StemCell Therapy

therapy treatment for stem cell therapy treatment for cerebral palsy by dr alok sharma, mumbai,
improvement seen in just 5 days after stem cell therapy treatment for cerebral palsy by dr alok sharma, mumbai, india. Stem Cell Therapy done date 31 Dec 201...

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REGULATED INFORMATION FEBRUARY 4, 2014

TiGenix reaches major cell therapy milestone with 1000th implant of ChondroCelect

Leuven (BELGIUM) - February 4, 2014 - TiGenix (NYSE Euronext: TIG), a leader in the field of cell therapy, announced today that it reached a major milestone with the performance of the 1000th ChondroCelect implantation for cartilage repair in the knee. ChondroCelect is the first cell therapy that was granted approval by the European Medicines Agency (EMA) as an Advanced Therapy Medicinal Product (ATMP). Today it is routinely used in orthopedic centers of excellence across several European countries.

"A 1000 patients have already benefited from this innovative therapy, further supporting its efficacy and safety profile," said Eduardo Bravo, CEO of TiGenix. "A milestone such as today's is a clear demonstration of how far the cell therapy field has progressed over recent years, and I have no doubt that it is on its way to become a mainstay in clinical practice. We will continue to work towards turning our ChondroCelect franchise into a cash flow positive asset, and to push the clinical development of our pipeline of stem cell programs to a successful conclusion."

About ChondroCelect An innovative treatment, ChondroCelect has been shown to result in long-term durable clinical benefits in patients with recent cartilage lesions. Five-year follow-up data confirm that the therapeutic effect and the clinical benefit of ChondroCelect gained over baseline is maintained up to at least five years after the cartilage repair intervention. In addition, the data confirm that early treatment with ChondroCelect results in a superior clinical benefit over microfracture, and a lower failure rate.

Cartilage lesions of the knee are a frequent cause of disability in the active population. Caused by repetitive microtraumata, or due to sports or traffic accidents, cartilage lesions rarely heal spontaneously. When untreated, they predispose to osteoarthritis, which causes disability and represents a major socioeconomic burden. A treatment that allows symptom relief and functional recovery is key. To meet this important medical need, TiGenix developed ChondroCelect, the first cell therapy that was granted approval by the EMA as an ATMP.

ChondroCelect is administered to patients in an autologous chondrocyte implantation procedure known as Characterized Chondrocyte Implantation. TiGenix has designed a sophisticated manufacturing process to preserve the cells' characteristics and biological activity, and to maintain their ability to produce high quality cartilage. This process meets the highest quality standards and has been approved by the EMA.

For more information: Eduardo Bravo Chief Executive Officer eduardo.bravo@tigenix.com

Claudia D'Augusta Chief Financial Officer claudia.daugusta@tigenix.com

About TiGenix

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TiGenix : reaches major cell therapy milestone with 1000th.

stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india. Stem Cell Therapy done date 7 ...

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stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india - Video

PHOENIX, Ariz. -

Stem cell research and therapy on humans has traveled a long and often politically troubled path.

Not so for pets, where stem cell treatment has been used for nearly 10 years and now it is so routine, and so successful, it can be done in a day.

Ava is a 90 pound, 2-year-old Akita, who is about to undergo stem cell surgery. A little IV, a little anesthesia and Ava is out.

"It is used for arthritis mostly," said Dr. Velvet Edwards.

Ava is just beginning her day at Pecan Grove Veterinary Hospital in Tempe. Dr. Edwards oversees the stem cell procedure.

"Stem cells are healing cells, so they seek out area of injury damage or destruction," explained Edwards. "They accelerate healing and help the animal, the patient, the pet just use their own natural abilities to get better."

Veterinary stem cells are harvested from the animal's own fat cells. They are separated and processed by machinery right inside the vet's office and then injected back into the dog's trouble spots.

Thanks to new technology developed by Meti Vet, the process is completed in just a day.

"The pet comes in the morning, it's anesthetized and I collect about two to four grams of fat usually behind the shoulder blade," said Edwards. "Then I hand that fat over to my technicians to run it through a series of steps.. basically to dissolve the fat and get down to a little stem cell pellet... Then we take that pellet and we reconstitute it and make it injectable. I will put it back into the animal's body wherever I need it later that day."

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Stem cell treatment: Controversial for humans, but not for pets

therapy treatment for spinal cord injury by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for spinal cord injury by dr alok sharma, mumbai, india. Stem Cell Therapy done date 7 Jan ...

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therapy treatment for spinal cord injury by dr alok sharma, mumbai, india - Video

Stem Cell Therapy: Non-Surgical Treatment for Neck Pain Whiplash
An informative guide to how Platelet Rich Plasma can heal the tough minority of whiplash cases where traditional treatments do not offer significant relief. For more information, visit http://www.stemcell...

By: StemCell ARTS

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Stem Cell Therapy: Non-Surgical Treatment for Neck Pain & Whiplash - Video

Stem Cell Therapy: Plantar Fasciitis
Understand whether the source of your pain might be Plantar Fasciitis, and how biologic regenerative treatments can repair this critical connecting tissue in your foot. For more information,...

By: StemCell ARTS

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Stem Cell Therapy: Plantar Fasciitis - Video

Failure to legislate will hurt research

Tuesday, January 28, 2014

Even though stem cell manufacture has just been licensed in this country, the Governments ongoing failure to legislate in this area means pharmaceutical giants will still be wary of investing here, according to an expert in stem cell therapy.

CCMI General Manager Andrew Finnerty, CCMI Director Tim O'Brien, Minister Sean Sherlock and President of NUI Galway Dr. James Browne. Photograph by Aengus McMahon

Once the stem cells are harvested from the bone marrow of adult donors, they are grown in the Galway laboratory to generate sufficient quantities.

The first clinical trial using these stem cells is being funded by the Health Research Board and Science Foundation Ireland and will investigate the safety of using mesenchymal stem cells (MSCs) isolated from bone marrow for the treatment of critical limb ischemia, a complication associated with diabetes which can lead to limb amputation.

John ODea of the Irish Medical Devices Association (IMDA) said the centre was a key step.

I look forward to seeing its continued growth to assist in developing the skill sets and techniques that will be needed to embrace the new manufacturing opportunities that this exciting area will bring, he said.

The centre, one of a handful in Europe authorised for stem cell manufacture, has been developed by researchers at NUIGs regenerative medicine institute.

However, Dr Stephen Sullivan, chief scientific officer with the Irish Stem Cell Foundation warned all stem cell research operates at a pan-global level driven by big pharma and international equity firms and these players will only engage with researchers in countries where there is solid stem cell legislation in place. He welcomed the centre as a first step but said if Ireland is to compete at a top international standard, legislation remains necessary.

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Failure to legislate ‘will hurt research’

Abandoned dog receives historic stem cell therapy
Veterinarians across the country now have a way to improve the lives of their patients by using a tool to combat osteoarthritis. On Thursday, one dog made hi...

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Abandoned dog receives historic stem cell therapy - Video

ELLSWORTH Visitors to the Bellaire pet crisis center With a Little help From My Friends get an official welcome from Moka.

The Labrador retriever was found behind a Bellaire restaurant in 2011 and now serves as the centers mascot.

Peforming her duties has been increasingly difficult for the dog, who suffers from severe arthritis in her hips. So recently the center turned to Ellsworth veterinarian Christian Randall of North Country Veterinary Services, the first in northern Michigan to offer in-clinic adipose stem cell therapy.

The procedure uses a pets own blood and tissue to produce plasma-rich platelets and stem cells that proliferate growth in damaged areas.

Dormant stem cells are separated from adipose -- fat tissue -- and activated with an LED technology that uses three different wave lengths of light. Then the cells are injected directly into the affected area or administered intravenously to help promote regeneration. The result is a decrease in pain and lameness and increased range of motion.

Its using the bodys own repair cells to repair damage, said Trey Smith, director of laboratory services for MediVet America, which developed the technology Randall uses.

The therapy is the first treatment to help heal and slow the progression of osteoarthritis and degenerative joint disease rather than just cope with the symptoms, said Randall, who saw the results while studying at Virginia Equine Imaging and now plans to use it on equine as well as canine and feline patients.

It concentrates, speeds up and amplifies the bodys own healing power, he said.

Stem cell therapy has been around for a while, but in-clinic availability of the technology is new. Only a handful of veterinarians in Ann Arbor and Grand Rapids offer the services, said Randall, who charges $1,800 to treat a dog or cat. Repeat injections are possible with banked plasma-rich platelets and stem cells.

Before the one-day procedure, veterinarians had to send blood and tissue to an outside lab for processing, a more costly three-day procedure that requires an animal's return visit to the vet for injection.

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Stem-cell therapy restores faith for arthritic pets

stem cell therapy treatment for global developmental delay by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for ______ by dr alok sharma, mumbai, india. Stem Cell Therapy done date 17/12/2013 After S...

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stem cell therapy treatment for Right Hemiparesis Cerebral Palsy by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for Right Hemiparesis Cerebral Palsy by dr alok sharma, mumbai, india. Stem Cell Therapy do...

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stem cell therapy treatment for Right Hemiparesis Cerebral Palsy by dr alok sharma, mumbai, india - Video

Yorkshire (PRWEB UK) 21 January 2014

Ongoing worldwide research is consistently proving that stem cells will be a cornerstone of medical treatments in the future. Already, literally thousands of stem cell therapies for a host of dangerous and life-threatening conditions have already been successfully performed, and specialists agree that many newly discovered treatments are just around the corner.

Stem cells are biological cell types found in multicellular organisms like mammals, and that, of course, includes us. The incredible thing about stem cells is that they are able to divide and change into other types of cell, and this is what gives them their unique ability to repair, or even replace, cells that have been damaged by disease or injury.

The potential for the health of younger and future generations is enormous.

Although stem cells are found in many different parts of our body, it is the stem cells found in our childrens teeth that are most precious in terms of their potential to safeguard health. While an inevitable crystallisation process makes adult teeth useless for stem cell therapies, first teeth and young wisdom teeth contain tooth pulp in perfect condition to provide useable stem cells. Whats more, children naturally lose 12 milk teeth over a 5-year period, and this means plenty of chances to collect the teeth most likely to be suitable for harvesting stem cells. The other big advantage of childrens teeth is that they fall out naturally, and that makes recovering the teeth a pain-free, risk-free and non-invasive process.

Today, scientists have the expertise and technologies to safely extract and store stem cells taken from baby teeth and wisdom teeth. Crucially, storing a persons stem cells for possible use in their own future medical treatment means that compatibility or finding the right match wont ever be an issue. This is one of the key factors that has given rise to people storing their own childrens cells as a way of protecting them against a future illnesses or conditions. Having access to a childs stem cells makes any future treatment far more likely to succeed, an extremely encouraging situation given that scientists are regularly discovering more and more conditions they can treat using stem cells.

So, what about the specific illnesses and conditions that tooth stem cells can be used to treat?

Scientists already know that stem cells within tooth pulp have the ability to develop into a wide range of tissues, including skin, nerve, muscle, fat, cartilage and tendon. This amazing versatility has huge and positive implications for medical uses of tooth stem cells, and thats why almost everyone has a vested interest in this medical breakthrough, from young adults, parents and expectant parents right through to those who might one day want a family.

Stem cell therapy has already enabled practitioners to grow skin, tracheas and corneas, as well as repair human hearts. Even more excitingly, it is now widely agreed that future stem cell therapies will allow medical practitioners to tackle a host of injuries, illnesses and heredity conditions. Among them, these are likely to include Type 1 diabetes; neuronal degenerative disorders like Alzheimers, Parkinsons and Huntingtons disease; cardiovascular disease; paralysis due to spinal cord injury; liver disease, strokes; heart attacks and joint repair. Stem cells can also help to repair the bodys immune system and, under the right conditions, can even be used to form organs, bone and other tissue.

BioEden have a UK team that has been right at the very heart of the science surrounding the extraction and storage of tooth cells in fact they are one of the worlds leading authorities on it.

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How saving their baby teeth could help save children’s lives

Poway, California (PRWEB) January 18, 2014

The leading Regenerative Veterinary Medicine Company, Vet-Stem, Inc., is proud to announce that its regenerative stem cell therapy has been used to treat 10,000 animals in the last 10 years of offering tissue processing services to veterinarians. Vet-Stem was founded in 2002, seeking to discover a successful treatment for horses with potentially fatal injuries to tendons and ligaments.

Dr. Robert Harman, CEO and Founder of Vet-Stem has spoken at many human and veterinary conferences sharing the results of real treatments. He has also authored or co-authored numerous peer-reviewed papers on stem cells as well as written book chapters on stem cells.

In 2003 Vet-Stem signed a worldwide exclusive license for adipose-derived (fat derived) stem cell technology for veterinary application, and the first horse was treated. Shortly after, the first dogs were treated with Vet-Stem Regenerative Cell Therapy. Vet-Stem started providing stem cell banking to their clients from the beginning so that cells could be stored for future use. By August of 2005 500 horses had been treated. Vet-Stem had effectively introduced a new, natural, injectable treatment to the equine and small animal veterinary industry that could serve as an alternative to euthanasia for some conditions.

By April 2006, 1000 animals had been treated using Vet-Stem cell therapy, including the first cat. Another milestone was the first ever randomized double-blinded placebo-controlled multi-centered study that was published reporting that using Vet-Stem processing, intra-articular injection of adipose-derived stem cells into the hip joint of a dog decreases patient discomfort and increases patient functional ability in relation to arthritis.

Only nine months after formally launching a Small Animal application, over 1,000 dogs had been treated for orthopedic conditions. At the same time Veterinary Therapeutics published a peer-reviewed study on the use of stem cells for treatment of chronic osteoarthritis in the elbow of dogs. The clinical trial reported significant improvement in lameness, range of motion, and functional ability in dogs treated with Vet-Stem Regenerative Cell Therapy.

Although the large majority of animals treated have been horses, dogs and cats, Vet-Stem has provided services for exotic species as well. The U.S. Navy, Office of Naval Research, awarded Vet-Stem a contract to engage in a collaborative study of stem cell biology in marine mammals in 2009. From this, the first peer-reviewed article was published showing successful isolation of stem cells from dolphin fat. Several media outlets featured a story on a panther from the Tallahassee Museum who received stem cell therapy by Vet-Stem for arthritis of the elbow in 2011. After the therapy he was able to stand up and scratch on his favorite tree with both front paws.

I started Vet-Stem in order to help horses with career ending injuries to their tendons and ligaments but so many more animals have been saved from a life of pain or even from euthanasia. I feel privileged and excited to be a part of this therapy that has changed how veterinary medicine is practiced as well as contributing to changes in human medicine, Robert Harman, DVM, CEO and Founder of Vet-Stem, Inc.

About Vet-Stem, Inc. Vet-Stem, Inc. was formed in 2002 to bring regenerative medicine to the veterinary profession. The privately held company is working to develop therapies in veterinary medicine that apply regenerative technologies while utilizing the natural healing properties inherent in all animals. As the first company in the United States to provide an adipose-derived stem cell service to veterinarians for their patients, Vet-Stem, Inc. pioneered the use of regenerative stem cells in veterinary medicine. The company holds exclusive licenses to over 50 patents including world-wide veterinary rights for use of adipose derived stem cells. In the last decade over 10,000 animals have been treated using Vet-Stem, Inc.s services, and Vet-Stem is actively investigating stem cell therapy for immune-mediated and inflammatory disease, as well as organ disease and failure. For more on Vet-Stem, Inc. and Veterinary Regenerative Medicine visit http://www.vet-stem.com or call 858-748-2004.

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Vet-Stem, Inc. is Proud to Announce Its 10,000th Animal in 10 Years of Stem Cell Therapy

Published:Tuesday, January 14, 2014

Updated:Tuesday, January 14, 2014 18:01

A new tool that could help facilitate future stem cell therapy has recently been identified by a UVM professor and his colleagues, according to UVMs College of Medicine.

The development of this tool could potentially help more than 700,000 Americans who suffer a heart attack each year.

Because stem cells have the potential to develop into a variety of cell types in the body, they may offer a renewable source of replacement cells to treat diseases, conditions and disabilities, and even regenerate damaged tissue and organs.

However, the field of regenerative medicine has struggled to successfully graft cells from culture back into injured tissue.

UVM Associate Professor of Medicine Jeffrey Spees, Ph.D., collaborated with the Center for Gene Therapy at Tulane University. His research team recently set out to develop ways to enhance graft success.

Dr. Spees and his team focused on a type of bone marrow-derived progenitor cell or biological cell that forms stromal cells or connective tissue cells.

They found that the medium contained Connective Tissue Growth Factor (CTGF) and the hormone insulin, and together, they have a synergistic effect, Spees said to UVMs College of Medicine.

The group found that the protective ligands resulted in improved graft success, breaking the record for engraftment.

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New tool assists stem cell therapy

one year after stem cell therapy by Dr Harry Adelson for an arthritic ankle
Jim discusses his outcome one year after stem cell therapy by Dr Harry Adelson for an arthritic ankle http://www.docereclinics.com.

By: Harry Adelson

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one year after stem cell therapy by Dr Harry Adelson for an arthritic ankle - Video

VAIL The Vail Symposium hosts Dr. Scott Brandt, Dr. Kristin Comella and Dr. Stan Jones who will lead an interactive discussion on the history, evolution, practical applications and clinical results around stem cell treatments Friday evening in Vail.

The program is part of the Symposiums ongoing Living at Your Peak series, which is dedicated to exploring new breakthroughs in medicine and helping people live healthier, more active lives.

This program fits perfectly with our Living at Your Peak series, said Tracey Flower, the Symposiums executive director. There is a lot surrounding this topic, and has been for quite some time. With recent research in a changing medical industry, it is a great topic to discuss.

An example of breakthroughs in stem cell therapy comes in the form of the record-shattering Broncos quarterback, Peyton Manning. After failed surgeries, Manning traveled to Germany to undergo stem cell treatment on his cervical spine. At 37, Manning is playing his best football.

During this educational program, panelists will discuss the evolution of the stem cell field, explain current procedures, present research and clinical findings, and talk about the potential for stem cell applications in the future.

Join the Vail Symposium at 5 p.m. Friday at the Antlers Hotel in Vail for this event, titled: Stem Cells: The Future of Medicine is Now. Space is limited; reserve your tickets at http://www.vailsymposium.org/calendar or call the Vail Symposium at 970-476-0954.

More about the panelists

Dr. Scott Brandt: Brandt, the medical director of ThriveMD in Edwards, specializes in regenerative and restorative medicine. Brandt completed his undergraduate studies at the University of Michigan at Ann Arbor, and attended medical school at Bowman Gray School of Medicine, Wake Forest University in North Carolina. He then completed his anesthesiology residency training and internship at the University of Illinois and Michael Reese Hospitals in Chicago. As a resident in anesthesiology, Brandt specialized in interventional pain management. Since 1997, this focus has kept him on the leading edge of medical innovations that provide longer lasting solutions for acute and chronic pain. The advancement of stem cell therapy, coupled with Brandts expertise in image-guided injections, has made joint rejuvenation an important part of his practice.

Dr. Kristin Comella: In 2013, Comella was named as one of the 25 most influential people in the stem cell field. She has more than 14 years of experience in regenerative medicine, training and education, research, product development and has served in a number of senior management positions with stem cell related companies. Comella has more than 12 years of cell culturing experience including building and managing the stem cell laboratory at Tulane Universitys Center for Gene Therapy. She has also developed stem cell therapies for osteoarthritis at Osiris Therapeutics. Comella has been a member of the Bioheart senior management team since 2004 and is currently serving as its chief scientific officer.

Dr. Stan Jones: Widely known for performing a ground-breaking stem cell infusion on Governor Rick Perry during a spinal surgery in 2011, Jones is a surgeon and stem cell expert. He received his bachelors degree from Texas Tech in Lubbock before earning his medical degree from the University of Texas Southwestern Medical School in Dallas. Jones continued his medical training at the University of Utah Medical School in Salt Lake City and a residency at the University of Texas Medical School at Houston. Jones was awarded a fellowship to study the lower back at Wellseley Hospital in Toronto, Canada. In addition, he served in the U.S. Army Medical Corp as a Captain. He is licensed to practice in the state of Texas and is certified by the American Board of Orthopedic Surgery.

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Learn about stem cell therapy and application at Vail event

Phoenix, AZ (PRWEB) January 08, 2014

The top Phoenix stem cell clinic in the Valley, Arizona Pain Stem Cell Institute, is now offering PRP therapy for joint arthritis relief. Platelet rich plasma therapy offers the potential for relieving the pain from knee, hip, shoulder and spinal arthritis. For more information and scheduling with the Board Certified Phoenix pain management doctors, call (602) 507-6550.

Platelet rich plasma therapy, known as PRP therapy, involves a simple blood draw. The blood is then spun in a centrifuge, which then concentrates platelets and growth factors for immediate injection into the arthritic joint. The PRP therapy then acts as an attractant for the body's stem cells.

Recent published studies have shown that PRP therapy offers significant pain relief for arthritic knees and helps preserve existing cartilage. One to three injections may be necessary to obtain optimal results, which are performed as an outpatient and entail minimal risk.

In addition to PRP therapy, the Arizona Pain Stem Cell Institute offers several other regenerative medicine treatments for both joint and spinal arthritis. This includes bone marrow and fat derived stem cell injections along with amniotic stem cell rich injections. These injections are offered for patients as part of numerous clinical research studies.

The stem cell injection studies are enrolling now at the Institute. The studies are industry subsidized, with the procedures performed by the Board Certified pain management physicians.

The Arizona Pain Stem Cell Institute is part of Arizona Pain Specialists. With 5 locations accepting over 50 insurances, the pain clinics offer comprehensive treatment options for patients with both simple and complicated pain conditions.

Call (602) 507-6550 for more information and scheduling.

Link:
Arizona Pain Stem Cell Institute Now Offering PRP Therapy for Joint Arthritis Relief

Beverly Hills, California (PRWEB) January 06, 2014

The top stem cell clinic in Beverly Hills and Los Angeles, Beverly Hills Institute of Cellular Therapy, is now offering revolutionary stem cell facelift procedures with a New Years pricing special. The procedure involves a nonoperative technique with amniotic stem cells performed by licensed providers. No incisions are necessary, and the outpatient procedures are being offered at 20% off regular price. Call (424) 253-5577 for more information and scheduling.

Traditional facelift procedures involve anesthesia, incisions and significant healing time. A stem cell facelift procedure is performed as an outpatient with no incisions or systemic anesthesia necessary. The Beverly Hills Institute utilizes amniotic stem cells, which are processed at an FDA regulated lab and have been used over 10,000 times without adverse events.

Stem cells have the capability to eliminate wrinkles and provide the skin with a more youthful, glowing appearance. The procedure allows patients to avoid the risks of infection and no stitches are necessary. It costs considerably less than a traditional facelift and now at 20% off is a great option for those desiring to look younger without going through separate procedures for each facial area.

As individuals age, the skin tone in the facial area and texture begin to decline. Stem cells are able to rejuvenate collagen deficient areas and have the capability to change into all types of cells in a procedure that is natural, affordable and safe.

Amniotic fluid is extremely rich in stem cells, growth factors, hyaluronic acid and anti-inflammatory cells. The combination works extremely well for the stem cell facial procedure, with results that are often noticeable quickly and long lasting.

This new technology is performed by licensed aestheticians, nurses and Double Board Certified physicians at the Institute. The procedure takes less than an hour to complete. In addition to the stem cell facelift, the Institute also offers stem cell injections for numerous musculoskeletal conditions including tendon and ligament injury along with degenerative arthritis. This includes stem cell therapy for knees, shoulders and hips.

For more information and scheduling to discuss options with stem cell procedures for looking and feeling younger while avoiding surgery, call the Beverly Hills Institue for Cellular Therapy at (424) 253-5577.

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Beverly Hills Institute for Cellular Therapy Now Offering Revolutionary Stem Cell Face Lift Procedure at Special New ...

One of the toughest problems facing embryonic stem cell therapy, immune rejection of transplanted cells, may have been solved, according to a UC San Diego-led research team.

The cells can be made invisible to the immune system by genetically engineering them to make two immune-suppressing molecules, according to the study. Researchers tested the approach in mice given a human immune system. Immune functioning in the rest of the animal remained active.

If the approach works in people, patients receiving transplanted tissue or organs made from embryonic stem cells wouldnt have to take harsh immune-suppressing drugs, said study leader Yang Xu, a UC San Diego professor of biology.

Human embryonic stem cells. The green markers indicate the presence of a protein expressed only in these cells. / Samantha Zeitlin, 2006 CIRM fellow

Researchers placed genes in the stem cells to produce the two molecules, called CTLA4-lg and PD-L1, naturally made in the body. The mice accepted transplants of heart and skin cells derived from the engineered stem cells. They rejected transplants derived from regular embryonic stem cells.

The study was published online Thursday in the journal Cell Stem Cell. Its findings will have to be confirmed for safety and effectiveness before human trials can be considered, which will take years.

Three scientists given the paper for comment had mixed reactions. While they praised the works scientific prowess, two said genetically engineering the transplanted cells could cause serious side effects that might preclude their use.

The researchers employed a clever strategy to use the immune systems natural regulatory systems, said Mitchell Kronenberg, president of the La Jolla Institute for Allergy & Immunology.

This is an especially promising approach, because it avoids the toxic side effects of the drugs now used to suppress the rejection response, and therefore this is an important step forward in showing the feasibility of using human embryonic stem cells from unrelated donors, Kronenberg said.

More skeptical were Jeanne Loring, a stem cell researcher at The Scripps Research Institute, and Craig M. Walsh, associate director of the Institute for Immunology at UC Irvine.

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Embryonic stem cell rejection problem fixed, study says