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Digital diabetes prevention program use tied to weight reduction among low-income patients with prediabetes – MobiHealthNews

February 16th, 2020 7:44 pm

A sample of low-income patients engaged with Omada Healths digital diabetes prevention program (DPP), achievedweight loss but no major difference in HbA1c levels after a year of use, according to study data recently highlighted by the company.

The results published late last year in the CDCs Preventing Chronic Disease journal and first previewed at a 2018 public health conference suggest an alternative approach to diabetes prevention for a population that more often has difficulty accessing in-person health services.

The Omada program lowers the barriers to access, and ultimately increases preventive health engagement among any population, Omada Director of Clinical Research Cynthia Castro Sweet, who was also an author on the paper alongside researchers from the University of Southern California, Los Angeles, said in a statement. Our program was developed to serve the needs of participants from all backgrounds, and all walks of life. The results of this trial dispels the myth that people with economic or educational disadvantages cant or wont use technology to engage in their health care.

TOPLINE DATA

From the 227 participants recruited and evaluated at baseline, 111 completed a follow-up roughly around the half-year mark (T1), 104 completed a roughly 12-month follow-up (T2) and 76 completed both follow-ups. One hundred and nine participants who completed the T1 follow-up were also matched to an unenrolled control patient using de-identified records.

At baseline, 81.3% of the participants were women, 51.5% identified as Hispanic/Latino and 43% had limited proficiency in English. The average age was 48.2 years. All groups and subgroups within the trial demonstrated similar sociodemographic variables, with the exceptions that those eventually lost to follow-up were significantly less likely to have Medicaid at T1 and T2, and more likely to be working full-time at T1.

At the first and second check-in, 41% and 37% of reporting participants, respectively, had lost more than 5% of their weight. The average loss was significant at both check-ins, with mean weight loss reported as 4.2% at T1 and 4.4% at T2. Similarly, mean BMI also dropped significantly by 1.5 from baseline at T1, and 1.6 at T2.

At both check-ins, completion of nine or more lessons was significantly associated with increased weight loss. HbA1c levels mostly remained stagnant, however, with roughly similar proportions of participants falling within a prediabetic range. The only decline came at the T1 check-in (but not the T2 check-in) among participants who lost more than 5% of their baseline weight.

HOW IT WAS DONE

Between February 2016 and March 2017, researchers recruited adults enrolled in Medicaid or another safety-net insurance plan who had evidence of prediabetes within their EHR.

These participants were enrolled in Omadas digital DPP, which includes virtual group support, lessons, personalized support from a live health coach and other tools to track their progress. It was modified for the studys low-income target population by reducing the reading level of the curriculum, introducing Spanish translation and cultural components, and by featuring bilingual and bicultural coaches.

The researchers recorded patient outcomes of interest at baseline, at 24 to 35 weeks (T1) and at 47 to 65 weeks (T2). Controls were generated by searching de-identified EHRs with an algorithm that sought cases of a similar age and sex within 12 months prior to the beginning of enrollment.

THE LARGER PICTURE

Omada isnt the only digital diabetes program maker in town. Solera Health and Livongo both offer a variety of tech-driven programs aimed at managing or preventing diabetes, while Virta Health often boasts of its products ability to reverse Type 2 diabetes.

But digital DPPs are just one of Omadas offerings, which include hypertension management, mental health support and other chronic disease products. The company raked in $73 million in funding last summer, which it said at the time would help scale its digital care program efforts.

ON THE RECORD

This study demonstrates that Omada achieves real outcomes with this difficult-to-reach population, Omada Health CEO Sean Duffy said in a statement. Digital health tools should be offered to all populations, especially when sufficient evidence shows that they can be as effective as in-person programs. By making virtual alternatives less accessible, we deny low-income patients an opportunity to lead healthier, more productive lives.

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Noninvasive Markers of Liver Disease May Improve Referrals, Predict Complications in Diabetes – Endocrinology Advisor

February 16th, 2020 7:44 pm

With the use of age-adjusted thresholds for noninvasive markers of liver steatosis and fibrosis, patients with type 2 diabetes (T2D) may be referred more efficiently to specialists, according to study results published in BMJ Open Diabetes Research & Care. Furthermore, the researchers found a consistent association between these markers and chronic complications of T2D.

Current guidelines for T2D care recommend routine screening for the presence of nonalcoholic fatty liver disease (NAFLD), as well as assessment of advanced liver fibrosis in high-risk patients, using ultrasound and serum biomarkers. Patients with T2D are at increased risk of progressing from NAFLD to steatohepatitis and liver-related mortality. The goal of the current study was to examine changes in specialist referrals after the use of suggested noninvasive biomarkers of steatosis and fibrosis in patients with T2D. In addition, the association between these biomarkers and cardiovascular and kidney morbidity was investigated.

The retrospective study included adults with T2D who were treated at the diabetes clinic at Policlinico di Monza in Monza, Italy, between 2013 and 2018.

Liver steatosis assessment was based on the Fatty Liver Index, Hepatic Steatosis Index, and NAFLD Ridge Score. Risk for advanced fibrosis was assessed by using the Fibrosis-4 (FIB-4) score, NAFLD Fibrosis Score, aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, and the AST to platelet ratio index.

Of 2770 patients with T2D included in the study, data on liver steatosis markers were available in 1519, 2076, and 1082 for Fatty Liver Index, Hepatic Steatosis Index, and NAFLD Ridge Score, respectively. Data needed to calculate liver fibrosis scores were available for 2096, 1429, 1421, and 370 patients for AST/ALT ratio, AST/platelet ratio index, FIB-4, and NAFLD Fibrosis Score, respectively.

High probability of liver steatosis was evident in most patients based on each of the 3 steatosis scores (65%-88%). However, there was a wide variation in the high probability of advanced fibrosis according to different noninvasive markers, ranging from 1% with the use of the AST/platelet ratio index to 33% using the NAFLD Fibrosis Score. A significant number of patients were classified as having indeterminate risk, ranging from 23.1% using the AST/platelet ratio index to 55.8% using the AST/ALT ratio.

With a sequential combination of 2 noninvasive markers of steatosis (Fatty Liver Index) and fibrosis (FIB-4) with standard cutoffs, 28.3% of patients would require referrals to specialized hepatologists because of either intermediate (253 patients) or high risk (36 patients). With the use of age-adjusted cutoffs, this rate significantly decreased to 13.4% of the entire population (102 patients with intermediate risk, 35 with high risk).

Biomarkers of steatosis were significantly associated with risk for albuminuria. Among patients with Fatty Liver Index scores in the intermediate- or high-risk category, prevalence of microalbuminuria was significantly higher (odds ratio [OR], 3.49; 95% CI, 2.05-5.94).

Cardiovascular disease was more common in patients within the intermediate- (OR, 2.0; 95% CI, 1.6-2.5) and high-risk (OR, 2.6; 95% CI, 1.7-4.0) categories for FIB-4 score and within the intermediate (OR, 1.73; 95% CI, 1.4-2.1) and high (OR, 1.86; 95% CI, 1.4-2.5) categories of the AST/ALT ratio. For patients within the lower-risk category for fibrosis, risks for coronary heart disease and stroke were significantly lower.

The researchers acknowledged the results may be limited given that other etiologies of liver disease were not examined.

While the use of different non-invasive fibrosis scores among patients with type 2 diabetes identify different proportion of patients with advanced fibrosis, the use of age-adjusted FIB-4 cut-offs leads to a drop in gray-zone results, making referrals to hepatologists more sustainable for the healthcare system, the researchers wrote.

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Reference

Ciardullo S, Muraca E, Perra S, et al. Screening for non-alcoholic fatty liver disease in type 2 diabetes using non-invasive scores and association with diabetic complications. BMJ Open Diabetes Res Care. 2020;8:e000904.

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If You Have Diabetes, Pay Attention to Your Heart – Next Avenue

February 16th, 2020 7:44 pm

When my husband, Dale, was diagnosed with type 2 diabetes in 2007, at the age of 46, his doctor prescribed medication, he attended a nutrition class and was instructed on testing his blood glucose level.

Dale had annual physical exams, which monitored his blood pressure and A1C level (an average of blood glucose over time).

We assumed doing all of this would also mitigate the increased risk of heart disease that presents with type 2 diabetes.

It most likely was a fatal assumption.

Dale died of a sudden, massive heart attack, the main artery blockage known as the widow maker, two days before Thanksgiving, on Nov. 20, 2018.

The longer a person has diabetes, the higher their chances are of developing heart disease.

According to the Centers for Disease Control and Prevention, 30 million Americans have diabetes and 90% to 95% of them have type 2 diabetes. Most cases are diagnosed after age 45. According to the American Heart Association, adults with diabetes are two to four times more likely to die from heart disease than those who dont have diabetes.

The longer a person has diabetes, the higher their chances of developing heart disease. This is because high blood glucose from diabetes can damage blood vessels and the nerves that control the heart, according to the National Institute of Diabetes and Digestive and Kidney Diseases, which is part of the National Institutes of Health.

Total management of the disease should include diet, exercise, regular cholesterol testing and glucose monitoring, said Dr. Jane E.B. Reusch, a cardio-endocrinologist at the University of Colorado Anschutz Medical Center in Aurora, Colo. She also practices at the Rocky Mountain Regional Veterans Affairs Medical Center in Aurora.

Hyvelle Ferguson, now 46, was just 33 and pregnant when she was diagnosed with type 2 diabetes. I began taking care of myself, but after I had my baby, I reverted back to my old ways, eating anything I wanted, says Ferguson. I thought Id be OK if I was taking my medication.

At 41, Ferguson suffered a stroke, and three weeks after being released from rehab, suffered a heart attack. Her main artery was 99% blocked. She underwent quadruple bypass surgery, but that wasnt the end of her health problems.

I called myself a professional patient, in 2014 to 2015, I was in the hospital every month, she says. Every time I went to the doctor, something else was wrong.

Ferguson began taking stock of her life, researching how she could control diabetes instead of allowing the disease to control her. She adopted a healthier diet and began walking for exercise. At first, it was just to the mailbox, and I went a bit farther each time, she says.

Although she still has many challenging days, Ferguson now volunteers with the American Heart Association and is an advocate for its Know Diabetes by Heart. The new program is partnership between the group and the American Diabetes Association to help inform doctors on educating their patients with diabetes about the risks of heart disease. It also tells patients with diabetes questions to ask their doctors.

Of course, not all patients with diabetes will develop heart disease, and Reusch points out that many other factors play into the risk. A1C is very important, but cholesterol should also be monitored closely in diabetes patients, she says. So many factors play into it, including genetics.

Care guidelines endorsed by many cardiologists require all diabetes patients to be placed on a low-dose statin drug, despite a patients lipid numbers (measuring cholesterol and fats in the blood), says Dr. Jorge Plutzky, a cardiologist with the Brigham and Womens Hospital and Harvard Medical School in Boston. Statins lower cholesterol levels in the blood.

We make recommendations based on what we know, Plutzky says. He points out numerous studies showing that diabetes patients who hadnt previously suffered a heart attack and were placed on low-dose statin drugs had a striking reduction for the risk of heart attack.

I thought Id be OK if I was taking my medication.

Plutzky says doctors have known for years that diabetes increases the risk factors for heart disease, but didnt understand why blood glucose drugs didnt reduce the heart disease risk. We just didnt have the right drugs yet, he says. Great strides have been made just within the past three years.

Plutzky says doctors and patients should know that certain new inhibitor drugs combined with statins can reduce the risk of heart disease in patients with diabetes. The Know Diabetes by Heart (web page) has this information, as well as all the latest information that needs to be put out there, he says.

He advises people with type 2 diabetes not to wait for their doctors to bring up the topic of heart disease. And he says patients should continue to see their primary care doctors or endocrinologists to help manage their disease.

Another preventive measure is one that coulld have saved my husband Dales life. Its called coronary artery (or cardiac) calcium screening, and more hospital systems, including the one near my small town, offer it at a relatively affordable cost ($99 at my hospital). The test is for individuals at high risk for heart disease and uses computerized tomography (CT) scans to measure the calcium build-up in the coronary arteries. A health systems screening program may also involve a cholesterol screening, body mass Index reading, an A1C screening and other tests.

Gary Heimbach, 70, of Bull Shoals, Ark., was diagnosed with type 2 diabetes in 1993 at 58. When his wife heard about coronary artery calcium screening, they both scheduled an appointment to have it done.

Although Gary had no previous symptoms, his results indicated hed already suffered a previously unknown heart attack. Further testing revealed a 95% blockage in a main artery and a 50% blockage in another. They put a stent in and I havent had any problems since, he says. It was painless and saved my life.

Ferguson stresses taking proactive measures, such as informing yourself and taking advantage of all available resources to reduce the risk of heart disease. I want people to know they can live, they can fight the smart fight, she said.

Kerri Fivecoat-Campbell is a freelance writer whose work has appeared on Forbes.com, AOL.com, Mainstreet.com, Creditcards.com, Bankrate.com and elsewhere.

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The role of gut microbiota in the development and progress of type 2 diabetes – Medical News Bulletin

February 16th, 2020 7:44 pm

According to the World Health Organization, diabetes was directly related to the deaths of around 1.6 million people around the world in the year 2016 alone. In addition to family history, sedentary lifestyle, and diet, there is increasing evidence that micro-organisms in the gut (microbiota) play an important role in the development of type 2 diabetes. However, despite the growing evidence for the role of gut bacteria in type 2 diabetes, consensus on the role of different families of bacteria in the development of this disease is lacking. To address this problem, researchers from Oregon State University, USA have published a systematic review of 42 human studies on the associations between microbial families and type 2 diabetes. This review was published in the journal EBioMedicine.

While the researchers were unable to find any consensus on specific microbial communities being implicated in the development of diabetes, some groups of bacteria show an association with either presence or absence of the disease. For example, a decrease in at least one of these five distinct families of bacteria that include Bacteroides, Roseburia, Faecalibacterium, Akkermansia and Bifidobacterium families of bacteria is consistently associated with protection from type 2 diabetes. In contrast, the Lactobacillus family of bacteria shows divergent associations with type 2 diabetes and the specific effects of the bacteria on diabetes appear to be species-specific. For example, L.acidophilus, L.gasseri, L.salivarius were increased and L. amylovorus was decreased in diabetes patients.

Gut bacteria can influence the development and progression of type 2 diabetes in several ways. Certain species of bacteria can cause changes in glucose metabolism either directly by affecting the digestion of sugars or indirectly by affecting the production of hormones that control the process of digestion. For instance, Bifidobacterium lactis can cause an increase in glycogen synthesis the main storage form of glucose in the body while also increasing glucose uptake, thus reducing blood sugar levels.

Gut bacteria can also affect intestinal barrier functions. Type 2 diabetes causes an increase in intestinal permeability, resulting in leakage of gut microbial products such as lipopolysaccharides into the blood. Floating lipopolysaccharides in the blood can create chronic long-term inflammation in the body. Two bacterial species, B. vulgatus and B.dorei, upregulate the genes involved in maintaining the intestinal barrier, thus reducing intestinal permeability.

Gut bacteria can also affect the activity of drugs. A recent study showed that a probiotic- B.animalis along with prebiotic polydextrose and sitagliptin (a diabetes drug) was effective in reducing several diabetes parameters. There are also indications that combining prebiotic polysaccharide with metformin and sitagliptin reduced high blood sugar levels to a larger extent than using the drugs alone.

The systematic literature review described here concludes that while there is greater understanding in the role of certain microbial families in the pathophysiology of type 2 diabetes, simple interpretations and solutions are still elusive due to the high degree of variation in both the disease manifestation and the impact of gut microbes on the disease.

Written by Bhavana Achary, Ph.D

References:

Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, Shulzhenko N. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 2020 Jan;51:102590.

Prevalence of diabetes in the US https://www.cdc.gov/diabetes/basics/type2.html

Global prevalence of diabetes https://www.who.int/news-room/fact-sheets/detail/diabetes

Image byArek SochafromPixabay

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Sweet diabetes is a medication in diabetes, roasting has many advantages – Sahiwal Tv

February 16th, 2020 7:44 pm

Sweet Potatoes Benefits In Hindi: Sweet Potato, which is wealthy in carbohydrates and Vitamin A (candy potato) candy potatoes vitamin ) Is a celebrity. Its consumption within the weight loss program helps to scale back irritation in colon most cancers cells along with sustaining mild of your eyes, decreasing blood sugar and stress, retaining digestion good.

->Sweet potatoes include vitamin reminiscent of ascorbic acid, thiamine, riboflavin and vitamin B6. According to a examine, its recent leaves include a considerable amount of ascorbic acid, which is more likely to be supply of water-soluble nutritional vitamins. The remaining starchy water after cooking the candy potato may help scale back fats fats. Let's know the advantages of candy potato stuffed with vitamin (ie candy potato) Sweet Potatoes Health Benefits ) about:-

Sweet Potatoes Regulate Blood Sugar Levels Controls Blood SugarSweet meals with low glycemic index ( Low Glycemic Index Foods ) is. It controls blood sugar by blocking insulin resistance. Sweet potato comprises a wealthy supply of soluble fiber, reminiscent of pectin, which might forestall blood sugar spikes by growing your satiety. It additionally comprises magnesium which is helpful for diabetics. Despite being candy, its useful for diabetics as a result of it is filled with many vitamins together with fiber. It reduces the danger of coronary heart illnesses by controlling your waste ldl cholesterol.

Reduces stress: Sweet Potatoes Reduce StressSweet potato comprises magnesium, which reduces stress and nervousness. Magnesium deficiency is a significant reason behind despair. This mineral protects the mind from stress, in addition to it helps in getting good sleep.

Sweet Potatoes Anti-Inflammatory Food is an anti-inflammatory mealsSweet potato comprises nutritional vitamins which have robust anti-inflammatory properties. It can be supply of choline, which reduces inflammatory within the physique. Purple candy potato comprises anthocyanin, which reduces and prevents irritation in colon most cancers cells. Additionally its also recognized to scale back cell proliferation in particular most cancers cells.

Sweet Potatoes Promote Gut Health promotes intestine micro organismSweet potato comprises fiber and antioxidants that promote the expansion of fine intestine micro organism and assist in wholesome bowels. Which improves your digestion.

Eye well being ( Sweet Potatoes Good For Eyesight )Sweet potatoes are wealthy in beta-carotene and anthocyanin antioxidants, which may help forestall Eyesight Loss and enhance eye well being.

Sweet Potatoes Boost ImmunitySweet potato is a wonderful supply of beta-carotene, which, being transformed to vitamin A, strengthens your immune system.

How to Eat Sweet PotatoesShankarakand means Sweet Potatoes You can embody some ways in your weight loss program. You can roast it, boil it or eat it as uncooked. But its best to roast it and eat it to benefit from the well being advantages of Shankarkand. Because its also straightforward to digest together with tasty.

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Are Options Traders Betting on a Big Move in Tandem Diabetes (TNDM) Stock? – Yahoo Finance

February 16th, 2020 7:44 pm

Investors in Tandem Diabetes Care, Inc. TNDM need to pay close attention to the stock based on moves in the options market lately. That is because the Mar 20, 2020 $60 Put had some of the highest implied volatility of all equity options today.

What is Implied Volatility?

Implied volatility shows how much movement the market is expecting in the future. Options with high levels of implied volatility suggest that investors in the underlying stocks are expecting a big move in one direction or the other. It could also mean there is an event coming up soon that may cause a big rally or a huge sell-off. However, implied volatility is only one piece of the puzzle when putting together an options trading strategy.

What do the Analysts Think?

Clearly, options traders are pricing in a big move for Tandem Diabetes shares, but what is the fundamental picture for the company? Currently, Tandem Diabetes is a Zacks Rank #2 (Buy) in the Medical Instruments industry that ranks in the Top 43% of our Zacks Industry Rank. Over the last 60 days, no analysts have increased their earnings estimates for the current quarter, while one analyst has revised the estimate downward. The net effect has taken our Zacks Consensus Estimate for the current quarter from a loss of 8 cents per share to a loss of 7 cents in that period.

Given the way analysts feel about Tandem Diabetes right now, this huge implied volatility could mean theres a trade developing. Oftentimes, options traders look for options with high levels of implied volatility to sell premium. This is a strategy many seasoned traders use because it captures decay. At expiration, the hope for these traders is that the underlying stock does not move as much as originally expected.

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Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free reportTandem Diabetes Care, Inc. (TNDM) : Free Stock Analysis ReportTo read this article on Zacks.com click here.Zacks Investment Research

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Dance kicks off in Westfield to support diabetes research – WWLP.com

February 16th, 2020 7:44 pm

WESTFIELD, Mass. (WWLP) The Westfield Centennial Lions will be hosting a dance Sunday afternoon to support diabetes research.

According to a news release sent to 22News, the dance will kick off at the Shaker Farms Country Club located on 866 Shaker Road from 2:00 p.m. to 6:00 p.m. Everyone will have the chance to enjoy raffles, a cash bar, light appetizers, a free dance lesson and more!

This event is not a competition. Participants will be showing off their choice of dance including the waltz, foxtrot, country two-step, Rumbo, hustle, cha-cha, mambo, and many others so be prepared to have fun. Dancers do not have to pay admission however, the entrance fee is $10 for others.

Lions focus on raising money for eye research and give back to their community by providing eye exams and glasses to those who qualify. They also focus on supporting other causes such as diabetes. If left untreated, diabetes can cause blindness.

For more information, contact Gary Francis at 413-562-1346.

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Effect of Diabetes on the Performance of Algorithms for the Detection of AMI Without ST-Elevation – Endocrinology Advisor

February 16th, 2020 7:44 pm

The performance of the European Society of Cardiology (ESC) algorithm, ESC 0/1-h, in ruling out acute myocardial infarction (AMI) without ST-elevation was comparable in patients with and without diabetes mellitus (DM), according to a study published in Diabetes Care.

The ESC 0/1-h and 0/3-h algorithms are used to diagnose patients with suspected acute non-ST-elevation myocardial infarction (NSTEMI). The levels of high-sensitivity cardiac troponin (hs-cTn) are often chronically elevated in individuals with DM, rendering it difficult to identify NSTEMI in this patient population. Investigators sought to assess whether the presence of DM affects the diagnostic abilities of 2 ESC algorithms in patients presenting to the emergency department with symptoms indicative of AMI.

In this secondary analysis of 2 studies, the Biomarkers in Acute Cardiac Care (BACC) and stenoCardia trials (ClinicalTrials.gov identifiers NCT02355457 and NCT03227159, respectively), 3,681 patients (mean age, 64.0 years; 64.2% men) with prospectively evaluated suspected acute NSTEMI with (n=563) and without DM, were enrolled. Data from the Advantageous Predictors of Acute Coronary Syndromes study (APACE; n=2895; ClinicalTrials.gov identifier NCT00470587) were used to calculate and externally validate alternative cutoffs for the algorithms.

The levels of hs-cTn were measured at admission, 1 hour (only in the BACC study), and 3 hours (in both studies). Negative and positive predictive values (NPV and PPV, respectively) for NSTEMI were calculated for both algorithms. The studys primary safety outcome was the NPV for NSTEMI (ie, for ruling out the condition), and the primary efficacy outcome was the PPV for ruling in NSTEMI. The sensitivity and specificity of both algorithms were the studys secondary endpoints.

Of 563 participants with DM, 137 (24.3%) had comorbid acute NSTEMI, compared with 15.9% of patients without DM (P <.001). Participants with DM were older and had more cardiovascular risk factors and comorbidities.

The ESC 0/1-h algorithm had a comparable NPV for NSTEMI in patients with and without DM (absolute difference [AD], -1.50; 95% CI, -5.95 to 2.96; P =.54), but the ESC 0/3-h algorithm had a lower NPV in patients with vs without DM (AD, -2.27; 95% CI, -4.47 to -0.07; P =.004). The diagnostic performance to rule-in NSTEMI was comparable for patients with vs without DM with both algorithms: ESC 0/1-h (AD, -6.59; 95% CI, -19.53 to 6.35; P =.34) and ESC 0/3-h (AD, 1.03; 95% CI, -7.63 to 9.7; P =.88).

The sensitivity for ruling out NSTEMI was comparable in patients with vs without DM with both ESC0/1-h (AD, -0.9; 95% CI, -5.1 to 3.3; P =1.00) and ESC 0/3-h (AD, -4.0; 95% CI, -10.4 to 2.4; P =.19) algorithms. The specificity for ruling in NSTEMI was higher for patients without vs with DM when using both the ESC 0/1-h (AD, -6.9; 95% CI -12.5 to -1.2; P =.0035) and ESC 0/3-h (AD, -4.4; 95% CI, -8.2 to 0.6; P =.01) algorithms. The use of alternative cutoffs improved the PPV of both algorithms.

Study strengths include large sample sizes and external validation of proposed alternative cutoffs. Study limitations include the sole use of data from the BACC study to evaluate the 0/1-h algorithm, possible misclassification of AMI and DM, and a lack of accounting for disease duration.

Although alternative cutoffs might be helpful, patients with DM remain a high-risk population in whom identification of AMI is challenging and who require careful clinical evaluation, noted the authors.

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Reference

Haller PM, Boeddinghaus J, Neumann JT, et al. Performance of the ESC 0/1-h and 0/3-h algorithm for the rapid identification of myocardial infarction without ST-elevation in patients with diabetes. Diabetes Care. 2019;43(2):460-467. doi: 10.2337/dc19-1327

This article originally appeared on The Cardiology Advisor

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Diabetic retinopathy as an indicator of other serious health risk – Diabetes.co.uk

February 16th, 2020 7:44 pm

The risk of experiencing a stroke has been shown to be higher in individuals with diabetic retinopathy.

The latest findings from the ACCORD Eye study (Action to Control Cardiovascular Risk in Diabetes) were unveiled at the International Stroke Conference.

Diabetic retinopathy is a common diabetes complication which is caused by consistent high blood sugar levels damaging the back of the eye.

According to the World Health Organisation, diabetic retinopathy is the cause of visual impairment for 4.2 million people.

Lead author Dr Ka-Ho Wong, said: As we know, large-artery atherosclerosis and atrial fibrillation are the primary causes of ischemic stroke. However, microvascular disease of the brain is also a cause of stroke and of vascular dementia.

Diabetic retinopathy is a common microvascular complication of diabetes, and we hypothesized that retinopathy would be an important biomarker of stroke risk in diabetic patients, and one that may precede ischemic stroke.

The research involved analysing the eyes of 2,828 people with diabetes. Just over five years later the researchers followed up with the participants and found that 117 people had experienced a stroke.Among those who experienced a stroke, 41% had diabetic retinopathy, whereas only 30.5% of people who did not have experience a stroke had diabetic retinopathy.

Dr Wong said: Patients with established diabetic retinopathy should pay particular attention to meeting all stroke prevention guidelines established by the American Heart Association.Because diabetic retinopathy is more common in patients with uncontrollable diabetes, and diabetic retinopathy increases the risk of having a stroke, it is important for patients to maintain good control of their diabetes.

This research raises the question of whether there is a specific vascular disease pathogenesis in patients with diabetic stroke. Currently, we do not have ongoing follow-up studies, but we are interested in proposing a prospective observational trial in stroke patients with baseline diabetic retinopathy to determine the most common mechanism of stroke in these patients, which would have important implications for prevention efforts.

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Type 2 diabetes can be reversed even after years of having the condition – this is how – inews

February 16th, 2020 7:44 pm

OpinionType 2 diabetes is not an inevitable life sentence. In 2020, the condition looks very different

Wednesday, 12th February 2020, 7:00 am

The idea that type 2 diabetes is a lifelong disease has been ingrained for so long. But the research explained in my new book, Life Without Diabetes, shows this is not necessarily true. As this is a condition that costs 10 per cent of NHS expenditure, that is good news.

Return to normal health is possible for almost everyone in the first few years of type 2 diabetes. Some people can achieve this even after many years of diabetes. Our research in Newcastle has shown exactly what causes type 2 diabetes for the first time and has traced both the underlying processes of returning to normal and the gruesome processes of developing the disease.

The role the liver and pancreas play

i's opinion newsletter: talking points from today

We measured the critical items in the two important organs of type 2 diabetes - liver and pancreas. In liver, we measured the fat content and the response to insulin control of sugar production. In the pancreas we developed new techniques to measure the fat content and the production of insulin. We were amazed to see that the hypothesis we tested was exactly correct: in the liver, fat content and insulin response were normal within seven days (so blood glucose first thing in the morning dropped to normal); and in the pancreas there was a gradual fall in fat content over eight weeks which was mirrored by a return to near normal insulin production.

The nub of the matter is removing the damaging effects of excess fat delivered to the insulin producing cells of the pancreas. Excess fat builds up first in the liver. Then the liver supplies excess fat to all tissues of the body including the pancreas. Not everyone is susceptible to this fat induced damage to the pancreas, but for those unlucky enough to be so disposed, the major hormone insulin can no longer be produced rapidly enough.

And the solution? Weight loss of about 15kg sounds impossible, but by developing a humanly possible, effective method we have been show that this can be done in a matter of weeks by anyone with motivation to return to health.

The greater challenge is preventing weight regain in the face of the slings and arrows that are part of everyday life. This is not easy, but many people have demonstrated that by following simple changes to habits it can be done. There is no magic diet individuals suit different approaches but a long term way of living life to the full can be successful.

Type 2, obesity and BMI

It's widely believed type 2 diabetes is due to obesity.But a glance at the hard information shows that this is simply untrue. One in two people developing the disease have a body mass index (BMI) under 30 and are not obese. So if half are obese and half are not, maybe there are two different diseases? Not so, as the underlying mechanisms have been shown to be the same over the range of BMIs. In fact one in 10 people have a normal BMI at the time of diagnosis and in contrast around three quarters of people with BMI over 45 do not have type 2 diabetes.

The truth is that we are all individuals, and simple statistical categorisation by BMI is inappropriate. Those of us with a genetic set to live in a body of BMI 25 may well get type 2 diabetes if their weight rises to 28. And those who have normal metabolism with a BMI of 34 may get the disease if they put on weight to say, a BMI of 37. The reverse process is useful to consider, as it is now very clear that someone with a BMI of 37 can return to normal sugar control and normal blood fats with a BMI of 34. That is why the 15kg weight loss target is appropriate for most people: as everyone has a personal threshold above which they will develop type 2 diabetes. It is nothing to do with the fixed BMI concept of obesity.

In other words, we all have a personal fat threshold above which mischief will start happening. This has been rather obscured by the present popularity of population level information to drive beliefs about what is relevant for individuals. But there is a clear bottom line: if a person has true type 2 diabetes, then they have become too heavy for their body.

Eating sweet things and high blood sugar

It's also widely believed that eating sweet things is the cause of high blood sugar. When you wake in the morning, all the sugar in your blood has been made by you by your liver. No molecule of sugar in the blood will have come directly from what was eaten yesterday. In type 2 diabetes the normal restraint on overproduction of sugar by the liver is lost, because the liver becomes resistant to the action of insulin. In turn, that is because there is too much fat inside the liver preventing insulin working normally. When you eat you get a double whammy: all your carbs are turned into sugar during digestion, and this load is additional to the outpouring of sugar from your liver which continued throughout the 24 hours. Certainly eating a lot of sugar or carbs with type 2 diabetes will make the blood sugar even higher, but the basic problem is lack of normal functioning of the hormone insulin. Loss of fat from liver and pancreas restores this.

So type 2 diabetes is not all doom, gloom and an inevitable life sentence. In 2020, the condition looks very different.

Life Without Diabetes by Professor Roy Taylor is published by Short Books, 9.99

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‘Complex’ issue of type 1 diabetes to be addressed in Australian schools – NEWS.com.au

February 16th, 2020 7:44 pm

Diabetes Australia Program Manager Renza Scibila has spoken with Sky News about the "complex" condition and a new program which is aimed at raising awareness and training for students with the disease. The 'Diabetes in Schools program' aims to develop a deliver a nationally consistent training program for both school-staff and teachers, to be able to safely administer and manage students who are impacted by the disease. Currently 25 percent of parents with children with type 1 diabetes are having to visit schools to administer insulin to their children. "There hasn't been a collaborative approach and we have that now with our new 'Diabetes in Schools Program'," Ms Scibila said. "Type 1 diabetes is a really complex condition so parents don't just send their kids off at the beginning of the day and then not think about it again."[For] children with diabetes, their management happens at home and then throughout the school day and then at the end of the day and overnight as well."

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My Third Stem Cell Treatment for MS – Everyday Health

February 15th, 2020 5:46 pm

Since 2014, I have had three stem cell treatments, each time hoping it would help fight off the progression of my multiple sclerosis (MS) symptoms. Because the procedures Ive undergone do not have a very long history of use or many studies to support them, Ive basically made myself a guinea pig by trying them.

So far, Ive experienced failure and success, but overall, the positives have been life-changing for me. I am continuing down this path of healing because there is currently no cure for MS, and now that Im 61, time is not on my side for a cure to be discovered!

In 2014, I had a procedure in which adult stem cells were isolated from my fat tissue, grown in a lab, and reinfused into my body. Initially I had great results, but they were short-lived, and within three months, all my MS symptoms had returned.

In 2018, I had a different type of procedure, in which 300 million stem cells derived from umbilical cord tissue were infused into my arm. I wrote about my experience in a blog just two months after that infusion. At the time, I was having a positive response, but I was also skeptical, since I had seen similar early improvements in 2014.

Two weeks after my 2018 treatment, my left-side drop foot was gone, I could jump off the floor, and I had regained some feeling in my left arm. But I needed to give this new stem cell treatment some more time before I could positively state that this one had worked. So I waited and kept working out in the gym as I have always done, pushing myself harder as time went by.

I found my body getting stronger and stronger as the months passed, and I even filmed myself squatting 500 pounds and posted it in our MS Fitness Challenge GYM Facebook group to show the community that I was not just imagining the results.

Months after the treatment, my left leg was almost as good as my right one, which has never been affected by MS, and my overall strength was increasing.

By the eighth month or so, I was running on the treadmill, and at approximately nine months post-infusion, I was jumping rope. I had not run or jumped rope in almost 14 years.

I was and am extremely happy with what my legs are now capable of, but I only got partial feeling back in my left arm and hand, and I want that back the same way I have my left leg back.

With that goal in mind, I reached out to the doctor who had performed my stem cell procedures and asked if I was eligible for more cells. I also asked if he thought more cells would bring back the feeling in my left arm and hand.

His response was that no one had predicted what results I would get from the 2018 treatment, and here I was running, jumping rope, and squatting like a champion. So we had nothing to lose by transfusing another 300 million cells into my body. We both thought that since my leg no longer needed the stem cells, maybe they would find their way to my arm!

Theoretically, stem cells go where theyre needed to repair the damage.It seemed worth a shot, so I booked my flight to the Cayman Islands for a January 2020 infusion. And now I am home.

Its only been a few weeks, but I can already feel hot and cold in my left hand, which I have not been able to do since 2006, when I was diagnosed.

Again, I am cautiously optimistic that I will get similar results in the areas I need them now. But only time will tell. All I can say is that this therapy has changed my life, and I am hopeful that an ongoing clinical trial of the stem cell treatment I received will provide evidence that it will also be helpful to others with MS.

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Indian doctors fix Yemeni man’s face in rare reconstructive surgery – The New Indian Express

February 15th, 2020 5:46 pm

By Express News Service

NEW DELHI: A 26-year-old man from Yemen received a fresh lease of life through a rare reconstructive surgery, performed by a team of Indian doctors. A few months back, the patients face and mouth was left completely disfigured after a mobile phone exploded while he held it between his teeth. Apart from severe disfigurment, the accident rendered him incapable to eat and speak properly.

The patient was admitted at KAS Medical Centre in the national capital where a team of facial reconstruction surgeons headed by Dr. Ajaya Kashyap performed a rare surgical procedure to give him his normal facial features back. As per the doctors, the blast was so strong that it burnt the inside of his mouth, tore up the muscles and the tongue leaving all the soft tissues damaged.

As the blast happened inside the mouth, the injury was rather unusual. After much assessment, the team decided to use flaps of tissue from inside the mouth as well as fat tissues from his body and use it as a flap. Ensuring facial sensations was another challenge. We are happy that the procedure went well and the patient regained his normal features, said Kashyap, Medical Director, KAS Medical Centre.

The muscles of the lips which had been split apart were repaired and flaps were used to close it. Autologous fat with stem cells and PRP were injected to restore volume and improve scarring.

The surgery was done a week back and now he is ready to fly back to his own country, added Kashyap.

Mobile phone blasts have lead to serious injuries in India. The most common reasons for a cell phone to explode are using it while the phone is being charged. Charging puts pressure on the device, using it during charging increases this pressure manifold. This causes cheap electronic components in some mobiles to explode.

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Fountain of Youth within reach without surgery – KIIITV.com

February 15th, 2020 5:46 pm

CORPUS CHRISTI, Texas In today's world, millions are spent on cosmetic surgery to keep that healthy glow everywhere we go. However, if you don't have thousands of dollars to pay for it, there are other, more safe alternatives that are non-surgical.

A few years ago I started noticing that no matter how much sleep I got, I just didn't look as fresh as I did when I was younger. I thought maybe it was time to talk to a professional about how I could get back that youthful appearance.

Stress, the daily rigor of life, and gravity all take their toll on the face, and there's nothing wrong with admitting you need a little help to look and feel a little better.

I visited with Dr. Vijay Bingdingdavale, a local cosmetic surgeon, to address my concerns and explore some options. The first thing he suggested was injections to relax my forehead area.

"That'll lift the eyebrows as well. What happens is when we inject these two areas, your eyebrows come a little bit higher, and giving you more of a refreshed look," Dr. Bingdingdavale said.

Then adding fullness to the upper cheeks would bring some balance to my face.

"You see how when you have a little bit more cheek fullness it harmonizes the face? It lifts this and fill this in as well," Dr. Bingdingdavale said.

Using fat transfer as opposed to artificial fillers has an additional benefit.

"We see this a lot, because there are stem cells in the fat, it makes the overlying skin more refreshed and more young-looking," Dr. Bingdingdavale said.

In the end, that's what we all want -- a more refreshed appearance even if we don't get our eight hours every night.

You can catch Dr. Vijay Bingdingdavale on First Edition on Sundays discussing skin care and healthy living.

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Get ready for micro HIIT: the seven-minute workout that could transform your body, and your life – Telegraph.co.uk

February 15th, 2020 5:46 pm

Its cold, its dark, and youve got zero motivation. Well, one trainer has good news for you: you only need to commit to seven minutes, three to four times a week. Not only could you lose weight and build muscle something thats essential for everyone over the age of 30 but it builds up bone density and targets belly fat, a common midlifer problem. Sounds do-able, right?

HIIT is nothing new you see people doing it in their local park every weekend. But Zana Morris, personal trainer and founder of The Clock gyms in London, has a unique take: we need to do it much harder and for a much shorter time. "You should be totally exhausted after six reps, Morris says, then you move on to the next exercise.

"The key is to think of it like sprint training: you wouldnt sprint for 45 minutes, you run all out for a few minutes. Its the same with HIIT when youre doing it right its about short, sharp bursts.

When I join Morris well-heeled, mainly middle-aged clients at her luxe Marleybone gym for a month in December, I do a different circuit on each visit, either legs and bum, shoulders and arms or back and chest, and am out the door in under 10 minutes. Its a get in, get on, get the job done approach, Morris laughs.

Her approach, which she has been honing for more than 20 years, is backed up by a plethora of research, including a recent study in The American College of Sports Medicine (ACSM) Journal which found that seven minutes was enough to get the fitness benefits. You really can see a difference fast when you do seven minute really intense sessions, Morris says. On average, when you team it with the right nutrition, we see clients lose around 6-7lbs of fat and gain 2-3lbs of muscle.

The reason, Morris explains, is down to our hormones, particularly insulin levels. Any weight around our middle is insulin related, she says. Put simply, insulin, the hormone that regulates the levels of glucose in the blood, can cause weight gain when the cells absorb too much glucose or blood sugar and convert it into fat. Not only can it make you fatter, but in a catch-22 situation, increased body weight can also lead to higher insulin levels. Sleep affects your insulin levels, as does eating carb-heavy or sugary foods and stress all midlifer concerns.

But micro HIIT sessions can reverse that a study published in the journal Frontiers found that a ten-week HIIT training programme in sedentary adult women at risk for type-2 diabetes had positive effects on their insulin levels, while a separate Brazilian study confirmed the same thing, looking at sleep-deprived men and the effect that HIIT had on their insulin levels.

Theres an added benefit to performing HIIT, according to Pamela Peeke, assistant professor of medicine at the University of Maryland and Equinox Health Advisory Board member: The healthy stress your body undergoes during HIIT triggers autophagy, which rids your body of cellular debris and stimulates the production of stem cells, the primary regenerative cells in the body. The more stem cells you have, the better you are able to induce super autophagyits a cycle. Think of it as a spring-clean for your cells.

Peeke recommends HIIT training three times per week plus find every opportunity to add one, two, three minutes of HIIT to your day." Such as doing as many squats as you can in a minute while you wait for the kettle to boil or racing for the bus at a full-out pelt.

But for added benefit, as Morris has found with herself (she has roughly the same body composition now shes in her mid-forties as she did as a 20-year-old) and her clients, is to add in weights. After the age of thirty, we lose between 3-5pcof muscle per decade in a process called sarcopenia (most men will lose about 30pcof their muscle mass during their lifetimes). Its problematic because it not only leads to diminished strength as we get older, but makes us more prone to breakages, according to a study from the American Society for Bone and Mineral Research.

More pressingly, the amount of muscle you have has affects on your weight. Its estimated that 1lb of muscle burns about 50-100 calories per day, Morris explains. So, by the time youre 40, if youve already lost around 5lbs of muscle due to natural age-related wastage, you would need 500 calories less per day. But not many of us reduce our calorific intake in fact, we often increase it. The antidote is to try to rebuild that muscle.

When I train with Morris for four weeks over December, I build up my strength surprisingly quickly. In four weeks I am able to lift 110 kgs on the bench press machine, up from 80kgs at the start. In a month I gain 2.5 lbs of muscle taking me back to my twenty-something levels.

While having a trainer on hand to set your weights up is a luxury, the exercises are easy to replicate at home or in your own gym. You can do 60 squats in a minute, or as many as you can do, or swimming sprints in your pool. You can do it with almost any exercise, Morris says. But dont in the zeal of January restarts think that more is better. In fact, going over the 30-minute mark has negative effects on our ability to build muscle because we start to produce cortisol, which can lead to muscle atrophy. Morris shudders when she thinks of midlifers doing marathons and triathlons (I darent tell her Im one of them).

At the same time nutritionist Mackenzie Dumas looks at my diet. She points out that theres little point training if Im going to continue with my nightly Maltesers/ half a bottle of wine habit. For the first 12 days Im on a high fat, low carbohydrate diet which comprises of a lot of avocado and eggs, and almost zero carbs. During this period, I lose eight pounds of fat, according to Dumas callipers. Then she moves me onto a more sustainable high protein, low carbohydrate diet, which is broadly what the surgeon Dr Andrew Jenkinson author of Why We Eat (Too Much), recently recommended in The Telegraph.

The month under Morris's guidance has been a huge re-education in fitness. Out goes the half-hearted Sunday morning boot campbootcamp in the park, replaced by seven-minute power sessions with my kettlebell.

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Mobile blast in mouth injure Yemen youth, gets fresh lease of life with facial reconstruction surgery in India – Devdiscourse

February 15th, 2020 5:46 pm

A 26-year-old youth from Yemen, Saad-Ul- Haq (name changed) has received a fresh lease of life by getting his normal face back through a rare reconstructive surgery, performed by a team of Indian doctors. A few months back, Saad's face and mouth was left completely disfigured after a mobile blasted in his mouth which he had held between his teeth while doing some work.

Apart from severe disfiguring, the accident rendered him incapable to eat and speak normally, said doctors. Team of facial Reconstruction Surgeons headed by Dr Ajaya Kashyap performed a rare surgical procedure to give Saad his normal facial features back.

The blast was so strong that it burnt the inside of his mouth, tore up the muscles and the tongue leaving all the soft tissues damaged, said the doctors. Dr Ajaya Kashyap, Medical Director, KAS Medical Centre, New Delhi said "As the blast happened inside the mouth, the injury was rather unusual. After much assessment, the team decided to use flaps of tissue from inside the mouth as well as fat tissues from his body and use it as a flap. Ensuring facial sensations was another challenge. We are happy that the procedure went well and the patient regained his normal features."

"The muscles of the lips which had been split apart were repaired and flaps were used to close it. Autologous fat with stem cells and PRP were injected to restore volume and improve scarring. The surgery of Saad was done a week back and now he is ready to fly back to his own country," said Dr Kashyap. Sharing his experience in India, Saad (patient) said, "The blast had taken everything that was positive in me. Unable to eat and speak, just a few months ago I was the most hopeless man. When we started off from Yemen, all I hoped was to get my normal features back. For me, the surgery has changed everything. Now I can get settled in my life and get married to my girl without feeling insecure about my looks." (ANI)

(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)

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Is soaking in a frozen lake the secret to good health? – The Detroit News

February 15th, 2020 5:44 pm

Richard Chin, Star Tribune (minneapolis) Published 5:55 p.m. ET Feb. 11, 2020

Ponce de Leons search for the fountain of youth in Florida is just a legend.

But about 1,500 miles to the north, in the icy waters of Cedar Lake in Minneapolis, dozens of people think theyve found the next best thing.

On a recent Sunday around 9:30 a.m., a diverse group of about 20 people dressed in swimsuits trekked to a spot near the shore on the west side of the lake and immersed themselves in an 8-by-12-foot rectangular hole cut in the ice. Later in the day, another group of people gathered to do the same thing.

This isnt a once-a-year, get-in, get-out, New Years Day plunge for Instagram bragging rights.

Throughout the winter, biohackers maintain a hole in the ice chopped into Cedar Lake in Minneapolis in the belief that regular cold water immersions make them healthier.(Photo: Richard Tsong-Taatarii / TNS)

This is something that happens every Sunday throughout the winter.

Some people come several times a week, and stay for a good, long soak of five, 10, 15 minutes or more. Except for the knit hats, they look like they could be relaxing in a hot tub as they stand in water that ranges from waist- to neck-deep.

Called cold therapy or cold thermogenesis, ice-water bathing is a practice that biohackers and assorted others believe makes them healthier.

The Twin Cities Cold Thermogenesis Facebook group, which was created in 2016, claims the frigid dips do everything from increase testosterone in men to boosting brown adipose tissue. (The so-called brown fat or good fat may be helpful in combating obesity because it burns calories to create heat.)

Cold-water immersion also strengthens the immune system, according to Svetlana Vold, a part-time firefighter and ultramarathon winter bike racer from St. Louis Park, who organizes the Sunday morning cold-immersion session.

Vold and others say chilling out in the water combats inflammation, helps them sleep better and improves their focus and endurance. Some said theyre inspired by Wim The Iceman Hof, a Dutchman famous for his breathing and cold exposure technique called the Wim Hof Method.

The Cedar Lake group would probably meet the approval of David Sinclair, a Harvard genetics professor and longevity expert who thinks that cold exposure may help slow the aging process.

Maria OConnell, the organizer of the afternoon session, has been immersing herself in an ice-filled horse trough in her backyard since 2011. Initially its a little uncomfortable, she said. You end up getting better the more you do it.

But many say the frigid dunks are a mood-altering, even pleasurable experience.

It hurts so damn good, said Stephen McLaughlin, a 61-year-old Minneapolis resident. You are just completely present.

It makes me happy. I think its adrenaline, said Allison Kuznia, 42, of Minneapolis.

Its kind of a treat to go out and get really cold, said Nick White, 46, of Minneapolis. It gives you a feeling of euphoria.

Read or Share this story: https://www.detroitnews.com/story/life/wellness/2020/02/11/soaking-frozen-lake-secret-good-health/41217451/

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My Corner, Your Corner: Gone, but never to be forgotten – The Sunday Dispatch

February 15th, 2020 5:44 pm

It was a rough two weeks for notables in Greater Pittston.

We lost centurion Michael Augello, and local musicians Charles Infantino and Ralph Barber.

Charles and Ralph lost their lives at a time when, at 67 and 65, respectively, there is a lot more living to do.

Charles and Ralph were music people where Charles played bass guitar and trombone and, I believe, Ralph played bass, as well.

Ralph played with the New York Times Band for over 30 years. If you never heard the band play, you missed out.

We also lost former PA State Police Trooper, Luzerne County sheriff and former West Pittston councilman Barry Stankus. Lets not forget his duties in the deli at Gerritys Market in West Pittston. Barry was 69 again, way too soon.

Barry was a great guy and loved by many; he was a West Pittstonian through and through growing up there, graduating from Wyoming Area, serving there and working in the community.

At 100 years old, Mr. Augello was definitely in the plus range. Not only did he live a long life, he was productive just about every single year of his life.

There are a few people I can think of in that age range who were very active in their later years like Bill Hastie, of West Pittston; Dr. John Markarian, also of West Pittston; and our buddy Chester Montante, all over 100.

I just met Hank Cordy, an Avoca native now living at Wesley Village, whos pretty active himself. I had the chance to write about Hank and everyone loved his success to a long life a nip and a nap a nip of booze and a nap to go with it. Not a bad idea, dont you think?

A decade ago, turning 100 was something so far-fetched it didnt seemed possible and was very rare. Ive covered my fair share of 100-year-old birthdays over the last several years.

John Markarian will turn 103 on June 7. From what I hear, it wasnt too long ago John was still hitting the links on the golf course. Ill have some of whatever hes eating.

Genetics, environment and what you eat assuredly play a roll in longevity. It always amazes me when I meet someone whos 100 yeas old and sharp. Most dont even look close to their age.

I met Josephine Lazzari in 2013. She was 100 years old at the time and I would have bet the farm she wasnt a day over 80. She was a member of the Blooms and Bubbles Chapter of the Red Hat Society.

I had the assignment of taking a photo of the Red Hats at Fox Hill Country Club where they were honoring Josephine on her 100th birthday. I walked into the small room filled with women in their red hats. As I stood near the table, I looked around, carefully trying to eye someone I thought could have been 100.

I got a glimpse of some of the women with walkers and canes and, yes, I was stereotyping at the time, but I had no idea which one was the guest of honor.

So I spoke up, Which one of you would be the birthday girl? No one raised their hand but, as I was scanning the room, the person sitting near me tugged on my jacket. I looked down and it was Josephine.

Naturally, my first reaction was, Youre not 100 years old!

I gathered the ladies and told them we would take the group photo in the lobby area. There was music playing throughout the PA system and, when the women started making their way to the lobby, Josephine got out of her chair and danced to the music on the way.

I was amazed at the energy she had. But what really shocked me was, she told me she had a major heart attack at the age of 80. This woman made the best of her life for the next 21 years. She said the secret of her life was to love everyone.

Josephine penned an article when she turned 100 stemming from that birthday party at Fox Hill.

The article appeared in the Sunday Dispatch on April 25, 2013 two days before her 100th birthday.

She said, Celebrating my 100th birthday has been like a Polish wedding. I have been honored and remembered by the St. Joseph Senior Social Club, the members of the Altar and Rosary Society of St. John the Evangelist Parish Community, my sister Red Hats of Blooms and Bubbles of Greater Pittston, the officials, firefighters and policemen of Pittston City and, on my birthday on April 27, with a family and friends party. I am very grateful to all who remembered me.

I sure havent forgotten Josephine and her zest for life at 100 years of age.

I wont forget Charles and all he touched, along with his contagious smile and his love of family, church and God.

I wont forget Barry and I wont forget Ralph and his musical talent.

I wont forget how, at 100, it was important to Michael Augello to get up every morning to make soup for his customers.

Rest easy you will never be forgotten.

Quote of the week

Just as a candle cannot burn without fire, men cannot live without a spiritual life. Buddha

Thought of the week

Love shall be our token; love be yours and love be mine. Christina Rossetti

Bumper sticker

Things are beautiful if you love them. Jean Anouilh

Reach the Sunday Dispatch newsroom at 570-991-6405 or by email at sd@psdispatch.com.

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13 Habits Linked to a Long Life (Backed by Science)

February 15th, 2020 5:43 pm

Many people think that life expectancy is largely determined by genetics.

However, genes play a much smaller role than originally believed. It turns out that environmental factors like diet and lifestyle are key.

Here are 13 habits linked to a long life.

The link between calorie intake and longevity currently generates a lot of interest.

Animal studies suggest that a 1050% reduction in normal calorie intake may increase maximum lifespan (1).

Studies of human populations renowned for longevity also observe links between low calorie intake, an extended lifespan, and a lower likelihood of disease (2, 3, 4).

What's more, calorie restriction may help reduce excess body weight and belly fat, both of which are associated with shorter lifespans (5, 6, 7).

That said, long-term calorie restriction is often unsustainable and can include negative side effects, such as increased hunger, low body temperature, and a diminished sex drive (3).

Whether calorie restriction slows aging or extends your lifespan is not yet fully understood.

Nuts are nutritional powerhouses.

They're rich in protein, fiber, antioxidants, and beneficial plant compounds. Whats more, theyre a great source of several vitamins and minerals, such as copper, magnesium, potassium, folate, niacin, and vitamins B6 and E (8).

Several studies show that nuts have beneficial effects on heart disease, high blood pressure, inflammation, diabetes, metabolic syndrome, belly fat levels, and even some forms of cancer (9, 10, 11, 12).

One study found that people who consumed at least 3 servings of nuts per week had a 39% lower risk of premature death (13).

Similarly, two recent reviews including over 350,000 people noted that those who ate nuts had a 427% lower risk of dying during the study period with the greatest reductions seen in those who ate 1 serving of nuts per day (14, 15).

When it comes to anti-aging strategies, turmeric is a great option. Thats because this spice contains a potent bioactive compound called curcumin.

Due to its antioxidant and anti-inflammatory properties, curcumin is thought to help maintain brain, heart, and lung function, as well as protect against cancers and age-related diseases (16, 17, 18, 19, 20, 21, 22).

Curcumin is linked to an increased lifespan in both insects and mice (23, 24, 25).

However, these findings have not always been replicated, and no human studies are currently available (26, 27).

Nevertheless, turmeric has been consumed for thousands of years in India and is generally considered safe.

Consuming a wide variety of plant foods, such as fruits, vegetables, nuts, seeds, whole grains, and beans, may decrease disease risk and promote longevity.

For example, many studies link a plant-rich diet to a lower risk of premature death, as well as a reduced risk of cancer, metabolic syndrome, heart disease, depression, and brain deterioration (28, 29, 30, 31).

These effects are attributed to plant foods nutrients and antioxidants, which include polyphenols, carotenoids, folate, and vitamin C (32).

Accordingly, several studies link vegetarian and vegan diets, which are naturally higher in plant foods, to a 1215% lower risk of premature death (33, 34).

The same studies also report a 2952% lower risk of dying from cancer or heart, kidney, or hormone-related diseases (33, 34).

Whats more, some research suggests that the risk of premature death and certain diseases increases with greater meat consumption (35, 36, 37).

However, other studies report either nonexistent or much weaker links with the negative effects seeming specifically linked to processed meat (38, 39).

Vegetarians and vegans also generally tend to be more health-conscious than meat eaters, which could at least partly explain these findings.

Overall, eating plenty of plant foods is likely to benefit health and longevity.

It should come as no surprise that staying physically active can keep you healthy and add years to your life (40).

As few as 15 minutes of exercise per day may help you achieve benefits, which could include an additional 3 years of life (41).

Furthermore, your risk of premature death may decrease by 4% for each additional 15 minutes of daily physical activity (41).

A recent review observed a 22% lower risk of early death in individuals who exercised even though they worked out less than the recommended 150 minutes per week (42).

People who hit the 150-minute recommendation were 28% less likely to die early. What's more, that number was 35% for those who exercised beyond this guidance (42).

Finally, some research links vigorous activity to a 5% greater reduction in risk compared to low- or moderate-intensity activities (43).

Smoking is strongly linked to disease and early death (44).

Overall, people who smoke may lose up to 10 years of life and be 3 times more likely to die prematurely than those who never pick up a cigarette (45).

Keep in mind that it's never too late to quit.

One study reports that individuals who quit smoking by age 35 may prolong their lives by up to 8.5 years (46).

Furthermore, quitting smoking in your 60s may add up to 3.7 years to your life. In fact, quitting in your 80s may still provide benefits (44, 46).

Heavy alcohol consumption is linked to liver, heart, and pancreatic disease, as well as an overall increased risk of early death (47).

However, moderate consumption is associated with a reduced likelihood of several diseases, as well as a 1718% decrease in your risk of premature death (47, 48).

Wine is considered particularly beneficial due to its high content of polyphenol antioxidants.

Results from a 29-year study showed that men who preferred wine were 34% less likely to die early than those who preferred beer or spirits (49).

In addition, one review observed wine to be especially protective against heart disease, diabetes, neurological disorders, and metabolic syndrome (50).

To keep consumption moderate, it is recommended that women aim for 12 units or less per day and a maximum of 7 per week. Men should keep their daily intake to less than 3 units, with a maximum of 14 per week (51).

It's important to note that no strong research indicates that the benefits of moderate drinking are greater than those of abstaining from alcohol.

In other words, there is no need to start drinking if you don't usually consume alcohol.

Feeling happy can significantly increase your longevity (52).

In fact, happier individuals had a 3.7% reduction in early death over a 5-year study period (53).

A study of 180 Catholic nuns analyzed their self-reported levels of happiness when they first entered the monastery and later compared these levels to their longevity.

Those who felt happiest at 22 years of age were 2.5 times more likely to still be alive six decades later (54).

Finally, a review of 35 studies showed that happy people may live up to 18% longer than their less happy counterparts (55).

Anxiety and stress may significantly decrease your lifespan.

For instance, women suffering from stress or anxiety are reportedly up to two times more likely to die from heart disease, stroke, or lung cancer (56, 57, 58).

Similarly, the risk of premature death is up to three times higher for anxious or stressed men compared to their more relaxed counterparts (59, 60, 61).

If you're feeling stressed, laughter and optimism could be two key components of the solution.

Studies show that pessimistic individuals have a 42% higher risk of early death than more optimistic people. However, both laughter and a positive outlook on life can reduce stress, potentially prolonging your life (62, 63, 64, 65).

Researchers report that maintaining healthy social networks can help you live up to 50% longer (66).

In fact, having just 3 social ties may decrease your risk of early death by more than 200% (67).

Studies also link healthy social networks to positive changes in heart, brain, hormonal, and immune function, which may decrease your risk of chronic diseases (68, 69, 70, 71, 72).

A strong social circle might also help you react less negatively to stress, perhaps further explaining the positive effect on lifespan (73, 74).

Finally, one study reports that providing support to others may be more beneficial than receiving it. In addition to accepting care from your friends and family, make sure to return the favor (75).

Conscientiousness refers to a person's ability to be self-disciplined, organized, efficient, and goal-oriented.

Based on data from a study that followed 1,500 boys and girls into old age, kids who were considered persistent, organized, and disciplined lived 11% longer than their less conscientious counterparts (76, 77).

Conscientious people may also have lower blood pressure and fewer psychiatric conditions, as well as a lower risk of diabetes and heart or joint problems (78).

This might be partly because conscientious individuals are less likely to take dangerous risks or react negatively to stress and more likely to lead successful professional lives or be responsible about their health (79, 80, 81).

Conscientiousness can be developed at any stage in life through steps as small as tidying up a desk, sticking to a work plan, or being on time.

Both coffee and tea are linked to a decreased risk of chronic disease.

For instance, the polyphenols and catechins found in green tea may decrease your risk of cancer, diabetes, and heart disease (82, 83, 84, 85, 86).

Similarly, coffee is linked to a lower risk of type 2 diabetes, heart disease, and certain cancers and brain ailments, such as Alzheimer's and Parkinson's (87, 88, 89, 90, 91, 92).

Additionally, both coffee and tea drinkers benefit from a 2030% lower risk of early death compared to non-drinkers (93, 94, 95, 96).

Just remember that too much caffeine can also lead to anxiety and insomnia, so you may want to curb your intake to the recommended limit of 400 mg per day around 4 cups of coffee (97, 98).

It's also worth noting that it generally takes six hours for caffeine's effects to subside. Therefore, if you have trouble getting enough high-quality sleep, you may want to shift your intake to earlier in the day.

Sleep is crucial for regulating cell function and helping your body heal.

A recent study reports that longevity is likely linked to regular sleeping patterns, such as going to bed and waking up around the same time each day (99).

Sleep duration also seems to be a factor, with both too little and too much being harmful.

For instance, sleeping less than 57 hours per night is linked to a 12% greater risk of early death, while sleeping more than 89 hours per night could also decrease your lifespan by up to 38% (100, 101).

Too little sleep may also promote inflammation and increase your risk of diabetes, heart disease, and obesity. These are all linked to a shortened lifespan (102, 103, 104, 105).

On the other hand, excessive sleep could be linked to depression, low physical activity, and undiagnosed health conditions, all of which may negatively affect your lifespan (106).

Longevity may seem beyond your control, but many healthy habits may lead you to a ripe, old age.

These include drinking coffee or tea, exercising, getting enough sleep, and limiting your alcohol intake.

Taken together, these habits can boost your health and put you on the path to a long life.

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13 Habits Linked to a Long Life (Backed by Science)

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How to live longer: Drinking this many cups of coffee can boost life longevity – Express

February 15th, 2020 5:43 pm

When it comes to living a life disease-free, filled with energy and happiness and an impressive amount of time - everyone is intrigued. In fact, internet searches on the matter is astronomical with everyone wanting to know what is the secret. A certain hot beverage has been proven to add extra years to ones life and even reduce the risk of developing Alzheimers.

Drinking as little as two cups of coffee a day can increase life expectancy by a staggering two years, according to researchers.

The research, published in the European Journal of Epidemiology, was conducted by analysing previous studies on the health benefits of drinking coffee.

Looking at the 40 studies conducted including 3,852 651 subjects and 450,256 causes of death, researchers found that drinking coffee had an inverse association with all-cause mortality irrespective of age, weight, alcohol consumption, smoking status and caffeine content of coffee.

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In recent years and decades, scientists have studied the effects of coffee on various aspects of health.

The research has shown that coffee doesnt just help to keep you awake - it can also make a person smarter.

Caffeine works in the brain by blocking the effects of an inhibitory neurotransmitter called adenosine.

By blocking the inhibitory effects of adenosine, caffeine actually increases neuronal firing in the brain and the release of other neurotransmitters like dopamine and norepinephrine, improving both mood and brain function.

More here:
How to live longer: Drinking this many cups of coffee can boost life longevity - Express

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