fibroblasts (POF) causes differentiation into germ cells (precursor cells of oocytes and spermatozoa), as evidenced by gene expression analysis.[62]

Human embryonic stem cells have been stimulated to form Spermatozoon-like cells, yet still slightly damaged or malformed.[63] It could potentially treat azoospermia.

In 2012, oogonial stem cells were isolated from adult mouse and human ovaries and demonstrated to be capable of forming mature oocytes.[64] These cells have the potential to treat infertility.

Destruction of the immune system by the HIV is driven by the loss of CD4+ T cells in the peripheral blood and lymphoid tissues. Viral entry into CD4+ cells is mediated by the interaction with a cellular chemokine receptor, the most common of which are CCR5 and CXCR4. Because subsequent viral replication requires cellular gene expression processes, activated CD4+ cells are the primary targets of productive HIV infection.[65] Recently scientists have been investigating an alternative approach to treating HIV-1/AIDS, based on the creation of a disease-resistant immune system through transplantation of autologous, gene-modified (HIV-1-resistant) hematopoietic stem and progenitor cells (GM-HSPC).[66]

On 23 January 2009, the US Food and Drug Administration gave clearance to Geron Corporation for the initiation of the first clinical trial of an embryonic stem-cell-based therapy on humans. The trial aimed evaluate the drug GRNOPC1, embryonic stem cell-derived oligodendrocyte progenitor cells, on patients with acute spinal cord injury. The trial was discontinued in November 2011 so that the company could focus on therapies in the "current environment of capital scarcity and uncertain economic conditions".[67] In 2013 biotechnology and regenerative medicine company BioTime (NYSEMKT:BTX) acquired Geron's stem cell assets in a stock transaction, with the aim of restarting the clinical trial.[68]

Scientists have reported that MSCs when transfused immediately within few hours post thawing may show reduced function or show decreased efficacy in treating diseases as compared to those MSCs which are in log phase of cell growth(fresh), so cryopreserved MSCs should be brought back into log phase of cell growth in invitro culture before these are administered for clinical trials or experimental therapies, re-culturing of MSCs will help in recovering from the shock the cells get during freezing and thawing. Various clinical trials on MSCs have failed which used cryopreserved product immediately post thaw as compared to those clinical trials which used fresh MSCs.[69]

There is widespread controversy over the use of human embryonic stem cells. This controversy primarily targets the techniques used to derive new embryonic stem cell lines, which often requires the destruction of the blastocyst. Opposition to the use of human embryonic stem cells in research is often based on philosophical, moral, or religious objections.[110] There is other stem cell research that does not involve the destruction of a human embryo, and such research involves adult stem cells, amniotic stem cells, and induced pluripotent stem cells.

Stem-cell research and treatment was practiced in the People's Republic of China. The Ministry of Health of the People's Republic of China has permitted the use of stem-cell therapy for conditions beyond those approved of in Western countries. The Western World has scrutinized China for its failed attempts to meet international documentation standards of these trials and procedures.[111]

State-funded companies based in the Shenzhen Hi-Tech Industrial Zone treat the symptoms of numerous disorders with adult stem-cell therapy. Development companies are currently focused on the treatment of neurodegenerative and cardiovascular disorders. The most radical successes of Chinese adult stem cell therapy have been in treating the brain. These therapies administer stem cells directly to the brain of patients with cerebral palsy, Alzheimer's, and brain injuries.[citation needed]

Since 2008 many universities, centers and doctors tried a diversity of methods; in Lebanon proliferation for stem cell therapy, in-vivo and in-vitro techniques were used, Thus this country is considered the launching place of the Regentime[112] procedure. http://www.researchgate.net/publication/281712114_Treatment_of_Long_Standing_Multiple_Sclerosis_with_Regentime_Stem_Cell_Technique The regenerative medicine also took place in Jordan and Egypt.[citation needed]

Stem-cell treatment is currently being practiced at a clinical level in Mexico. An International Health Department Permit (COFEPRIS) is required. Authorized centers are found in Tijuana, Guadalajara and Cancun. Currently undergoing the approval process is Los Cabos. This permit allows the use of stem cell.[citation needed]

In 2005, South Korean scientists claimed to have generated stem cells that were tailored to match the recipient. Each of the 11 new stem cell lines was developed using somatic cell nuclear transfer (SCNT) technology. The resultant cells were thought to match the genetic material of the recipient, thus suggesting minimal to no cell rejection.[113]

As of 2013, Thailand still considers Hematopoietic stem cell transplants as experimental. Kampon Sriwatanakul began with a clinical trial in October 2013 with 20 patients. 10 are going to receive stem-cell therapy for Type-2 diabetes and the other 10 will receive stem-cell therapy for emphysema. Chotinantakul's research is on Hematopoietic cells and their role for the hematopoietic system function in homeostasis and immune response.[114]

Today, Ukraine is permitted to perform clinical trials of stem-cell treatments (Order of the MH of Ukraine 630 "About carrying out clinical trials of stem cells", 2008) for the treatment of these pathologies: pancreatic necrosis, cirrhosis, hepatitis, burn disease, diabetes, multiple sclerosis, critical lower limb ischemia. The first medical institution granted the right to conduct clinical trials became the "Institute of Cell Therapy"(Kiev).

Other countries where doctors did stem cells research, trials, manipulation, storage, therapy: Brazil, Cyprus, Germany, Italy, Israel, Japan, Pakistan, Philippines, Russia, Switzerland, Turkey, United Kingdom, India, and many others.

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AJRCCM – Home (ATS Journals)

October 16th, 2016 6:43 am

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Entertainment – CBC News

October 16th, 2016 6:43 am

TELEVISION

Breaking new ground: Kim's Convenience to be Canada's 1st sitcom led by Asians

TELEVISION

Fresh start for Steven Sabados, 'sexy' crime thriller Shoot the Messenger and more debut on CBC-TV

Italian journalist claims to reveal the true identity of Elena Ferrante

Robin Williams was fighting 'terrorist within his brain,' widow says in essay

'Indian Group of Seven' artist Daphne Odjig dead at 97

MOVIE REVIEW

Deepwater Horizon, Queen of Katwe and more

VISUAL ART

VR an eye-popping new canvas for artists using Tilt Brush

Video

Queen of Katwe a refreshingly positive African story

FILM

Deepwater Horizon explores riggers' side of the story

Lawren Harris mountainscape featured in Steve Martin exhibit set for auction

Esports franchise Team Liquid sold to Magic Johnson, NBA co-owners group

Pokemon Go fervour has cooled, but the game isn't dead yet

Emma Donoghue, Madeleine Thien shortlisted for $100K Giller Prize

Photos

Contenders for the Turner Prize include a train, a brick suit and giant buttocks

Inuk artist Annie Pootoogook found dead in Ottawa

Photos

From darkness to light: Inside D.C.'s new African-American museum

FILM REVIEW

Storks a surprisingly snappy and contemporary comedy, says CBC's Eli Glasner

FILM

Xavier Dolan's It's Only the End of the World explores imperfect family relations

The Magnificent Seven 'like a jazz band,' says director Antoine Fuqua

TELEVISION

Does loosening Cancon rules hobble Canadian TV creators?

Disney pulls boy's costume critics lambasted as 'Polyface'

MUSIC

'I have no regrets,' rogue Tenor Remigio Pereira says after O Canada stunt

Winnipeg artist 'blown away' by $25K national prize win

CBC BOOKS

Anosh Irani, Katherena Vermette make Rogers Writers' Trust Fiction Prize shortlist

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How Light Works | HowStuffWorks

October 16th, 2016 6:43 am

Light is at once both obvious and mysterious. We are bathed in yellow warmth every day and stave off the darkness with incandescent and fluorescent bulbs. But what exactly is light? We catch glimpses of its nature when a sunbeam angles through a dust-filled room, when a rainbow appears after a storm or when a drinking straw in a glass of water looks disjointed. These glimpses, however, only lead to more questions. Does light travel as a wave, a ray or a stream of particles? Is it a single color or many colors mixed together? Does it have a frequency like sound? And what are some of the common properties of light, such as absorption, reflection, refraction and diffraction?

You might think scientists know all the answers, but light continues to surprise them. Here's an example: We've always taken for granted that light travels faster than anything in the universe. Then, in 1999, researchers at Harvard University were able to slow a beam of light down to 38 miles an hour (61 kilometers per hour) by passing it through a state of matter known as a Bose-Einstein condensate. That's almost 18 million times slower than normal! No one would have thought such a feat possible just a few years ago, yet this is the capricious way of light. Just when you think you have it figured out, it defies your efforts and seems to change its nature.

Still, we've come a long way in our understanding. Some of the brightest minds in the history of science have focused their powerful intellects on the subject. Albert Einstein tried to imagine what it would be like to ride on a beam of light. "What if one were to run after a ray of light?" he asked. "What if one were riding on the beam? If one were to run fast enough, would it no longer move at all?"

Einstein, though, is getting ahead of the story. To appreciate how light works, we have to put it in its proper historical context. Our first stop is the ancient world, where some of the earliest scientists and philosophers pondered the true nature of this mysterious substance that stimulates sight and makes things visible.

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Hematology Conferences | Blood Disorder Conferences | USA …

October 13th, 2016 9:46 am

9thInternational Conference on Hematology

Date: November 02-04, 2017

Venue: Las Vegas, USA

Hematology 2016 has been designed with many interesting and informative scientific sessions; it includes all possible aspects of Hematology research.

Hematology

Erythrocytesare also known as red blood cells which carry oxygen to the body and collect carbon dioxide from the body by the use of hemoglobin and its life span of 120 days. along the side the leucocytes helps in protecting the healthy cells because the W.B.C (leucocytes) act as the defending cells in protecting the immune system from the foreign cells. Theseleucocytesare multipotent cells in bone marrow and there life span is of 3-4 days where the yellow blood cells are called as thrombocytes they are where small and irregular in shape they have life span of 5-9 days they are mostly seen in mammals they help in clotting of blood which are in fibrin form called as thrombosis these lead to heart stroke, blockage of blood in blood mostly in arms and legs. where C.B.C is known ascomplete blood countis done to know the number of cells in a body these are mainly done by lab technician presently they are been tested by automatic analyzer the high and low amount of cells will lead to many diseases. Decrease of R.B.C in the body these causes of anemia which leads to weakness, feeling of tired, shortness of breath and person will be noticeably pale. Formation of blood cellular components are called as Hematopoiesis and all the cellular blood components are derived from hematopoiesis stem cells in a healthy individual nearly 10111012new blood cells are produced these help in steady peripheral circulation. If there is a increases of R.B.C in the body these causes polycythemia these can be measured through hematocrit level.

Blood Disorders

Hemophilia Ais a genetic deficiency in clottingfactor VIII,which causes increased bleeding and usually affects males. About 70% of the time it is inherited as an X-linked recessive trait, but around 30% of cases arise from spontaneous mutations. Hemophilia B is ablood clottingdisorder caused by amutationof thefactor IXgene, leading to a deficiency of factor IX. It is the second-most common form ofhaemophilia, rarer thanhaemophilia A. It is sometimes calledChristmas disease, named afterStephen Christmas, the first patient described with this disease.In addition, the first report of its identification was published in the Christmas edition of theBritish Medical Journal.Hemophilia C is a mild form of haemophiliaaffecting both sexes. However, it predominantly occurs in Jews ofAshkenazidescent. It is the fourth most common coagulationdisorder aftervon Willebrand's diseaseandhaemophiliaAandB.In theUSAit is thought to affect 1 in 100,000 of the adult population, making it 10% as common as haemophilia A. Idiopathic thrombocytopenic purpura(ITP), also known asimmune thrombocytopenia,primary immune thrombocytopenia,primary immune thrombocytopenic purpuraorautoimmune thrombocytopenic purpura, is defined as isolated low platelet count (thrombocytopenia) with normalbone marrowand the absence of other causes of thrombocytopeniaVon Willebrand diseasesis the most common hereditarycoagulationabnormality described in humans. Platelets also called "thrombocytes" areblood cellswhose function (along with thecoagulation factors) is to stop bleeding by clumping and clogging blood vessel injuries.Platelets have nocell nucleus: Coagulation is highlyconservedthroughout biology; in allmammals, coagulation involves both a cellular (platelet) and aprotein(coagulation factor) component and these are occoured due togenetic blood disorders

Hematologic Malignancies

Lymphatic leukemiawhich effect the white blood cells(w.b.c) they are closely related to the lymphomas and some of them are unitary diseases which related to the adult T cells leukemia these come under the lymphoproliferative disorders. Mostly they involve in the B-cell sub type lymphocytes. The myeloid leukemia is preferred to the granulocyte precursor in the bone marrow and spinal cord and these arises the abnormal growth in the blood from tissues in the bone marrow. They are mainly related to the hematopoietic cells and these sub title into acute and chronic lymphoblastic leukemia. The acute leukemia is that rapidly producing immature blood cells as they are bulk number of cells healthy cells are not produced in bone marrow due this spill over the blood stream which spread to other body parts. Where as in chronic leukemia highly bulid of matured cells are formed but still abnormal white cells are formed these can not be treated immediately mostly seen in older people. The cancer which originate from white blood cells are called as lymphoma and this disorder is mainly seen inHodgkin lymphomathese diseases is treated by radiation and chemotherapy, orhematopoietic stem cell transplantation. The cancer which starts with in the cell are called as Non Hodgkin lymphocytes and these lymphocytes are of lymph nodes. The bone marrow which develops too many white blood cells leads tomultiple myleoma. The further details on malignance are been discussed inHematology oncology conference-2015.

Hematology and immunology

Blood groupsare of ABO type and but at present the Rh blood grouping of 50 well defined antigens in which 5 are more important they are D,C,c,E and e and Rh factors are of Rh positive and Rh negative which refers to the D-antigen. These D-antigen helps in prevention of erythroblast fetalis lacking of Rh antigen it defined as negative and presences of Rh antigen in blood leads to positive these leads to rh incompatibility. The prevention treatment of diseases related to the blood is called as the Hematology. The hematologists conduct works on cancer to. The disorder of immune system leading to hypersensitivity is called asClinical Immunologyand the abnormal growth of an infection are known as Inflammation and the arise of an abnormal immune response to the body or an immune suppression are known as Auto immune disorder. The stem cell therapy is used to treat or prevent a disease or a condition mostly Bone marrow stem cell therapy is seen and recently umbilical cord therapy Stem cell transplantation strategies remains a dangerous procedure with many possible complications; it is reserved for patients with life-threatening diseases.

Blood Transplantation

Theumbilical cordis a conduit between the developingembryoorfetusand theplacenta. The umbilical vein supplies the fetus with nutrient-richbloodfrom theplacenta The hematopoitic bone marrow transplant, the HSC are removed from a large bone of the donor, typically thepelvis, through a largeneedlethat reaches the center of the bone. Acute myeloid leukemia is a cancerof themyeloidline of blood cells, characterized by the rapid growth of abnormalwhite blood cellsthat accumulate in thebone marrowand interfere withthe production of normal blood cells and the Thrombosis is the formation of ablood clot inside ablood vessel, obstructing the flow ofbloodthrough thecirculatory system. TheHemostaticis a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel this is the first stage of wound healing. Metabolic syndromeis a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions, obesity,elevated blood pressure,elevated fasting plasma glucose,high serum triglycerides, and lowhigh-density lipoprotein(HDL) levels. Metabolic syndrome increases the risk developingcardiovascular diseaseanddiabetes.

Diagnosis and Treatment

Palliative careis amultidisciplinary approachto specialisedmedical carefor people with seriousillnesses The spleen, similar in structure to a largelymph node, acts as a blood filter. Anticoagulants(antithrombics) are a class of drugs that work to prevent thecoagulation(clotting) of blood. Some anticoagulants are used in medical equipment, such astest tubes ,blood transfusionbags, andrenal dialysisequipment. Anvena cava filteris a type of vascular filter, amedicaldevice that is implanted byinterventional radiologistsor vascular surgeons into theinferior vena cavato presumably prevent life-threateningpulmonary emboliistherapyusingionizing radiation, generally as part of cancer treatmentto control or killmalignantcells. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. The subspecialty ofoncologythat focuses on radiotherapy is calledradiation oncology. Translational research is another term fortranslated researchandtranslational science, Applying knowledge from basic science is a major stumbling block in science, partially due to the compartmentalization within science. Targeted drug delivery is a method of deliveringmedicationto a patient in a manner that increases theconcentrationof the medication in some parts of the body relative to others.

New Drug Development in Haematology

The development of antibiotic resistance in particular stems from the drugs targeting only specific bacterial molecules. Because the drugisso specific, any mutation in these molecules will interfere with or negate its destructive effect, resulting in antibiotic resistance. Known asDrug deliveryConditions treated with combination therapy includetuberculosis,leprosy,cancer,malaria, andHIV/AIDS. One major benefit of combination therapies is that they reduce development ofdrug resistance, since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously.Artemisinin-based monotherapies for malaria are explicitly discouraged to avoid the problem of developing resistance to the newer treatment. Drug Induced Blood Disorders causes of sickle cell anemia,pale skin non steroids antiinflammatory drugswhich causes ulcers Using drug repositioning, pharmaceutical companies have achieved a number successes, for examplePfizer'sViagrainerectile dysfunctionandCelgene'sthalidomidein severe erythema nodosum leprosum. Smaller companies, including Ore Pharmaceuticals,Biovista, Numedicus,Melior Discoveryand SOM Biotech are also performing drug repositioning on a systematic basis. These companies use a combination of approaches including in silico biology and in vivo/in vitro experimentation to assess a compound and develop and confirm hypotheses concerning its usage for new indications.

Hematology Research

Lymphatic diseasesthis is a type of cancer of the lymphatic system. It can start almost any where in the body. It's believed to be caused by HIV, Epstein-Barr Syndrome, age and family history. Symptoms include weight loss, fever, swollen lymph nodes, night sweats, itchy skin, fatigue, chest pain, coughing and/or trouble swallowing. Thelymphatic systemis part of thecirculatory system, comprising a network oflymphatic vesselsthat carry a clear fluid called lymph directionally towards the heart. The lymphatic system was first described in the seventeenth century independently byOlaus RudbeckandThomas Bartholin. Unlike thecardiovascular systemthe lymphatic system is not a closed system. The human circulatory system processes an average of 20 litres ofbloodper day throughcapillary filtrationwhich removesplasmawhile leaving theblood cells. Roughly 17 litres of the filtered plasma get reabsorbed directly into the blood vessels, while the remaining 3 litres are left behind in theinterstitial fluid. One of the main functions of the lymph system is to provide an accessory return route to the blood for the surplus 3 litres. Lymphatic diseases are ofNon-Hodgkin's Lymphoma, Hodgkins. Thethymusis a specialized primarylymphoidorgan of theimmune system. Within the thymus,T cellsor Tlymphocytesmature. T cells are critical to theadaptive immune system, where the body adapts specifically to foreign invaders.One of the example of lymph node development. Formation oflymph nodeinto the tumor which lead to cancer called oncology.

Various Aspects of Haematology

Pediatric Haematology and Oncologyis an internationalpeer-reviewedmedical journalthat covers all aspects ofpediatrichematologyandoncology. The journal covers immunology, pathology, and pharmacology in relation to blood diseases and cancer in children and shows how basic experimental research can contribute to the understanding of clinical problems. Physicians specialized in hematology are known ashematologistsorhaematologists. Their routine work mainly includes the care and treatment of patients with hematological diseases, although some may also work at the hematology laboratory viewingblood filmsandbone marrowslides under themicroscope, interpreting various hematological test results andblood clotting testresults. In some institutions, hematologists also manage the hematology laboratory. Physicians who work in hematology laboratories, and most commonly manage them, are pathologists specialized in the diagnosis of hematological diseases, referred to as hematopathologistsorhaematopathologists.Experimental Hematologyis apeer-reviewedmedical journalofhematology, which publishesoriginal researcharticles and reviews, as well as the abstracts of the annual proceedings of theSociety for Hematology and Stem Cells and they should be done under theHematology guidlines.

Blood Based Products

Ablood substituteis a substance used to mimic and fulfill some functions ofbiologicalblood. It aims to provide an alternative toblood transfusion, which is transferring blood orblood-based productsfrom one person into another. Thus far, there are no well-acceptedoxygen-carryingblood substitutes, which is the typical objective of ared blood celltransfusion; however, there are widely available non-bloodvolume expandersfor cases where only volume restoration is required. These are helping doctors and surgeons avoid the risks of disease transmission and immune suppression, address the chronic blood donor shortage, and address the concerns of Jehovah's Witnesses and others who have religious objections to receiving transfused blood.Pathogen reductionusing riboflavin and UV lightis a method by which infectiouspathogensinblood for transfusionare inactivated by addingriboflavinand irradiating withUV light. This method reduces the infectious levels of disease-causing agents that may be found in donated blood components, while still maintaining good quality blood components for transfusion. This type of approach to increase blood safety is also known as pathogen inactivation in the industry. Anartificial cellorminimal cellis an engineered particle that mimics one or many functions of abiological cell. The term does not refer to a specific physical entity, but rather to the idea that certain functions or structures of biological cells can be replaced or supplemented with a synthetic entity. Often, artificial cells are biological or polymeric membranes which enclose biologically active materials. As such,nanoparticles,liposomes,polymersomes, microcapsules and a number of other particles have qualified as artificial cells.Manufacturing of semi synthetic products of drugs are known as therapeutic biological products.Anticoagulants(antithrombics) are a class of drugs that work to prevent thecoagulation(clotting) of blood. Such substances occur naturally in leeches and blood-sucking insects.

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Blindness by Jose Saramago – Powell’s Books

October 9th, 2016 1:43 pm

Awards

Winner of the 1998 Nobel Prize for Literature A New York Times Notable Book of the Year A Los Angeles Times Best Book of the Year

A devastating and often horrific look at societal breakdown, Blindness is one of the most acclaimed novels from Jos Saramago, Portugal's only Nobel laureate for literature. Far more than a mere dystopian plague novel, Blindness is a metaphorical account of society's basest tendencies in the face of catastrophe. Saramago's magnificently wending sentences and trademark style lend grace and beauty to an otherwise gruesome tale of epidemic chaos. Recommended By Jeremy G., Powells.com

A city is hit by an epidemic of "white blindness" which spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and raping women. There is one eyewitness to this nightmare who guides seven strangers among them a boy with no mother, a girl with dark glasses, a dog of tears through the barren streets, and the procession becomes as uncanny as the surroundings are harrowing. A magnificent parable of loss and disorientation and a vivid evocation of the horrors of the twentieth century, Blindness has swept the reading public with its powerful portrayal of man's worst appetites and weaknesses and man's ultimately exhilarating spirit. The stunningly powerful novel of man's will to survive against all odds, by the winner of the 1998 Nobel Prize for Literature.

"Beautifully written in a concise, haunting prose...this unsettling, highly original work is essential reading." Library Journal

"Saramago's Blindness is the best novel I've read since Gabriel Garcia Marquez' Love in the Time of Cholera. It is a novel of enormous skill and authority....Like all great books it is simultaneously contemporary and timeless, and ambitiously confronts the human condition without a false note struck anywhere. Saramago is one of the great writers of our time, and Blindness, ironically is the product of his extraordinary vision." David Guterson, author of Snow Falling on Cedars

"Blindness may be as revolutionary in its own way and time as were, say, The Trial and The Plague were in theirs. Another masterpiece." Kirkus Reviews, starred review

"Saramago writes phantasmagoria in the midst of the most astonishing fantasy he has a meticulous sense of detail. It's very eloquent stuff." Harold Bloom, author of The Western Canon

"It is the voice of Blindness that gives it its charm. By turns ironic, humorous and frank, there is a kind of wink of humor between author and reader that is perfectly imbued with fury at the excesses of the current century. Blindness reminds me of Kafka roaring with laughter as he read his stories to his friends....Blindness' impact carries the force of an author whose sensibility is significant." The Washington Post

"Blindness is a shattering work by a literary master." The Boston Globe

"More frightening than Stephen King, as unrelenting as a bad dream, Jos Saramago's Blindness politely rubs our faces in apocalypse....A metaphor like 'white blindness' might easily seem forced or labored, but Saramago makes it live by focusing on the stubbornly literal; his account of a clump of newly blind people trying to find their way to food or to the bathroom provides some surprisingly gripping passages. While this epidemic has a clear symbolic burden, it's also a real and very inconvenient affliction." Salon

In Blindness, a city is overcome by an epidemic of blindness that spares only one woman. She becomes a guide for a group of seven strangers and serves as the eyes and ears for the reader in this profound parable of loss and disorientation. We return to the city years later in Saramagos Seeing, a satirical commentary on government in general and democracy in particular. Together here for the first time, this beautiful edition will be a welcome addition to the library of any Saramago fan.

Jos Saramago (1922-2010) was the author of many novels, among them Blindness, All the Names, Baltasarand Blimunda, and The Year of the Death of Ricardo Reis. In 1998 he was awarded the Nobel Prize for Literature.

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Home | EMBO Reports

October 8th, 2016 5:48 pm

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Article

These two authors contributed equally to this work

Using a histone FRAP method, this study identifies Gadd45a as a chromatin relaxer and somatic cell reprogramming enhancer. Gadd45a destabilizes histoneDNA interactions and facilitates the binding of Yamanaka factors to their targets.

Using a histone FRAP method, this study identifies Gadd45a as a chromatin relaxer and somatic cell reprogramming enhancer. Gadd45a destabilizes histoneDNA interactions and facilitates the binding of Yamanaka factors to their targets.

FRAP is used to assess heterochromatin/euchromatin dynamics in somatic cell reprogramming.

Gadd45a is a chromatin relaxer and improves somatic cell reprogramming.

Gadd45a destabilizes histoneDNA interactions and facilitates the binding of Yamanaka factors to their targets.

Keshi Chen, Qi Long, Tao Wang, Danyun Zhao, Yanshuang Zhou, Juntao Qi, Yi Wu, Shengbiao Li, Chunlan Chen, Xiaoming Zeng, Jianguo Yang, Zisong Zhou, Weiwen Qin, Xiyin Liu, Yuxing Li, Yingying Li, Xiaofen Huang, Dajiang Qin, Jiekai Chen, Guangjin Pan, Hans R Schler, Guoliang Xu, Xingguo Liu, Duanqing Pei

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What is Integrative Medicine? – AIHM

October 8th, 2016 5:46 pm

1. American Hospital Association (AHA), Samueli Institute. More Hospitals Offering Complementary and Alternative Medicine Services. September 7, 2011 + Kralovec, Peter. Interview with Director at American Hospital Association. E-mail interview with Sita Ananth. June 20, 2014.

2. Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 20022012. National health statistics reports; no 79. Hyattsville, MD: National Center for Health Statistics.2015.

Callahan, L.F., Wiley-Exley E.K., Mielenz, T.J., Brady, T.J., Xiao, C., Currey S.S. et al. (2009, April) Use of complementary and alternative medicine among patients with arthritis. Preventing Chronic Disease;6(2). Retrieved from: http://www.cdc.gov/pcd/issues/2009/apr/08_0070.htm. Barnes PM, Bloom B, Nahin R. CDC National Health Statistics Report #12.Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007. December 10, 2008

3.Dusek, J. & Knutson, L. (2012, May). The impact of integrative medicine on inpatient satisfaction at Abbott Northwestern Hospital. International Research Congress on Integrative Medicine and Health, Portland, OR.

Casida J., & Lemanski, S. (2010). An evidence-based review on guided imagery utilization in adult cardiac surgery. Clinical Scholars Review, 3(1), 23-31.

4.Guarneri E, Horrigan B, Pechura C. The Efficacy and Cost Effectiveness of Integrative Medicine: A Review of the Medical and Corporate Literature. The Bravewell Collaborative Web site. Published June 2010. http://www. bravewell.org/integrative_medicine/efficacy_cost. Accessed July 8, 2014

Looking for additional statistics? Two helpful resources: National Center for Complementary and Integrative Health | NCCIH National Academy of Medicine (formally Institute of Medicine)

Highlighted Journals Integrative Medicine: A Clinicians Journal (IMCJ) Global Advances in Health and Medicine (GAHMJ) Explore: The Journal of Science and Healing

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Molecular Genetics and Cell Biology

October 7th, 2016 7:45 pm

operates within the Division of Biological Sciences. Its faculty investigate molecular aspects of biological phenomena that operate on a cellular scale. The Department currently represents research on a wide range of biological problems and systems - its internationally recognized strengths include:

- invertebrate and vertebrate development - plant development and plant pathogen interactions - molecular biology - immunology - microbiology - cellular structure and function - yeast genetics

The department administers the Cell and Molecular Biology Graduate program in the Molecular Biosciences Graduate Training Program Cluster. The cluster combines five programs: Cell and Molecular Biology (CMB), Biochemistry and Molecular Biology (BMB), Human Genetics (HG), Genetics, Genomics & Systems Biology (GGSB), and Development, Regeneration, and Stem Cell Biology (DRSB). MGCB also plays key roles in the undergraduate biology curricula at the University.

The University of Chicago's Grossman Institute of Neuroscience and the Dept. of Molecular Genetic and Cell Biology jointly invite applications for tenure-track faculty in Cellular and Molecular Neuroscience. Please see http://tinyurl.com/pu4oc46 for more information and to apply.

Lucia B. Rothman-Denes, PhD, Professor in the Department of Molecular Genetics and Cell Biology, has been elected by her peers to be a member of the National Academy of Sciences, May 2, 2014

(News archives)

Administrative Information (on-campus-only)

MGCB SEMINARS

JANUARY - MAY 2016

All seminars are at 4:00 PM in CLSC 101 (*unless indicated).

JANUARY 26, 2016 Principles of genome defense Hiten Madhani, University of California, San Francisco

FEBRUARY 23, 2016 Genome structure and integrity Doug Koshland, University of California, Berkeley

MARCH 17, 2016 Measuring the Intracellular Dew Point: Phase Transitions in Cells Cliff Brangwynne, Princeton University

APRIL 21, 2016 11th ANNUAL HASELKORN LECTURE Morality in the Microbial World the Social lives of Bacterial Cells E. Peter Greenberg, University of Washington

APRIL 26, 2016 TBA Stirling Churchman, Harvard University

MAY 26, 2016 Specificity and Evolution of Protein-Protein Interactions Michael Laub, MIT

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Explore More: Genetic Engineering – iptv.org

October 6th, 2016 7:49 am

Watch the full show online! Visit the Explore More Genetic Engineering video page...

Would you want to clone your pet? Would you change your child's eye color? Do you care if your strawberry contains a gene for fish?

Explore More: Genetic Engineering tells you the story, gives you the facts, and then takes a closer look to help you unravel the core issues. Take a look at and interact with the content. Discuss what you learn with other people, form your own opinion on the subjects, but always keep an open mind.

As you go through this site, think about how genetic engineering is changing the way we live. This is a fascinating area that deserves our attention. Decisions and choices we make in our lifetime will affect how and why genetic engineering is used.

Investigate Explore More Teacher Resources WebQuests, Web links, lesson plans, teaching strategies, discussion questions, standards, and project goals help you leverage Explore More content to help student achievement and motivation. Get your students thinking with this useful collection of tools and tips! Find out more.

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Pain Medicine 2017 | Pain Medicine Conferences | Pain …

October 5th, 2016 1:47 am

Track 1:Pain Management and Rehabilitation

The specialty of Pain Medicine, or Algiatry, is a discipline within the field of medicine that is concerned with the prevention of pain, and the evaluation, treatment, and rehabilitation of persons in pain. The typical pain management team includesmedical practitioners,Pharmacists, Clinical Psychologist, occupational therapists, physician assistant, nurse practitioners and clinical nurse specialists. Pain can be managed using pharmacological or interventional procedures by usingpain reliefs. There are many interventional procedures typically used forchronic back paininclude epidural steroid injections, facet joint Injections, neurolytic blocks, spinal cord stimulators and intrathecal drug delivery system implants. The Management goals when treatingback painare to achieve maximal reduction in pain intensity as rapidly as possible, to restore the individuals ability to function in everyday activities, to help the patient cope with residual pain, to assess for side effects of therapy, and to facilitate the patients passage through the legal and socioeconomic impediments to recovery. For many the goal is to keep the pain to a manageable level to progress with rehabilitation, which can then lead to long term pain relief. Also, for some people the goal is to use non-surgical therapies to manage the pain and avoid major surgery, while for others surgery may be the quickest way to feel better.Migrainestypically present with self-limited, recurrent severe headacheassociated with autonomic symptoms. About 15-30% of people with migraines experience migraines with an aura. And those who have migraines with aura also frequently have migraines without aura. There are four possible phases of Headache: The prodrome, which occur hours or days before the headache, Theaura, which immediately precedes the headache, The pain phase also known as headache phase, The postdrome, the effects experienced following the end of a migraine attack.

Related Conferences of Pain Management and Rehabilitation:

2nd World Congress and Exhibition on Antibiotics and Antibiotic Resistance, October 13-15, 2016 Manchester, UK; 8th Annual Pharma Middle East Congress, October 10-12, 2016 Dubai, UAE; International Conference on Pharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE; 5th International Conference and Exhibition on Pharmacology and Ethnopharmacology, March 27-29, 2017 Orlando, USA; World Congress on Biotherapeutics, May 25-26, 2017 Mexico city, Mexico; International Conference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9th International Conferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting on Cardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE.

Track 2:NSAIDs & Analgesics

Nonsteroidal anti-inflammatory drugs are a drug class that groups together drugs that provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and, in higher doses, anti-inflammatory effects. The termnonsteroidaldistinguishes these drugs fromsteroids, which, among a broad range of other effects, have a similareicosanoid-depressing, anti-inflammatory action. First used in 1960, the term served to distance new drugs from steroid relatediatrogenictragedies. The most prominent members of this group of drugs,aspirin,ibuprofenandnaproxen, are all availableover the counterin most countries.Paracetamol (acetaminophen) is generally not considered an NSAID because it has only little anti-inflammatory activity. It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body. Most NSAIDs inhibit the activity ofcyclooxygenase-1 (COX-1) andcyclooxygenase-2 (COX-2), and thereby, the synthesis ofprostaglandinsandthromboxanes. It is thought that inhibiting COX-2 leads to the anti-inflammatory, analgesic and antipyretic effects and that those NSAIDs also inhibiting COX-1, particularly aspirin, may cause gastrointestinal bleeding and ulcers.

Ananalgesicorpainkilleris any member of the group ofdrugsused to achieve analgesia, relief frompain. Analgesic drugs act in various ways on theperipheralandcentralnervous systems. They are distinct fromanesthetics, which temporarily affect, and in some instances completely eliminate,sensation. Analgesics includeparacetamol(known in North America asacetaminophenor simply APAP), thenon-steroidal anti-inflammatory drugs(NSAIDs) such as thesalicylates, andopioiddrugs such asmorphineandoxycodone. In choosing analgesics, the severity and response to other medication determines the choice of agent; theWorld Health Organization(WHO)pain ladder specifies mild analgesics as its first step. Analgesic choice is also determined by the type of pain: Forneuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such astricyclic antidepressantsandanticonvulsants.

Related Conferences of Classification of Pain Relief Analgesics:

7th Annual Global Pharma, August 22-24, 2016 New Orleans, Louisiana, USA; Conference on Pharmacovigilance & Pharmaceutical Industry, August 22-24, 2016 Vienna, Austria; Conference on Pharmacognosy, Phytochemistry & Natural Products, August 29-31, 2016 Sao Paulo, Brazil; Conference on Drug Formulation & Bioavailability, September 05-06, 2016 Beijing, China; Conference on Neuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference on Biopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference on Pharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 3:Physical and Physiological Approaches in Pain Medicine

Pain medicineandrehabilitationemploys numerous physical techniques like thermal agents and electrotherapy, such as therapeutic exercise and behavioral medical care, traditional pharmacotherapy to treat pain, sometimes as a district of knowledge domain or multidisciplinary program Transcutaneous electrical nerve stimulation has been found to be ineffective forlower back pain, but it would facilitate withdiabetic neuropathy.Acupuncture involves the insertion and manipulation of needles into specific points on the body to alleviate pain or for therapeutic functions. Research has not found proof that light therapy like low level optical device medical care is a good medical care forpain reliefCognitive behavioral Therapy(CBT) for pain helps patients with pain to know the link between one's physiology (e.g., pain and muscle tension), thoughts, emotions, and behaviors. A meta-analysis of studies that used techniques targeted around the thought of mindfulness, concluded, "Findings counsel that MBIs decrease the intensity of pain forchronic painpatients." Occupational therapists could use a range of interventions as well as training program, relaxation, goal setting, drawback determination, planning, and carry this out at intervals each cluster and individual settings. Therapists may go at intervals a clinic setting, or within the community as well as the work, school, home and health care centers. Activity therapists could assess activity performance before and when intervention, as a live of effectiveness and reduction in disability.

Related Conferences of Physical and Physiological Approaches in Pain Medicine:

InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9th InternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting onCardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE. Conference on Pharmacognosy, Phytochemistry & Natural Products, August 29-31, 2016 Sao Paulo, Brazil; Conference onDrug Formulation & Bioavailability, September 05-06, 2016 Beijing, China; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 4:Anesthesia as Pain Drug

In the practice ofmedicine(especiallysurgery) anddentistry,anesthesia is a temporary induced state with one or more ofanalgesia (relief from or prevention ofpain),paralysis(muscle relaxation),amnesia(loss of memory), andunconsciousness. Apatientunder the effects of anestheticdrugs is referred to as beinganesthetized. Anesthesia is freedom from pain. Each year, millions of people in the United States undergo some form of medical treatment requiring anesthesia. Anesthesia, in the hands of qualified professionals like Certified Registered Nurse Anesthetists (CRNAs), is a safe and effective means of alleviating pain during nearly every type of medical procedure. Anesthesia care is not confined to surgery alone. The process also refers to activities that take place both before and after an anesthetic is given. In the majority of cases, anesthesia is administered by a CRNA. CRNAs work with your surgeon, dentist or podiatrist, and may work with an anesthesiologist (physician anesthetist). CRNAs are advanced practice registered nurses with specialized graduate-level education in anesthesiology. For more than 150 years, nurse anesthetists have been administering anesthesia in all types of surgical cases, using all anesthetic techniques and practicing in every setting in which anesthesia is administered. Anesthesia enables the painless performance of medical procedures that would cause severe or intolerable pain to an un-anesthetized patient.

Related Conferences ofAnesthesia:

Conference and Exhibition onPharmacology and Ethnopharmacology, March 27-29, 2017 Orlando, USA; World Congress on Biotherapeutics, May 25-26, 2017 Mexico city, Mexico; InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9th InternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting on Cardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE; 7th AnnualGlobal Pharma, August 22-24, 2016 New Orleans, Louisiana, USA; Conference on Pharmacovigilance & Pharmaceutical Industry, August 22-24, 2016 Vienna, Austria; Conference on Pharmacognosy, Phytochemistry & Natural Products, August 29-31, 2016 Sao Paulo, Brazil; InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France.

Track 5:Pain Syndrome

Carpal tunnel syndrome(CTS) may be a medical condition within which the median nerve is compressed because it travels through the carpus at the carpal tunnel and causes pain, symptom and tingling, within a part of the hand that receives sensation from the median nerve.Piriformis syndromemay be a neuromuscular disorder that happens once the Sciatic nerve is compressed or otherwise irritated by the piriformis muscle inflicting pain, tingling and symptom within the buttocks and on the trail of the nerve descending the lower thigh and into the leg. Complex regional pain syndrome (CRPS) it's a chronic general un-wellness characterized by severe pain, swelling, and changes within the skin. CRPS usually worsens over time. it's going to at the start associate effect on} an arm or leg and unfold throughout the body; thirty fifth of individuals report symptoms throughout their whole body. Alternative potential effects include: general involuntary dysregulation; animal tissue edema; system, endocrine, or medical specialty manifestations; and changes in urological or gi operate.Central pain syndrome may be a neurologic condition caused by injury or malfunction within the Central system (CNS) that causes a sensitization of the pain system. The extent of pain and also the area unit as affected are associated with the reason behind the injury. Compartment syndrome is augmented pressure inside one in all the body's compartments that contains muscles and nerves. Compartment syndrome most typically happens in compartments within the leg or arm. There are unit 2 main sorts of compartment syndrome:acuteandchronic. Fibromyalgia(FM) may be a medical condition characterized by chronic widespread pain and a heightened and painful response to pressure. Symptoms apart from pain might occur, resulting in the utilization of the term Fibromyalgia syndrome (FMS). Alternative symptoms embrace feeling tired to a degree that ordinary activities area unit affected, sleep disturbance, and joint stiffness. Some folks additionally report problem with swallowing bowl and bladder abnormalities.

Related Conferences of Pain Syndrome:

Conference onDrug Formulation & Bioavailability, September 05-06, 2016 Beijing, China; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 6:Pharmacological Approaches for Pain

There are several pharmacological interventions that may be accustomed manage pain in arthritis. However, in choosing the acceptable approach, the practitioner must take into account to consider the efficacy. Adverse side effects, dosing frequency, patient preference, and cost in choosing medication for pain management. When a patient develops the primary signs of an inflammatory arthritis, the most priority is symptom relief, with pain being the cardinal sign of inflammation that patients most wish facilitate with. However, it has become more and more clear that for inflammatory arthropathies like RA merely treating the symptoms with non- Steroidal anti- inflammatory drugs (NSAIDs) or analgesics in adequate, because features of the disease that lead to damage to the joints, and then to disability will carry on uncheck. In addition to symptoms relieving drugs, patients also need disease-modifying pain drugs that have been demonstrated to slow down or stop the damaging aspects of disease There are two aims in the pharmacological treatment; firstly to reduce inflammation or modulate the auto immune response and secondly to modulate the pain response. Medications is thought-about in 5 classes: simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), Disease modifying anti-rheumatic-drugs (DMARDS), Steroids, Biologics and other relevant Adjuvant analgesics (ex. antiepileptic and antidepressants used for pain relief).

Related Conferences of Physical and Physiological Approaches in Pain Medicine:

InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9th InternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting onCardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE. Conference onPharmacognosy, Phytochemistry & Natural Products, August 29-31, 2016 Sao Paulo, Brazil; Conference onDrug Formulation & Bioavailability, September 05-06, 2016 Beijing, China; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 7:Pain Management Specialist

To a certain extent, medical practitioners have always been specialized. Specialization was common among Roman physicians. The particular system of modern medical specialties evolved gradually during the 19th century. Informal social recognition of medical specialization evolved before the formal legal system. The particular subdivision of the practice of medicine into various specialties varies from country to country, and is somewhat arbitrary. Currently, there is no single field of medicine or health care that represents the preferred approach to pain management. Indeed, the premise of pain management is that a highly multidisciplinary approach is essential. Pain management specialists are most commonly found in the following disciplines:Physiatry (also called Physical medicine and rehabilitation),Anesthesiology,Interventional radiology,Physical therapy. Specialists in psychology, psychiatry, behavioral science, and other areas may also play an important role in a comprehensive pain management program. Selection of the most appropriate type of health professional - or team of health professionals - largely depends on the patient's symptoms and the length of time the symptoms have been present.

Related Conferences ofPain Management Specialist:

Conference and Exhibition onPharmacology and Ethnopharmacology, March 27-29, 2017 Orlando, USA; WorldCongress on Biotherapeutics, May 25-26, 2017 Mexico city, Mexico; InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9thInternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting onCardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 8:Chronic Pain and Prevention

Chronic painispainthat lasts a drawn-out time. In medication, the excellence betweenacute painand chronic pain has historically has been determined by an discretional interval of your time since onset; the 2 most typically used markers being 3 months and 6 months since onset, though some theorists and researchers have placed the transition from acute to chronic pain at twelve months.Electrical Nerve Stimulationfor Chronic Pain may be a procedure that uses AN electrical current to treat chronicpain managementPeripheral nerve stimulation (PNS) space 2 varieties of electrical nerve stimulation. In either, atiny low generator sends electrical pulses to the nerves (In peripheral nerve stimulation) or to the funiculus (in funiculus stimulation) These pulses interfere with the nerve impulses that cause you to feel pain.

Related Conferences of Chronic Pain Management:

Conference and Exhibition onPharmacology and Ethnopharmacology, March 27-29, 2017 Orlando, USA; WorldCongress on Biotherapeutics, May 25-26, 2017 Mexico city, Mexico; InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9thInternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting onCardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE; 7th AnnualGlobal Pharma, August 22-24, 2016 New Orleans, Louisiana, USA; Conference onPharmacovigilance & Pharmaceutical Industry, August 22-24, 2016 Vienna, Austria; Conference onPharmacognosy, Phytochemistry & Natural Products, August 29-31, 2016 Sao Paulo, Brazil; InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France.

Track 9: Pain Medications

Narcoticsalso referred to asopioidpain relievers are used only for pain that's severe and is not helped by other forms of painkillers. When used rigorously and underneath a doctor's direct care, these medications are often effective at reducing pain. Narcotics work by binding to receptors into the brain that blocks the sensation of pain. When used rigorously and underneath a doctor's direct care, they'll be effective at reducing pain. Antidepressant medication for treatment of depression as well as other different disorders that will occur alone or together with depression, likechronic pain,sleep disorders, oranxiety disorders.Antidepressantsare medication used for the treatment of major depressive disorder and different conditions, chronic pain and neuropathic pain. Anticonvulsants, or anti-seizure medications, work as adjuvant analgesics. In different words, they can treat some forms of chronic pain even if they're not designed for that purpose. whereas the most use ofanti-seizuremedication is preventing seizures,anticonvulsantsdo seem to be effective at treating certain forms of chronic pain. These include neuropathic pain, like peripheral neuropathy, and chronic headaches like migraines.

Related Conferences ofPain Medications:

Conference onDrug Formulation & Bioavailability, September 05-06, 2016 Beijing, China; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 10:Pain Management Nursing

PerianesthesiaNursingcould be a nursing specialty practice area involved with providing medical care to patients undergoing or convalescent fromanesthesia. Perianesthesia nursing encompasses many subspecialty observe space and represents a various range of practice environment and skill sets. Pain managementnurses are typically thought-about to be perianesthesia nurses, given the cooperative nature of their work with anesthetists and also thefact that a large proportion of acute pain issues are surgery related. However, distinct pain management certifications exist through the American Society forPain ManagementNurses.

Related Conferences ofPain Management Nursing:

InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9th InternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting onCardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE. Conference onPharmacognosy, Phytochemistry & Natural Products, August 29-31, 2016 Sao Paulo, Brazil; Conference onDrug Formulation & Bioavailability, September 05-06, 2016 Beijing, China; Conference onNeuropharmacology, September 14-16, 2016 San Antonio, Texas, USA; Conference onBiopharmaceutics and Biologic Drugs, September 14-16, 2016 San Antonio, Texas, USA; Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE.

Track 11:Orofacial Pain

Orofaical painis a general term covering anypainwhich is felt in the mouth, jaws and the face. Orofacial pain is a commonsymptom, and there are many causes.Orofacial pain has been defined as "pain localized to the region above the neck, in front of the ears and below theorbitomeatal line, as well as pain within theoral cavity,pain of dental origin and temporomandibular disorders".It is estimated that over 95% of cases of orofacial pain result from dental causes (i.e.toothachecaused bypulpitisor adental abscess).However, some orofacial pain conditions may involve areas outside this region, e.g. temporal pain in TMD. Toothache, or odontalgia, is any pain perceived in the teeth or their supporting structures (i.e. theperiodontium). Toothache is therefore a type of orofacial pain.Craniofacialpain is an overlapping topic which includes pain perceived in the head, face, and related structures, sometimes includingneck pain.All other causes of orofacial pain are rare in comparison, although the fulldifferential diagnosisis extensive.

Related Conferences ofOrofacial Pain:

2nd World Congress and Exhibition onAntibiotics and Antibiotic Resistance, October 13-15, 2016 Manchester, UK; 8th AnnualPharma Middle East Congress, October 10-12, 2016 Dubai, UAE; International Conference onPharmaceutical Method Development and Validation, November 24-25, 2016 Dubai, UAE; 5thInternational Conference and Exhibition onPharmacology and Ethnopharmacology, March 27-29, 2017 Orlando, USA; WorldCongress on Biotherapeutics, May 25-26, 2017 Mexico city, Mexico; InternationalConference on Biotech Pharmaceuticals, October 23-25, 2017 Paris, France; 9th InternationalConferences on Immunopharmacology and Immunotoxicology, November 20-22, 2017 Melbourne, Australia; 6th Global Experts Meeting onCardiovascular Pharmacology and Cardiac Medications, April 13-14, 2017 Dubai, UAE.

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Nanomedicine Fact Sheet – National Human Genome Research …

October 5th, 2016 1:45 am

Nanomedicine Overview

What if doctors had tiny tools that could search out and destroy the very first cancer cells of a tumor developing in the body? What if a cell's broken part could be removed and replaced with a functioning miniature biological machine? Or what if molecule-sized pumps could be implanted in sick people to deliver life-saving medicines precisely where they are needed? These scenarios may sound unbelievable, but they are the ultimate goals of nanomedicine, a cutting-edge area of biomedical research that seeks to use nanotechnology tools to improve human health.

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A lot of things are small in today's high-tech world of biomedical tools and therapies. But when it comes to nanomedicine, researchers are talking very, very small. A nanometer is one-billionth of a meter, too small even to be seen with a conventional lab microscope.

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Nanotechnology is the broad scientific field that encompasses nanomedicine. It involves the creation and use of materials and devices at the level of molecules and atoms, which are the parts of matter that combine to make molecules. Non-medical applications of nanotechnology now under development include tiny semiconductor chips made out of strings of single molecules and miniature computers made out of DNA, the material of our genes. Federally supported research in this area, conducted under the rubric of the National Nanotechnology Initiative, is ongoing with coordinated support from several agencies.

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For hundreds of years, microscopes have offered scientists a window inside cells. Researchers have used ever more powerful visualization tools to extensively categorize the parts and sub-parts of cells in vivid detail. Yet, what scientists have not been able to do is to exhaustively inventory cells, cell parts, and molecules within cell parts to answer questions such as, "How many?" "How big?" and "How fast?" Obtaining thorough, reliable measures of quantity is the vital first step of nanomedicine.

As part of the National Institutes of Health (NIH) Common Fund [nihroadmap.nih.gov], the NIH [nih.gov] has established a handful of nanomedicine centers. These centers are staffed by a highly interdisciplinary scientific crew, including biologists, physicians, mathematicians, engineers and computer scientists. Research conducted over the first few years was spent gathering extensive information about how molecular machines are built.

Once researchers had catalogued the interactions between and within molecules, they turned toward using that information to manipulate those molecular machines to treat specific diseases. For example, one center is trying to return at least limited vision to people who have lost their sight. Others are trying to develop treatments for severe neurological disorders, cancer, and a serious blood disorder.

The availability of innovative, body-friendly nanotools that depend on precise knowledge of how the body's molecular machines work, will help scientists figure out how to build synthetic biological and biochemical devices that can help the cells in our bodies work the way they were meant to, returning the body to a healthier state.

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Last Updated: January 22, 2014

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BRCA1 and BRCA2: Cancer Risk and Genetic Testing Fact …

October 5th, 2016 1:44 am

What are BRCA1 and BRCA2?

BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. These proteins help repair damaged DNA and, therefore, play a role in ensuring the stability of the cells genetic material. When either of these genes is mutated, or altered, such that its protein product either is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer.

Specific inherited mutations in BRCA1 and BRCA2 increase the risk of female breast and ovarian cancers, and they have been associated with increased risks of several additional types of cancer. Together, BRCA1 and BRCA2 mutations account for about 20 to 25 percent of hereditary breast cancers (1) and about 5 to 10 percent of all breast cancers (2). In addition, mutations in BRCA1 and BRCA2 account for around 15 percent of ovarian cancers overall (3). Breast and ovarian cancers associated with BRCA1 and BRCA2 mutations tend to develop at younger ages than their nonhereditary counterparts.

A harmful BRCA1 or BRCA2 mutation can be inherited from a persons mother or father. Each child of a parent who carries a mutation in one of these genes has a 50 percent chance (or 1 chance in 2) of inheriting the mutation. The effects of mutations in BRCA1 and BRCA2 are seen even when a persons second copy of the gene is normal.

How much does having a BRCA1 or BRCA2 gene mutation increase a womans risk of breast and ovarian cancer?

A womans lifetime risk of developing breast and/or ovarian cancer is greatly increased if she inherits a harmful mutation in BRCA1 or BRCA2.

Breast cancer: About 12 percent of women in the general population will develop breast cancer sometime during their lives (4). By contrast, according to the most recent estimates, 55 to 65 percent of women who inherit a harmful BRCA1 mutation and around 45 percent of women who inherit a harmful BRCA2 mutation will develop breast cancer by age 70 years (5, 6).

Ovarian cancer: About 1.3 percent of women in the general population will develop ovarian cancer sometime during their lives (4). By contrast, according to the most recent estimates, 39 percent of women who inherit a harmful BRCA1 mutation (5, 6) and 11 to 17 percent of women who inherit a harmful BRCA2 mutation will develop ovarian cancer by age 70 years (5, 6).

It is important to note that these estimated percentages of lifetime risk are different from those available previously; the estimates have changed as more information has become available, and they may change again with additional research. No long-term general population studies have directly compared cancer risk in women who have and do not have a harmful BRCA1 or BRCA2 mutation.

It is also important to note that other characteristics of a particular woman can make her cancer risk higher or lower than the average risks. These characteristics include her family history ofbreast, ovarian, and, possibly, other cancers; the specific mutation(s) she has inherited; and other risk factors, suchas her reproductivehistory. However, at this time, based on current data, none of these other factors seems to be as strong as the effect of carrying a harmful BRCA1 or BRCA2 mutation.

What other cancers have been linked to mutations in BRCA1 and BRCA2?

Are mutations in BRCA1 and BRCA2 more common in certain racial/ethnic populations than others?

Yes. For example, people of Ashkenazi Jewish descent have a higher prevalence of harmful BRCA1 and BRCA2 mutations than people in the general U.S. population. Other ethnic and geographic populations around the world, such as the Norwegian, Dutch, and Icelandic peoples, also have a higher prevalence of specific harmful BRCA1 and BRCA2 mutations.

In addition, limited data indicate that the prevalence of specific harmful BRCA1 and BRCA2 mutations may vary among individual racial and ethnic groups in the United States, including African Americans, Hispanics, Asian Americans, and non-Hispanic whites (15, 16).

Are genetic tests available to detect BRCA1 and BRCA2 mutations?

Yes. Several different tests are available, including tests that look for a known mutation in one of the genes (i.e., a mutation that has already been identified in another family member) and tests that check for all possible mutations in both genes. DNA (from a blood or saliva sample) is needed for mutation testing. The sample is sent to a laboratory for analysis. It usually takes about a month to get the test results.

Who should consider genetic testing for BRCA1 and BRCA2 mutations?

Because harmful BRCA1 and BRCA2 gene mutations are relatively rare in the general population, most experts agree that mutation testing of individuals who do not have cancer should be performed only when the persons individual or family history suggests the possible presence of a harmful mutation in BRCA1 or BRCA2.

In December 2013, the United States Preventive Services Task Force recommended that women who have family members with breast, ovarian, fallopian tube, or peritoneal cancer be evaluated to see if they have a family history that is associated with an increased risk of a harmful mutation in one of these genes (17).

Several screening tools are now available to help health care providers with this evaluation (17). These tools assess family history factors that are associated with an increased likelihood of having a harmful mutation in BRCA1 or BRCA2, including:

When an individual has a family history that is suggestive of the presence of a BRCA1 or BRCA2 mutation, it may be most informative to first test a family member who has cancer if that person is still alive and willing to be tested. If that person is found to have a harmful BRCA1 or BRCA2 mutation, then other family members may want to consider genetic counseling to learn more about their potential risks and whether genetic testing for mutations in BRCA1 and BRCA2 might be appropriate for them.

If it is not possible to confirm the presence of a harmful BRCA1 or BRCA2 mutation in a family member who has cancer, it is appropriate for both men and women who do not have cancer but have a family medical history that suggests the presence of such a mutation to have genetic counseling for possible testing.

Some individualsfor example, those who were adopted at birthmay not know their family history. In cases where a woman with an unknown family history has an early-onset breast cancer or ovarian cancer or a man with an unknown family history is diagnosed with breast cancer, it may be reasonable for that individual to consider genetic testing for a BRCA1 or BRCA2 mutation. Individuals with an unknown family history who do not have an early-onset cancer or male breast cancer are at very low risk of having a harmful BRCA1 or BRCA2 mutation and are unlikely to benefit from routine genetic testing.

Professional societies do not recommend that children, even those with a family history suggestive of a harmful BRCA1 or BRCA2 mutation, undergo genetic testing for BRCA1 or BRCA2. This is because no risk-reduction strategies exist for children, and children's risks of developing a cancer type associated with a BRCA1 or BRCA2 mutation are extremely low. After children with a family history suggestive of a harmful BRCA1 or BRCA2 mutation become adults, however, they may want to obtain genetic counseling about whether or not to undergoing genetic testing.

Should people considering genetic testing for BRCA1 and BRCA2 mutations talk with a genetic counselor?

Genetic counseling is generally recommended before and after any genetic test for an inherited cancer syndrome. This counseling should be performed by a health care professional who is experienced in cancer genetics. Genetic counseling usually covers many aspects of the testing process, including:

How much does BRCA1 and BRCA2 mutation testing cost?

The Affordable Care Act considers genetic counseling and BRCA1 and BRCA2 mutation testing for individuals at high risk a covered preventive service. People considering BRCA1 and BRCA2 mutation testing may want to confirm their insurance coverage for genetic tests before having the test.

Some of the genetic testing companies that offer testing for BRCA1 and BRCA2 mutations may offer testing at no charge to patients who lack insurance and meet specific financial and medical criteria.

What does a positive BRCA1 or BRCA2 genetic test result mean?

BRCA1 and BRCA2 gene mutation testing can give several possible results: a positive result, a negative result, or an ambiguous or uncertain result.

A positive test result indicates that a person has inherited a known harmful mutation in BRCA1 or BRCA2 and, therefore, has an increased risk of developing certain cancers. However, a positive test result cannot tell whether or when an individual will actually develop cancer. For example, some women who inherit a harmful BRCA1 or BRCA2 mutation will never develop breast or ovarian cancer.

A positive genetic test result may also have important health and social implications for family members, including future generations. Unlike most other medical tests, genetic tests can reveal information not only about the person being tested but also about that persons relatives:

What does a negative BRCA1 or BRCA2 test result mean?

A negative test result can be more difficult to understand than a positive result because what the result means depends in part on an individuals family history of cancer and whether a BRCA1 or BRCA2 mutation has been identified in a blood relative.

If a close (first- or second-degree) relative of the tested person is known to carry a harmful BRCA1 or BRCA2 mutation, a negative test result is clear: it means that person does not carry the harmful mutation that is responsible for the familial cancer, and thus cannot pass it on to their children. Such a test result is called a true negative. A person with such a test result is currently thought to have the same risk of cancer as someone in the general population.

If the tested person has a family history that suggests the possibility of having a harmful mutation in BRCA1 or BRCA2 but complete gene testing identifies no such mutation in the family, a negative result is less clear. The likelihood that genetic testing will miss a known harmful BRCA1 or BRCA2 mutation is very low, but it could happen. Moreover, scientists continue to discover new BRCA1 and BRCA2 mutations and have not yet identified all potentially harmful ones. Therefore, it is possible that a person in this scenario with a "negative" test result actually has an as-yet unknown harmful BRCA1 or BRCA2 mutation that has not been identified.

It is also possible for people to have a mutation in a gene other than BRCA1 or BRCA2 that increases their cancer risk but is not detectable by the test used. People considering genetic testing for BRCA1 and BRCA2 mutations may want to discuss these potential uncertainties with a genetic counselor before undergoing testing.

What does an ambiguous or uncertain BRCA1 or BRCA2 test result mean?

Sometimes, a genetic test finds a change in BRCA1 or BRCA2 that has not been previously associated with cancer. This type of test result may be described as ambiguous (often referred to as a genetic variant of uncertain significance) because it isnt known whether this specific gene change affects a persons risk of developing cancer. One study found that 10 percent of women who underwent BRCA1 and BRCA2 mutation testing had this type of ambiguous result (18).

As more research is conducted and more people are tested for BRCA1 and BRCA2 mutations, scientists will learn more about these changes and cancer risk. Genetic counseling can help a person understand what an ambiguous change in BRCA1 or BRCA2 may mean in terms of cancer risk. Over time, additional studies of variants of uncertain significance may result in a specific mutation being re-classified as either harmful or clearly not harmful.

How can a person who has a positive test result manage their risk of cancer?

Several options are available for managing cancer risk in individuals who have a known harmful BRCA1 or BRCA2 mutation. These include enhanced screening, prophylactic (risk-reducing) surgery, and chemoprevention.

Enhanced Screening. Some women who test positive for BRCA1 and BRCA2 mutations may choose to start cancer screening at younger ages than the general population or to have more frequent screening. For example, some experts recommend that women who carry a harmful BRCA1 or BRCA2 mutation undergo clinical breast examinations beginning at age 25 to 35 years (19). And some expert groups recommend that women who carry such a mutation have a mammogram every year, beginning at age 25 to 35 years.

Enhanced screening may increase the chance of detecting breast cancer at an early stage, when it may have a better chance of being treated successfully. Women who have a positive test result should ask their health care provider about the possible harms of diagnostic tests that involve radiation (mammograms or x-rays).

Recent studies have shown that MRI may be more sensitive than mammography for women at high risk of breast cancer (20, 21). However, mammography can also identify some breast cancers that are not identified by MRI (22), and MRI may be less specific (i.e., lead to more false-positive results) than mammography. Several organizations, such as the American Cancer Society and the National Comprehensive Cancer Network, now recommend annual screening with mammography and MRI for women who have a high risk of breast cancer.

No effective ovarian cancer screening methods currently exist. Some groups recommend transvaginal ultrasound, blood tests for the antigen CA-125, and clinical examinations for ovarian cancer screening in women with harmful BRCA1 or BRCA2 mutations, but none of these methods appears to detect ovarian tumors at an early enough stage to reduce the risk of dying from ovarian cancer (23). For a screening method to be considered effective, it must have demonstrated reduced mortality from the disease of interest. This standard has not yet been met for ovarian cancer screening.

The benefits of screening for breast and other cancers in men who carry harmful mutations in BRCA1 or BRCA2 is also not known, but some expert groups recommend that men who are known to carry a harmful mutation undergo regular mammography as well as testing for prostate cancer. The value of these screening strategies remains unproven at present.

Prophylactic (Risk-reducing) Surgery. Prophylactic surgery involves removing as much of the "at-risk" tissue as possible. Women may choose to have both breasts removed (bilateral prophylactic mastectomy) to reduce their risk of breast cancer. Surgery to remove a woman's ovaries and fallopian tubes (bilateral prophylactic salpingo-oophorectomy) can help reduce her risk of ovarian cancer. Removing the ovaries also reduces the risk of breast cancer in premenopausal women by eliminating a source of hormones that can fuel the growth of some types of breast cancer.

No evidence is available regarding the effectiveness of bilateral prophylactic mastectomy in reducing breast cancer risk in men with a harmful BRCA1 or BRCA2 mutation or a family history of breast cancer. Therefore, bilateral prophylactic mastectomy for men at high risk of breast cancer is considered an experimental procedure, and insurance companies will not normally cover it.

Prophylactic surgery does not completely guarantee that cancer will not develop because not all at-risk tissue can be removed by these procedures. Some women have developed breast cancer, ovarian cancer, or primary peritoneal carcinomatosis (a type of cancer similar to ovarian cancer) even after prophylactic surgery. Nevertheless, the mortality reduction associated with this surgery is substantial: Research demonstrates that women who underwent bilateral prophylactic salpingo-oophorectomy had a nearly 80 percent reduction in risk of dying from ovarian cancer, a 56 percent reduction in risk of dying from breast cancer (24), and a 77 percent reduction in risk of dying from any cause (25).

Emerging evidence (25) suggests that the amount of protection that removing the ovaries and fallopian tubes provides against the development of breast and ovarian cancer may be similar for carriers of BRCA1 and BRCA2 mutations, in contrast to earlier studies (26).

Chemoprevention. Chemoprevention is the use of drugs, vitamins, or other agents to try to reduce the risk of, or delay the recurrence of, cancer. Although two chemopreventive drugs (tamoxifen and raloxifene) have been approved by the U.S. Food and Drug Administration (FDA) to reduce the risk of breast cancer in women at increased risk, the role of these drugs in women with harmful BRCA1 or BRCA2 mutations is not yet clear.

Data from three studies suggest that tamoxifen may be able to help lower the risk of breast cancer in BRCA1 and BRCA2 mutation carriers (27), including the risk of cancer in the opposite breast among women previously diagnosed with breast cancer (28, 29). Studies have not examined the effectiveness of raloxifene in BRCA1 and BRCA2 mutation carriers specifically.

Oral contraceptives (birth control pills) are thought to reduce the risk of ovarian cancer by about 50 percent both in the general population and in women with harmful BRCA1 or BRCA2 mutations (30).

What are some of the benefits of genetic testing for breast and ovarian cancer risk?

There can be benefits to genetic testing, regardless of whether a person receives a positive or a negative result.

The potential benefits of a true negative result include a sense of relief regarding the future risk of cancer, learning that one's children are not at risk of inheriting the family's cancer susceptibility, and the possibility that special checkups, tests, or preventive surgeries may not be needed.

A positive test result may bring relief by resolving uncertainty regarding future cancer risk and may allow people to make informed decisions about their future, including taking steps to reduce their cancer risk. In addition, people who have a positive test result may choose to participate in medical research that could, in the long run, help reduce deaths from hereditary breast and ovarian cancer.

What are some of the possible harms of genetic testing for breast and ovarian cancer risk?

The direct medical harms of genetic testing are minimal, but knowledge of test results may have harmful effects on a persons emotions, social relationships, finances, and medical choices.

People who receive a positive test result may feel anxious, depressed, or angry. They may have difficulty making choices about whether to have preventive surgery or about which surgery to have.

People who receive a negative test result may experience survivor guilt, caused by the knowledge that they likely do not have an increased risk of developing a disease that affects one or more loved ones.

Because genetic testing can reveal information about more than one family member, the emotions caused by test results can create tension within families. Test results can also affect personal life choices, such as decisions about career, marriage, and childbearing.

Violations of privacy and of the confidentiality of genetic test results are additional potential risks. However, the federal Health Insurance Portability and Accountability Act and various state laws protect the privacy of a persons genetic information. Moreover, the federal Genetic Information Nondiscrimination Act, along with many state laws, prohibits discrimination based on genetic information in relation to health insurance and employment, although it does not cover life insurance, disability insurance, or long-term care insurance.

Finally, there is a small chance that test results may not be accurate, leading people to make decisions based on incorrect information. Although inaccurate results are unlikely, people with these concerns should address them during genetic counseling.

What are the implications of having a harmful BRCA1 or BRCA2 mutation for breast and ovarian cancer prognosis and treatment?

A number of studies have investigated possible clinical differences between breast and ovarian cancers that are associated with harmful BRCA1 or BRCA2 mutations and cancers that are not associated with these mutations.

There is some evidence that, over the long term, women who carry these mutations are more likely to develop a second cancer in either the same (ipsilateral) breast or the opposite (contralateral) breast than women who do not carry these mutations. Thus, some women with a harmful BRCA1 or BRCA2 mutation who develop breast cancer in one breast opt for a bilateral mastectomy, even if they would otherwise be candidates for breast-conserving surgery. In fact, because of the increased risk of a second breast cancer among BRCA1 and BRCA2 mutation carriers, some doctors recommend that women with early-onset breast cancer and those whose family history is consistent with a mutation in one of these genes have genetic testing when breast cancer is diagnosed.

Breast cancers in women with a harmful BRCA1 mutation are also more likely to be "triple-negative cancers" (i.e., the breast cancer cells do not have estrogen receptors, progesterone receptors, or large amounts of HER2/neu protein), which generally have poorer prognosis than other breast cancers.

Because the products of the BRCA1 and BRCA2 genes are involved in DNA repair, some investigators have suggested that cancer cells with a harmful mutation in either of these genes may be more sensitive to anticancer agents that act by damaging DNA, such as cisplatin. In preclinical studies, drugs called PARP inhibitors, which block the repair of DNA damage, have been found to arrest the growth of cancer cells that have BRCA1 or BRCA2 mutations. These drugs have also shown some activity in cancer patients who carry BRCA1 or BRCA2 mutations, and researchers are continuing to develop and test these drugs.

What research is currently being done to help individuals with harmful BRCA1 or BRCA2 mutations?

Research studies are being conducted to find new and better ways of detecting, treating, and preventing cancer in people who carry mutations in BRCA1 and BRCA2. Additional studies are focused on improving genetic counseling methods and outcomes. Our knowledge in these areas is evolving rapidly.

Information about active clinical trials (research studies with people) for individuals with BRCA1 or BRCA2 mutations is available on NCIs website. The following links will retrieve lists of clinical trials open to individuals with BRCA1 or BRCA2 mutations.

NCIs Cancer Information Service (CIS) can also provide information about clinical trials and help with clinical trial searches.

Do inherited mutations in other genes increase the risk of breast and/or ovarian tumors?

Yes. Although harmful mutations in BRCA1 and BRCA2 are responsible for the disease in nearly half of families with multiple cases of breast cancer and up to 90 percent of families with both breast and ovarian cancer, mutations in a number of other genes have been associated with increased risks of breast and/or ovarian cancers (2, 31). These other genes include several that are associated with the inherited disorders Cowden syndrome, Peutz-Jeghers syndrome, Li-Fraumeni syndrome, and Fanconi anemia, which increase the risk of many cancer types.

Most mutations in these other genes are associated with smaller increases in breast cancer risk than are seen with mutations in BRCA1 and BRCA2. However, researchers recently reported that inherited mutations in the PALB2 gene are associated with a risk of breast cancer nearly as high as that associated with inherited BRCA1 and BRCA2 mutations (32). They estimated that 33 percent of women who inherit a harmful mutation in PALB2 will develop breast cancer by age 70 years. The estimated risk of breast cancer associated with a harmful PALB2 mutation is even higher for women who have a family history of breast cancer: 58 percent of those women will develop breast cancer by age 70 years.

PALB2, like BRCA1 and BRCA2, is a tumor suppressor gene. The PALB2 gene produces a protein that interacts with the proteins produced by the BRCA1 and BRCA2 genes to help repair breaks in DNA. Harmful mutations in PALB2 (also known as FANCN) are associated with increased risks of ovarian, pancreatic, and prostate cancers in addition to an increased risk of breast cancer (13, 33, 34). Mutations in PALB2, when inherited from each parent, can cause a Fanconi anemia subtype, FA-N, that is associated with childhood solid tumors (13, 33, 35).

Although genetic testing for PALB2 mutations is available, expert groups have not yet developed specific guidelines for who should be tested for, or the management of breast cancer risk in individuals with, PALB2 mutations.

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Home | The EMBO Journal

October 5th, 2016 1:43 am

Open Access

Article

The Arabidopsis CERK1associated kinase PBL27 connects chitin perception to MAPK activation

These authors contributed equally to this work as first authors

These authors contributed equally to this work as third authors

Chitin receptor CERK1 transmits immune signals to the intracellular MAPK cascade in plants. This occurs via phosphorylation of MAPKKK5 by the CERK1associated kinase PBL27, providing a missing link between pathogen perception and signaling output.

Chitin receptor CERK1 transmits immune signals to the intracellular MAPK cascade in plants. This occurs via phosphorylation of MAPKKK5 by the CERK1associated kinase PBL27, providing a missing link between pathogen perception and signaling output.

CERK1associated kinase PBL27 interacts with MAPKKK5 at the plasma membrane.

Chitin perception induces disassociation of PBL27 and MAPKKK5.

PBL27 functions as a MAPKKK kinase.

Phosphorylation of MAPKKK5 by PBL27 is enhanced upon phosphorylation of PBL27 by CERK1.

Phosphorylation of MAPKKK5 by PBL27 is required for chitininduced MAPK activation in planta.

Kenta Yamada, Koji Yamaguchi, Tomomi Shirakawa, Hirofumi Nakagami, Akira Mine, Kazuya Ishikawa, Masayuki Fujiwara, Mari Narusaka, Yoshihiro Narusaka, Kazuya Ichimura, Yuka Kobayashi, Hidenori Matsui, Yuko Nomura, Mika Nomoto, Yasuomi Tada, Yoichiro Fukao, Tamo Fukamizo, Kenichi Tsuda, Ken Shirasu, Naoto Shibuya, Tsutomu Kawasaki

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Worlds Leading Immunology Congress | Conferenceseries

October 3rd, 2016 9:43 pm

Accreditation Statement

This activity (World Immunology Summit 2016) has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of PeerPoint Medical Education Institute and Conference Series, LLC. PeerPoint Medical Education Institute is accredited by the ACCME to provide continuing medical education for physicians.

Designation Statement

PeerPoint Medical Education Institute designates the live format for this educational activity for AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Conference series invites participants from all over the world to attend "6th International Conference and Exhibition on Immunology" October 24-26, 2016 Chicago, USA includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

Presenters can availupto 20 CME credits..

The annual International Conference on Immunology offer a unique platform for academia, Societies and Industries interested in immunology and Biomedical sciences to share the latest trends and important issues in the field. Immunology Summit-2016 brings together the Global leaders in Immunology and relevant fields to present their research at this exclusive scientific program. The Immunology Conference hosting presentations from editors of prominent refereed journals, renowned and active investigators and decision makers in the field of Immunology. Immunology Summit 2016 Organizing Committee also intended to encourage Young investigators at every career stage to submit abstracts reporting their latest scientific findings in oral and poster sessions.

Track 1:ClinicalImmunology: Current & Future Research

Immunology is the study of the immune system. The immune system is how all animals, including humans, protect themselves against diseases. The study of diseases caused by disorders of the immune system is clinical immunology. The disorders of the immune system fall into two broad categories:

Immunodeficiency, in this immune system fails to provide an adequate response.

Autoimmunity, in this immune system attacks its own host's body.

Related:Immunology Conferences|Immunologists Meetings|Conference Series LLC

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Track 2:Cancer and Tumor Immunobiology

The immune system is the bodys first line of defence against most diseases and unnatural invaders.Cancer Immunobiologyis a branch ofimmunologyand it studies interactions between theimmune systemandcancer cells. These cancer cells, through subtle alterations, become immortal malignant cells but are often not changed enough to elicit an immune reaction.Understanding how the immune system worksor does not workagainst cancer is a primary focus of Cancer Immunology investigators. Certain cells of the immune system, including natural killer cells, dendritic cells (DCs) and effector T cells, are capable of driving potent anti-tumour responses.

Tumor Immunobiology

The immune system can promote the elimination of tumours, but often immune responses are modulated or suppressed by the tumour microenvironment. The Tumour microenvironment is an important aspect of cancer biology that contributes to tumour initiation, tumour progression and responses to therapy. Cells and molecules of the immune system are a fundamental component of the tumour microenvironment. Importantly, therapeutic strategies can harness the immune system to specifically target tumour cells and this is particularly appealing owing to the possibility of inducing tumour-specific immunological memory, which might cause long-lasting regression and prevent relapse in cancer patients. The composition and characteristics of the tumour micro environment vary widely and are important in determining the anti-tumour immune response. Tumour cells often induce an immunosuppressive microenvironment, which favours the development of immuno suppressive populations of immune cells, such as myeloid-derived suppressor cells and regulatory T cells.

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Track 3:Inflammation and Therapies

Inflammation is the body's attempt at self-protection; the aim being to remove harmful stimuli, including damaged cells, irritants, or pathogens - and begin the healing process. In Inflammation the body's whiteblood cellsand substances they produce protect us from infection with foreign organisms, such as bacteria and viruses. However, in some diseases, likearthritis, the body's defense system, the immune system triggers an inflammatory response when there are no foreign invaders to fight off. In these diseases, called autoimmune diseases, the body's normally protective immune system causes damage to its own tissues. The body responds as if normal tissues are infected or somehow abnormal. Inflammation involves immune cells, blood vessels, and molecular mediators. The purpose of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and to initiate tissue repair. signs of acute inflammation are pain, heat, redness, swelling, and loss of function

Therapies

Inflammation Therapy is a treatment for chronic disease involving a combination of lifestyle factors and medications designed to enable the immune system to fight the disease. Techniques used include heat therapy, cold therapy, electrical stimulation, traction, massage, and acupuncture. Heat increases blood flow and makes connective tissue more flexible. It temporarily decreases joint stiffness, pain, and muscle spasms. Heat also helps reduce inflammation and the buildup of fluid in tissues (edema). Heat therapy is used to treat inflammation (including various forms of arthritis), muscle spasm, and injuries such as sprains and strains. Cold therapy Applying cold may help numb tissues and relieve muscle spasms, pain due to injuries, and low back pain or inflammation that has recently developed. Cold may be applied using an ice bag, a cold pack, or fluids (such as ethyl chloride) that cool by evaporation. The therapist limits the time and amount of cold exposure to avoid damaging tissues and reducing body temperature (causing hypothermia). Cold is not applied to tissues with a reduced blood supply (for example, when the arteries are narrowed by peripheral arterial disease).

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Track 4:Molecular and Structural Immunology

Molecular Immunology

Molecular immunology deals with immune responses at cellular and molecular level. Molecular immunology has been evolved for better understanding of the sub-cellular immune responses for prevention and treatment of immune related disorders and immune deficient diseases. Journal of molecular immunology focuses on the invitro and invivo immunological responses of the host. Molecular Immunology focuses on the areas such as immunological disorders, invitro and invivo immunological host responses, humoral responses, immunotherapies for treatment of cancer, treatment of autoimmune diseases such as Hashimotos disease, myasthenia gravis, rheumatoid arthritis and systemic lupus erythematosus. Treatment of Immune deficiencies such as hypersensitivities, chronic granulomatous disease, diagnostic immunology research aspects, allografts, etc..

Structural Immunology

Host immune system is an important and sophisticated system, maintaining the balance of host response to "foreign" antigens and ignorance to the normal-self. To fulfill this achievement the system manipulates a cell-cell interaction through appropriate interactions between cell-surface receptors and cell-surface ligands, or cell-secreted soluble effector molecules to their ligands/receptors/counter-receptors on the cell surface, triggering further downstream signaling for response effects. T cells and NK cells are important components of the immune system for defending the infections and malignancies and maintaining the proper response against over-reaction to the host. Receptors on the surface of T cells and NK cells include a number of important protein molecules, for example, T cell receptor (TCR), co-receptor CD8 or CD4, co-stimulator CD28, CTLA4, KIR, CD94/NKG2, LILR (ILT/LIR/CD85), Ly49, and so forth.

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Track 5:Transplantation Immunology

Transplantation is an act of transferring cells, tissues, or organ from one site to other. Graft is implanted cell, tissue or organ. Development of the field of organ and tissue transplantation has accelerated remarkably since the human major histocompatibility complex (mhc) was discovered in 1967. Matching of donor and recipient for mhc antigens has been shown to have a significant positive effect on graft acceptance. The roles of the different components of the immune system involved in the tolerance or rejection of grafts and in graft-versus-host disease have been clarified. These components include: antibodies, antigen presenting cells, helper and cytotoxic t cell subsets, immune cell surface molecules, signaling mechanisms and cytokines that they release. The development of pharmacologic and biological agents that interfere with the alloimmune response and graft rejection has had a crucial role in the success of organ transplantation. Combinations of these agents work synergistically, leading to lower doses of immunosuppressive drugs and reduced toxicity. Significant numbers of successful solid organ transplants include those of the kidneys, liver, heart and lung.

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Track 6:Infectious Diseases, Emerging and Reemerging diseases: Confronting Future Outbreaks

Infectious diseasesare disorders caused by organisms such as bacteria, viruses,fungior parasites. Many organisms live in and on our bodies. They're normally harmless or even helpful, but under certain conditions, some organisms may causedisease.Someinfectious diseasescan be passed from person to person. Many infectious diseases, such asmeaslesand chickenpox, can be prevented by vaccines. Frequent and thorough hand-washing also helps protect you from infectious diseases.

There are four main kinds of germs:

Bacteria - one-celled germs that multiply quickly and may release chemicals which can make you sick

Viruses- capsules that contain genetic material, and use your own cells to multiply

Fungi - primitive plants, like mushrooms or mildew

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Track 7:Autoimmune Diseases

An autoimmune disease develops when your immune system, which defends your body against disease, decides your healthy cells are foreign. As a result, your immune system attacks healthy cells. An autoimmune disorder may result in the destruction of body tissue, abnormal growth of an organ, Changes in organ function. Depending on the type, an autoimmune disease can affect one or many different types of body tissue. Areas often affected by autoimmune disorders include Blood vessels, Connective tissues, Endocrineglands such as the thyroid or pancreas, Joints Muscles, Red blood cells, Skin It can also cause abnormal organ growth and changes in organ function. There are as many as 80 types of autoimmune diseases. Many of them have similar symptoms, which makes them very difficult to diagnose. Its also possible to have more than one at the same time. Common autoimmune disorders include Addison's disease, Dermatomyositis, Graves' disease, Hashimoto's thyroiditis, Multiple sclerosis, Myasthenia gravis, Pernicious anemia, Reactive arthritis. Autoimmune diseases usually fluctuate between periods of remission (little or no symptoms) and flare-ups (worsening symptoms). Currently, treatment for autoimmune diseases focuses on relieving symptoms because there is no curative therapy.

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Track 8:Viral Immunology: Emerging and Re-emerging Diseases

Immunology is the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Viruses are strongly immunogenic and induces 2 types of immune responses; humoral and cellular. The repertoire of specificities of T and B cells are formed by rearrangements and somatic mutations. T and B cells do not generally recognize the same epitopes present on the same virus. B cells see the free unaltered proteins in their native 3-D conformation whereas T cells usually see the Ag in a denatured form in conjunction with MHC molecules. The characteristics of the immune reaction to the same virus may differ in different individuals depending on their genetic constitutions.

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Track 9:Pediatric Immunology

A child suffering from allergies or other problems with his immune system is referred as pediatric immunology. Childs immune system fights against infections. If the child has allergies, their immune system wrongly reacts to things that are usually harmless. Pet dander, pollen, dust, mold spores, insect stings, food, and medications are examples of such things. This reaction may cause their body to respond with health problems such as asthma, hay fever, hives, eczema (a rash), or a very severe and unusual reaction calledanaphylaxis. Sometimes, if your childs immune system is not working right, he may suffer from frequent, severe, and/or uncommon infections. Examples of such infections are sinusitis (inflammation of one or more of the sinuses), pneumonia (infection of the lung), thrush (a fungus infection in the mouth), and abscesses (collections of pus surrounded by inflamed tissue) that keep coming back.

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Track 10:Immunotherapy & Cancer Immunotherapy: From Basic Biology to Translational Research

Immunotherapy is treatment that uses certain parts of a persons immune system to fight diseases such as cancer. This can be done in a couple of ways:

Stimulating your own immune system to work harder or smarter to attack cancer cells Giving you immune system components, such as man-made immune system proteins

Some types of immunotherapy are also sometimes called biologic therapy or biotherapy. In the last few decades immunotherapy has become an important part of treating some types of cancer. Newer types of immune treatments are now being studied, and theyll impact how we treat cancer in the future. Immunotherapy includes treatments that work in different ways. Some boost the bodys immune system in a very general way. Others help train the immune system to attack cancer cells specifically.

Cancer immunotherapy is the use of the immune system to treat cancer. The main types of immunotherapy now being used to treat cancer include:

Monoclonal antibodies: these are man-made versions of immune system proteins. Antibodies can be very useful in treating cancer because they can be designed to attack a very specific part of a cancer cell.

Immune checkpoint inhibitors: these drugs basically take the brakes off the immune system, which helps it recognize and attack cancer cells.

Cancer vaccines: vaccines are substances put into the body to start an immune response against certain diseases. We usually think of them as being given to healthy people to help prevent infections. But some vaccines can help prevent or treat cancer.

Other, non-specific immunotherapies: these treatments boost the immune system in a general way, but this can still help the immune system attack cancer cells.

Immunotherapy drugs are now used to treat many different types of cancer. For more information about immunotherapy as a treatment for a specific cancer, please see our information on that type of cancer.

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Track 11:Immunology and Diabetes

Immunologyis the study of the immune system, which is responsible for protecting the body from foreign cells such as viruses, bacteria and parasites. Immune system cells called T and B lymphocytes identify and destroy these invaders. Thelymphocytesusually recognize and ignore the bodys own tissue (a condition called immunological self-tolerance), but certain autoimmune disorders trigger a malfunction in the immune response causing an attack on the bodys own cells due to a loss ofimmune tolerance.

Type 1 diabetes is anautoimmune diseasethat occurs when the immune system mistakenly attacks insulin-producing islet cells in the pancreas. This attack begins years before type 1 diabetes becomes evident, so by the time someone is diagnosed, extensive damage has already been done and the ability to produceinsulinis lost.

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Track 12:Immune Tolerance

Immunological toleranceis the failure to mount animmuneresponse to an antigen. It can be: Natural or "self"tolerance. This is the failure (a good thing) to attack the body's own proteins and other antigens. If the immunesystem should respond to "self",an autoimmune diseasemay result. Natural or "self" tolerance: Induced tolerance: This is tolerance to externalantigens that has been created by deliberately manipulating theimmune system.

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Track 13:Vaccines and Immunotherapy

Vaccine is a biological preparation that improves immunity to particular disease. It contains certain agent that not only resembles a disease causing microorganism but it also stimulates bodys immune system to recognise the foreign agents. Vaccines are dead or inactivated organisms or purified products derived from them. whole organism vaccines purified macromolecules as vaccines,recombinant vaccines, DNA vaccines. The immune system recognizes vaccine agents as foreign, destroys them, and "remembers" them. The administration of vaccines is called vaccination. In order to provide best protection, children are recommended to receive vaccinations as soon as their immune systems are sufficiently developed to respond to particular vaccines with additional "booster" shots often required to achieve "full immunity".

Immunotherapy is treatment that uses certain parts of a persons immune system to fight diseases such as cancer. This can be done in a couple of ways:

Stimulating your own immune system to work harder or smarter to attack cancer cells

Giving you immune system components, such as man-made immune system proteins

Some types of immunotherapy are also sometimes called biologic therapy or biotherapy. In the last few decades immunotherapy has become an important part of treating some types of cancer. Newer types of immune treatments are now being studied, and theyll impact how we treat cancer in the future. Immunotherapy includes treatments that work in different ways. Some boost the bodys immune system in a very general way. Others help train the immune system to attack cancer cells specifically. Immunotherapy works better for some types of cancer than for others. Its used by itself for some of these cancers, but for others it seems to work better when used with other types of treatment.

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Track 14:Immunologic Techniques, Microbial Control and Therapeutics

Immunological techniques include both experimental methods to study the immune system and methods to generate or use immunological reagents as experimental tools. The most common immunological methods relate to the production and use of antibodies to detect specific proteins in biological samples. Various laboratory techniques exist that rely on the use of antibodies to visualize components of microorganisms or other cell types and to distinguish one cell or organism type from another. Immunologic techniques are used for: Quantitating and detectingantibodiesand/orantigens, Purifying immunoglobulins, lymphokines and other molecules of the immune system, Isolating antigens and other substances important in immunological processes, Labelling antigens and antibodies, Localizing antigens and/or antibodies in tissues and cells, Detecting, and fractionatingimmunocompetent cells, Assaying forcellular immunity, Documenting cell-cell interactions, Initiating immunity and unresponsiveness, Transplantingtissues, Studying items closely related to immunity such as complement,reticuloendothelial systemand others, Molecular techniques for studying immune cells and theirreceptors, Imaging of the immune system, Methods for production or their fragments ineukaryoticandprokaryotic cells.

Microbial control:

Control of microbial growth, as used here, means to inhibit or prevent growth of microorganisms. This control is achieved in two basic ways: (1) by killing microorganisms or (2) by inhibiting the growth of microorganisms. Control of growth usually involves the use of physical or chemical agents which either kill or prevent the growth of microorganisms. Agents which kill cells are called cidal agents; agents which inhibit the growth of cells (without killing them) are referred to as static agents. Thus, the term bactericidal refers to killing bacteria, and bacteriostatic refers to inhibiting the growth of bacterial cells. A bactericide kills bacteria, a fungicide kills fungi, and so on. In microbiology, sterilization refers to the complete destruction or elimination of all viable organisms in or on a substance being sterilized. There are no degrees of sterilization: an object or substance is either sterile or not. Sterilization procedures involve the use of heat, radiation or chemicals, or physical removal of cells.

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Track 15:Immunodeficiency

Immunodeficiency is a state in which theimmune system's ability to fightinfectious diseaseis compromised or entirely absent. Immunodeficiency disorders prevent your body from adequately fighting infections and diseases. An immunodeficiency disorder also makes it easier for you to catch viruses and bacterial infections in the first place. Immunodeficiency disorders are often categorized as either congenital or acquired. A congenital, or primary, disorder is one you were born with. Acquired, or secondary, disorders are disorders you get later in life. Acquired disorders are more common thancongenital disorders. Immune system includes the following organs: spleen, tonsils, bone marrow, lymph nodes. These organs make and release lymphocytes. Lymphocytes are white blood cells classified as B cells and T cells. B and T cells fight invaders called antigens. B cells release antibodies specific to the disease your body detects. T cells kill off cells that are under attack by disease. An immunodeficiency disorder disrupts your bodys ability to defend itself against these antigens. Types of immunodeficiency disorder are Primary immunodeficiency disorders & Secondary immunodeficiency disorders.

Primary immunodeficiency disorders are immune disorders you are born with. Primary disorders include:

X-linked agammaglobulinemia (XLA)

Common variable immunodeficiency (CVID)

Severe combined immunodeficiency(SCID)

Secondary disorders happen when an outside source, such as a toxic chemical or infection, attacks your body. Severe burns and radiation also can cause secondary disorders.

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Chamomile: A herbal medicine of the past with bright future

October 3rd, 2016 9:42 pm

Abstract

Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and hemorrhoids. Essential oils of chamomile are used extensively in cosmetics and aromatherapy. Many different preparations of chamomile have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day. In this review we describe the use of chamomile in traditional medicine with regard to evaluating its curative and preventive properties, highlight recent findings for its development as a therapeutic agent promoting human health.

Keywords: chamomile, dietary agents, flavonoids, polyphenols, human health

The interplay of plants and human health has been documented for thousands of years (13). Herbs have been integral to both traditional and non-traditional forms of medicine dating back at least 5000 years (2, 46). The enduring popularity of herbal medicines may be explained by the tendency of herbs to work slowly, usually with minimal toxic side effects. One of the most common herbs used for medicinal purposes is chamomile whose standardized tea and herbal extracts are prepared from dried flowers of Matricaria species. Chamomile is one of the oldest, most widely used and well documented medicinal plants in the world and has been recommended for a variety of healing applications (7). Chamomile is a native of the old World and is a member of the daisy family (Asteraceae or Compositae). The hollow, bright gold cones of the flowers are packed with disc or tubular florets and are ringed with about fifteen white ray or ligulate florets, widely represented by two known varieties viz. German chamomile (Matricaria chamomilla) and Roman chamomile (Chamaemelum nobile) (8) . In this review we will discuss the use and possible merits of chamomile, examining its historical use and recent scientific and clinical evaluations of its potential use in the management of various human ailments.

Different classes of bioactive constituents are present in chamomile, which have been isolated and used as medicinal preparations and cosmetics (9). The plant contains 0.24%1.9% volatile oil, composed of a variety of separate oils. When exposed to steam distillation, the oil ranges in color from brilliant blue to deep green when fresh but turns to dark yellow after storage. Despite fading, the oil does not lose its potency. Approximately 120 secondary metabolites have been identified in chamomile, including 28 terpenoids and 36 flavonoids (10, 11). The principal components of the essential oil extracted from the German chamomile flowers are the terpenoids -bisabolol and its oxide azulenes including chamazulene and acetylene derivatives. Chamazulene and bisabolol are very unstable and are best preserved in an alcoholic tincture. The essential oil of Roman chamomile contains less chamazulene and is mainly constituted from esters of angelic acid and tiglic acid. It also contains farnesene and -pinene. Roman chamomile contains up to 0.6% of sesquiterpene lactones of the germacranolide type, mainly nobilin and 3-epinobilin. Both -bisabolol, bisabolol oxides A and B and chamazulene or azulenesse, farnesene and spiro-ether quiterpene lactones, glycosides, hydroxycoumarins, flavanoids (apigenin, luteolin, patuletin, and quercetin), coumarins (herniarin and umbelliferone), terpenoids, and mucilage are considered to be the major bio-active ingredients (12, 13). Other major constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin as glucosides and various acetylated derivatives. Among flavonoids, apigenin is the most promising compound. It is present in very small quantities as free apigenin, but predominantly exists in the form of various glycosides (1418).

Chamomile is known to be used in various forms of its preparations. Dry powder of chamomile flower is recommended and used by many people for traditionally established health problems. Medicinal ingredients are normally extracted from the dry flowers of chamomile by using water, ethanol or methanol as solvents and corresponding extracts are known as aqueous, ethanolic (alcoholic) and/or methanolic extracts. Optimum chamomile extracts contain about 50 percent alcohol. Normally standardized extracts contain 1.2% of apigenin which is one of the most effective bioactive agents. Aqueous extracts, such as in the form of tea, contain quite low concentrations of free apigenin but include high levels of apigenin-7-O-glucoside. Oral infusion of chamomile is recommended by the German Commission E (19, 20).Chamomile tea is one of the worlds most popular herbal teas and about a million cups are consumed every day. Tea bags of chamomile are also available in the market, containing chamomile flower powder, either pure or blended with other popular medicinal herbs. Chamomile tincture may also be prepared as one part chamomile flower in four parts of water having 12% grain alcohol, which is used to correct summer diarrhea in children and also used with purgatives to prevent cramping. Chamomile flowers are extensively used alone, or combined with crushed poppy-heads, as a poultice or hot foment for inflammatory pain or congestive neuralgia, and in cases of external swelling, such as facial swelling associated with underlying infection or abscess. Chamomile whole plant is used for making herb beers, and also for a lotion, for external application in toothache, earache, neuralgia and in cases of external swelling (20). It is also known to be used as bath additive, recommended for soothing ano-genital inflammation (21). The tea infusion is used as a wash or gargle for inflammation of the mucous membranes of the mouth and throat (22, 23). Inhalation of the vaporized essential oils derived from chamomile flowers is recommended to relieve anxiety, general depression. Chamomile oil is a popular ingredient of aromatherapy and hair care (24, 25). Roman chamomile is widely used in cosmetic preparations and in soothing and softening effect on the skin (26, 27).

Traditionally, chamomile has been used for centuries as an anti-inflammatory, antioxidant, mild astringent and healing medicine (28). As a traditional medicine, it is used to treat wounds, ulcers, eczema, gout, skin irritations, bruises, burns, canker sores, neuralgia, sciatica, rheumatic pain, hemorrhoids, mastitis and other ailments (29, 30). Externally, chamomile has been used to treat diaper rash, cracked nipples, chicken pox, ear and eye infections, disorders of the eyes including blocked tear ducts, conjunctivitis, nasal inflammation and poison ivy (31, 32). Chamomile is widely used to treat inflammations of the skin and mucous membranes, and for various bacterial infections of the skin, oral cavity and gums, and respiratory tract. Chamomile in the form of an aqueous extract has been frequently used as a mild sedative to calm nerves and reduce anxiety, to treat hysteria, nightmares, insomnia and other sleep problems (33). Chamomile has been valued as a digestive relaxant and has been used to treat various gastrointestinal disturbances including flatulence, indigestion, diarrhea, anorexia, motion sickness, nausea, and vomiting (34, 35). Chamomile has also been used to treat colic, croup, and fevers in children (36). It has been used as an emmenagogue and a uterine tonic in women. It is also effective in arthritis, back pain, bedsores and stomach cramps.

The flowers of chamomile contain 12% volatile oils including alpha-bisabolol, alpha-bisabolol oxides A & B, and matricin (usually converted to chamazulene and other flavonoids which possess anti-inflammatory and antiphlogistic properties (12, 19, 35, 36). A study in human volunteers demonstrated that chamomile flavonoids and essential oils penetrate below the skin surface into the deeper skin layers (37). This is important for their use as topical antiphlogistic (anti-inflammatory) agents. One of chamomiles anti-inflammatory activities involve the inhibition of LPS-induced prostaglandin E(2) release and attenuation of cyclooxygenase (COX-2) enzyme activity without affecting the constitutive form, COX-1 (38).

Most evaluations of tumor growth inhibition by chamomile involve studies with apigenin which is one of the bioactive constituents of chamomile. Studies on preclinical models of skin, prostate, breast and ovarian cancer have shown promising growth inhibitory effects (3943). In a recently conducted study, chamomile extracts were shown to cause minimal growth inhibitory effects on normal cells, but showed significant reductions in cell viability in various human cancer cell lines. Chamomile exposure induced apoptosis in cancer cells but not in normal cells at similar doses (18). The efficacy of the novel agent TBS-101, a mixture of seven standardized botanical extracts including chamomile has been recently tested. The results confirm it to have a good safety profile with significant anticancer activities against androgen-refractory human prostrate cancer PC-3 cells, both in vitro and in vivo situation (44).

Common cold (acute viral nasopharyngitis) is the most common human disease. It is a mild viral infectious disease of the upper respiratory system. Typically common cold is not life-threatening, although its complications (such as pneumonia) can lead to death, if not properly treated. Studies indicate that inhaling steam with chamomile extract has been helpful in common cold symptoms (45); however, further research is needed to confirm these findings.

It has been suggested that regular use of flavonoids consumed in food may reduce the risk of death from coronary heart disease in elderly men (46). A study assessed the flavonoid intake of 805 men aged 6584 years who were followed up for 5 years. Flavonoid intake (analyzed in tertiles) was significantly inversely associated with mortality from coronary heart disease and showed an inverse relation with incidence of myocardial infarction. In another study (47), on twelve patients with cardiac disease who underwent cardiac catheterization, hemodynamic measurements obtained prior to and 30 minutes after the oral ingestion of chamomile tea exhibited a small but significant increase in the mean brachial artery pressure. No other significant hemodynamic changes were observed after chamomile consumption. Ten of the twelve patients fell into a deep sleep shortly after drinking the beverage. A large, well-designed randomized controlled trial is needed to assess the potential value of chamomile in improving cardiac health.

An apple pectin-chamomile extract may help shorten the course of diarrhea in children as well as relieve symptoms associated with the condition (47). Two clinical trials have evaluated the efficacy of chamomile for the treatment of colic in children. Chamomile tea was combined with other herbs (German chamomile, vervain, licorice, fennel, balm mint) for administration. In a prospective, randomized, double-blind, placebo-controlled study, 68 healthy term infants who had colic (2 to 8 weeks old) received either herbal tea or placebo (glucose, flavoring). Each infant was offered treatment with every bout of colic, up to 150 mL/dose, no more than three times a day. After 7 days of treatment, parents reported that the tea eliminated the colic in 57% of the infants, whereas placebo was helpful in only 26% (P<0.01). No adverse effects with regard to the number of nighttime awakenings were noted in either group (48). Another study examined the effects of a chamomile extract and apple pectin preparation in 79 children (age 0.55.5 y) with acute, non-complicated diarrhea who received either the chamomile/pectin preparation (n = 39) or a placebo (n = 40) for 3 days. Diarrhea ended sooner in children treated with chamomile and pectin (85%), than in the placebo group (58%) (49). These results provide evidence that chamomile can be used safely to treat infant colic disorders.

Topical applications of chamomile have been shown to be moderately effective in the treatment of atopic eczema (50). It was found to be about 60% as effective as 0.25% hydrocortisone cream (51). Roman chamomile of the Manzana type (Kamillosan (R)) may ease discomfort associated with eczema when applied as a cream containing chamomile extract. The Manzana type of chamomile is rich in active ingredients and does not exhibit chamomile-related allergenic potential. In a partially double-blind, randomized study carried out as a half-side comparison, Kamillosan(R) cream was compared with 0.5% hydrocortisone cream and a placebo consisting only of vehicle cream in patients suffering from medium-degree atopic eczema (52). After 2 weeks of treatment, Kamillosan(R) cream showed a slight superiority over 0.5% hydrocortisone and a marginal difference as compared to placebo. Further research is needed to evaluate the usefulness of topical chamomile in managing eczema.

Chamomile is used traditionally for numerous gastrointestinal conditions, including digestive disorders, "spasm" or colic, upset stomach, flatulence (gas), ulcers, and gastrointestinal irritation (53). Chamomile is especially helpful in dispelling gas, soothing the stomach, and relaxing the muscles that move food through the intestines. The protective effect of a commercial preparation (STW5, Iberogast), containing the extracts of bitter candy tuft, lemon balm leaf, chamomile flower, caraway fruit, peppermint leaf, liquorice root, Angelica root, milk thistle fruit and greater celandine herb, against the development of gastric ulcers has been previously reported (54). STW5 extracts produced a dose dependent anti-ulcerogenic effect associated with a reduced acid output, an increased mucin secretion, an increase in prostaglandin E (2) release and a decrease in leukotrienes. The results obtained demonstrated that STW5 not only lowered gastric acidity as effectively as a commercial antacid, but was more effective in inhibiting secondary hyperacidity (54).

Studies suggest that chamomile ointment may improve hemorrhoids. Tinctures of chamomile can also be used in a sitz bath format. Tincture of Roman chamomile may reduce inflammation associated with hemorrhoids (55, 56).

It has been claimed that consumption of chamomile tea boosts the immune system and helps fight infections associated with colds. The health promoting benefits of chamomile was assessed in a study which involved fourteen volunteers who each drank five cups of the herbal tea daily for two consecutive weeks. Daily urine samples were taken and tested throughout the study, both before and after drinking chamomile tea. Drinking chamomile was associated with a significant increase in urinary levels of hippurate and glycine, which have been associated with increased antibacterial activity (57). In another study, chamomile relieved hypertensive symptoms and decreased the systolic blood pressure significantly, increasing urinary output (58). Additional studies are needed before a more definitive link between chamomile and its alleged health benefits can be established.

Inflammation is associated with many gastrointestinal disorders complaints, such as esophageal reflux, diverticular disease, and inflammatory disease (5961). Studies in preclinical models suggest that chamomile inhibits Helicobacter pylori, the bacteria that can contribute to stomach ulcers (60). Chamomile is believed to be helpful in reducing smooth muscle spasms associated with various gastrointestinal inflammatory disorders. Chamomile is often used to treat mild skin irritations, including sunburn, rashes, sores and even eye inflammations (6265) but its value in treating these conditions has not been shown with evidence-based research.

Mouth ulcers are a common condition with a variety of etiologies (66). Stomatitis is a major dose-limiting toxicity from bolus 5-fluorouracil-based (5-FU) chemotherapy regimens. A double-blind, placebo-controlled clinical trial including 164 patients was conducted (22). Patients were entered into the study at the time of their first cycle of 5-FU-based chemotherapy and were randomized to receive a chamomile or placebo mouthwash thrice daily for 14 days. There was no suggestion of any stomatitis difference between patients randomized to either protocol arm. There was also no suggestion of toxicity. Similar results were obtained with another prospective trial on chamomile in this situation. Data obtained from these clinical trials did not support the pre study hypothesis that chamomile could decrease 5-FU-induced stomatitis. The results remain unclear if chamomile is helpful in this situation.

Osteoporosis is a metabolic bone disease resulting from low bone mass (osteopenia) due to excessive bone resorption. Sufferers are prone to bone fractures from relatively minor trauma. Agents which include selective estrogen receptor modulators or SERMs, biphosphonates, calcitonin are frequently used to prevent bone loss. To prevent bone loss that occurs with increasing age, chamomile extract was evaluated for its ability to stimulate the differentiation and mineralization of osteoblastic cells. Chamomile extract was shown to stimulate osteoblastic cell differentiation and to exhibit an anti-estrogenic effect, suggesting an estrogen receptor-related mechanism (67). However, further studies are needed before it can be considered for clinical use.

Traditionally, chamomile preparations such as tea and essential oil aromatherapy have been used to treat insomnia and to induce sedation (calming effects). Chamomile is widely regarded as a mild tranquillizer and sleep-inducer. Sedative effects may be due to the flavonoid, apigenin that binds to benzodiazepine receptors in the brain (68). Studies in preclinical models have shown anticonvulsant and CNS depressant effects respectively. Clinical trials are notable for their absence, although ten cardiac patients are reported to have immediately fallen into a deep sleep lasting for 90 minutes after drinking chamomile tea (47). Chamomile extracts exhibit benzodiazepine-like hypnotic activity (69). In another study, inhalation of the vapor of chamomile oil reduced a stress-induced increase in plasma adrenocorticotropic hormone (ACTH) levels. Diazepam, co-administered with the chamomile oil vapor, further reduced ACTH levels, while flumazenile, a BDZ antagonist blocked the effect of chamomile oil vapor on ACTH. According to Paladini et al. (70), the separation index (ratio between the maximal anxiolytic dose and the minimal sedative dose) for diazepam is 3 while for apigenin it is 10. Compounds, other than apigenin, present in extracts of chamomile can also bind BDZ and GABA receptors in the brain and might be responsible for some sedative effect; however, many of these compounds are as yet unidentified.

Chamomile has been reported in the treatment of generalized anxiety disorder (GAD). But the reports seem contradictory as an earlier report suggests that German chamomile showed significant inhibition of GAD activity (71). The recent results from the controlled clinical trial on chamomile extract for GAD suggests that it may have modest anxiolytic activity in patients with mild to moderate GAD (72). Extracts of chamomile (M. recutita) possess suitable effects on seizure induced by picrotoxin (73). Furthermore, apigenin has been shown to reduce the latency in the onset of picrotoxin-induced convulsions and reduction in locomotor activity but did not demonstrate any anxiolytic, myorelaxant, or anticonvulsant activities (16).

Studies suggest that chamomile ameliorates hyperglycemia and diabetic complications by suppressing blood sugar levels, increasing liver glycogen storage and inhibition of sorbitol in the human erythrocytes (74). The pharmacological activity of chamomile extract has shown to be independent of insulin secretion (75), and studies further reveal its protective effect on pancreatic beta cells in diminishing hyperglycemia-related oxidative stress (76). Additional studies are required to evaluate the usefulness of chamomile in managing diabetes.

The efficacy of lubrication of the endo-tracheal tube cuff with chamomile before intubation on postoperative sore throat and hoarseness was determined in a randomized double-blind study. 161 patients whose American Society of Anesthesiologists (ASA) physical status was I or II, and undergoing elective surgical, orthopedic, gynecological or urological surgeries were divided in two groups. The study group received 10 puffs of chamomile extract (Kamillosan M spray, total 370 mg of Chamomile extract) at the site of the cuff of the endotracheal tube for lubrication, while the control group did not receive any lubrication before intubations. Standard general anesthesia with tracheal intubations was given in both groups. 41 out of 81 patients (50.6%) in the chamomile group reported no postoperative sore throat in the post-anesthesia care unit compared with 45 out of 80 patients (56.3%) in the control group. Postoperative sore throat and hoarseness both in the post-anesthesia care unit and at 24 h post-operation were not statistically different. Lubrication of endo-tracheal tube cuff with chamomile extract spray before intubations can not prevent post operative sore throat and hoarseness (77). Similar results were obtained in another double blind study (78).

Vaginal inflammation is common in women of all ages. Vaginitis is associated with itching, vaginal discharge, or pain with urination. Atrophic vaginitis most commonly occurs in menopausal and postmenopausal women, and its occurrence is often associated with reduced levels of estrogen. Chamomile douche may improve symptoms of vaginitis with few side effects (79). There is insufficient research data to allow conclusions concerning possible potential benefits of chamomile for this condition.

The efficacy of topical use of chamomile to enhance wound healing was evaluated in a double-blind trial on 14 patients who underwent dermabrasion of tattoos. The effects on drying and epithelialization were observed, and chamomile was judged to be statistically efficacious in producing wound drying and in speeding epithelialization (80). Antimicrobial activity of the extract against various microorganisms was also assessed. The test group, on day 15, exhibited a greater reduction in the wound area when compared with the controls (61 % versus 48%), faster epithelialization and a significantly higher wound-breaking strength. In addition, wet and dry granulation tissue weight and hydroxyproline content were significantly higher. The increased rate of wound contraction, together with the increased wound-breaking strength, hydroxyproline content and histological observations, support the use of M. recutita in wound management (81). Recent studies suggest that chamomile caused complete wound healing faster than corticosteroids (82). However, further studies are needed before it can be considered for clinical use.

Essential oils obtained from Roman chamomile are the basic ingredients of aromatherapy. Clinical trials of aromatherapy in cancer patients have shown no statistically significant differences between treated and untreated patients (83). Another pilot study investigated the effects of aromatherapy massage on the anxiety and self-esteem experience in Korean elderly women. A quasi-experimental, control group, pretest-posttest design used 36 elderly females: 16 in the experimental group and 20 in the control group. Aromatherapy massage using lavender, chamomile, rosemary, and lemon was given to the experimental group only. Each massage session lasted 20 min, and was performed 3 times per week for two 3-week periods with an intervening 1-week break. The intervention produced significant differences in the anxiety and self-esteem. These results suggest that aromatherapy massage exerts positive effects on anxiety and self-esteem (8486). However, more objective, clinical measures should be applied in a future study with a randomized placebo-controlled design.

A relatively low percentage of people are sensitive to chamomile and develop allergic reactions (87). People sensitive to ragweed and chrysanthemums or other members of the Compositae family are more prone to develop contact allergies to chamomile, especially if they take other drugs that help to trigger the sensitization. A large-scale clinical trial was conducted in Hamburg, Germany, between 1985 and 1991 to study the development of contact dermatitis secondary to exposure to a mixture of components derived from the Compositae family. Twelve species of the Compositae family, including German chamomile, were selected and tested individually when the mixture induced allergic reactions. During the study, 3,851 individuals were tested using a patch with the plant extract (88). Of these patients, 118 (3.1%) experienced an allergic reaction. Further tests revealed that feverfew elicited the most allergic reactions (70.1% of patients) followed by chrysanthemums (63.6%) and tansy (60.8%). Chamomile fell in the middle range (56.5%). A study involving 686 subjects exposed either to a sesquiterpene lactone mixture or a mixture of Compositae extracts led to allergic reactions in 4.5% of subjects (89). In another study it was shown that eye washing with chamomile tea in hay fever patients who have conjunctivitis exacerbates the eye inflammation, whereas no worsening of eye inflammation was noted when chamomile tea was ingested orally (90). Chamomile is listed on the FDA's GRAS (generally recognized as safe) list. It is possible that some reports of allergic reactions to chamomile may be due to contamination of chamomile by "dog chamomile," a highly allergenic and bad-tasting plant of similar appearance. Evidence of cross-reactivity of chamomile with other drugs is not well documented, and further study of this issue is needed prior to reaching conclusions. Safety in young children, pregnant or nursing women, or those with liver or kidney disease has not been established, although there have not been any credible reports of toxicity caused by this common beverage tea.

4. Philip RB. Herbal remedies: the good, the bad, and the ugly. J. Comp. Integ. Med. 2004;1:111.

8. Hansen HV, Christensen KIb. The common chamomile and the scentless may weed revisited. Taxon. International Association for Plant Taxonomy. 2009;Vol. 58:261264.

9. Der MA, Liberti L. Natural product medicine: A scientific guide to foods, drugs, cosmetics. George, Philadelphia: F. Stickley Co.; 1988.

10. Mann C, Staba EJ. In herbs, spices and medicinal plants: recent advances in botany. In: Craker LE, Simon JE, editors. Horticulture and Pharmacology. Phoenix, Arizona: Oryx Press; 1986. pp. 235280.

20. Hamon N. Herbal medicine. The Chamomiles. Can Pharm J. 1989;612

28. Weiss RF. In: Herbal Medicine. Arcanum AB, editor. Beaconsfield, U.K: Beaconsfield publishers; 1988. pp. 2228.

29. Rombi M. Cento Piante Medicinali. Bergamo, Italy: Nuovo Insttuto d'Arti Grafiche; 1993. pp. 6365.

30. Awang -Dennis VC. Taylor and Francis group. New York: CRC Press; 2006. The herbs of Choice: The therapeutic use of Phytomedicinals; p. 292.

31. Martens D. Chamomile: the herb and the remedy. The Journal of the Chiropractic Academy of Homeopathy. 1995;6:1518.

32. Newall CA, Anderson LA, Phillipson JD. Herbal medicine: A guide for health care professionals. Vol. 296. London: Pharmaceutical Press; p. 996.

36. Pea D, Montes de Oca N, Rojas S. Anti-inflammatory and anti-diarrheic activity of Isocarpha cubana Blake. Pharmacologyonline. 2006;3:744749.

45. Saller R, Beschomer M, Hellenbrecht D. Dose dependency of symptomatic relief of complaints by chamomile steam inhalation in patients with common cold. Eur J Pharmacol. 1990;183:728729.

68. Avallone R, Zanoli P, Corsi L, Cannazza G, Baraldi M. Benzodiazepine compounds and GABA in flower heads of matricaria chamomilla. Phytotherapy Res. 1996;10:177179.

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Chamomile: A herbal medicine of the past with bright future

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Why Russia? | From Russia with Lisa…

October 2nd, 2016 10:46 am

Are you cringing? Russia for medical treatment, and such a devastating procedure? YES! Why?

Many reasons, first and foremost is that I have utter faith, confidence and assurance in Dr. Denis Fedorenko and his skills to perform a stem cell transplant. Secondly is the cost, approximately $40,000-50,000 depending on hospitalization and need for transfusions or plasma. Third, Dr. Fedorenko will treat patients with my type of MS at my age, something very few, if any, will do in the U.S. I have been communicating with Amy Peterson of Round Rock, Texas. She was the first person in the U.S. to travel to Moscow for HSCT, and has done beautifully! Read about her story athttp://amygoesninja.wordpress.com. She is an inspiration!

The following is information provided by George Goss, the guru of HSCT here in the United States. He is the go to man for questions, help, support and inspiration. He too went overseas for HSCT to Germany which is considered the best of the best. Unfortunately, Germany will not treat my type of MS.

Thank you George

This is anon-myeloablativeHSCT treatment protocol utilizing Cyclophosphamide + Rituxamab or alternatively Cyclophosphamide + Carmustine

Approximate cost USD $40,000+I have spoken with Dr. Fedorenko at Maximov in Moscow on the phone to discuss his HSCT-for-MS treatment. He is a very nice and pleasant personthat clearly is a very knowledgeable medical scientist and clinician and I found him to be open & helpful with my questions.Maximov/Perigovis a well-respected hospital facility. And the best news is that Dr. Fedorenko is definitely extremely knowledgeable and he clearly understands well all the fundamental medical science behind HSCT for treatment and cure of a wide range of hematologically-rooted autoimmune disorders. (Perhaps he can be thought of as providing a similar treatment service in Russia as Dr. Burt does in the USA.) Dr. Fedorenko is also well-published on the subject of HSCT treatment of autoimmune disorders, being involved with numerous and ongoing scientific and medical international symposiums and publications, a few such as listed here (there are many more than just these):

Based upon his publications and experience, Dr. Fedorenko has the credentials establishing him as an expert in the field of HSCT treatment for autoimmune disorders.

Here is the Maximov website: http://www.gemclinic.ru/english.php

Here is relevant info I have learned about Maximovs HSCT treatment for MS:

Maximov performs HSCT for both bone marrow malignancies (such as leukemia) and also several types of autoimmune diseases.

For autoimmune disorders they perform a non-myeloablative HSCT protocol utilizing primarily a combination of carmustine + cyclophosphamide. I never previously heard of this specific chemical combination being used, but it makes sense to me and seems like a reasonable treatment application. I dont see any red flags.

Maximov has ten treatment beds for treating a maximum of ten patients at one time. Five beds reserved for cancer patients, and five beds for patients with autoimmune disorders.

HSCT treatment criteria for autoimmune (MS) conditions:

Exclude patients greater than 50 years of age although he has agreed to accept me pending MRI review

Must be in sufficiently good health to tolerate HSCT procedure) includes good heart and renal function and generally be in good overall health),

And specifically for Multiple Sclerosis patients:

Must not be severely disabled (patient must be ambulatory with an EDSS of less than approximately 6.0) I am on the border here, so I need to get there ASAP!

Will treat any evolutionary form of MS (RRMS, SPMS and PPMS); all allowed but must demonstrate active MRI lesion activity or alternatively if without active lesions must have experienced greater than a 1.0 worsening of EDSS over a period of one year.

Maximov previously treated more than approximately 200 patients (mostly Russians) with autoimmune disorders in which a very small number (3-5) developed serious treatment complications (such as sepsis), of which everyone recovered. There have been no deaths or Treatment Related Mortality (0% TRM).

Treatment Schedule:

Maximum pre-treatment exam duration = 1 week.

Hematopoietic stem cell PBSC mobilization (with G-CSF) = 4-5 days (2-4M HSCs / kg body weight collected).

Peripheral blood stem cell collection / apheresis = 1-2 days.

Usual total in-patient hospital stay (inclusive of all procedures) = 30-45 days. An additional week is required at a nearby hotel to ensure patient health and good blood counts before traveling back to Oklahoma

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why is age so an important part of the requirement, Like I am fit the only problem I have is balance. I am 58 yrs old are we then just left to suffer this disease? I have had it now for 24 years

Dr. Fedorekno has now removed the age limit for MS. I was the oldest to receive the stem call transplant last summer and did very well! He has lifted it due to my success, and a woman age 64 is leaving next week for Moscow and treatment by Dr. Fedorekno. If you are interested, there is a Facebook page you can ask to subscribe to which has great information on HSCT. That is where I became educated. Search for Hematopioetic Stem Cell Transplant MS & Autoimmune Diseases on Facebook. Lisa

I lied, I am 59 today,but it is good to know that he has lifted the age gap, I will have to inform the rest of the group who, go for physio every week and we are in our 50s , the only thing is the price tag for the treatment is not clear, the other question is Russia the only country that is doing this treatment?

The procedure is done in the US in phase III clinical trials, but they will only accept under age 50 with mild cases of RRMS. Germany and India do myeloablative HSCT for $98,000, which is a harsher form of HSCT and takes a full year to recover physically. Non myeolablative (which I had) has been proven just as effective, with a faster recovery period of 3 months on average, 6 months at the very most. Russia costs $40,000; Italy also has just begun to accept MS patients but I do not know their fee. Dr. Fedorenko in Moscow was fabulous, and I put their standards up against any of the finest hospital in the US.

Thank you very much for that, I am off to see the specialist next month and will see what she has to say with Prof Pender, but it looks hopeful.

Neurologists are not fans of HSCT, they are not educated as to the process and the benefits. Hematologists have been doing the procedure for over 20 years for cancer, and 10 years in European countries for MS. As time and news of the success spreads, neurologist will come on board. It will take a few years, however. Do not give up! It has been a life changer and saver for me!

Hello Lisa, My name is Kim I am 55 and have had RRMS for 5 years now I am been on Copaxone for nearly a year and follow a very strict lifestyle of very low saturated fat, meditation,vitamin D,Fish oil no Dairy no meat or chicken just plant base seafood diet which was developed by Proffessor George Jelenek who has MS himself and runs retreats to teach you about this lifesyle ,It has made a huge difference to me in two years I also have acupuncture once a week as well. I had a right hip replacment almost at the same time as my diagnosis and the MS and surgery didnt like eachother so my right leg got worse after surgery. I walk with a cane when Im out but not a home , Im very interested if I would be a candidate for the Stem Cell transplant with Dr Federenko, how could I find out , thankyou Lisa , kind regards , Kim

I feel you would be an excellent candidate. I went from a cane to a walker when out very quickly. Dr. Fedorekno, or any hematologist, would require you be off Copaxone for 3 months before treatment begins. Due to lesions on the spine and brain stem, I would be wheelchair bound right now this very day. HSCT did save me, and has restored many functions, not all of course, but so many! It costs $40,000 US dollars, but my Copaxone cost more than that. Ak me any questions, I will help in any way! Contact Dr. Fedorenko at: info@gemclinic.ru Also find the Facebook page: Russia HSCT for MS & Autoimmune Diseases for more help and information. It is a wonderful group who have been, or are headed to Moscow. Lisa

Hi Lisa I am currently on Techfidera. Would I have to stop that for a certain time before going? Also, do i need a referral and records from my neurologist? Thank you Kind Regards Diana

You would need to stop all treatment, except for medications for symptoms such as Baclofen, etc, before beginning treatment. Dr. Fedorenko usually requires a 3 month cleanse of any disease modifying medications. When I first contacted him by email, I sent a brief description of my disease date and age at onset, date of diagnosis, a full list of symptoms dated from onset to the month I applied, and list of disease modifying meds and how long I had been on each. After he answered, I sent him a CD of my most recent MRI, and a print out of the above mentioned symptoms, onset and meds. Full medical records are usually too much for him to cover, so he has, in the past, gone on the patients notes on their MS. He makes a decision based on what you have told him, and the MRI. He is an amazing physician, never will you find a anyone who cares more about helping people from divesting diseases. Lisa

Hi Lisa

Thank you for your blog. I was diagnosed 1 year ago. I have 2 young children. I have pins and needles and altered sensations on my left leg and both feet. I dont currently require aids to walk. I am overweight. Does this program insist on weight loss? I am Australian and I am on Tysabri. Would I have to come off that first?

To my knowledge, Dr. Fedorenko does not require weight loss. I have had quite a few women whom I now call my best friends who were overweight and had beautifully successful stem cell transplants. I encourage you to proceed with an email to Dr. F. It is your best chance at recovery, and stopping progression, as well as regaining abilities permanently. You wold have to come off Tysabri for 3 months to wash it out of your system before beginning treatment. lisa

Hi Lisa , can I ask you how long has it been since the end of your treatment, and symptoms how are they now ,how long were you sick for during the treatment? my main fear is infection over the isolation period of the transplant and how sterile everything is in the hospital Im very interested in doing this next year ,is there a long waiting list ? Thank you very much Lisa I really appreciate all your advice , kind regards ,Kim xx

I returned home August 12th last year. My symptoms now are so much better, some I have not experienced at all! I am 85% better! Only very few signs of MS remain. I still have at stutter at times, balance issues sometimes, but that is about it! ALL other symptoms are gone no foot pain and burning, no tremors, no paralysis all gone. I suggest you go ahead and apply with Dr. Fedorenko now, as he is booking into early October right now. That will give you time to pursue more research and questions, and will give you time to change your mind should you decide to do so but I think you will not. It is a life saving/changing treatment.

I experienced NO illness during treatment, only sever fatigue. Only slight nausea for a few days, and the rest of the time I was just tired. A sleep 20 hours a day kind of tired. Your body needs the rest so it is beneficial to sleep. The hospital is amazingly, over the top sterile. While in isolation ( go back and see my pics) no one comes in without owning up. Food is twice cooked to ensure all bacteria is removed, and the room cleaned daily with anti bacterial. There is not a more infection free space on this earth. The equipment used during transplant are the newest available, made in Boston, and run on Apple computers designed for this stem cell machine. I was so fearful of going to Russia in the beginning, and all hesitation was wiped away upon meeting Dr. F. He is an angel and all he cares about is helping his patients have a good quality of life, as free of MS as they can be. He did it for me! Lisa

Hi Lisa Just to let you know after your replies from my questions< I contacted my MS clinic and spoke to my consultant and she no way should I consider having this done as they do not tell you about the procedures that went wrong, so I kave made up my mind to wait a bit longer. I am pleased that it worked out for you and it did not go wrong.

Steve

I was diagnosed just Feb of this year. I am in the process of changing Drs at the moment. My Dr did not want to speak about this procedure and literally walked out of the room while I was talking to him. The US doesnt want a cure for this. Drug companies float more $ to Drs for pushing their overpriced immune suppressant drugs than Drs salary most times. Im looking further into this option. I had to find and research it on my own.. still doing a bunch of research. It sounds a million times better than being stuck on Tysabri which will likely cause many other health issues and isnt making me any better. I would love to speak with Lisa! Im mailing my records and MRI to Germany next week.

One of my doctors received $295,500 from pharmaceuticals last year! They DO NOT want a cure. This is an incredible treatment, and gave me so much more than any drug I had been on. It is amazing and has halted the disease! I suggest you try Germany, Moscow now has a long wait list. Singapore does HSCT, as does Florence, Italy a great choice.

Thank you so much Lisa youre a wealth of information and to me this treatment seems so much more beneficial and less dangerous than the horrible MS drugs that the neurologists are prescribing . Five years ago I was an active power walker / gym junkie and now my walking is affected in my right leg I would do anything to walk normally again without a stick . My eldest son is getting married this sept and I want to be an active grandmother one day in the near future and am willing to risk anything for that, Although you have certainly eleviated a lot of my concerns ,I just hope it will help my walking and tingly fingers , thanks again Lisa ,love Kim

Hi lisa as I am one of Jehovahs Witness and dont accept Blood transfusions is it still possible to have this treatment without it? Would they give me something else if my blood count dropped very low? In Australia they give us Erythropoietin, also known as erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte precursors in the bone marrow. I would really appreciate your answer.

In Dr. Fedorenkos 280+ HSCTs, no one has ever had a blood transfusion. I am friends with 15 of the first from the U.S. to go over, and only two of us had to receive platelets. And it was not even medically necessary, but I opted to have them due to fatigue. Hope this helps! Lisa

I am just considering my options and whether or not Russia would be feasible.

I now have two good reports on Russia but more bridges have to be crossed but I have been told that I could be fitted in January 2015. I will keep you posted.

A lot of information can be gained from joining the HSCT group on Facebook, and the Russia HSCT treatment group also has a forum, but it is best to join both. The forum is moderated by two physicians so the information is accurate. And the support gained is invaluable! If you cannot find it, let me know. Lisa

Dear Lisa , may I ask how old you were when you had your stem cell transplant Im 55 but was only diagnosed at 50 I m in extremely good health apart from having MS Im terrified dr Federenko may not accept me , I dont want to get worse I still have a long time and a lot to look forward to in my life ,like becoming a grandmother in the not to distant future, thanks Lisa , I think I read somewhere that he had lifted the age and disability limit ?

My symptoms began at 54, diagnosed at 55 and HSCT at 56. I feel you are an excellent candidate, the earlier in your disease you receive treatment the better outcome. I suggest you contact him today. He is working on a paper and is out of the office for about 2 weeks. His wait list is one year, but well worth it. I asked to be admitted early if there were cancellations and I was! Also, check into joining the Facebook HSCT auto immune disease group, and the HSCT Russia forum for great info and support! Lisa

Thank you Lisa I have joined the group its a wonderful source of information , I have was and contacted George Goss as well, I get on it x

Hi Lisa, I am writing to you on behalf of my nephew, Matt, who is 35 and was diagnosed with PPMS about 7 or 8 years ago. His EDSS is currently 6.0. I have been doing extensive research about HSCT for him but he is hesitant. Can you offer any advice? He has a beautiful wife & 2 gorgeous little girls.

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Lot of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help.

Hi Lisa, my partner has been suffering RRMS for approx 10 years. He has over the past month had his medication changed from injections to tablets due to his latest MRI showing he now has 2 lesions on his spine. We had made travel arrangements to attend Kristys seminar yesterday but had to cancel as Chris became very unwell which we have put down to the change in his meds. The new medication, Gilenya has had adverse side affects including severe headaches daily, severe constipation and a wave like feeling to add to his many symptoms of Ms. We are very interested in going to Russia for treatment and would like to go ASAP?? We attended The Sans Emergency dept Friday evening and were seen by a Dr who proceeded to ask what we wanted him to do for my partner? He went away and came back and asked the very same question a further 2 times!! Well by the third time, I blurted out, yes I know what you can do, RING CANBERRA HOSPITAL & DEMAND THAT THE COMMITTEE REINSTATE THE SCTP IMMEDIATELY!!!! He told us he could not help him and we left!

We do not want to wait until he gets more lesions and cannot walk. All info would be gratefully appreciated x Kind Regards Chris & Michelle Sydney

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A lot of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help. Lisa

I was diagnosed with primary progressive MS may 2010. My left leg is where it is bad I use stick. How do I go about getting HSCT. Paraic Heneghan

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Loy of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help. Lisa

Do you know what other conditions he treats? Specifically, myalgic encephalomyelitis (CFIDS in the US). I tried the email to him directly but it failed.

I am not sure about that disease. Email him again in a few days. He has been inundated as a patient appeared on 60 Minutes, Australia. The mailbox is full, but he should be able to answer mail again soon.

Thank you. May I also ask how you got your diagnosis? I have been reading a comparison of MS and ME and they are almost identical in terms of symptoms and abnormal test results..I cant find a doctor. How did you find your doctor who diagnosed you?

It took a year and I went through two neurologists before I found one that was persistent. My MRIs did not have enhancing lesions. The diagnosis came through a lumbar puncture. It showed elevated igG synthesis rate, but no oligloconal bands. It takes one or both to confirm MS. I had every blood test in the book and two MRIs before they agreed to do the LP. Mine was so difficult as it came on suddenly and later in life than most MS cases, hence the PPMS diagnosis.

Hi Lisa I recently got diagnosed with MS and seriously considering the stem transplant procedure. Where do I start from?

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Loy of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help.

Hi hi My name is Hanne And I am 45 years young. Soon to be 46 31.08.1968 I have had MS since April 1998 and I want to Take HSCT. My RRMS has been kind to me but there are a lot of things I cant do And I want to do everything Can you help me please Dr.F??? With love from Norway:-)))

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Loy of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help. Lisa

Hi,

I am attempting to raise 40000 pounds to pay for HSCT treatment in Russia.

I plan to have coverage of my journey on local and national press.

I look forward to hearing from you.

Regards

Barry McArthur

Link:
Why Russia? | From Russia with Lisa...

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