StemCell Therapy

Disease-causing changes or mutations found only in the sperm of the father could predict the risk of autism in children.

A team of scientists, led by researchers from the University of California (UC) San Diego School of Medicine tested the sperm of fathers who were already parents of children with an autism spectrum disorder (ASD). They found that the disease-causing mutations were present in up to 15% of the fathers sperm cells -- information that could not be determined through other means such as blood samples.

The causes of autism spectrum disorder (ASD) in children are not fully understood, and researchers believe that both genetics and the environment have a role to play. In some cases, the disorder is linked to mutations that appear only in the child and are not inherited from either parents DNA.

Clinicians continue to face an ever-increasing incidence of autism spectrum disorders, without effective strategies available to prevent disease or counsel families.

Recent studies suggest gene-damaging spontaneous mutations are involved in at least 10% to 30% of ASD cases. Researchers believe that the number of mutations increases with the fathers age at time of conception. Such mutations occur spontaneously in parents sperm or eggs or during fertilization. When a disease-causing mutation occurs for the first time in a family, the probability that it could happen again in a future child is not known. Thus, families must make a decision with a great deal of uncertainty, say experts.

According to the researchers, they have developed a method to measure disease-causing mutations found only in the sperm of the father and assess chances the mutations will cause disease. The team says the new method -- described in Nature Medicine -- provide expectant parents with a more accurate assessment of autism risk in future children.

Autism afflicts 1 in 59 children and we know that a significant portion is caused by de novo (spontaneous) DNA mutations, yet we are still blind to when and where these mutations will occur, says Dr. Jonathan Sebat, professor and chief of the Beyster Center for Molecular Genomics of Neuropsychiatric Diseases at UC San Diego School of Medicine, in the analysis.

With our new study, we can trace some of these mutations back to the father, and we can directly assess the risk of these same mutations occurring again in future children, says Dr. Sebat, a co-senior author of the study.

The US Centers for Disease Control and Prevention (CDC) describes autism spectrum disorder as a developmental disability that can cause significant social, communication and behavioral challenges. For 2014, the overall prevalence of ASD in the US was estimated at 16.8 per 1,000 (one in 59) children aged 8 years.

There are likely many causes for multiple types of ASD. There may be many different factors that make a child more likely to have an ASD, including environmental, biologic and genetic factors. Most scientists agree that genes are one of the risk factors that can make a person more likely to develop this disorder, says CDC.

For their study, the researchers analyzed the sperm of eight fathers of autistic children. The objective, says the team, was to look for the presence of multiple, genetically different sets of cells in the same person, a condition called mosaicism.

While medical textbooks teach us that every cell in the body has an identical copy of DNA, this is fundamentally not correct. Mutations occur every time a cell divides, so no two cells in the body are genetically identical, says first author Dr. Martin Breuss, an assistant project scientist in the lab of Dr. Joseph Gleeson, also a co-senior study author.

The researchers explain that mosaicism can cause cancer or can be silent in the body. If a mutation occurs early in development, then it will be shared by many cells within the body. But if a mutation happens just in sperm, then it can show up in a future child, but not cause any disease in the father, says Breuss.

The researchers used a technique called deep whole-genome sequencing. They found genetic variants in the children that were matched only in the fathers sperm.

Previously research by the team, says Dr. Gleeson, showed that mosaicism in a child can lead to diseases like epilepsy. Here, we show that mosaicism in one of the parents is at least as important when thinking about genetic counseling, says Dr. Gleeson, professor of neuroscience at UC San Diego School of Medicine and director of neuroscience research at the Rady Childrens Institute for Genomic Medicine.

The researchers said that if the study is developed into a clinical test, fathers could have their sperm studied to determine their precise risk of recurrence in future children. The method might also be applied to men who have not had children yet, but who want to know the risk of having a child with a disease, says the team.

Continued here:
Mutations in a fathers sperm could predict the risk of autism in children: Study - MEAWW

Its been a banner year for First Opinion. We published nearly 500 essays written by more than 600 authors from industry, academia, government, and private life in the United States and beyond. They took on the mundane, like the implications of the Elijah E. Cummings Lower Drug Costs Now Act (aka H.R. 3), and the fanciful, like why we need a Public Domain Day to highlight when drugs go off patent.

Authors addressed the opioid crisis, patent thickets, the personal toll imposed by drug shortages, drug costs, deaths of despair, the oxymoron of having a waiting room in an emergency department, shoddy production of generic drugs by foreign manufacturers, the burgeoning use of artificial intelligence and machine learning in new drug research and development and health care, and much, much more.

Here are the five most widely read First Opinions of 2019. If you didnt get to read them when they first appeared, now is as good a time as any:

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1. 23andMe had devastating news about my health. I wish a person had delivered it Dorothy Pomerantz thought it would be fun to have her DNA analyzed, so she sent her spit to 23andMe. A link in an email took her to the companys website, where she learned she was at very high risk of developing breast and ovarian cancer. Im not the first person to get surprising and terrible news from an at-home genetic testing company. With the increasing popularity of 23andMe, and other companies like it, I wont be the last. But she wished she had gotten the news from a person.

2. Time in range: a new way for people with diabetes to monitor blood sugar More and more people with diabetes are using continuous glucose meters, which measure blood sugar every few minutes. That information offers a new way to evaluate how well someone is controlling his or her diabetes: time in range. The University of Washingtons Dr. Lorena Alarcon-Casas Wright explains how it works.

3. Our child received a devastating diagnosis before she was born. We decided to protect her Allison Chang learned that, at 15 weeks of gestation, her daughter had severe malformations due to trisomy 18, a deadly genetic condition. She and her husband could not protect our daughter from trisomy 18, but we could shield her from any pain or agony that would come with it.

4. I have spinal muscular atrophy. Critics of the $2 million new gene therapy are missing the point Nathan Yates has lived with spinal muscular atrophy for all 30 years of his life. He answers critics upset over the $2.1 million cost of Zolgensma, a new drug to treat the condition, and asks them to take into account its long-term benefits.

5. Ghost networks of psychiatrists make money for insurance companies but hinder patients access to care When Jack Turban started his training to become a psychiatrist, he went looking for a therapist of his own. What he found were ghost networks of mental health providers.

And heres a bonus: Published in July 2018, the essay Physicians arent burning out. Theyre suffering from moral injury was the third most widely read First Opinion of 2019.

On to 2020!

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5 most widely read First Opinions of 2019 - STAT

Scientists adding human brain genes to monkeys its the kind of thing youd see in a movie like Rise of the Planet of the Apes. But Chinese researchers have done just that, improving the short-term memories of the monkeys in a study published in March in the Chinese journal National Science Review. While some experts downplayed the effects as minor, concerns linger over where the research may lead.

The goal of the work, led by geneticist Bing Su of Kunming Institute of Zoology, was to investigate how a gene linked to brain size, MCPH1, might contribute to the evolution of the organ in humans. All primates have some variation of this gene. However, compared with other primates, our brains are larger, more advanced and slower to develop; the researchers wondered whether differences that evolved in the human version of MCPH1 might explain our more complex brains.

Su and his team injected 11 rhesus macaque embryos with a virus carrying the human version of MCPH1. The brains of the transgenic monkeys those with the human gene developed at a slower pace, akin to that of a human, than those in transgene-free monkeys. And by the time they were 2 to 3 years old, the transgenic monkeys performed better and answered faster on short-term memory tests involving matching colors and shapes. However, there werent any differences in brain size or any other behaviors.

But the results arent what has the scientific community buzzing. Some individuals question the ethics of inserting a human brain gene into a monkey an action Rebecca Walker, a bioethicist at the University of North Carolina, argues could be the start of a slippery slope toward imbuing animals with humanlike intelligence. In a 2010 paper, James Sikela, a geneticist at the University of Colorado School of Medicine, and coauthors asked whether a humanized monkey would fit into its society, or would live in inhumane conditions due to its altered genes.

To justify the work, Su and his co- authors suggested that it could provide insights into neurodegenerative and social disorders but they dont describe what those applications might be. I dont really see anything in the paper that would make me think that [the experiment] was necessarily a good idea, says Walker.

Su declined Discovers request for comment, but said in an article for China Daily, Scientists agree that monkey models are at times irreplaceable for basic research, especially in studying human physiology, cognition and disease. And in the research paper, the authors contend that the relatively large phylogenetic distance (about 25 million years of divergence from humans) alleviates ethical concerns. (Rhesus macaques are less like humans in terms of social and cognitive capacities than primates such as chimpanzees, which are more closely related to us.) This greater evolutionary distance suggests it would be harder to wind up with a macaque that acts like a human.

But that reasoning falls flat for Walker. It doesnt really matter when they became differentiated from humans on the phylogenetic tree, she says. Theyre talking about improved short-term memory, which would be putting them sort of closer to us in terms of those cognitive abilities. She thinks manipulating these skills makes the work ethically dubious and requires stronger justification.

While monkeys and humans have similar genomes, Su said in the China Daily article, there are still tens of millions of genetic differences. Changing one gene carefully designed for research will not result in drastic change.

Sikela agrees that such a change may be minor. Still, he wonders about the possibility of finding a gene with a large effect on cognition.

Theres some risky elements to going down this road, Sikela says. One needs to think about the consequences of where this is leading and whats the best way to study these kinds of questions.

Walker also worries about where this work leads. Could we enhance human brains through these methods? she asks. While she thinks were nowhere close to that yet, she notes that science can advance surprisingly quickly. For instance, CRISPR the gene-editing technique that once seemed far removed from human research was used in China to edit the genomes of twins in 2018. (See our No. 11 story of the year, page 32.)

It does feel worrisome to be doing this research in primates, Walker says. And then potentially thinking about how that could be used in humans.

[This story originally appeared in print as "Researchers React to Human Genes in Monkeys."]

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Scientists Put a Human Intelligence Gene Into a Monkey. Other Scientists are Concerned. - Discover Magazine

P. Todd Stukenberg, PhD, of UVAs Department of Biochemistry and Molecular Genetics and the UVA Cancer Center, works in his lab. Credit: Dan Addison | UVA

Scientists at the University of Virginia School of Medicine have discovered a strange new organelle inside our cells that helps to prevent cancer by ensuring that genetic material is sorted correctly as cells divide.

The researchers have connected problems with the organelle to a subset of breast cancer tumors that make lots of mistakes when segregating chromosomes. Excitingly, they found their analysis offered a new way for doctors to sort patient tumors as they choose therapies. They hope these insights will allow doctors to better personalize treatments to best benefit patients sparing up to 40 percent of patients with breast cancer, for example, a taxing treatment that wont be effective.

Some percentage of women get chemotherapy drugs for breast cancer that are not very effective. They are poisoned, in pain and their hair falls out, so if it isnt curing their disease, then thats tragic, said researcher P. Todd Stukenberg, PhD, of UVAs Department of Biochemistry and Molecular Genetics and the UVA Cancer Center. One of our goals is to develop new tests to determine whether a patient will respond to a chemotherapeutic treatment, so they can find an effective treatment right away.

The organelle Stukenberg and his team have discovered is essential but ephemeral. It forms only when needed to ensure chromosomes are sorted correctly and disappears when its work is done. Thats one reason scientists havent discovered it before now. Another reason is its mind-bending nature: Stukenberg likens it to a droplet of liquid that condenses within other liquid. That was the big wow moment, when I saw that on the microscope, he said.

These droplets act as mixing bowls, concentrating certain cellular ingredients to allow biochemical reactions to occur in a specific location. Whats exciting is that cells have this new organelle and certain things will be recruited into it and other things will be excluded, Stukenberg said. The cells enrich things inside the droplet and, all of a sudden, new biochemical reactions appear only in that location. Its amazing.

P. Todd Stukenberg, PhD, of UVAs Department of Biochemistry and Molecular Genetics and the UVA Cancer Center, discovered an unknown organelle in our cells that helps ensure genetic material is sorted correctly when cells divide. Credit: Dan Addison | UVA

Its tempting to think of the droplet like oil in water, but its really the opposite of that. Oil is hydrophobic it repels water. This new organelle, however, is more sophisticated. Its more of a gel, where cellular components can still go in and out but it contains binding sites that concentrate a small set of the cells contents, Stukenberg explained. Our data suggests this concentration of proteins is really important. I can get complex biochemical reactions to occur inside a droplet that Ive been failing to reconstitute in a test tube for years. This is the secret sauce Ive been missing.

While its been known for about eight years that cells make such droplets for other processes, but it was unknown that they make them on chromosomes during cell division. Stukenberg believes these droplets are very common and more important than previously realized. I think this is a general paradigm, he said. Cells are using these non-membranous organelles to regulate much of their work.

In addition to helping us understand mitosis how cells divide Stukenbergs new discovery also sheds light on cancer and how it occurs. The organelles main function is to fix mistakes in tiny microtubules that pull apart chromosomes when cells are dividing. That ensures each cell winds up with the correct genetic material. In cancer, though, this repair process is defective, which can drive cancer cells to get more aggressive.

He has also developed tests to measure the amount of chromosome mis-segregation in tumors, and he hopes that this might allow doctors to pick the proper treatment to give cancer patients. We have a way to identify the tumors where the cells are mis-segregating chromosomes at a higher rate, he said. My hope is to identify the patients where treatments such as paclitaxel are going to the most effective.

Having looked at breast cancer already, he next plans to examine the strange organelles role in colorectal cancer.

###

Stukenberg and his colleagues have described their discovery in the scientific journal Nature Cell Biology. The research team consisted of Prasad Trivedi, Francesco Palomba, Ewa Niedzialkowska, Michelle A. Digman, Enrico Gratton and Stukenberg.

Reference: The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex by Prasad Trivedi, Francesco Palomba, Ewa Niedzialkowska, Michelle A. Digman, Enrico Gratton and P. Todd Stukenberg, 3 September 2019, Nature Cell Biology.DOI: 10.1038/s41556-019-0376-4

The research was supported by the National Institutes of Health, grants R01GM124042, R24OD023697 and P41-GM103540; and the National Science Foundation, grant MCB-1615701.

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Strange New Organelle That Helps Prevent Cancer Discovered in Our Cells - SciTechDaily

Illustration by Andy Potts

Say goodbye to insulin injections and hello to snake toxins.

From penicillin to 3D-printed kidneys, the medical field has long served as a major catalyst of human ingenuity. In Colorado, that innovation doesnt appear to be slowing down. Centennial State institutions are helping pioneer treatments that could revolutionize health careboth today and in the years ahead.

A Gilded PillAbout 416,000 adults in Colorado suffer from diabetes. No wonder, then, that oral insulin (read: no more needles) is considered the holy grail of diabetes care. Denvers Creekside Endocrine Associates is part of the quest as one of only 37 places in the country testing an insulin pill developed by New Yorks Oramed Pharmaceutical. The key is ensuring the capsule reaches the liver before dissolving in stomach acid. If successful, the pill could also drastically lower the average cost of diabetes care, which is currently nearly $10,000 a year in the United States.

Conversation StarterThis past August, UCHealth introduced the world to Alexas nerdy cousin, Livi. An artificial-intelligence-based virtual assistant, Livi can be summoned on an Amazon Echo by saying Alexa, ask UCHealth. Users can then pepper her with commands like Email me information on Crohns disease or Find me a neurologist, and Livi will consult network sources to locate the information. UCHealth hopes to expand Livis capabilities over the next few years. This fall, for example, she was integrated into its electronic medical record system and mobile app so she can check your test results and appointment times.

Game TheoryIn 2017, Childrens Hospital Colorado unveiled one of the first full-time hospital gaming and technology departments in the world. Patients with movement-debilitating illnesses such as cerebral palsy get the much-needed, potentially dexterity-improving activity they require by donning virtual reality and augmented reality headsets and, for example, exploring alien planets. The diversions can also make it easier for kids to undergo difficult treatments: The anxiety a child feels before a lumbar puncturean injection of medicine into her spinal fluidmight be lessened if she can confront the procedure while wielding a lightsaber.

Snake Venom SalesmanA professor at the University of Northern Colorado might have finally found a way for serpents to pay penance for the whole exile-from-Eden thing: Stephen Mackessys Venom Analysis Lab, which launched in the mid-1990s, has shown that toxins from some venomous snakes are capable of preventing cancer cells from metastasizing. The next step (likely still years away) is finding an application method that would weaponize compounds in the venom against a humans cancer without harming the humans body.

Good GenesBoth Lutheran Medical Center and Kaiser Permanente are early practitioners of pharmacogenomicsbasically, how your DNA affects your bodys reactions to medicines. In Lutherans pilot program, primary care providers give some patients the option of a 20-second cheek swab. Pharmacists and doctors can use subsequent genetic-testing reports to provide recommendations, such as lowering a dosage because genetic traits reveal your body might absorb drugs faster or suggesting you avoid a particular medication.

This article appeared in the 2020 issue of 5280 Health.

Excerpt from:
The Innovations That Will Revolutionize Health Care in Colorado - 5280 | The Denver Magazine

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Stem Cell Alopecia Treatment Market Segmentation, Top Companies, Applications, Comprehensive Research Report and Forecast to 2026 - Market Research...

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Stem Cell Cartilage Regeneration Market Key players, Geographical Regions and Growth Analysis Outlook Up To 2028 - Sound On Sound Fest

The end of privacy

Vanessa Walker is the Morgan assistant professor of diplomatic history at Amherst College.

At the close of the 2010s, political polarization, reactionary nationalism and escalating public conflict over systemic racism, gender inequality and climate change dominated characterizations of the decade. Less noticed, the decade marked the end of privacy. State surveillance was nothing new. The war on terror in the aughts had already ushered in new invasive profiling practices. But the pervasive, hyper-individualized, corporate-based collection and aggregation of personal data in partnership with government marked a new frontier in surveillance. The collection of personal information through individuals phones, computers and virtual assistantsand the social media and online platforms they utilizedinformed almost every aspect of social and political interactions. Over the decade, these instruments insinuated themselves into peoples everyday lives for convenience, for entertainment, for basic daily information and communication in a way that made it difficult to imagine functioning without them. Like the proverbial frog being boiled alive, people became accustomed not only to trading their personal information for basic services, but also the idea that they were always being watched. Appeased by the pretense of being able to opt out, consumers accepted vague assertions that data collection was consensual, anonymous and secure. Yet, as the decade drew to a close, law enforcement officials, political campaigns and foreign governments increasingly used information gathered for commercial purposes in ways completely at odds with the assurances of privacy and consent. As scandals like Cambridge Analytica revealed, the use of this data was also at odds with the integrity of democratic institutions and confidence in the electoral process. Big data clearly contained potential benefits for society in terms of health innovations, service optimization and energy efficiencies. However, without meaningful transparency over what was collected, who had access and how it was used, the looming surveillance states threat to individual freedom and collective security dwarfed those potential benefits.

James Goodman is a history professor at Rutgers.

The decade that began with hard times ended like the Wizard of Oz. The recovery from the Great Recession was slow and uneven. The backlash against Barack Obama, the country's first black president, was swift and sustained. Obama won a second term in 2012, but four years later that backlash, combined with economic insecurity and a successful effort to portray Hillary Clinton as corrupt, led to the election of Donald Trump, a New York City real estate developer and reality television host, who promised to "Make America Great Again." Trump attempted to keep Muslims out with a travel ban and Central Americans migrants out with a wall across the Mexican border. He resumed deportation of undocumented immigrants brought here as children. He won a huge tax cut for corporations and the wealthiest Americans, and he reversed or weakened dozens of Obama era rules designed to regulate the financial industry, reduce greenhouse gases, clean up the air and water, and expand civil rights. Even as Trump cozied up to the U.S.'s longtime rival Russia and undermined free trade with punishing tariffs, the vast majority of Republicans stuck with him. He himself bragged that he could shoot someone without alienating his base. In late 2019, a whistleblower charged that Trump had pressured the president of the Ukraine to announce a corruption investigation of former Vice President Joseph Biden, his leading political rival: No announcement, no military aid. The Democratically controlled House of Representatives launched an inquiry, which led to two counts of impeachment, charging him with abuse of power and obstruction of Congress. He was impeached along strict party lines and then acquitted the same way. Extreme polarization appeared to be a permanent feature of American politics. But just 11 months later, in the presidential election of 2020, Trump was handily defeated by Joseph Biden and Stacey Abrams. Perhaps even more surprising, Trumps spell was broken. His base turned like the Winkie Guards in the castle of the Wicked Witch of the West. They made heroes of the "Never Trumpers," the handful of Republicans who had resisted the president and who now gained control of a more moderate, temperate GOP. In the 1980s, Ronald Reagan had pushed the political center of gravity well to the right. In the late 2010s, Bernie Sanders, Elizabeth Warren, and a "squad" of fiery young congresswomen pushed it back the other way. In office, Biden and his team of rivals worked with Congress on the party's agenda: health care, economic inequality, climate change, racial disparities in the criminal justice system, immigration reform and infrastructure. The Supreme Court played nice, realizing that in America there is no place like the center, wherever the center happens to be.

Sarah E. Igo is a professor of history and political science at Vanderbilt.

In the 2010s, Americans reckoned with their neglect of vital infrastructures: political, technological and environmental. Their constitutional democracy was the most obvious system in disarray. Vulnerable to Russian cyberattacks during the 2016 election, U.S. political institutions suffered equally from the unchecked flouting of governing norms by the reality-TV star president, Donald Trump, who was the beneficiary of those attacks. Americans communications infrastructure also proved precarious. As news and exchanges of all sorts moved onto electronic platforms in that decade, they became ever-more captive to corporate profits, eroding individual privacy as well as the means for achieving verifiable facts. Finally, in common with people around the world, Americans grasped in that decade the potentially irreversible harm humans had done to the natural systems supporting life on the planet. Raging fires, hurricanes and floods; attacks on democratic processes; social media surveillance and fake news. These were the shocks that exposed the fragility of the systems Americans depended onbut that also galvanized citizens to repair them in the 2020s.

David M. Kennedy is professor emeritus of history at Stanford University.

Still waters run deep. Sometimes turbulent waters do too. In the 21st centurys tumultuous second decade, several currents flowing out of the previous centurys closing years swelled to a torrential maelstrom that swept away the very foundations of the social and political order that had prevailed since World War II. Irony abounded. The internet, hailed at its birth in the 1960s as heralding an emerging global village, instead helped to spawn rancorous tribalism around the globe, conspicuously including the United States, where toxic political rivalries bred cynical disillusionment with established institutions and parties, paralyzed governance in the face of systemic threats from climate change and economic dislocation, and fed a resurgent isolationism. The end of the Cold War and the collapse of the Soviet Union in 1991 gave promise of a permanently pacified, united Europe and even an end of history. But ethno-nationalist sentiments welled up across the former Soviet states and satellites alike, while Britains decision to exit the European Union in 2016 ended an era of building multi-lateral institutions and put paid to the dream of European unity. In perhaps the greatest irony of all, the supposedly enervated capitalist economic system whose massive financial crisis had opened the decade, loudly blamed for widening inequality and populist anger in the West, picked up phenomenal energy, volume and velocity in nominally communist China, lifting hundreds of millions of people into the global bourgeoisie in less than two generations, and acutely stressing the rich western societies that had given birth to capitalism some four centuries earlier. The combined force of these technological, political and economic tsunamis opened the floodgates to the massive transformations that have washed over the planet in succeeding decades, including deepening social fragmentation in all societies, intensifying competition among them, and the dramatic shift of geopolitical power from the West to Asia.

Tom Nichols is a professor at the U.S. Naval War College.

From A Century of Change: The United States from 1945-2045:

Historians have struggled to explain the paradox of the 2010s. On the one hand, it was a decade of economic and military recovery that was by any standard peaceful and prosperous, even under two very different American presidents. And yet, it was characterized by a poisonous anger and extreme polarization that is normally the hallmark of defeated and bankrupted states on the verge of collapse. In retrospect, the 2010s represented an unexpected and politically destructive synergy between peace, affluence and technology. Despite skyrocketing income inequality, for example, an array of technological advances narrowed the daily living standards between rich and poor compared with even a few decades earlier. These advances, in turn, spurred increasingly unattainable demands from the public on both government and industry for even higher living standards and more consumer choices. Universal education produced unprecedented levels of literacy, but electronic entertainment and media undermined the ability of literacy to create informed citizens; by 2020, it was fair to say that never in modern history had a more educated people rejected science and rationalism in such numbers. Abroad, America was still supremely powerful, with interstate war nearly unheard of, and terrorism mostly contained at great distances (albeit at great cost). Yet this increased security reduced the sense of shared threat among Americans and thus dissolved any chance that foreign affairs might prove to be an arena of common interest. And the era of social media, as we refer to it today, not only allowed Americans to peer into heavily edited versions of each others livesthus fueling huge social resentmentsbut encouraged them to voice their views in the most extreme manner, with each citizen offered a chance at notoriety if even for only a moment. By their end, the 2010s raised a question which remains unanswered as America heads toward completing its third century of existence: Can democracies cope with success?

More:
How Will History Books Remember the 2010s? - POLITICO

Diabetic Neuropathy Market Report 2018-2026includes a comprehensive analysis of the present Market. The report starts with the basic Diabetic Neuropathy industry overview and then goes into each and every detail.

Diabetic Neuropathy Market Report contains in depth information major manufacturers, opportunities, challenges, and industry trends and their impact on the market forecast. Diabetic Neuropathy also provides data about the company and its operations. This report also provides information on the Pricing Strategy, Brand Strategy, Target Client, Distributors/Traders List offered by the company.

Description:

Diabetic Neuropathy is the damage caused to the nerve due to diabetes which often leads to pain and numbness in feet or lower legs. The pain can be experienced in other parts of the body such as hips, wrist and back depending upon the effect of neuropathy. There are different types of neuropathy such as focal neuropathy, proximal neuropathy, peripheral neuropathy and autonomic neuropathy. An estimated 50% of diabetic population suffers from diabetic neuropathy across the globe. Further, as per CDC estimates, 6-7 people per 1000 diabetic population suffer from diabetic neuropathy in the U.S. Rise in aging population coupled with rise in prevalence of diabetes, the patient pool for diabetic neuropathy will increase significantly, in turn fueling growth of the diabetic neuropathy market.

Diabetic Neuropathy Market competition by top manufacturers/players, with Diabetic Neuropathy sales volume, Price (USD/Unit), Revenue (Million USD) and Market Share for each manufacturer/player; the top players including: Eli Lilly and Company, GlaxoSmithKline, Pfizer, Johnson & Johnson and Janssen Pharmaceuticals

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Important Features that are under offer & key highlights of the report:

What all regional segmentation covered? Can the specific country of interest be added?Currently, the research report gives special attention and focus on the following regions:North America (U.S., Canada, Mexico), Europe (Germany, U.K., France, Italy, Russia, Spain etc), South America (Brazil, Argentina etc) & Middle East & Africa (Saudi Arabia, South Africa etc)** One country of specific interest can be included at no added cost. For inclusion of more regional segment quote may vary.

What all companies are currently profiled in the report?The report Contain the Major Key Players currently profiled in this market.** List of companies mentioned may vary in the final report subject to Name Change / Merger etc.

Can we add or profiled new company as per our need?Yes, we can add or profile new company as per client need in the report. Final confirmation to be provided by the research team depending upon the difficulty of the survey.** Data availability will be confirmed by research in case of a privately held company. Up to 3 players can be added at no added cost.

Can the inclusion of additional Segmentation / Market breakdown is possible?Yes, the inclusion of additional segmentation / Market breakdown is possible to subject to data availability and difficulty of the survey. However, a detailed requirement needs to be shared with our research before giving final confirmation to the client.** Depending upon the requirement the deliverable time and quote will vary.

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Diabetic Neuropathy Market Dynamics in the world mainly, the worldwide 2018-2026 Diabetic Neuropathy Market is analyzed across major global regions. CMI also provides customized specific regional and country-level reports for the following areas:

Region Segmentation:

North America (USA, Canada and Mexico)Europe (Germany, France, UK, Russia and Italy)Asia-Pacific (China, Japan, Korea, India and Southeast Asia)South America (Brazil, Argentina, Columbia etc.)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Further in the report, the Diabetic Neuropathy market is examined for Sales, Revenue, Price and Gross Margin. These points are analyzed for companies, types, and regions. In continuation with this data, the sale price is for various types, applications and region is also included. The Diabetic Neuropathy industry consumption for major regions is given. Additionally, type wise and application wise figures are also provided in this report.

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In this study, the years considered to estimate the market size of 2018-2026 Diabetic Neuropathy Market are as follows:History Year: 2015-2017Base Year: 2017Estimated Year: 2018Forecast Year 2018 to 2026

This post was originally published on Market Research Sheets

Read more:

Diabetic Neuropathy Market Poised to Take Off by 2026 - Market Research Sheets

Nerve pain is a crucial problem that occurs in people who have diabetes or are experiencing the after-effects of chemotherapy. It can be stressful and discomforting if not treated and taken care of by a professional physician. Neuropathy treatment is rather conventional, whereby the physician has to come up with a better way to relieve pain through supplements, vitamins, and herbs. This medication helps in avoiding any treatment that may result in negative side effects on ones nervous system. Consultation is the key approach method once you realize that you have neuropathy. This way, the doctor can guide you on ways that you can avoid nerve pain. Neuropathy mostly affects the hands and feet, making movement challenging to most patients. It also induces muscle weakness and lack of sensation. Nevertheless, there are easy treatments that you can rely on to ensure that your lifestyle does not change. Here are three affordable herbs and vitamins that you should try for nerve pain relief:

1) B Vitamins

Neuropathy is a critical condition that requires you to be keen on the mode of treatment you are taking. Lack of vitamins in the body has been linked with nerve pain, which can develop permanent damage. These vitamins include B1, B6, and B12. You can get these essential vitamins through the consultation of the doctor. You can also check out Neuropathy Relief Guide to understand different ways of handling your condition with good vitamins and herbs. Benfotiamine, which is also vitamin B1, is said to reduce nerve pain by a high percentage. It is also used in getting rid of inflammation in the legs and hands.

On the other hand, vitamin B6 is recommended since it helps in covering nerve ends to avoid any further damages that may occur to the nervous system. However, it is advised that you do not take any extra dosage since it can interfere with the nerves leading permanent damage. Vitamin B6 has proven to improve the immune system, which is linked with healing any nerve damage present in the body.

2) Fish Oil

Nerve pain is a progressive condition that can lead to serious damage to the body organs. This is because it causes numbness and weakness to the body muscles. This way, you have a better approach method on how you can ensure your nerves are healthy. If you are undergoing chemotherapy or suffering from diabetes, it is easy to have complications like neuropathy. Therefore, you are advised to take fish oil, which is a natural medication. Through research, it was proven that fish oil is beneficial since it has an anti-inflammatory effect that has posed a positive impact on healing the nerves.

Moreover, it has shown to help in reducing pain and decreasing muscle soreness, which is a great challenge for most patients. Fish oil contains omega-3 fatty acids, which are the main acting agents in stimulating the growth of nerves instead of damaging. This is similar to vitamin B6, which is used in covering the ends of nerves to prevent further complications. Fish oil has been encouraged by most physicians since it is highly available and can help in healing other diseases that may be chronic. Moreover, it is a cheap product, yet it can have significant benefits in preventing any nerve pain.

3) Capsaicin

Herbal treatment has been there for decades, making it the best method of treating any disease due to its natural effect on the body. This is unlike other medications that come with side effects that may lead to permanent damage. Neuropathy is a manageable condition that requires a patients attention and effort to avoid pain. Capsaicin is a component found in pepper, which makes your mouth hot once you consume it. Despite its hotness, it has proved to be beneficial in the treatment of peripheral neuropathy. Here, you are required to apply it on the skin where it blocks any transmission of pain. It also comes into two forms, capsaicin cream, and capsaicin patches. These two have helped patients to avoid inflammation on the joints and muscles, making you relieve any pain present on the body. This is has been considered the most affordable herb for treating neuropathy since it is highly available and easy to use. The bottom line in this is that capsaicin makes the nerves numb and insensitive. Therefore, you cannot experience any pain. You are also recommended to use ginger or turmeric if you experience any allergic reactions with capsaicin. This way, it will be comfortable to ease pain rather than inducing any further problems.

Go here to read the rest:

3 Affordable Herbs & Vitamins that you should try for nerve pain relief - Explosion

The Food and Drug Administrations accelerated approval of Padcev offers patients with advanced bladder cancer a potential standard of care.

BY Kristie L. Kahl

The agency granted accelerated approval to the application for Padcev (enfortumab vedotin-ejfv) for this patient population, who had no standard of care prior.

Typically, for this patient population, there really wasn't anything that was active (in treating patients), and what weve seen is about 12% of patients have a complete tumor disappearance. Overall, about 40% of patients have whats called a partial response and 84% of patients have some form of tumor reduction, explained Dr. Daniel Petrylak, professor of medicine, medical oncology and urology, and co-leader of Cancer Signaling Networks, at Yale Cancer Center. So this is really a remarkable finding. To my knowledge, this is the most active single agent (in treating advanced bladder cancer). It is even more active than drugs they've been using in the earlier setting.

The agency based its decision on data from the multicenter, single-arm, phase 2 pivotal EV-201 trial designed to evaluate Padcev, which is directed against Nectin-4, a protein located on the surface of cells and highly expressed in bladder cancer, in 125 patients with locally advanced or metastatic urothelial cancer who received prior treatment with a PD-1 or PD-L1 inhibitor and a platinum-based chemotherapy.

The first-in-class antibody-drug conjugate is approved under the FDAs Accelerated Approval Program, which allows approval of a medicine based on a surrogate endpoint if the medicine fills an unmet medical need for a serious condition. In this instance, the accelerated approval was based on tumor response rate, the studys primary endpoint.

We had a certain goal that we had to meet, which was 30%, and we exceeded that, Petrylak said. Patients demonstrated an objective response rate of 44%, including 15 complete responses (12%) and 40 partial responses (32%).

Moreover, duration of response, a secondary endpoint of the study, was 7.6 months.

The most common serious side effects were urinary tract infection (6%), cellulitis (5%), febrile neutropenia (4%), diarrhea (4%), sepsis (3%), acute kidney injury (3%), dyspnea (3%) and rash (3%). Peripheral neuropathy led to treatment discontinuation in 6% of patients. Common side effects of any grade included fatigue (56%), peripheral neuropathy (56%), decreased appetite (52%), rash (52%), alopecia (50%), nausea (45%), dysgeusia (42%), diarrhea (42%), dry eye (40%), pruritus (26%) and dry skin (26%).

Continued approval of Padcev will be contingent upon further evaluation to verify and describe the clinical benefit of the drug in a confirmatory trial.

There are a lot of next steps. This is an exciting drug, and it has a tremendous amount of activity, Petrylak said. Were looking to move this up earlier, in the course of disease. There's a trial being done in patients who've had frontline chemotherapy, and we're looking to (add Padcev) in the neoadjuvant setting prior to somebody having their bladder taken out. And so the thought is that perhaps we'll have more activity earlier.

Petrylak added that researchers are also looking to add the agent to other combinations, like checkpoint inhibitors.

Read CUREs original coverage of the approval.

Read more:

What You Need to Know About the FDA - Curetoday.com

You may be heading into 2020 without 20/20 vision, but you can simplify the vision testing process. To cut down on optometrist visits, you can pick up an EyeQue Personal Vision Tracker for just $19.99 with our New Year promo code.

The whole process is verysimple: Just attach the EyeQue to your phone and press start. The paired app then runs through tests to help determine your Eyeglass Numbers. You cant completely abandon your doctor, but the EyeQue does make it far easier to track your prescription throughout the year.

The EyeQue Vision Tracker is no pretender either. Its an MIT-patented device that took home awards at CES 2017. If you come from a family of glasses-wearers, you can all share the same device as long as everyone has their own account.

The EyeQue Personal Vision Tracker has a retail value of $35, and the potential to save tons of time at the optometrist. You can pick up your very own for just $19.99 with the promo code 20SAVE20 at the Tech Deals checkout.

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Read the original:
Keep an eye on your eyesight with the EyeQue Vision Tracker - Android Authority

Maddie Meyer/Getty Images

Boston Celtics guard Marcus Smart still hasn't been cleared but is nearing a return to the court after an eye infection he described as "hell."

"Just really, really painful and really not knowing," Smart told reporters. "I thought I was going to go blind for a while. The doctors said it was the worst case of viral conjunctivitis that they've seen, so basically I was a guinea pig to see how to handle this if it ever happens again with anybody else.

"But it was the worst pain that I've been through in a very long time, and I don't wish it on anybody. But I'm here. The eyes feel better. I'm still trying to adjust to some lights, light sensitivity. But everything, the contagious part is gone. They cleared me. They said from here on everything should be OK. I still have to see them kind of on a daily basis. They say it's so my cornea doesn't get white spotted behind it and mess up my eyesight. So it's definitely a process. It's an annoying process, but I'm just blessed to be able to come back and get through this."

Smart said doctors told him they were afraid the infection had gotten so bad it would permanently affect his vision:

"The way it was going, they were so worried about it affecting my cornea and my vision, so it was a little scary. At first we thought it was an allergic reaction, because I broke out in hives like the day before my eyes started having allergic reaction. But we caught it so early that the same symptoms came off, and then about three days later it transferred from my left eye to my right eye, and that's when we ruled out that an allergic reaction was the cause. They said it was a virus called the (adenovirus), and it was caused by having a cold already and being sick, so it makes sense because right before that, those two days after the Denver game, Dec. 6th, the 7th and 8th, I came down with an allergic reaction and a really bad cold."

"The Celtics actually sent me home, because I was feeling really bad, and it just kind of broke my immune system down and opened it up for everything else. Everything else in my body went haywire. It was just some unfortunate events that happened, but on the good side, I got to rest and heal up the injuries that I had and just let my body do what it does."

Smart has been out nearly three weeks due to the virus, but he did travel with the Celtics to their Christmas Day game against the Toronto Raptors. He's averaging 11.8 points, 4.6 assists and 3.4 rebounds while shooting 38.3 percent from the field and defending the best wing player on the opposing roster every night.

The Celtics have managed to stay afloat with Smart out of the lineup, posting a 4-2 record, including three straight victories heading into Christmas.

Thankfully, it appears the worst is over and Smart will be back out on the floor sooner than later.

Read more here:
Celtics' Marcus Smart Says Eye Infections Were 'Hell,' Put Vision at Risk - Bleacher Report

Poor nutrition increases the risk of vision loss 3 foods to include in diet to keep eyes healthy   |  Photo Credit: Getty Images

New Delhi: As children sway more towards processed foods, junk and unhealthy diet, and increase their screen time with the use of smartphones, laptops, tablets, television, etc, parents often find themselves worried about the effect it may have on their eyes and their vision. Getting glasses is, of course, the solution, but it comes with added complications and responsibility, that very young children may not be able to take. Weak eyesight in childhood can also lead to vision complications as the child grows up.

According to a recent study, the parents' fear may actually be real, because a new study has linked poor nutrition with the risk of vision loss. Parents must try to include nutritious foods, especially healthy for the eyes, in their child's diet to ensure their eyes stay safe, especially during their growth years.

To ensure reduced risk of weak eyesight and vision loss, include these foods in your child's diet.

Leafy vegetables like cabbage, kale, lettuce, spinach, fenugreek, etc which are abundantly available in the winter season are very healthy and nutritious foods, especially for the eyes. Rich in calcium, iron, vitamins, and fibre, they are also a great inclusion in a diet for boosting immunity, losing weight, etc.

Oily fish rich in omega-3 and omega-6 fatty acids can really work wonders for good eyesight. Tuna and salmon are the two most popular oily fishes. They are also healthy for the heart and the skin.

Protein plays an important role in keeping our eyesight healthy. Include eggs, and other protein sources of food like beans, lentils, dairy, etc to ensure that the risk of vision loss is minimized, and your child is nourished and healthy.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

Continued here:
Poor nutrition increases the risk of vision loss 3 foods to include in diet to keep eyes healthy - Times Now

If youre tired of struggling with poor eyesight, specifically someone who wants to improve their vision, reverse glaucoma, cataract, near-sightedness and wants to stop using glasses, then here is good news.

I have discovered a natural herbal remedy that has helped over 2,742 Nigerian men, women and children restore eyesight, improve vision and cure severe eye problems within few weeks.

You see, I was once in your shoes, I used to battle severe eye problems that made me had blurred vision, dry itchy eyes.

But my eye doctor told me I could only live with it, so my optician kept on recommending eye glasses lens (or spectacles) so I could manage it to improve my vision.

But, as time went by this became ineffective, caused several eye irritations and also negatively affected my self esteem.

3 years later, my eye condition had worsened after several eye exams, I was diagnosed with glaucoma in the right eye.

Again, several solutions like eye drops, pills and surgery was recommended.

Eye surgery which was the best long term treatment was really expensive, and even comes with its own side effects after several months or years.

So, I decided to start using eye drops just so I could manage to see because at this point, I was literally going blind.

You see, the problem with eye drops is that most of them came with serious side effects, so one has to continue changing them until you see the most suitable one.

Sadly, within few months I used over 5 eye drops.

While for over the counter eye drugs, they take almost forever to work and give you perfect eye so you keep on spending and spending on the drugs for several years.

So, I decided to start searching for an alternative solution, something herbal that comes with no side effects and will naturally reverse glaucoma, cataracts, near-sightedness, and other severe eye problems.

But the entire situation changed when I came in contact with an old time friend, Uwem, he used to work in a particular eye clinic in Abuja .

We have been friends since our NYSC days for over 7years till date. Although, it has been a long time we spoke because he relocated to Canada to continue his profession.

We started talking as usual, and he asked me about my eye condition, if it has improved for better.

I explained how I was already tired of looking for solution to the eye problem, and how I have spent lots of money on drugs, supplements, eye drops and glasses, desperately looking for solution but without any improvement, insteadI was almost getting blind instead!

He explained that most people wearing eye glasses suffer from myopia (nearsightedness), glaucoma and cataract.

He later explained that there ispermanent cure for most of the eye problems, and natural remedy that helps treat and reverse glaucoma, cataract, myopia and other severe eye problems.

Most of these cases he has handled in the eye specialist clinic he works with in canada, and his patients improved their eyesight, and they never had to wear glasses or go for expensive eye surgery again.

But sadly, the solution is very rare to find because its imported, specially for Eye clinics in the USA, UK, Canada and some developing African countries as well.

That was when he introduced me to aspecial herbal teathat have been in existence for several years, that help cures severe eye problems, reverse cataract, glaucoma and myopia.

At first, I was shocked and surprised. But he told me the exact plant extracts contained inside the herbal tea, and how they improves overall eyesight health and restores vision.

I quickly pleaded with him to help me send a complete supply of the herbal tea. The next morning, I quickly sent the money to him.

After about a week, the complete supply of the herbal tea was delivered to me.

Immediately, I started it using it as prescribed (serving size of 1 tea bag in morning, and 1 tea bag in the evening).

To my surprise, in less than 2 weeks of using it, it was almost like a miracle cure to my eyesight problem and it helped improve my vision.

My eyes became crystal clear, my vision was never blurry again, and I started to feel that my glaucoma was gone.

To ensure it was really effective,I had to give the same herbal tea to about 2 of my colleagues in a different branch office, and some of my relatives using spectacles just to confirm if it could help them improve their eye health and cure eye problems.

Within 30 days or less of using it, all of them came back to testify that this herbal tea helped them improve their eyesight and cure eye problems like cataracts, glaucoma, near-sightedness, hyperopia, and blurry vision, and they didnt have to continue wearing glasses anymore.

To ensure that this solution really works, I went to my eye doctor, just to be completely sure be about it.

After several eye exams, he confirmed that my eye was much better than before, and that the herbal tea also contained some ingredients that are very rare to find, but are highly effective in improving eyesight naturally

Without wasting time, let me introduce you to the Herbal Remedy that Has Helped me and over 642 Nigerian men and women Improve Eyesight, vision and PROVEN to cure Severe Eye Problems

Eye Restore Tea

Eye Restore Teais a herbal remedy formulated to treat and permanently cure all kinds of eye problems such as glaucoma, myopia, hyperopia, cataracts and lot more

It helps restore your eyesight, promotes eye health and improves vision.

Eye Restore Tea is made up of finely blended plant herbal extractssuch as bilberry extract, chrysanthemum, chinese wolfberry, cassia seed and green tea.

A pack of eye restore tea contains 20 tea bags, which you use daily, morning and evening.

The best part is that the Eye Restore tea is purely herbal, comes without any side effect and curative for the treatment of most eye problems. And within few days of taking this herbal tea, you can start seeing improvement in your vision and eye health.

Eye Restore Tea has the highest standard of approval by International FDA bodies. Its produced in the best, biggest and professional tea manufacturing factory withcertificate of GMP Good Manufacturing Practice, HACCP, Food Production License, QS etc.

So you can be sure that, Eye Restore Tea is Safe, 100% Herbal and Healthy, No Side Effects.

Do you want to dump your glasses, and also put an end to using expensive eye drugs that takes almost forever to work?

Then pay attention to this.

Eye Restore Teais made of herbal extracts, that after several years of research, scientist prove that these herbs help eliminate any form of eye problems, gives a crystal clear eye, improves eye sight and vision naturally.

Heres how this special herbal tea works

When you order for the Eye Restore Tea, each pack contains 20 tea bags. Put 1 tea bag in the cup, add boiled water, you can add honey or lemon (depending on your taste). Drink the tea in the morning when you wake up, and in the night before bed.

Within 3 weeks or less, I can guarantee that it will cure whatever eyesight problem you are experiecing at the moment. It will improve and perfect your eyesight, you will be able to read better anytime of the day. It will help you see comfortably without your glasses.

THATS how powerful it is.

Right now, my eyes are crystal clear, no more blurry vision, I see clearly without my eye glasses, glaucoma has gone, and no more cataracts.

And after this worked for me, Ive gone to share this amazing eye restore secret with almost everyone (family, friends and collegues) that I know that uses spectacles, or have severe eye problems for many years.

And once they started using Eye Restore Tea, they experienced similar results, their joy knew no bounds and they were able to dump their glasses, save money on expensive drugs and eye drops.

While it has also helped them to have a much improved vision, eyesight and totally natural cure to glaucoma, cataracts, myopia, hyperopia, eyestrain and other eye problems.

And to Prove It, Here Are What People Who Have Used theEye Restore Tea Are Saying About it, and How TheyveSeen Great Results Using it

For over 3 years of having glaucoma in my right eye, Ive been eye drops that my eye doctors prescribed. After using it for a long time, I noticed that the eye was becoming useless, and I only had my left eye for all purpose.Until I came accross Eye restore tea, I decided to use it instead. Within few weeks, I began to see better. I went to the Eye center, and after the examination doctor say that my eye has improved and the IOP has dropped.Thanks so much for this wonderful solution that saved my eyes

James Gwarimpa, Abuja=================

I suffered from Glaucoma for about 2 years now, and I had to use eye drops to control it. But the eye drops have serious side effects that made me uncomfortable so I had to keep changing them and used 5 types of eye drop.Luckily, a friend introduced me to Eye restore tea, so I decided to give it a trial. My vision now have improved up to the extent that I no longer need spectacles or any eye drop again.

Mrs. Tolulope Ketu, Lagos===============

Immediately after my cataract sugery, I used to have a foggy or cloudy vision and colors are not vivid as they were. I got corrective sight vision lens, and after many months I still get this blurry vision sometimes which is frustrating.

My wife helped me order for the Eye Restore tea, and I decided to use it, within 6weeks, my eyesight is clear and has corrected itself with time. Ive gone on to recommend this for my elder brother with similar eye problems. Thanks so much for this miracle tea

Mr. Victor Onitsha, Anambra

============ After seeing an opthalmologist for an eye exam, it was revealed an eye pressure of 25 in both eyes, and my right eyes looked suspicious for glaucoma. I continued using eye drops.

I stumbled upon your eye restore tea product, and decided to go for it. Within few weeks of using the tea, am seeing obvious changes, and finally stopped using eye drops. i will keep you updated on my progress, really appreciate this!

Olawale warri, Delta

Truth is, I could load more and more testimonials from these people who have used the Eye Restore tea but it will only be saying the same thing this product works like crazy!

As you have seen, these people were once like you suffering form similar eye conditions that were a threat to their vision, but they took action got the Eye Restore tea and cured severe eye problems.

As we speak lots of people are raving about this natural miracle eye treatment solution. I wonder what happens when people begin to post experiences and testimonials on social media (Facebook, Instagram, Twitter etc.)

Customers will continue telling friends, and the news keeps on spreading like wildfire.

By word of mouth, theres so much huge demand, supplies are going off the shelf fast even my colleagues and inner circle friends picked up 143 packs of the Eye Restore Herbal tea.

So, there are just 257 packs remaining.

The miracle eye treatment solution is spreading like wildfire and demand is so heavy much of the stocks are running out fast.

Right now, thousand of people are on this website and stocks are extremely limited.

We have no idea when the next stocks will arrive, so get your supplies now while you can.

The best part is, you can get it at an affordable discount price when you place order right away.

I cannot assure you will get it at the same discount price if you procrastinate.

SO WHATS IT COST?

Let me ask you whats something like this worth?

What would it be worth to be able to see clearly again, without spending lots of money on presciption pills, eye drops or expensive surgery?

What would it be worth to improve all aspects of your vision using a natural solution that completely reverses glaucoma, cataract, shortsightedness and other eye problems?

A natural solution that makes you never scared again about having dry itchy eyes, blurred vision, or even worse going blind.

So that, you will be able to enjoy your eyes, watch tv, read newspapers, reports, documents without depending on your glasses ever again.

Eye restore tea, is like giving you a brand new set of perfect eyeballs faster, more safer, and more easily.

What would that be worth?

You see, you wont pay a lot for this miracle herbal tea.

And if you go ahead and get it now, you will enjoy

=> the discount introductory price

=> 100% FREE Shipping to every state in Nigeria

=> Payment at the point of delivery (or at your DOORSTEP)

This means you will pay for the products only when it has been brought down to you face to face by our courier company or delivery man.

Heres a breakdown of the price (depending on the supply you are ordering for)

Yes, at this affordable price youll get access to this miracle tea that improves your vision, reverses glaucoma, cataract, shortsightedness and other severe eye problems.The specially recommended option is for 2Months supply, so you get perfect results from it, and youll never have to spend money again on this.

Also, the 2months supply is for a severe Glaucoma, cataract, shortsightedness, etc. and also for people who have done (or considering) eye surgery, but still experience eye pains, blurred vision and other eye complications.

However, both the 1month supply and 2months supply options will give tremendous results when you make use of them.

But to Make It Even Better, When You Order for the 2MONTHS Supply of Eye Restore Tea, You will Also Get a FREE BONUS ENCLOSED to Your Parcel *NOT available anywhere else

Heres how to get it: When you order for 2months supply of the Eye Restore tea at N45,000 you will get your own free bonus of the Nature Tea that helps in the treatment of high blood pressure etc.

See the original post:
How 63-year-old Benin grandpa discovered herbal remedy that improves eyesight, treats glaucoma, cataracts without eyedrops - Daily Post Nigeria

In an interview, Henry Cavill revealed that his eyesight was almost impaired by wearing contact lenses in The Witcher. In the series, his character Geralt has yellow eyes:

I could only wear the lenses three hours at a time, well, I should only wear three hours at a time. The problem is not getting dry eyes, but the eyes are the only part of the body that receives oxygen from the air and not from the blood. So if you leave them covered for a long time, you are not receiving oxygen and after a long time it can harm your eyes. Not worth it.

Cavill stated that his ophthalmologist warned him to take the lens off after a certain period of time, but he was a little stubborn and thought it was okay to continue filming a bit more. She said I could start going blind after a while.

The star revealed that the most dramatic moment was after a few shootings in the Canary Islands, when the dust of the place got behind the contact lenses and began to scratch his eyes. Cavill thought he was just tired, but his doctor found him and advised, There came a point where she found me hiding in the shadows, because everything was so clear. I said I was fine, but she said the recordings wouldnt continue until I took the lens off.

The rest is here:
The Witcher Henry Cavill almost had vision impaired by contact lenses - Somag News

TORONTO Celtics guard Marcus Smart said the eye infections that have sidelined him since Dec. 9 have been hell, and that the condition was so severe there were some concerns he could permanently lose some of his vision.

It was the worst pain that Ive been through in a very long time, Smart said before Wednesdays 118-102 victory over the Raptors, speaking to the media for the first time since he was sidelined. I dont wish it on anybody. But Im here. My eyes feel better.

Smart said doctors initially thought he was having some kind of allergic reaction, but that was ruled out after the issue spread to from his left eye to his right eye, and he was diagnosed with viral conjunctivitis. He said doctors told him it was the worst case they had ever seen.

The greatest concern, Smart said, was that the virus could spread to the back of his corneas, which could possibly cause permanent damage to his vision.

It was painful, it was burning, it was really hard, Smart said. I couldnt see. I had outdoor sunglasses everywhere. Even in the dark, I was wearing sunglasses. It was that bad.

Smart said his eyes were sealed shut with discharge every morning and doctors had to pry the mucus out just so he could open them.

I was bleeding tears every time they did it, for like a day, he said. They did that for about four days straight. The first day was probably the worst, just because it built up so much that it started to scab under my eyelids, and they had to open the scab and then pull it out. It felt like they were putting needles in my eyes.

Smart, whose eyes appeared sleepy Sunday but no longer as puffy as they did earlier this month, said he is still undergoing daily checkups to ensure that there is no issue with his corneas. He is using two kinds of eye drops each day, which is a small sign of progress, because previously he was using three.

He is still adjusting to light he said he could not even watch television initially and that he has lost about six pounds since he contracted the virus. He said if there is a silver lining to this ordeal, its that the time off has allowed his other bumps and bruises to heal.

Smart was scheduled to complete an on-court workout prior to the Celtics game against the Raptors on Wednesday. He said he feels like he is about 80 percent ready to return. He does not expect to play against the Cavaliers on Friday, but could be back soon after that.

Its definitely a process, Smart said. Its an annoying process. But Im just blessed to be able to come back and get through this.

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Read more from the original source:
I dont wish it on anybody: Marcus Smart details pain, severity of his eye infections - Boston.com

People with visual impairment are more cautious when stepping over obstacles but this increased their risk of falls, a new study has found.

Published in Scientific Reports and performed at Anglia Ruskin University, researchers simulated blurred vision in participants before asking them to negotiate at 10cm high obstacle under a specified time. Researchers recorded how participants negotiated the obstacle and where their gaze.

Researchers reported that participants with impaired vision raised their lead foot 43% higher and 10% slower than the control group. Furthermore, this affected participants stability.

The study observed that those with visual impairment also showed 32% more anxiety than the control group, regardless of time. They also looked down more often and for longer when completing the task.

Study author and director of the Vision and Eye Research Institute at the Anglia Ruskin University, Professor Shahina Pardhan, explained: Walking with vision loss requires significantly more mental effort, and this research shows that even when performing a simple task like stepping over an obstacle, people with sight problems have considerable anxiety about falling, particularly when they might be in a hurry.

Image credit: Pixabay/MabelAmber

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Cautiousness of visually impaired people results in increased falls risk, study finds - AOP

For a little while, Boston Celtics guard Marcus Smart worried he might lose his sight.

Already out to a variety of illnesses and injuries, the Texan developed a severe eye infection which spread from one to both eyes instead of healing in the usual seven-to-ten day period his doctors anticipated.

At first, they thought it could be the result of an allergic reaction, but soon realized it was viral, specifically conjunctivitis and the worst theyd ever seen.

As it spread, concern arose it could permanently damage his vision should it affect the back of his corneas, reports the Boston Globes Adam Himmelsbach.

It was painful, it was burning, it was really hard, explained Smart. I couldnt see. I had outdoor sunglasses everywhere. Even in the dark I was wearing sunglasses.

It was that bad, he added.

It was literal torture for his doctors to care for him, requiring prying open eyes crusted shut with the pus his eyes generated to flush the virus out of his system.

I was bleeding tears every time they did it, for like a day They did that for about four days straight. The first day was probably the worst, just because it built up so much that it started to scab under my eyelids, and they had to open the scab and then pull it out. It felt like they were putting needles in my eyes

Now nearly back to normal but six pounds lighter for his efforts the Oklahoma State product feels about 80 % of his usual self. He doesnt expect to play in Fridays game against the Cleveland Cavaliers, but could perhaps return for the home rematch with the Toronto Raptors.

While the ordeal was a terrible one, it did force the always-ready Smart to rest long enough to get entirely healthy, something the Flower Mound native was having difficulty letting himself do before the infection nearly robbed him of his sight.

It goes without saying that the 25-year-old would prefer an alternate path to complete health in the future, though. It was the worst pain that Ive been through in a very long time, Smart said.

I dont wish it on anybody. But Im here. My eyes feel better.

Read the original here:
Marcus Smart nearly lost sight from infection; plans return soon - Celtics Wire

There are 366 days of 2020 ahead of us. Lets just get this all out of the way now, shall we? There are more catchy, cute, and creative slogans, themes, and promotional ideas for 2020 than we have days to advertise. They involve throw-backs to the Roaring (18)20s, rhymes, and obviously eyesight. Im starting a 2020 collection:

I can see clearly now, my nice green lawn. (Adapt as needed.)

Have the perfect vison with (insert company name here.)

With us, the future is clear. (Works for almost everyone.)

This one, or this one? This one, or this one? (Get it?)

Moving along as we get off to a terrific start in 2020, the Charlotte County Chamber of Commerce calendar for January is already bursting at the margins. The Government Affairs Committee will meet at 5 p.m. on Jan. 6 followed by the Chamber ACTION Committee the next morning. These are two of the most important committees of the chamber.

The Government Affairs Committee has historically been the arm of the chamber assisting with monitoring, and relaying information to and from, government entities to its business members, and vice-versa. The committee remains proactively involved in the government process with the overall goal being the advancement of prosperity and general welfare of the chambers business members and the community they serve.

Serving on the Government Affairs committee alongside local business professionals are representatives from Charlotte County Administration, City of Punta Gorda, Charlotte County Public Schools, Punta Gorda Airport, Charlotte County Convention and Visitors Bureau, Charlotte County Sheriffs Office, and the Charlotte County Economic Development Office. Its at these meetings that requests are often made for initiative or project support. Action can be taken by the committee in the form of support, nonsupport, or abstaining from the issue. This recommendation is then sent to the chamber board of directors for the final determination. Over the past 95 years, the Government Affairs Committee has taken a level-headed approach to representing the business interests of Charlotte County. To ensure continuity from year to year, the immediate past board president serves as the committee chair and its guidance and support are frequently requested.

The ChamberACTION Committee is all about the membership! Chambers are membership driven. These committee members support all of our activities, disseminates information, and provides education about the multitude of benefits to being a member of the Charlotte County Chamber of Commerce. Ive always wondered why a qualified business wouldnt want to be a member of the chamber and excuse my bluntness Ive yet to hear a valid reason. This committee makes sure the value of membership is spread far and wide, hither and yon, over hill and dale.

Along with those two committee meetings, the Jan. 8 Networking at Noon (11 a.m.) event will be harbor-tastic as we enjoy a fun and relaxing cruise with King Fisher Fleet. Please make a note that noon does mean 11 a.m. this month! The cost remains $15 and reservations can be made by calling the chamber at 941-627-2222 or by visiting the Chamber Store at charlottecountychamber.org.

On Jan. 9, the Leadership Class of 2020 will experience Education Day as they travel throughout the county. Many of these community leaders have not been on a school bus or in a classroom since their own school days let alone have a conversation with school board members and the superintendent.

Also on Jan. 9, we will be cutting the ribbon at 5:30 p.m. to celebrate Labor Solutions at 2726 Tamiami Trail, Suite A, in Port Charlotte. All chamber members are invited to attend.

Wow, and thats just the first few days of 2020! Oh yes, please feel free to send me your unique 2020 slogans to share as we navigate through the year! Do you have the perfect vision? (20rry not 20rry!)

Teri Ashley is the executive director of the Charlotte County Chamber of Commerce, with offices in both Punta Gorda and Port Charlotte. She can be reached at 941-639-2222 or at tashley@charlottecountychamber.org.

Continued here:
A Perfect vision roaring into the 20s hindsight is 2020 - yoursun.com