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Decoding the Genetic Mechanisms of Aging – Technology Networks

October 11th, 2019 1:44 pm

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could be developed to extend healthy human lifespan. But as is often the case in science, the genetic regulation of aging is more complicated than it first appeared.

The nature of this complexity is illuminated in a new paper byMDI Biological LaboratoryscientistsJarod Rollins, Ph.D., andAric Rogers, Ph.D., co-corresponding authors, which describes the mechanisms by which longevity is regulated post-transcriptionally, or after a genetic blueprint has been transcribed from an organism's DNA. The identification of these mechanisms will serve as a road map for screening new, more specific drugs to prolong healthy lifespan.

The research was conducted inC. elegans, a tiny nematode worm that is a popular model in aging research because of its genetic similarity to humans and because of its short lifespan, which allows scientists to easily study lifespan-extending interventions.

"The MDI Biological Laboratory is deeply committed to translational research, or research that can be translated into therapies to improve human health in our focus areas of regeneration and aging," saidHermann Haller, M.D., president. "Because it identifies new potential drug targets in the form of the post-transcriptional mechanisms governing longevity, this research will be hugely important in screening for new therapies to extend healthy human lifespan."

The paper, "Dietary Restriction Induces Post-transcriptional Regulation of Longevity Genes," which was recently published in the journalLife Science Alliance, is the product of five years of research in the Rollins and Rogers laboratories at the MDI Biological Laboratory.

The scientists used bioinformatics, or data analysis, techniques to compare genes in worms fed normal diets with those whose diets were restricted.Dietary restriction, or DR, which refers to calorie restriction without malnutrition, is the most robust intervention known for extending lifespan, and has been demonstrated to increase lifespan and delay the onset of age-related degenerative disease in a wide range of species, from one-celled yeasts to primates.

The scientific evidence on the lifespan-prolonging effects of DR has ignited a quest to develop "DR mimetics," or drugs that mimic the effects of DR without the need to dramatically reduce calories. In addition to being difficult to adhere to, such a diet is associated with negative side effects including increased sensitivity to cold and loss of energy and libido. The identification of these new mechanisms opens up the possibility of developing new, more precise DR mimetics.

"Science already knows a lot about how longevity is regulated at the genetic level, but the picture isn't complete if we just look at transcription," Rollins said. "With this research, we are drilling down to additional layers of regulation, which brings us one step closer to extending healthy human lifespan without the need to dramatically restrict calories or to take drugs that, because they are less selectively targeted, are more likely to cause adverse reactions."

The goal of DR mimetics is to access the adaptive programs in the cell that are activated when an organism is exposed to an existential threat such as a scarcity of nutrients. In such a case, the cellular machinery shifts from an emphasis on growth and reproduction, which is costly in terms of cellular resources, to an emphasis on survival. In order to ensure that an organism survives to reproduce when conditions improve, nature seeks to ensure that its cells function at peak efficiency.

In addition to confirming existing theories about the adaptive response to DR, the paper highlights the importance of post-transcriptional regulation -- or regulation that occurs after a gene has been "read" or "transcribed" from the DNA in the nucleus of the cell. The identification of the mechanisms that govern post-transcriptional levels of gene expression charts a pathway for screening, or testing, drugs that may have pro-longevity effects.

"We found that hundreds of genes are being regulated almost solely at the post-transcriptional level," Rollins said. "These are genes that weren't previously known to have a role in longevity. This level of regulation can be missed if scientists are looking at the transcriptional level alone. The identification of these mechanisms gives us a better idea of how DR works and opens up a whole new area of potential investigation for the aging biology community."

Reference: Rollins et al. 2019.Dietary restriction induces posttranscriptional regulation of longevity genes. Life Science Alliance. DOI: 10.26508/lsa.201800281.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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The longevity of ‘Little Women’ – WCVB Boston

October 11th, 2019 1:44 pm

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

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ANTHONY: A GRAND CELEBRATION CALLS FOR A FRESH COAT OF PAINT AT THIS ORCHARD HOUSE IN CONCORD. 2018 MARKED THE SESQUICENTENNIAL OF THE PUBLISHING -- PUBLICATION OF LITTLE WOMEN. >> I AM REREADING IT WITH MY BEST FRIEND. IT WAS NEAT BEING ABLE TO COME AND SEE THE HOUSE. ANTHONY: WRITTEN HERE 150 YEARS AGO, NEVER OUT-OF-PRINT, TRANSLATED INTO 50 LANGUAGES. HOLLYWOOD HAS MADE ANOTHER MOVIE OF THE CLASSIC. THIS ONE DIRECTED BY OSCAR NOMINATED GRETA GERWIG. >> GRETA GERWIG AND THE ACTRESSES HAVE COME THROUGH MULTIPLE TIMES ASKING QUESTIONS, WANTING TO ABSORB THE HOUSE. THEY WANTED THE EXACT RANGE COLOR. THEY HAVE BEEN PASSIONATE ABOUT GETTING IT RIGHT. ANTHONY: THERE IS NO SHORTAGE OF PASSION FOR ORCHARD HOUSE, SAYS EXECUTIVE DIRECTOR JAN TURNQUIST . VISITORS FROM AROUND THE WORLD FIND THEIR WAY HERE. >> IT SEEMS TO SPEAK TO THE HEART OF SO MANY READERS, THE MATTER WHAT THEIR CULTURE. THE FACT YOU CAN COME INTO THE ROOMS AND FEEL AS IF THE FAMILY HAS JUST LEFT A MOMENT AGO, IT IS AS CLOSE AS THEY CAN COME TO MEETING THE AUTHOR. ANTHONY: MOST NOTABLE IS LOUISAS WRITING DESK. >> BRONSON AND ABIGAIL GOT -- THEY FELT THEIR DAUGHTERS SHOULD FILL THEIR OWN DESTINY. A DESK OF HER OWN IN ANOTHER EMILY WOULD HAVE BEEN CONSIDERED FOR BITTEN. PHYSICIANS HAD PROVED SUPPOSEDLY BRAINWORK LIKE WRITING WOULD DESTROY A WOMANS HEALTH. THEY THOUGHT IT WAS RIDICULOUS. BRONSON BUILT LOUISA THE DESK AND MRS. ELLICOTT GAVE HER A PEN. THE MAVIS PENN USED TO INSPIRE WHEN WRAPPED IN -- [INDISCERNIBLE] ANTHONY: THE EDUCATOR FOUNDED THE CONCORD SCHOOL OF PHILOSOPHY AND LITERATURE IN HIS STUDY. HE BUILT A LECTURE HALL OUTSIDE. THE SCHOOL IS SLATED FOR ITS HOLLYWOOD DEBUT. >> THE MAKERS OF THIS MOVIE WANTED SO MUCH TO DO SOME OF THE FILMING HERE AT THE SCHOOL. THEY THOUGHT IT WOULD WORK FOR THE SCENE WHEN AMY MARCH BRINGS PICKLE BLINDS TO SCHOOL. ANTHONY: 150 YEARS AND STILL GOING STRONG. WHAT WOULD LOUISA MAKE OF ALL THE FUSS. >> SHE WOULD COMPLETELY ASTONISHED IT COULD CONTINUE LONG AFTER THE PUBLICATION OF HER BOOK. 150 YEARS. SHE WOULD BE AMUSED, PLEASED AND MOSTLY AMAZED. ANTHONY: ALL OF THE ABOVE. LITTLE WOMEN CHRISTMAS DAY. SHAYNA: THAT IS CHRONICLE FOR TODAY. THANK YOU FOR JOINING US. I AM SHAYNA SEYMOUR. ANTH

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

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Lordi Envision Greater Longevity With ‘Killection’ Album – Loudwire

October 11th, 2019 1:44 pm

The records state that Lordi formed in 1992 and released their first album in 2002, but what if they actually had been around much longer? That's a bit of the idea behind their latest album, Killection.

According to the press announcement for the new album, the group has envisioned the release as if they had actually been around making music since the early '70s, with this selection of songs spanning that entire era.

"Killection is a compilation album that simply says what if Lordi had been in existence since the early 70's. It contains all their imaginary hit singles from different periods done with painstaking attention to detail using authentic studios and vintage technology. This is how they would have sounded if Lordi would have made music back then and therefore would have had the hit material to release this compilation now," reads a description for the album.

Mr. Lordi himself adds, "Killection is a fictional compilation album. It contains songs that Lordi would have written between the early 70's through the mid-90's. The compilation contains one "brand new" song from 2019 as well, cause thats somehow always typical for compilations."

Killection is due Jan. 31 and you can check out the artwork and track listing below. At present, they have a one-off in Helsinki, Finland on Dec. 13, but will return to the road in earnest in February for a month-and-a-half long European tour. See all their dates here.

Lordi, Killection Artwork + Track Listing

01 Radio SCG 1002 Horror for Hire03 Shake the Baby Silent04 Like a Bee to the Honey05 Apollyon06 SCG10 the Last Hour07 Blow My Fuse08 I Dug a Hole in the Yard For You09 Zombimbo10 Up To No Good11 SCG10 Demonic Semitones12 Cutterfly13 Evil14 Scream Demon15 SCG10 I Am Here

10 Best Masked Rock + Metal Acts

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The longest-living people in the world have these 9 things in common – Well+Good

October 11th, 2019 1:44 pm

In the US, the average life expectancy is 78 years. But there are a few places in the worldspecifically Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; and Icaria, Greecewhere living to be over 100 isnt uncommon at all. In these regions, known as Blue Zones, the life expectancy isnt just higher; centenarians are generally also healthy, their minds and bodies still working well.

National Geographic journalist Dan Buettner spent years studying each culture, pinpointing the exact reasons why they thrived before publishing his findings in the best selling book, The Blue Zones: Lessons for Living Longer From the People Whove Lived the Longest.Buettner found that despite the geographical differences, people living in the Blue Zones all had nine key lifestyle habits in common, which he named the Power 9. Here, each pillar is explained, with input from doctors about why its so crucially connected to health and longevity. Keep reading for the complete intel, including how to apply the pillars to your own life.

Buettner found that in all the Blue Zones communities, movement was a regular part of daily life for the residents. The Longevity Plan author John Day, MD saw this first-hand as well when he spent a year living in remote China. Even in their advanced age, he saw centenarians working in the fields and throughout the village.

Of course, here in the States, our jobs are a lot more sedentary. But Dr. Day still says we can work this pillar into everyday life. Unfortunately, our modern lifestyles have been engineered in a way to take movement out of our lives, so it is up to us to get in as much as we can during the day, he says. For example, you could take a vow to never use an elevator or escalator again unless the stairs are restricted. Other options include an evening walk or doing everything possible to avoid having to use a car. Even vacations can be scheduled in a way that are physically active, like a vacation centered around skiing, hiking, or cycling.

Richard Honaker, MD, who works with Your Doctors Online, echoes this saying, The more exercise you can fit into your day, the better. Even walking is good for your health. His recommendation is to aim for a minimum of 30 minutes of exercise three times a week. This is the bare minimum amount of exercise to do that will benefit your health, he says.

Having a clear sense of why you wake up in the morning is connected to living a long, healthy life. Purpose is related to happiness, and happiness is associated with better health than sadness or indifference, Dr. Honaker says.

Dr. Day adds that the connection between the mind, health, and a sense of purpose is powerful. Whether your goal is to beat cardiovascular disease or cancer, or even to live a long and healthy life, study after study has found an association of purpose in life with all kinds of better health outcomesan effect that stands regardless of age, sex, education or race, he says. You have to have a reason to get out of bed every morning. Something that pushes and motivates you. For without purpose it is next to impossible to maintain the healthy behaviors and lifestyle that is conducive to a long and healthy life.

PSA: Chronic stress is terrible for your health, which is why stress management is one of the pillars for living a long, healthy life. We all have stress. The key is how you perceive your stress, Dr. Day says. If you view stress as something that is making you stronger or refining you then it can be a good thing. If you view stress as something destructive then it probably is.

During his time in China, he saw that simple lifestyle habits such as eating nourishing foods, being physically active, getting good sleep, and socializing with family and neighbors all helped negate the stress the townspeople experienced, showing that the pillars are intertwined and connected to each other.

Here in the States, generous, oversized portions of food are valued greatly. But in Blue Zones, Buettner found that people stopped eating when they were mostly full, not when they finished everything on their plate or were too stuffed to eat another bite. He also observed that the biggest meal of the day occurred in late afternoon or early evening, not right close to bedtime. Scientific research has shown that eating late at night is linked to unhealthy weight gain, which isnt exactly great for lifespan.

Speaking of Blue Zones, heres what to know about the expert-loved Mediterranean diet:

While were on the subject of food, people in Blue Zones tend to eat a diet thats primarily plant-based, consuming meat only a few times a month on special occasions. Processed foods and added sugar have never shown to have a health benefit. Cutting them out is 90 percent of a a healthy diet right there, Dr. Day says. [In Chinas longevity village], they picked their own produce and ate it the same day. And since they were essentially cut off from the rest of the world, they didnt have any access to sugar or processed foods. He also adds that they ate fish about twice a week, which of course brings to mind the Mediterranean diet, a long-beloved eating plan by doctors and dietitians.

Across Blue Zones, Buettner observed that alcohol was consumed, but moderately, at one to two glasses a day, with friends or food. This makes sense, as light to moderate drinking (particularly of wine) has been associated with a longer lifespan. According to a 2017 333,000-person, eight-year analysis, those who enjoyed an occasional drinkseven or less per week, to be exactwere 20 percent less likely to die of any cause and 25 percent to 30 percent less likely to die of cardiovascular disease than those who were completely sober. The key, of course, is to be mindful.

A sense of family and community is important in all Blue Zones communities, which Dr. Honaker says has been directly linked to health. Many studies have shown lower rates of hypertension, obesity, diabetes, and possibly even cancer for people with lots of friends and loving relationships in their lives, he says.

Dr. Day observed first-hand how belonging affected the health of the people in Chinas longevity village. Our research showed that as long as people stayed in the village and adopted the village lifestyle, they were healthy and aging was slowed, he says. However, if they left for employment in one of the big cities in China then their health suffered.

Similarly, in Blue Zones, families tend to be close, both geographically and emotionally. Younger generations value and help care for older ones. Dr. Day says that healthy aging requires a close network of friends and family who share their health goals and values, not something people can do on their own. This may too be related to a sense of belonging. This may be in part to the healthy lifestyles happy people adopt along with other factors we cannot measure, Dr. Honaker says.

People in Blue Zones areas not only have supportive families and communities, they actively participate in them. For some, faith may be the cornerstone of their social life, which Dr. Honaker says can provide both comfort and camaraderie through a shared beliefs system. As with purpose, study after study suggests that having a faith may increase longevity, Dr. Days says of this connection, adding that faith often involves frequent social gatherings. Another study published in 2016 emphasizes the importance of even casual social relationships when it comes to longevity.

Heres more intel on exactly how relationships impact your health. Plus, why chili peppers are linked to longevity.

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The longest-living people in the world have these 9 things in common - Well+Good

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The Alife Guys Talk About Longevity and New Collabs – Highsnobiety

October 11th, 2019 1:44 pm

On this weeks episode of The Dropcast, hosts Jian DeLeon and Noah Thomas are joined by Treis Hill and Rob Cristofaro, partners-in-crime at Alife, who are on to celebrate the 20th anniversary of the New York City-based lifestyle, street, and skatewear brand.

The quick hits start off with Kiths co-branded apparel capsule in collaboration with Nobu and their dinner event which took place at the worlds most recognized Japanese restaurant (2:48). While Noah was filling up on sushi as a Nobu regular (shout out to Uncle Woody), Jian was knee-deep in work at the office. Treis notes the merging of food with fashion as the cast expresses their mutual love for authentic restaurant merch (4:30). Somehow, discussion of the Snow Peak x New Balance sneakers brings us back to food again more specifically, food utensils, including the worlds most luxurious spork (8:06).

Talk of Burberrys Nova Check fleece jacket drop leads to Rob and Treis sharing the lack of high fashion pieces in their closets and Alifes history of collabs (11:10). Rather, the duo emphasizes the importance of finding relevance in co-branding as seen through their work with Foot Lockers Project Greenhouse (16:13). The initiative focuses on sustainable product design and empowering youth culture through collaboration with mentors.

Alifes multifaceted identity, which includes being a museum, extends their storytelling beyond pure products as seen with their recent partnerships with Brooklyn Museum and The Bronx Museum of the Arts. When the latter held an exhibit for street art photographer Henry Chalfant who produced a body of work referred to as the Bible of graffiti (22:53), Alife injected their contemporary DNA into the collaboration by creating a pop-up retail space selling a capsule featuring Chalfants work.

In light of their 20th anniversary, Alife is collaborating with Lee Jeans who are also celebrating 130 years in the making (26:00). This leads up to the Question of the Week (QOTW): Whats your favorite Alife collab? (29:08) with the hosts giving their takes.

The cast wraps up the episode by making the rounds in Whatd You Cop? Rob got his hands on the iPhone 11 Pro while Treis got a pair of red Chuck 70s.

Check up on our next QOTW out Monday on Highsnobietys Instagram, and make sure to leave us a voicemail on The Dropcast hotline at 833-HIGHSNOB (833-444-4766) for a chance to be featured in a future episode.

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What you might have missed – Cosmos

October 11th, 2019 1:44 pm

Here's a snapshot of a few stories we particularly enjoyed. Click on the links to read them in full. You can also see all the week's yarns here.

Nature giveth, and humans taketh away

Nature has been supporting life on Earth for millennia. But human exploitation of her generous resources is wearing thin, and an interactive global map created by a large team of scientists from the US, Canada and Europe models where and how.

Read the full story here.

Rumbles, screams and dinks and donks: the sounds of Mars

Scientists listening to recordings made by NASA's Mars InSight lander have discovered a rich haul although many of the sounds captured turn out to made by the machine itself.

Read the full story here.

Canine pals could be key to longevity

As most dog owners will attest, four-legged canine companions generate boundless love and joy through their playful antics and tail-wagging devotion.

Accordingly, much research finds they can improve mental health - and now, evidence for their tangible physical health benefits is growing.

Read the full story here.

Would you like some chemicals with that?

If anyone needs another good reason for choosing home-cooked food over restaurants or take-out, here it is: a study has found it lowers exposure to fluorinated chemicals commonly lurking in food packaging.

Read the full story here.

Traffic-light system can predict repeat earthquakes

Earthquake researchers believe they have found a traffic-light style warning system that can determine if a big earthquake is a prelude to an even larger event, or is itself the main shock.

Read the full story here.

More fuel for early Anthropocene

New research from the nation of Belize, Central America, has revealed that ancient Maya culture responded to population and environmental pressures by creating massive agricultural features in wetlands, potentially increasing atmospheric CO2 and methane through burning forests and farming.

Read the full story here.

And here's our image of the week

European Southern Observatory

The rather uninspired name of this jellyfish galaxy, ESO 137-001, belies this breathtaking image, created by composite data from several telescopes.

To view all this week's featured images, click here.

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This Social Security Change in 2020 Will Happen for Only the 10th Time in 85 Years – The Motley Fool

October 11th, 2019 1:44 pm

This has been a big week for Social Security beneficiaries. Yesterday, nearly 64 million monthly benefit recipients found out exactly how much of a "raise" they'll be getting in 2020. And while it's nowhere near as robust as the cost-of-living adjustment (COLA) that was passed along this year, it's far and away better than the 0% COLA passed along in 2010, 2011, and 2016, or the minuscule 0.3% COLA in 2017.

However, Social Security's COLA reveal also means it's time to look forward to a host of changes in the program for the following year. For example, the rich will have to hand over a bit more in payroll tax in 2020 than they did in 2019, and the long-term disabled (along with the blind) will be able to earn more each month before their disability checks would be stopped.

Image source: Getty Images.

But the most notable change of all might just be the increase in the full retirement age by another two months to 66 years and eight months for those born in 1958. The full retirement age (also known as "normal retirement age" by the Social Security Administration) is the age at which you become eligible to receive 100% of your monthly benefit, as determined by your birth year.

When Social Security was signed into law back in August 1935, the full retirement age was set at 65. It would remain at this level through the year 1999. Mind you, the system didn't work back then as it does today. This is to say that beneficiaries didn't have the option of choosing to claim earlier than age 65. The early claiming option that allowed workers to begin taking a reduced payout as early as age 62 was signed into law in 1961 by President John F. Kennedy. Thus, up until 1961, workers had no choice but to wait until age 65 to receive their payout.

Since 2000, the full retirement age has increased nine times, as part of the Reagan administration overhaul passed in 1983. Each of these increases to the full retirement age has been in two-month increments. Between 2000 and 2005, the full retirement age for persons between 1938 and 1943 increased by two months annually, ultimately rising from 65 to 66. Then, after a more-than-one-decade lull when the full retirement age stood at 66, it began increasing again in 2017. It'll peak at age 67 in 2022 for those born in 1960 and later.

Next year, when the program's full retirement age climbs to 66 years and eight months, it'll mark just the 10th time in 85 years that it's increased.

Image source: Getty Images.

This may not seem like a big deal, but the full retirement age is arguably one of the biggest problems with the Social Security program.

Back in 1940, when the very first benefit checks were doled out to eligible workers, the average life expectancy for a baby born in the U.S. was 60.8 years for men and 65.2 years for women. As of 2017, it had risen to 78.6 years for the average baby. Put another way, in the time it's taken for Social Security's full retirement age to rise by less than two years, the average life expectancy has increased by approximately 15 years. There are some pretty major implications for this disparity.

When the program was signed into law, it was designed with the idea that it would provide a financial foundation for those workers who could no longer provide for themselves. But the expectation is that these payouts would continue for years, not decades. Today, the Social Security Administration finds that the average 65-year-old will live another 20 years. That's potentially two or more decades of payouts, and it's clearly becoming a burden on the program.

Rising income inequality has also led to the exploitation of this disparity between the full retirement age and longevity. Since the well-to-do have little or no financial constraints when it comes to receiving preventative care, medical care, or prescription medicine, they're living substantially longer than the low-income workers that Social Security was truly designed to protect. Not only does this mean that wealthier individuals are, on average, receiving a Social Security payout for decades at a time, but this payout is considerably higher than the average monthly benefit paid to retired workers.

Image source: Getty Images.

So, why hasn't the full retirement age been increased to reflect rising longevity and ease some of the burden on the Social Security program? The issue is that increasing the full retirement age is akin to cutting benefits, and that's a big no-no for a lot of politicians on Capitol Hill.

Since your full retirement age represents the point at which you become eligible to receive 100% of your monthly payout, gradually raising it over a period of years or decades means reducing the lifetime earning potential of future generations of workers.

For example, one of the core solutions to Social Security's imminent cash shortfall offered by Republicans is the idea of gradually increasing the full retirement age from 67 to as high as 70. While sparing current and near-term retirees, such a move would likely require millennials and generation Z to either wait longer to collect their full payout or to accept an even steeper reduction by taking their benefit early. Thus, future generations of retired workers would have fewer years to collect if they wait, or would receive even less each month if claiming early. No matter their choice, the amount paid out by the program would be less than under the current model. It's a cut to long-term benefits.

Democrats in Washington, D.C. simply won't support any legislation that reduces benefits, either on an up-front or long-term basis. This is why legislation that increases the full retirement age, or even offers to index it to longevity, is unlikely to be addressed anytime soon.

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Sustainability and Longevity: New Trends in the Global Automotive ACC ECU Market 2020-2029 – Motor Expo

October 11th, 2019 1:44 pm

Reports Predict Growth in Global Automotive ACC ECUMarket research report highlights 2020 projection of business, market supercharge growth and challenges, new strategic technology and progressive approach innovations, future roadmap and forecast to 2029.

Acumulative analysis on Automotive ACC ECU Markethas included a report by Market.us, offers an exhaustive study based on current trends influencing this vertical throughout assorted geographies. Key data regarding different market size, world new comparative market share, statistics, growing application, and revenue are compiled in the research to develop an ensemble prediction. Additionally, this research provides an in-depth competitive analysis concentrating on business prognosis highlighting expansion plans accepted by marketplace volatility.

The portrays information of the report starts with the inclusion of basicdata as well as an overview of the market profile. It assembles information about key manufacturing technology and applications that informs about the growth of the automotive acc ecumarket. Based on the entire market overview, the market has been segmented into various segments, which also includes the maximum market share during the forecast period by 2029. The in-depth summary of the automotive acc ecu marketis also provided based on highly competitive scale, key players, and their market revenue in the particular year. Apart from this, the players from global, regional, and country-specific, who are making the automotive acc ecu market highly fragmented are also included.

Dont miss out on business opportunities inAutomotive ACC ECU Market | Get PDF Sample For Technological Breakthroughs:https://market.us/report/automotive-acc-ecu-market-request-sample/

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Competitive Analysis:

The global automotive acc ecu market 2020, research study putt a lot of stress on regulative problems, macro-economic influencing factors, key market trends and growth drivers that are changing the industry dynamics of the market. The study incorporates industry esteem chain, powerful business strategies, cost, structure, creation limit, conveyance, market range and limits usage rate. The Research study evaluating the region-wise market status, highlighting opportunities, risk analysis, and leveraged with strategic decision-making support bytop manufacturers-Bosch, Denso, Fujitsu, Continental, Autoliv, Delphi, ZF, Valeo, Hella.

Abstract:

1. New 2020 report covers the forecast and analysis for the Automotive ACC ECU Market on a global and regional level.

2. The technological advancements expected to boost revenue generated by thetop industry players has been analyzed in the report.

3. The market numbers have been calculated using top-down and bottom-up approaches.

4. The Automotive ACC ECU Market has been analyzed using Porters Five Forces Analysis.

5. The report includes trends, strategy and growth factor, SWOT analysis and detailed company profiles of the prominent market players.

The Goal Of The Report:

The main goal of this research study is to provide a clear picture and a better understanding of the market for the research report to the manufacturers, suppliers, and the distributors operational in it. The readers can gain a deep insight into this market from this piece of information that can enable them to formulate and develop critical strategies for the further expansion of their businesses.

Fill the Pre-Order Inquiry form for the report (Use Corporate Details Only):https://market.us/report/automotive-acc-ecu-market/#inquiry

Segment Snapshot:

By Type Coverage (Volume and Value from 2020 to 2029)

OEMAftermarket

By End-Use Application Coverage (Volume and Value from 2020 to 2029)

Passenger VehicleCommercial Vehicle

Promising Regional Description:

The most substantial areas covered from the accounts of global automotive acc ecu market areEurope, Asia-Pacific, North America, Latin America and the Middle East and Africa.

Factors that can be investigated through Global Automotive ACC ECU Market research include:

Market information:

* Prices of different commodities in the market

* Supply and demand situation.

Market Trends:Market trends are the upward or downward movement of a market, during a period of time.

SWOT Analysis:SWOT is a written analysis of the Strengths, Weaknesses, Opportunities and Threats to a business entity

Some of the Major Highlights of TOC Covers:

Chapter 1.Industry Overview

Chapter 2.Executive Summary

Chapter 3.Methodology and Scope

Chapter 4.Market Insights

Chapter 5.Market Dynamics, PESTLE Analysis, Opportunity Map Analysis, PORTERS Five Forces Analysis, Market Competition Scenario Analysis

Chapter 6.Company Profiles

Chapter 7.Appendix

Chapter 8.Research Conclusion

Reasons to Investment this Report:

1. Statistical Information Of Automotive ACC ECU Market Risk Factors, Challenges And Scope.

2. Qualitative and quantitative analysis of the market based on the segmentation.

3. Provision of market value (USD Million) data.

4. Diagnosis by geography emphasizing the ingestion of this product/service.

5. Competitive landscape which incorporates the market ranking.

6. The current as well as the future market outlook of the industry.

7. Top-Vendor Landscape of Automotive ACC ECU Market.

Highlights from the Automotive ACC ECU Market Report

An embellished scenario of the parent market

Transformations in the market dynamics

comprehensive segmentation of the target market

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‘Groomed for success’ | Local kennel discusses the secret to their longevity – 11Alive.com WXIA

October 11th, 2019 1:43 pm

EAST POINT, Ga. When Ricky Bevins started working part-time at Dandie Scottie Kennel nearly ten years ago, he never dreamed that one-day, taking care of pets would become his full-time career. However, in the fall of 2016, he became the third owner of one of the oldest kennels in the Tri-Cities.

Tucked alongside the rows of non-descript buildings that line the industrial corridor of Central Ave, the modest pea soup green one-story barely registers a glance in the shadow of the massive SA Recycling scrap yard. Chances are that many a Tri-Cities resident has driven past it as they trek from East Point to Hapeville or vice-versa.

Dandie Scottie originally began as a dog breeder for Scottish Terriers but Bevins tells My East Point news that by the time he took over the reins, that practice had fallen by the wayside. Although, he is proud to admit that the last dog breed at the kennel is still kicking and still gets groomed at Dandie Scottie.

While he may not have been the original owner of the kennel for its sixty-plus year history, Bevins attributes the longevity of the business to 3 things: customer service, knowing your product and refusal to quit.

Anyone that does business in East Point, lives in East Point, comes through East Point. Its their responsibility to try to lift East Point up, said Bevins.

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The 10 new cars owners keep the longest are mostly sports cars, SUVs – INSIDER

October 11th, 2019 1:43 pm

The new cars that owners keep the longest before reselling are mostly sports cars and SUVs, according to a study by car search engine iSeeCars.com.

Most owners keep their new cars for an average of 8.4 years, but the ten vehicles on the list averaged 9.7 to 11.4 years.

Almost all the sports cars on the list with the exception of the Porsche 911 in the coupe body style are the convertible versions. iSeeCars CEO Phong Ly claims this is because convertibles are the least-driven type of car and typically amass 60% fewer miles than the average car.

Read more: The 10 cars owners ditch after less than a year more than any other, according to data

"Sports cars typically aren't daily drivers and don't accrue high mileage as a result, so it takes them longer to show signs of wear and tear," Ly said in a prepared statement. "Because sports cars aren't typically used as primary vehicles, owners likely aren't as concerned with having the latest and greatest technology and safety features."

iSeeCars.com analyzed over 5 million cars to identify which models were kept the longest before being sold by their original owners between January 1, 2014 and December 31, 2018. Cars owned for less than five years were excluded from the data set.

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Push-ups? Here’s what can really help you live to a ripe old age – The Australian Financial Review

October 11th, 2019 1:43 pm

The problem with any of these approaches is that you would just be training for a particular test, which misses the point. It's not the push-up itself that makes you live longer; it's that you are still strong and nimble enough to execute one.

What these tests have in common is they're good shorthand of things that matter for longevity: overall health, fitness and muscle strength. A fit person walks faster than someone out of shape, and getting up off the floor is tricky for people with weak bones and muscles.

"Frailty is a really bad thing starting in middle age, and even worse as you get older," says Michael Joyner, a physician and human physiology researcher at the Mayo Clinic.

One way to think of longevity is "not as some magic property of a body, but as the lucky state of not having a fatal disease", says Steve Cole, professor of medicine and psychiatry and bio-behaviouralsciences at the UCLA School of Medicine. "By and large, people don't die of being old; they die of disease." Therefore, the study of longevity is a way of looking at disease risk or the rate of disease development, he says.

Over the years, various drugs and nutritional supplements have been studied for their potential to help us live longer, but nothing has been shown to work in humans to the extent that would be required for the Food and Drug Administration's approval, says Gordon Lithgow, chief academic officer at the California-based Buck Institute for Research on Aging.

While researchers continue searching for a pill to extend life, you'll have to try these verified methods.

The most powerful way to promote longevity and improve your long-term health is also simple and, depending on how you do it, free.

"There's no question that exercise is the biggest anti-ageing medicine there's ever going to be - it's really huge," Lithgow says.

"Hands down, nothing compares to exercise," says Laura Carstensen, founding director of the Stanford Center on Longevity. "The great thing is that most people can do it, and you don't need 10,000 steps per day to get the benefits." It takes remarkably little exercise to get longevity benefits.

Even 10 to 15 minutes a day provides measurable rewards, says Michael Joyner, a physician and human physiology researcher at the Mayo Clinic. Going from sedentary to even just a bit of exercise is where you get the biggest payoffs. The health benefits - such as reducing your risk of heart disease and diabetes - increase with greater amounts of exercise, until you get to about an hour of exercise per day. After that, the rewards start to level off.

"Almost anyone doing more than that is doing it for things other than health," Joyner says.

Go ahead and train for that Ironman if that's what you want, but if you're exercising for health and longevity, you don't need to run a marathon. Work by Iowa State University epidemiologist Duck-Chul Lee suggests that even running a little less than 10 minutes a day could decrease your mortality risk by about 30 per cent.

But you don't have to run. Walking or other moderate activities are just as good if you're looking for a longevity boost.

Some of the early evidence for the heart benefits of moderate exercise came from studies in the 1950s by British epidemiologist Jeremy Morris showing that conductors on double-decker buses, who spent their shifts walking up and down, had lower rates of coronary heart disease and thus lived longer than bus drivers who spent their workday sitting. Since then, studies showing the cardiovascular benefits of exercise have been "incredibly consistent", Joyner says.

But there's more. Physical activity also reduces the risk of diabetes, which one study found shaved six years off life expectancy.

And it keeps your brain healthy, too. "Exercise has better effects on cognitive performance than sitting around playing brain games," Carstensen says. A 2006 study in Neuroscience found that exercise spurs the brain to release growth factors that promote new connections between neurons, keeping the brain healthy. There's even research suggesting that strength training can reverse some age-related changes in your muscles.

There seems to be something about keeping an active lifestyle, too.

When you look at centenarians as a group, they might not be Arnold Schwarzeneggers, but they typically maintain a high level of physical function, says author Bill Gifford, who interviewed quite a few of them while writing his book, Spring Chicken: Stay Young Forever (Or Die Trying). "They can go up and down stairs, probably because they never stopped going up and down stairs," Gifford says.

His research for the book spurred him to make sure he was exercising at least a little bit every day.

Extend your life span while you sleep. It sounds like a bad infomercial, but it turns out that sleeping well is a good way to keep your body healthy for the long haul. Sleep is a time when your brain gets caught up on maintenance. In 2013, a team led by Maiken Nedergaard at the University of Rochester Medical Center published a study in Science concluding that sleep helps the brain clear out metabolic waste that accumulated during waking hours, providing a kind of restorative maintenance.

Skimp on sleep, and you hinder this important work.

If you've ever missed a night of slumber, you know that sleep deprivation hampers your mood and makes it hard to think clearly, but it can have severe consequences for your metabolic health, as well. Take someone who needs seven hours of sleep a night and restrict them to only five hours of shut-eye for five nights and they experience metabolic changes that look a lot like diabetes, says Satchidananda Panda, who studies circadian biology at the Salk Institute for Biological Studies.

Indeed, numerous studies have shown that sleep deprivation can decrease insulin sensitivity - a measure of how well your body regulates blood sugar - and increase your risk of diabetes. A 2015 meta-analysis found that Type 2 diabetes risk was higher in people who sleep less than seven hours or more than nine hours, compared with people who got seven to eight hours a night.

So why is sleeping more than nine hours associated with greater mortality? "People who sleep 14 hours per day are probably not healthy," Carstensen says, but it's hard to say right now whether it's possible to get too much sleep. Most people are on the other end of the spectrum.

Regularly sleeping too long may indicate a health problem

The consensus among sleep researchers is that seven to eight hours of sleep is ideal, but that's just a best guess based on the current data, Carstensen says.

"The biggest problem is that most of the data is self-reported and people are really bad at that," Carstensen says.

The advent of sleep trackers can help with the measurements, but they aren't always accurate, so avoid fixating too much on the exact numbers or you may end up in a cycle of anxiety that prevents you from sleeping. The problem is common enough that researchers have coined a term for it - orthosomnia.

Don't make a habit of skimping on sleep during the week with the idea that you'll catch up on the weekends. It doesn't take many nights of short sleep to reduce insulin sensitivity, and a small study published this year in Current Biology found that recouping on sleep over the weekend didn't entirely make up for the metabolic problems that developed during sleep deprivation. Furthermore, when volunteers in the study were given the opportunity to catch up on sleep over the weekend, they ended up shifting their body clocks so that it became harder to get up on Monday morning.

(Getting enough sleep every night might also improve your work life. In the throes of writing his book, Gifford made a decision to start prioritising sleep over work. His deadline was fast approaching, and he'd been getting up early and staying up late. Allowing his body to sleep as long as it needed to led to a "radical transformation in my ability to write", Gifford says. "I'd been trying to work 14 hours per day, and then suddenly I was getting twice as much done in six or seven hours.")

Forget all those headlines you've seen about "anti-ageing diets" and anti-aging "superfoods".

"These notions are generally not supported by science," Lithgow says. That's not to say diet isn't important, only that "nutrition is just a very difficult science", he says.

Severely restricting calories in lab animals makes them live longer, but "it's not clear that it works in humans", Lithgow says. Although there's plenty of evidence that it's not good to overeat, he says, whether drastically limiting food intake can extend life in people remains an open question. The joke, of course, is that calorie restriction will surely make your life seem longer.

It might be possible to get some of the benefits of calorie restriction without giving up so much food. Intriguing work by Panda suggests that restricting the timing of when you eat, rather than the amount, might provoke some of the healthy metabolic changes that reduce the risk of diabetes. Most of these studies have been done in mice, however, and Panda acknowledges that the human studies are small.

Although Panda is confident enough in the results to have written a book, The Circadian Code, which includes instructions on how to try it, some scepticism is warranted, Joyner says.

"Time-restricted eating has shown some interesting results in small studies," Joyner says, but "will it be sustainable over time in the real world? This is important because most dietary strategies work only if they are adhered to."

He says he wonders whether the metabolic benefits that Panda has found with time-restricted eating is really about the timing or simply related to people eating less when their dining hours are restricted. One thing shown repeatedly in anti-ageing studies is that things that initially look like magic bullets never live up to their initial hype, Joyner says.

What does seem clear, however, is that metabolic health is important for long-term health, because it keeps diabetes in check and that insulin sensitivity in particular appears crucial.

Given what we know right now, a Mediterranean diet - with its heart-healthy emphasis on fish, vegetables, fruits, nuts, healthy fats like olive oil, whole grains and limited consumption of red meat - "is probably the best approach for improving longevity", Carstensen says.

But the benefits are pretty modest. If you hate eating that way, then the payoff probably won't feel worth it to you, she says. At least try to eat a diet rich in fruits and vegetables.

The idea of red wine as a health elixir became popular in the 1980s with the observation that rates of coronary heart disease were low in France, despite the predominance of a diet relatively high in fat and cholesterol. The French penchant for a glass of red wine with dinner was proposed as an explanation for this "French Paradox", popularisingthe notion of red wine as heart helper.

Subsequent studies have indeed found that moderate alcohol consumption may reduce the risk of coronary heart disease, and a two-year randomisedclinical trial in Israel showed that people with Type 2 diabetes who were assigned to drink a glass of red wine with dinner every night experienced some improvements in blood markers associated with cardiovascular disease risk.

But other studies suggest that alcohol may raise the risk of many cancers, and a report published last year in the journal Lancet concluded that there's no amount of alcohol that improves health. What gives?

"Alcohol studies are very much like nutrition studies - based almost exclusively on self-reports, and we know that people are really bad at self-reporting," Carstensen says. "Most people, when they say they're drinking two drinks per day, are probably consuming more. We don't know the amounts that people are consuming nor do we know what else they do."

There's some evidence that people who abstain from alcohol are sicker or less healthy than those who imbibe a little.

"That probably reflects not a lack of alcohol in their system, but something about their world - that they're sick or isolated or don't have friends to meet at the pub," Carstensen says. "I've never seen a study that's really controlled for all of those factors." Which means that the studies calculating the health consequences of alcohol consumption depend on consumption figures that are inherently unreliable and may fail to account for other factors that could be at play.

Drinking to excess - more than one or two drinks a day - is unhealthy, and will take a toll on your longevity - no doubt about it. But taking the published studies together, "I don't think we have a lot of evidence that moderate alcohol is bad for you," Carstensen says. At the same time, she'd "be very hesitant to recommend that people who don't drink should start".

In today's world, it's easy to live in a state of chronic stress, and the problem isn't just that stress feels lousy. It also makes you more susceptible to diseases that could shorten your life.

Researchers are now learning that many conditions associated with older age - such as cancer, heart attacks and Alzheimer's disease - share a common ingredient: inflammation.

Under normal conditions, inflammation is simply the body's response to injury - it's how the body heals cuts and wounds and other insults, Cole says. "Inflammation by itself is not inherently evil." But when we're feeling chronically threatened or under siege, our bodies amp up their inflammatory machinery to ready our biological response to injury, and that inadvertently fuels the development of an array of age-related diseases, where inflammation is a common fertiliser, Cole says.

Research has identified chronic stresses that can provoke harmful biological changes, including living in poverty, caregiving for a dying spouse, losing a loved one, suffering post-traumatic stress disorder, and experiencing prejudice.

"Any way of feeling threatened or insecure seems to be enough to activate the body to produce more inflammation," Cole says. "This is one of the best defined connections between the world as we experience it and how we end up generating a body that's a fertile ground for the development of these diseases."

Your chance of developing chronic inflammation also rises with the passing years. "Inflammation seems to be a general sign of aging, where our inflammatory processes are being turned on or accumulated," Lithgow says. "Age-related inflammation is very much like inflammation from an injury, but now it's coming on without a source of infection."

What's the antidote? "Obviously we should all just be happy," Cole says with a laugh, as if it were that easy. He knows that it's not and says you probably can't eliminate stress from your life, but you can find ways to manage it. Identify the recurring stressors in your life, and work on a plan to diffuse them.

Wellness strategies such as yoga, tai chi and meditation can reliably help diffuse stress, Cole says, although he acknowledges that they often don't make a huge difference.

Forging connections with other people has been found to be a powerful way to manage stress and improve your overall wellbeing.

"People who report having stronger relationships live longer than people who are socially isolated," Carstensen says. A meta-analysis published in 2015 calculated that loneliness and social isolation were associated with 29 per cent and 26 per cent increases in mortality risk, respectively, and living alone was linked to a 32 per cent increase risk of dying.

What's clear is that people who have a strong sense of purpose and meaning in their lives have a markedly lower risk of death than those who don't.

"How we can bottle that and make it useful is more of a challenge," says Cole, who has studied loneliness and longevity.

Telling a lonely person to stop being lonely doesn't work, Cole says, "but if you can go to the lonely person and say, 'Hey, we really need your help. Is there anything you can do to help others?' - that is incredibly powerful. The mechanism here seems to be turning attention away from yourself and your own suffering and toward a community or cause greater than yourself."

Centenarians tend to have a sense of purpose in their lives.

"It's really important that people who are entering the later phases of life have a clear purpose, something to get up for every day," Lithgow says. That thing can be anything from looking after a grandchild or working or tending a garden.

Many centenarians continued working into their 80s, 90s and beyond, Lithgow says, and usually these jobs are in environments where they interact with younger people.

Interacting with other generations can keep older people engaged, and some retirement communities and nursing facilities are now taking steps to give their residents opportunities to connect with kids - for instance, placing kindergarten classrooms in nursing homes.

Most of the proven tips for living a long, healthy life are not products that you buy, but good lifestyle habits that you adopt (or bad ones, such as smoking, that you either quit or never take up and are clearly associated with diminished longevity).

Even something as simple as always wearing a seat belt can reduce your chances of dying early. Most of the things that make up a longevity lifestyle are simple - exercise, eat (and drink) healthily, sleep adequately, stay engaged - if only people would do them.

"To me, the bottom line is: Live a reasonably moderate life and you'll be OK," Carstensen says.

Washington Post

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‘NCIS’: How the Cast Feels About Not Receiving an Emmy – Showbiz Cheat Sheet

October 11th, 2019 1:43 pm

Most would agree NCIS is a great show. It has a huge fan base and is one of the most-watched television dramas. However, the shows following hasnt translated into an Emmy award (at least not yet). Heres how the NCIS cast feels about the series being passed over for an Emmy after all these years.

Mark Harmon told Entertainment Tonight host Kevin Frazier he knows how fortunate he is to be part of NCIS. Harmon said he tells actors who decide to leave the show that theyre leaving a special place with a lot of support. He also reminds them theyre leaving one of the top shows in the world:

And if we can talk about awards or talk about whatever, the longevity of this show, I tell young actors all the time. I say, Hey, are you gonna leave? Thats great. Good luck. And I said, But you come here, and you have a chance to work every day with friends who are going to support you. You work with a tremendous safety net underneath you here that nobodys going to let you fail. And I said, And theyre paying you. And, oh yeah, by the way, its the number one show in the world.

Harmon told Frazier the people who are part of NCIS genuinely enjoy being there. He says its a family environment where everyone comes together to just chat and talk about whats going on in their personal lives. I think its great that people love it, and people enjoy it. And we all sit here and laugh and talk about our day and how we approach it. But theres a bunch of professionals here who know what theyre doing. And I dont know that this kind of thing in network television is going to happen again, Harmon said.

Frazier asked the cast how they feel about doing such great work but never receiving an Emmy. This show has done Emmy-caliber work, but youve never won an Emmy. When you think about that, does it bother you? he asked. Rocky Carroll, who plays NCIS Director Leon Vance, says he isnt bothered about the lack of an Emmy when he thinks about the fate of shows that have one multiple Emmy awards. I think of all the shows that have won multiple Emmys that are not on the air, that have run their course. And, you know, I say that jokingly, but there are a lot of shows that have stood on the podium and accepted Emmys, but theyre in the Where are They Now? file now. And were still here, Carroll said.

Brian Dietzen (Jimmy Palmer) says not receiving an Emmy doesnttake away from the fact that theyre a talented cast:

I do think that 16 years, longevity doesnt preclude it from having some pretty awesome performances. I mean, whether its guest stars or some of the people in these chairs. There have been some amazing performances this year. The fact that we dont get recognized for awards season, its a bummer. I think wed all love to see that happen and whatnot, but that doesnt mean that the good work isnt happening right here. The fact that the people who do watch this show, see that and appreciate it, I think thats kind of what we hang our hat on.

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Insilico Medicine Becomes the Face of AI Drug Discovery – Nanalyze

October 11th, 2019 1:43 pm

In many industries, theres usually one or two companies that become nearly synonymous with their particular market. One of the most obvious examples is Coca Cola (KO). Think about it: We still refer to a soda as a coke, even though the soft drink manufacturer allegedly abandoned using cocaine in its formulation long ago. In emerging technologies like artificial intelligence, its more difficult to pinpoint a clear leader in many cases. Nvidia (NVDA) is still the obvious choice for AI chips. After that, there are very few household names that represent anything close to a pure play in AI technology. However, one name has emerged in the last few years that has become the face of AI drug discovery: Insilico Medicine.

Regular readers will certainly recognize the startup as a key player in the longevity industry. Weve profiled the company on several lists here and here related to drug discovery, as part of our ongoing coverage of life extension science. September was a particularly good month for the Rockville, Maryland startup. At the beginning of the month, it published a paper in Nature Biotechnology that detailed its efforts to design and validate a drug candidate for treating fibrosis and other diseases in just 46 days, shaving off months if not years from the discovery process, not to mention saving millions of dollars. A week later, the five-year-old startup completed a $37 million Series B, bringing its total disclosed funding to $51.3 million.

Insilico Medicine co-founder and CEO Alex Zhavoronkov

We recently caught up with Insilico Medicine co-founder and CEO Alex Zhavoronkov, who is on a crusade to prove that automation will be a big part of the future of healthcare. We talked about the companys recent achievement in accelerating the drug discovery process; its open challenge to big pharma; Insilicos numerous partnerships and joint ventures; the difficulties in getting funding for longevity therapy research and development; and the AI hype surrounding healthcare in general.

We wont spend too much time dissecting Insilicos latest achievement, as thats already gotten plenty of press. You can find a good deep dive into the paper and its significance by Margaretta Colangelo, a managing partner at Deep Knowledge Ventures, which made some of the first investments in the company about five years ago. It wasnt just the fact that Insilico Medicines new AI platform, called Generative Tensorial Reinforcement Learning (GENTRL), accomplished the feat of designing and validating a drug in such a short timeframe. It was also the first time anyone had combined two AI techniques known as generative adversarial networks (GANs) and generative reinforcement learning for drug discovery. Both Colangelo and Zhavoronkov refer to the achievement as pharmas AlphaGo moment, referring to Google DeepMinds defeat of a professional Go player.

Insilico Medicines AI platform, called Generative Tensorial Reinforcement Learning (GENTRL), combines two AI techniques known as generative adversarial networks and generative reinforcement learning for drug discovery. Credit: Insilico Medicine

Zhavoronkov first presented the paper at a conference in Basal, Switzerland, hometown to two of big pharmas biggest players Roche and Novartis. The choice of venue was obviously intentional, as Insilico has actively sought the spotlight since it was founded in 2014 in order to prove the value of AI to improve human health and quality of life. In 2015, for example, a group of Zhavoronkovsstudents and colleagues founded, Youth Laboratories, listing him as an adviser. It was a machine vision company that focused on aging and skin health which made headlines in 2016 for hosting an online beauty contest, Beauty.AI, that was judged solely by machines and attracted a bit of controversy for picking mostlyfair-skinned people. That led to yet another project, Diversity.AI, an effort to use machine learning to make sure we all have an equal opportunity to be spied on marketed to. Last year, the company was named to CB Insights prestigious AI 100 list.

But back to Insilicos primary focus: defeating age-related disease. Zhavoronkov believes his companys AI platform has advanced to the point where it could automate drug pipeline development from end to end and produce a marketable drug within 24 months or less with the right kind of backing. So while its efforts have focused on pre-clinical activities like identifying drug targets and developing therapeutic molecules around those specific disease targets, Insilicos AI also boasts predictive powers.

Insilico Medicine applies artificial intelligence throughout the drug development pipeline. Credit: Insilico Medicine

We also work with some of our pharma partners on predicting clinical trial outcomes; we also analyze clinical trials data, said Zhavoronkov, who is looking to partner with a major pharmaceutical company on an XPRIZE-type challenge where Insilico races against the clock to develop the first drug fully developed using artificial intelligence and one that targets a rare disease. If no contenders emerge, Zhavoronkov said he still believes it will be possible to develop a viable drug using AI within four or five years.

He noted that investment banks are also interested in Insilicos AI predictive analytics around clinical outcomes. The reason for the attention is obvious: If investors can leverage a tool that can better predict the chance of success or failure of a particular drug, that would surely influence how much money if any they are willing to put into a particular project or company. Weve noted previously that venture capitalists are increasingly turning toward AI to guide their investments into the hottest startups.

While Insilico awaits to see what big pharma company will emerge to take up its challenge, it has plenty of other partnerships and ventures to juggle. In fact, the company just announced today a new collaboration worth up to $200 million with one of Chinas biggest pharmaceutical companies, Jiangsu Chia Tai Fenghai Pharmaceutical Co. The goal of the collaboration is to accelerate drug discovery for triple-negative breast cancer using artificial intelligence.

We actually started making those kind of advanced partnerships where we would plan to take products into [clinical trials] only recently, Zhavoronkov said, for about the last year or so.

He noted that his company has about 16 ongoing collaborations, including several with one of the key players in the longevity industry Juvenescence. One of the more advanced joint ventures with Juvenescence is with a company called Generait Pharmaceuticals that is targeting senescent cells, which are cells that have stopped dividing but continue to secrete inflammatory molecules that damage nearby cells and tissues, leading to disease and an earlier death. Generait has already identified several disease targets but Zhavoronkov could not go into details at this time.

A sampling of some of the deals and partnerships brokered by Insilico Medicine. Credit: Insilico Medicine

Another joint venture between Juvenescence and Insilico, which also includes the nonprofit Buck Institute for Research on Aging, is Napa Therapeutics. Insilico has already done its part and Napa is now working on several potential drug molecules that could help boost the levels of an oxidized compound called nicotinamide adenine dinucleotide (NAD+), which is involved in getting the power plant of the cell called the mitochondria revved up again. So far, the molecules look very good, Zhavoronkov said.

Many [partnerships] are with smaller companies, you know, where we do get less money up front, but we do get the data, he noted. We need their pre-clinical data so we can train [our algorithms].

While Zhavoronkov is obviously pleased to have just pocketed $37 million from investors like Chinese AI tech giant Baidu and a pharmaceutical firm like Eli Lilly and Company, he feels that respect for the longevity industry is still lacking. For example, few of Insilicos major investors backed the company because they are specifically interested in life extension science, according to Zhavoronkov.

They invested not because of longevity. I actually need to divest of some of my longevity-focused programs, he explained. They invested because of the generative chemistry. It works; they know it works. Thats a major disruption. So thats why they invested. They didnt consider longevity; longevity is not being perceived as credible in financial circles yet.

Legitimacy is also difficult to build when there is so much hype around artificial intelligence.

There are lots and lots of scientific charlatans very often re-positioning very old technology as AI, he said. Suddenly, every statistician within big pharma became an AI scientist.

In terms of direct competitors, Zhavoronkov noted that he deeply respects the work being done by San Francisco-based Atomwise, but the technology from others is mostly smoke and mirrors. Thats why Insilico is focused on publishing its work in peer-reviewed journals in order to back up its claims. The company has published about 60 papers in the last five years.

Thats because Zhavoronkov believes that there is nothing more important than longevity, whether youre talking about the big-picture economics of healthcare or living more productive, healthier years in the twilight of life.

The goal is to create the longevity economy, he said. So, in the next couple years, as we ingest a little bit more data and develop more advanced algorithms, we will be able to go after more complex problems.

If the longevity industry does live up to its lofty goals of becoming the biggest industry in human history, Insilico Medicine will likely play a major role in that success. Even if we dont all end up living as old as Moses, the potential to cure some of humanitys most debilitating diseases is too good to ignore. And, right now, no one is ignoring Insilico Medicine.

We thinkthis AI-powered weight loss app could be a multi-billion dollar business - not because it's backed by the world's most sophisticated investors- but because it works. If you want to lose weight and keep it off for good, check out Noom. People who use Noom lose weight and keep it off for good.

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The Aesthetic Medicine Congress to bring trends in plastic surgery to Dubrovnik – The Dubrovnik Times

October 11th, 2019 1:42 pm

"The Aesthetic Medicine Congress", in collaboration with the British College of Aesthetic Medicine, takes place at the Hotel Palace from October 11 to 13. Top international and local experts will present trends in aesthetic medicine, rejuvenation and facial and body shaping for around 400 announced participants.

In addition to presenting the latest technology and research results, there will also be live demonstrations, interactive panels and lectures on topics ranging from aesthetic medicine to medical tourism.

The Second Congress of Aesthetic Medicine in Dubrovnik, under the high auspices of the President of the Republic of Croatia, Kolinda Grabar-Kitarovic, will be opened by Tourism Minister Gari Cappelli.

Apart from Croatia and the region, participants from Congress come from Britain, Ireland, Italy, Germany, Netherlands, Belgium, Switzerland, France, Greece, USA, Mexico, India, UAE

The famous names of aesthetic medicine are coming to the congrees, such as Raj Kanodia, Tapan Patel, Matt Stefanelli, Bob Khanna, Herve Raspaldo, Tracy Mountford, Tom van Eijk, Iman Nurlin, Dimitris Sykianakis, Ravi Jain and David Ecclestone. The local experts and lecturers are Sinisa Glumicic, Mario Zambelli, Nikola Milojevic, Davor Mijatovic, Zoran Zgaljardic, Tomica Bagatin, Zeljana Bolanca, Aleksandar Milenovic, Mladen Dudukovic and others.

TAMC 2019 is an international aesthetic congress that offers an interactive, evidence-based, multidisciplinary program and provides a platform to encourage the exchange of ideas and experiences, educate, initiate intense discussions, and expand opportunities for new contacts.

TAMC 2019 covers all aspects of aesthetic medicine, and this year's highlights include: anti-aging and face shaping dermal fillers, skin rejuvenation treatments including stem cell and blood plasma treatments, aesthetic gynecology, life extension (gerontology), body shaping and fat reduction, Botulinum toxin type A basic and advanced techniques, complication management, anatomy, cosmetic surgery, cosmetic dentistry, patient communication, business building and marketing, as well as medical tourism.

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The Aesthetic Medicine Congress to bring trends in plastic surgery to Dubrovnik - The Dubrovnik Times

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Sarah Ferguson was in pain during Eugenies wedding – and needed treatment to recover – Express

October 11th, 2019 1:41 pm

The Duchess of York, affectionately known as Fergie by the British public, decided to have pioneering regenerative stem cell therapy to be able to wear heels again. Fergie had to give up on her stilettos for a long time due to the excruciating pain she felt every time she tried to walk in them. And if she forced herself to wear high heels to mark important occasions she had to endure pain throughout the whole day.

Her feet caused Fergie trouble even during Princess Eugenies wedding last October.

Speaking to the Daily Mail, the Duchess of York said her feet were in such pain she felt relieved to be able to sit down in the pew and rest them for a while before Eugenie entered St Georges Chapel.

The source of the pain seemed to be her big toe, and now, thanks to regenerative stem cell therapy the Duchess is no longer in pain every time she opts to wear shows other than flats.

Fergie headed to the Bahamas to undergo stem cell therapy - an alternative to surgery which is yet to be proven fully safe and effective on humans and is therefore not widely available in the UK.

Speaking about her trip, she said: I went to the Bahamas in March to have the treatment.

I think my toes were ruined by all the riding I did when I was young.

They shaved the bone here and implanted stem cells 20 million of them taken from my midriff into my feet to make new cartilage.

It takes about six months to heal but now I can walk in heels!

READ MORE:The touching reason Beatrice will have British wedding

Fergie underwent a series of treatments during the years, including vitamin injections, organic fillers and botox - which she had a long time ago, when there was nothing else available.

Ahead of Eugenies wedding, Fergie underwent laser treatment to look her best.

Fergie attributed her glowing skin on October 12, the day of Princess Eugenies wedding, to her happiness.

But she also revealed she did seek the help of a professional to improve her natural beauty.

She said: The happiness was shining out of me because my daughter was getting married.

DON'T MISS

I was so glad. I love Jack. When Im passionate about anything, my eyes shine.

Above all, it was being joyful for Eugenie that made me look good.

But Id had some laser treatment on my face which helped, too.

Despite having used several techniques to stave off ageing, Fergie said there is one she is no longer going to have - Botox.

She said: I had Botox a long time ago when there was nothing else available.

I really dont like the frozen look.

Im so animated and I like to be myself.

I dont like the thought of needles and am very glad if I look well and happy.

Fergie also said she has stopped sunbathing after suffering two losses in her life which helped her realise she must take care of her skin just as well as any other organs.

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R3 Stem Cell Announces Addition of World Renowned Exosome Expert Dr. Ian White to Training Course – Yahoo Finance

October 11th, 2019 1:41 pm

The nation's leading regenerative training company, R3 Stem Cell, today announced the addition of world renowned Exosomes expert Dr. Ian White as a speaker at its training courses. He will be speaking at the October 18, 2019 course on Exosomes and there are still a few spots remaining!

LAS VEGAS, Oct. 10, 2019 /PRNewswire-PRWeb/ -- R3 Stem Cell announces it has added an exosome presentation to its upcoming regenerative training courses. The next course is October 18-19th, 2019 in Las Vegas with spots still open.

The speaker, Dr. Ian White PhD, is a world renowned expert on exosomes. He completed training at several Ivy League universities including Cornell, Harvard and Dartmouth. He currently serves as the Chief Scientific Officer at IMAC Regeneration Centers along with being President of Biofirma, which is a regenerative tissue manufacturing company.

Dr. White regular speaks worldwide on the topic of exosomes, stem cells and how they participate clinically to help optimize regenerative therapy outcomes. Exosome stem cell therapy is an amazing therapeutic option for patients, however, most providers do not understand the biologics and how to implement them properly.

According to R3 CEO David Greene, MD, MBA, "Obtaining knowledge on exosomes is important now, as patients are asking about them! Providers need to understand when to use them, how they work, and should have hands on experience with them. Our training course provides all of that experience."

R3 Stem Cell is the nation's leader in regenerative training, and provides a comprehensive education and hands on experience for providers to become their local leader. Along with offering the first rate exosome presentation, R3 will also have exosomes products on hand for attendees to try in a hands on setting.

Limited spots are still available for the upcoming October 18-19, 2019 training in Las Vegas. R3 is still offering $1000 off for the training, visit https://stemcelltrainingcourse.org/registration/ to sign up or call (844) GET-STEM.

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Stem Cell Therapy for Multiple Sclerosis Market 2025: Topmost manufacturers With Size, Regions, Types, Major Drivers, Profits – TheFinanceTime

October 11th, 2019 1:41 pm

A research report on Stem Cell Therapy for Multiple Sclerosis Market 2019 Industry Research Report is being published by researchunt.com. This is a key document as far as the clients and industries are concerned to not only understand the competitive market status that exists currently but also what future holds for it in the upcoming period, i.e., between 2018 and 2025. It has taken the previous market status of 2013 2018 to project the future status. The report has categorized in terms of region, type, key industries, and application.

A sample of report copy could be downloaded by visiting the site:marketreports.co/global-stem-cell-therapy-for-multiple-sclerosis-market-size-status-and-forecast-2019-2025/172555/#Free-Sample-Report

Global Stem Cell Therapy for Multiple Sclerosis revenue was xx.xx Million USD in 2013, grew to xx.xx Million USD in 2017, and will reach xx.xx Million USD in 2023, with a CAGR of x.x% during 2018-2023.

Major Geographical Regions

The study report on Global Stem Cell Therapy for Multiple SclerosisMarket 2018 would cover every big geographical, as well as, sub-regions throughout the world. The report has focused on market size, value, product sales and opportunities for growth in these regions. The market study has analyzed the competitive trend apart from offering valuable insights to clients and industries. These data will undoubtedly help them to plan their strategy so that they could not only expand but also penetrate into a market.

The researchers have analyzed the competitive advantages of those involved in the industries or in the Stem Cell Therapy for Multiple Sclerosisindustry. While historical years were taken as 2013 2017, the base year for the study was 2017. Similarly, the report has given its projection for the year 2018 apart from the outlook for years 2018 2025.

Key Players and Type

Like any other research material, the report has covered key geographical regions such as Europe, Japan, United States, India, Southeast Asia and Europe. Researchers have given their opinion or insights of value, product sales, and industry share besides availability opportunities to expand in those regions. As far as the sub-regions, North America, Canada, Medico, Australia, Asia-Pacific, India, South Korea, China, Singapore, Indonesia, Japan, Rest of Asia-Pacific, Germany, United Kingdom, France, Spain, Italy, Rest of Europe, Russia, Central & South America, Middle East & Africa are included.

Major players in the report included are :

Types covered in theStem Cell Therapy for Multiple Sclerosisindustryare :

Applications covered in the report are :

Report Aims

The objective of the researchers is to find out sales, value, and status of the Stem Cell Therapy for Multiple Sclerosisindustry at the international levels. While the status covers the years of 2013 17, the forecast is for the period 2018 25 that will enable market players to not only plan but also execute strategies based on the market needs.

Read Detailed Index of full Research Study at @marketreports.co/global-stem-cell-therapy-for-multiple-sclerosis-market-size-status-and-forecast-2019-2025/172555/

The study wanted to focus on key manufacturers, competitive landscape, and SWOT analysis for Stem Cell Therapy for Multiple Sclerosisindustry. Apart from looking into the geographical regions, the report concentrated on key trends and segments that are either driving or preventing the growth of the industry. Researchers have also focused on individual growth trend besides their contribution to the overall market.

There are 15 Chapters to display the GlobalStem Cell Therapy for Multiple Sclerosismarket.

Sections 1. Industry Synopsis of Global Stem Cell Therapy for Multiple Sclerosis Market.

Sections 2. Stem Cell Therapy for Multiple Sclerosis Market Organization Producers analysis and Profiles.

Sections 3. Stem Cell Therapy for Multiple Sclerosis Market Size by Type and Application.

Sections 4. Global Stem Cell Therapy for Multiple Sclerosis Market 2018 Analysis by key traders.

Sections 5. Europe Stem Cell Therapy for Multiple Sclerosis Industry Report Development Status and Outlook.

Sections 6. Japan Stem Cell Therapy for Multiple Sclerosis Industry Report Development Status and Outlook.

Sections 7. Development Status and improvements of Stem Cell Therapy for Multiple Sclerosis Market in the United States.

Sections 8. Southeast Asia Stem Cell Therapy for Multiple Sclerosis Market Improvement Status and Outlook.

Sections 9. China Stem Cell Therapy for Multiple Sclerosis Market Report Development Status and Outlook.

Sections 10. India Stem Cell Therapy for Multiple Sclerosis Market Development Status and Outlook.

Sections 11. Stem Cell Therapy for Multiple Sclerosis Market Figure by Aoplications, areas, and Sorts (2018-2023)

Sections 12. Stem Cell Therapy for Multiple Sclerosis Market Factors Analysis.

Sections 13. Stem Cell Therapy for Multiple Sclerosis Market Dynamics.

Sections 14. Research Findings and Conclusions of Stem Cell Therapy for Multiple Sclerosis Market.

Sections 15. Appendix.

Browse Detailed TOC, Tables, Figures, Charts And Companies Mentioned In Stem Cell Therapy for Multiple Sclerosis Market Research Report At@marketreports.co/global-stem-cell-therapy-for-multiple-sclerosis-market-size-status-and-forecast-2019-2025/172555/#Buying-Enquiry

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Stem Cell Therapy for Multiple Sclerosis Market 2025: Topmost manufacturers With Size, Regions, Types, Major Drivers, Profits - TheFinanceTime

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Translational Regenerative Medicine Market Estimated to Expand at a Robust CAGR over 2017 2025 – Online News Guru

October 11th, 2019 1:41 pm

Regenerative medicine is a segment of translational research in molecular biology and tissue engineering. It involves the process of regeneration of human cells, tissues, or organs to re-establish their normal functions through stimulation of bodys repair system. They are widely used in the treatment of many degenerative disorders occurring in the areas of dermatology, orthopedic, cardiovascular and neurodegenerative diseases. Stem cell therapy is the available tool in the field of translational regenerative medicine. It has gained importance in the past few years as it is a bio-based alternative to synthetic options. Stem cells have high power of regeneration. Hence, these enable production of other cells in the body. This has increased demand for stem cell therapy in the treatment of degenerative diseases. Currently, stem cell therapy has applications in the treatment of diseases such as autism, cancer, retinal diseases, heart failure, diabetes, rheumatoid arthritis, Alzheimers. Extensive research is being carried out on stem cell therapy. The Centre for Commercialization of Regenerative Medicine (CCRM) has reported around 1900 active clinical trials undergoing currently. It also reported 574 active industry-sponsored cell therapy clinical studies, 50 of these are in phase 3 development. Hence, stem cell therapy is projected to contribute to the growth of the translational regenerative medicine market. However, ethical issues in the use of embryonic stem cells is likely to restrain the market.

Rising prevalence of degenerative diseases, aging population, rapid growth of emerging countries, and technical advancements in developed countries are the major factors fueling the growth of the translational regenerative medicine market.

Browse more detail information about this report visit at at https://www.transparencymarketresearch.com/translational-regenerative-medicine-market.html

The global translational regenerative medicine market has been segmented based on product type, therapy, application, and region. In terms of product type, the market has been categorized into cellular and acellular. The cellular segment dominated the global market in 2016. Based on therapy, the global translational regenerative market has been segmented into cell therapy, gene therapy, immunotherapy, and tissue engineering. Immunotherapy is projected to be the fastest growing segment during the forecast period. In terms of application, the market has been segmented into orthopedic & musculoskeletal, cardiology, diabetes, central nervous system diseases, dermatology, and others. Cardiology and orthopedic & musculoskeletal are anticipated to be the fastest growing segments of the global translational regenerative medicine market.In terms of region, the global translational regenerative medicine market has been segmented into North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America dominated the global regenerative medicine market owing to a large number of leading companies and expansion of research and development activities in the U.S. Increased medical reimbursement and advanced health care also drive the market in the region. Orthopedic is the leading application segment contributing to the growth of the market in the region. Asia Pacific is forecasted the huge growth because of large consumer pool, rising income, and health care expenditure. However, the market in Asia Pacific could face challenges such as high cost of bio-based medicines and stringent regulatory policies.

The global translational regenerative medicine market is dominated by key players such as CONMED Corporation, Arthrex, Inc., Organogenesis, Inc., Nuvasive, Inc., Osiris Therapeutics, Inc., Celgene Corporation, Brainstorm Cell Therapeutics Inc. and Medtronic.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

Request For Custom Research At https://www.transparencymarketresearch.com/sample/sample.php?flag=CR&rep_id=30440&source=atm

The study is a source of reliable data on: Market segments and sub-segments Market trends and dynamics Supply and demand Market size Current trends/opportunities/challenges Competitive landscape Technological breakthroughs Value chain and stakeholder analysis

The regional analysis covers: North America (U.S. and Canada) Latin America (Mexico, Brazil, Peru, Chile, and others) Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg) Eastern Europe (Poland and Russia) Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand) Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industrys value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report: A complete backdrop analysis, which includes an assessment of the parent market Important changes in market dynamics Market segmentation up to the second or third level Historical, current, and projected size of the market from the standpoint of both value and volume Reporting and evaluation of recent industry developments Market shares and strategies of key players Emerging niche segments and regional markets An objective assessment of the trajectory of the market Recommendations to companies for strengthening their foothold in the market

Note:Although care has been taken to maintain the highest levels of accuracy in TMRs reports, recent market/vendor-specific changes may take time to reflect in the analysis.

Request for TOC of This Report visit at https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=30440&source=atm

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Food As Medicine: What Biochemistry And Genetics Are Teaching Us About How To Eat Right – Forbes

October 10th, 2019 9:49 am

We often talk about genetics as if its set in stone. She just has good genes or He was born with it are common phrases.

However, over the past decade, biochemists and geneticists have discovered that your genetic expression changes over time. Based on environmental factors, certain genes may be strongly expressive while others are dormant.

In fact, a 2016 study of human longevity found that only 25% of health outcomes are attributable to genetics. The other 75% of outcomes are attributable to environmental factors. Among those environmental factors, diet and nutrition play a major role.

An entire branch of scientific research has now exploded around nutrigenomics, the study of the interaction between nutrition and genetics. Scientists now understand that genes set the baseline for how your body can function, but nutrition modifies the extent to which each gene is expressed.

As more data comes in about the types and quality of food that improve health outcomes, high-tech farmers are also entering the nutrigenomics conversation. Using precision agriculture, they hope to produce food thats targeted to deliver a nutrient-rich, genetically beneficial diet.

Implications Of Nutrigenomics

Researchers have found that theres no such thing as a perfect diet. Dietary recommendations are not one-size-fits-all. Each individual needs different nutritional choices for optimal health and gene expression. In addition, each person is different in the extent to which their genes and health are impacted by their diet.

Geneticists and nutritionists are working together to study the dietary levers that most impact genetic expression. If theyre successful, it may be possible to prevent and treat disease through individualized nutrition tailored to your genetic profile. Indeed, you may walk into a doctors office and leave with a dietary prescription customized to your DNA.

In the near future, instead of diagnosing and treating diseases caused by genome or epigenome damage, health care practitioners may be trained to diagnose and nutritionally prevent or even reverse genomic damage and aberrant gene expression, reports Michael Fenech, a research scientist at CSIRO Genome Health and Nutrigenomics Laboratory.

The initial results of nutrigenomics studies are promising. A healthy, personalized diet has the potential to prevent, mitigate, or even cure certain chronic diseases. Nutrigenomics has shown promise in preventing obesity, cancer and diabetes.

If Food Is Medicine, Food Quality Matters

Nutrient abundance or deficiency is the driving factor behind nutrigenomics. Foods that have grown in poor conditions have a lower nutritional density. In turn, eating low-quality foods can have a significant impact on human gene expression. In order to take advantage of the findings of nutrigenomics, consumers need access to high-quality, nutrient-dense foods.

Similar to human health, plant health is impacted by the combination of genes and nutrient intake. Healthy soil, correctly applied fertilization techniques, and other forms of environmental management lead to healthy crops.

However, applying these custom growing techniques at a large scale is a major challenge. Agriculture technology (AgTech) will play a big role in allowing farmers to precisely manage the growing conditions and nutrient delivery for their crops. In turn, this precision farming will make crops more nutritious and targeted for nutrigenomics-driven diets.

Making Food Thats Better For Us

Plant health relies on nutrient uptake from the soil. In order to ensure plants receive the nutrients they need, farmers need to precisely apply additives where theyre needed. With in-ground sensors, advanced mapping of crop quality across a field, and other technologies, farmers can target their applications of water and nutrients to match plant needs. The days of broadly applying generic fertilizer to entire fields are coming to an end.

Farmers play an integral role in providing access to diverse, nutritious food, explains Remi Schmaltz, CEO of Decisive Farming. Nutrient deficiency in plants and the soil can contribute to the deficiencies found in humans. The opportunity exists to address these deficiencies through precision nutrition delivered by the agriculture sector.

Additionally, CRISPR and other technologies allow us to experiment with the genetic makeup of plants, increasing nutrition and flavor, both pluses for consumers. In recent years, genetic modification has produced disease-resistant bananas, more flavorful tomatoes, lower gluten wheat, non-browning mushrooms and sustainable rice. While there has been a lot of skepticism over genetically-modified crops, multiple studies have shown that GMOs are safe for consumption and can even improve plant health and nutrition.

Using Biochemistry And Big Data To Create Better Food And Healthier People

Nutrigenomics will completely change how we think about health and disease prevention. Indeed, personalized diet recommendations that are tailored to your genes could be a new form of medicine for chronic illnesses.

Nevertheless, a key part of making nutrigenomics effective is having access to high-quality, nutrient-dense foods. AgTech is using the internet of things, AI, precision farming and gene editing to make nutrient-dense food more readily available. The benefits to public health from these efforts could change the way we think about medicine, longevity and what it means to be healthy.

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Food As Medicine: What Biochemistry And Genetics Are Teaching Us About How To Eat Right - Forbes

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The thorny ethics of collecting genetic data – Quartz

October 10th, 2019 9:49 am

In 2009, researchers collected DNA from four elderly men in Namibia, each from one of the many San indigenous communities scattered across southern Africa. A year later, analyses of the mens DNA were published in the journal Naturealongside that of South African human rights activist Desmond Tutu. The intention, in part, was to increase the visibility of southern, indigenous Africans in genetic-based medical research. Soon after, a nongovernmental organization representing indigenous minorities in Southern Africa took issue with the consent procedures used to gather the data and wrote to Natures editors accusing the papers authors of absolute arrogance, ignorance, and cultural myopia.

The San case highlights the thorny ethics of collecting genetic data. Yet today, to make medicine more equitable, scientists see the importance of sampling DNA from more diverse populations. Most genetic research uses DNA from descendants of Europeans, which means the related medical applicationssuch as genetic tests to see the likelihood of developing a certain disease, called polygenic risk assessments can only benefit those populations. In 2018 in the United States, for example, the National Institutes of Health launched All of Us, a research program that aims to collect DNA, electronic health records, and other data, from about one million Americans with emphasis on including many different groups of people.

When we do genetic studies, trying to understand the genetic basis of common and complex diseases, were getting a biased snapshot, said Alicia Martin, a geneticist at the Massachusetts General Hospital and the Broad Institute, a biomedical and genomics research center affiliated with Harvard and MIT.

Research to capture these snapshots, called genome-wide association studies, can only draw conclusions about the data thats been collected. Without studies that look at each underrepresented population, genetic tests and therapies cant be tailored to everyone. Still, projects intended as correctives, like All of Us and the International HapMap Project, face an ethical conundrum: Collecting that data could exploit the very people the programs intend to help.

Researchers with All of Us have already collected data from about 1,600 Native Americans, some of whom live in cities outside of sovereign lands, where tribal approval is not necessary for genetic research, according to Krystal Tsosie, a geneticist at Vanderbilt University who is co-leading a study in collaboration with a tribal community in North Dakota .

Obviously theres an interest in monetizing biomarkers collected from diverse populations and underrepresented populations, Tsoise said, so without adequate protections, the concern becomes about exploitation.

Medical genetic research generally works like this: Geneticists use powerful computers to compare the genomes of people affected by a particular disease to healthy controls. Researchers mark genetic patterns that are common in people with, say, diabetes, but not the controls, as associated with the disease. The more samples geneticists feed to the algorithms, the more likely that the findings reflect reality.

But studies restricted to descendants of Europeans will only find associations between diseases and variants that are common in European ancestry populations, said Martinif those variants are common enough to be found.

Scientists use the results to develop polygenic risk scores, which count the risky variants on someones genome to estimate their susceptibility to a disease. But if studies dont use the genomes of non-white populations, the tests wont pick up on the problematic variants in different groups of people. One 2019 Nature Genetics study, on which Martin was an author, determined that these blind spots reduce the accuracy of polygenic tests by approximately two and five times in South or East Asian, and black populations, respectively.

In many cases, the groups whose DNA is missing have worse health care outcomes compared to their white counterparts, and genetic medicine could worsen these disparities. I think theres a huge responsibility, said Martin. If we look at the history of the field, over the past decade weve gone from participants in genetic studies being 96% European ancestry to about 80 percent. Weve shifted gears a little bit, but not nearly enough to be able to serve minority populations. Jantina De Vries, a bioethicist at the University of Cape Town, agreed that representation in genomics research can bring health benefits, particularly if it is paired with measures to build research capacity so that, eventually, there are researchers at every level within the groups themselves.

Collecting broader genetic samples poses a host of challenges. Efforts to collect and study the genomes of indigenous peoples, for example, have been controversial since the early 90s. The first such project, called the Human Genome Diversity Project (HGDP), was meant to explore the full range of genome diversity within the human family by collecting DNA samples from about 500 distinct groups, with an emphasis on indigenous peoples that might soon vanish. Indigenous-rights organizations criticized the project, taking issue with being treated as mere objects of scientific interest and potential for commercialization. All of Us, more recently, has run into similar objections from the National Congress of American Indians.

The concerns are linked to the long history of exploitative encounters between researchers and vulnerable populations. The Tuskegee Studyin which the US Public Health Service withheld treatment from African American men with syphilislasted from 1932 until 1972, ending less than 20 years before the HGDP proposal. And in 1989, researchers from Arizona State University collected DNA samples from the Havasupai Tribe and reused the data for research to which the participants hadnt consented: on schizophrenia, inbreeding, and migration history. Tsosie said this context has created a climate in which weve seen tribes deciding to disengage from biomedical research completely.

All the geneticists and ethicists Undark spoke with agreed that community engagement is crucial to establish trust. But they didnt agree on the degree of the engagement. Some believed that gaining the consent of communities is necessary for ethical research, while others said it was enough to have respect and open dialogue between researchers and the people theyd like to study.

But both approaches are difficult in the context of collecting and analyzing genetic data, since geneticists take DNA from individuals to make conclusions about entire populations. For instance, the San paper in Nature extrapolated findings regarding individual genomes to discuss the genomes of the broader communities. Ones genome is not their own specifically; ones genome is informed by their recent ancestry, their family structures, and their more distant ancestry, said Tsosie. Geneticists are never talking about an individual thats siloed.

The gap between individual and collective consent is partly responsible for the continued friction between genetic science and indigenous peoples. Collective consent, said Tsosie, who is herself Navajo, is more culturally consistent with how tribal groups govern themselves. In 2017, Andries Steenkamp, a San leader, and Roger Chennells, a lawyer, wrote that the Nature study failed in this regard by only getting informed consent from the indigenous individuals who participated.

Not everyone agrees that collective consent can or should be a requirement for all genetic studies. For instance, de Vries said, it depends what sort of community were talking about, drawing a contrast between small, rural, communities and larger populations spread across several cities or countries. If were talking about the entire Yoruba population, who would you even talk to? she added. The Yoruba are an ethic group of more than 20 million individuals, most of whom live in Nigeria, with smaller populations in Benin, Togo, and across several diaspora communities. De Vries believes the onus lies on researchers to think in terms of respecting communities, rather than in terms of collective consent.

Gaining collective consent involves logistical hurdles, especially for large-scale projects. The NIHs All of Us program, for example, wasnt able to get input from each of the 573 federally-recognized tribes. According to Tsosie, during the planning stages, there was talk of gaining tribal input, but that plan seemed to be abandoned early on. The All of Us website does have a section on tribal engagement, but only offers formal consultation and listening sessions for ongoing projects, not guidance on how to approach these issues before a project starts.

Among non-indigenous policymakers and scientists, Tsosie noted, theres a magical notion that stakeholders from every tribe can be brought together in one room when, in reality, that is not how we make consensus decisions for ourselves.

Even more difficult than logistics, perhaps, may be conceptualizing the genetic studies to begin withfor example, deciding which people belong in which groups. One of the greatest political acts, acts of power, that we perform as human beings is dividing ourselves up for the purpose of knowing and governing ourselves, said Jenny Reardon, a sociologist who specializes in genomics at the University of California, Santa-Cruz.

Globally, indigenous peoples are so culturally distinct from one another that a single understanding of a community wont resonate with everyone. Finding a method for data collection that crosses all indigenous groups is going to be really hard, said Vanessa Hayes, a geneticist at the Garvan Institute of Medical Research and the University of Sydney in Australia who conducts fieldwork in South Africa. Because, straightaway, thats assuming all indigenous people are the same. Without common ground, scientists must do the hard work of understanding each unique community. As Hayes put it, every group that you work with, you have to respect that group, and take the time to understand what is important in that group.

Hayes was one of the authors of the 2010 Nature study on the San, and she was responsible for obtaining consent, gathering samples, and discussing the results with the community. While Steenkamp and Chennells suggested the researchers were hasty in their data collection and ignored governance structures, Hayes countered that, at the time of the study, shed already been working in these communities for more than a decade and they were working directly with government agencies. Shed been in contact with the Working Group of Indigenous Minorities in Southern Africa (WIMSA)the NGO which would eventually criticize the studybefore it began. But, she said, when I went back to the community and asked if they knew who WIMSA was, they said no. I asked them if they wanted WIMSA to represent them, and they said, Hell no.

(As an organization, WIMSA is currently being restructured. The South African San Council, which now represents the San communities of South Africa, declined an interview with Undark, citing a requirement for financial compensation and a signed contract.)

Hayes followed the principles of collective consent, she said, just at a lower level than formal institutions like WIMSA or the San Council: Their decision was made as a group. They are the group, they are the band, they are the family. She added, No one can represent them that is not them.

The difficulties in defining a group make collective consent even more challenging.

In the clearest of circumstances, where an established organization exists, approval processes can be difficult to navigate and can take months. But within some indigenous and minority groups, issues of representation remain controversial. Often, a scientist will have to invest a lot of time interacting with potential subjects in order to judge what consent procedures are appropriate. Few scientists have the necessary time and resources.

There is no easy way to choose which organizations to deal with, especially when there are internal disagreements about representation. Or, as Reardon put it: The folks that are trying to democratize the science are going to have the same problem as the people who were attempting to treat it as Were just going to go out and get these groups, and study them from a scientific perspective.

Although the repeated controversies surrounding research and indigenous groups may have slowed their inclusion in genetic science, the researchers Undark spoke with said ensuring these concerns are heard and addressed is a vital part of the work. Indigenous groups are demanding a greater say in research that concerns them, whether under the All of Us program or conducted by individual researchers in Africa. Resolving the ethical ambiguities is no easy task, but, as Hayes asked: Why should it be easy?

This article was originally published on Undark. Read the original article.

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