106-year-old woman shares hobbies, habits she says helped longevity Business Insider
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106-year-old woman shares hobbies, habits she says helped longevity - Business Insider
NN Group gets 13bn longevity risk transfer with Prudential and Swiss Re Reinsurance News
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NN Group gets 13bn longevity risk transfer with Prudential and Swiss Re - Reinsurance News
Tips to Improve Your Health & Longevity in the New Year KATU
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Tips to Improve Your Health & Longevity in the New Year - KATU
A fresh perspective on longevity savannahmagazine
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A fresh perspective on longevity - savannahmagazine
Este Lauder targets age reversal with Stanford Center on Longevity partnership Cosmetics Business
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Este Lauder targets age reversal with Stanford Center on Longevity partnership - Cosmetics Business
Longevity means taking a proactive approach to prevention Longevity.Technology
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Longevity means taking a proactive approach to prevention - Longevity.Technology
Decoding Longevity: Centenarian Traits and Aging Research BNN Breaking
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Decoding Longevity: Centenarian Traits and Aging Research - BNN Breaking
Brain Age: The Science of Cognitive Longevity BNN Breaking
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Brain Age: The Science of Cognitive Longevity - BNN Breaking
The Role of Exercise in Longevity: A Holistic Approach to Health and Fitness Medriva
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The Role of Exercise in Longevity: A Holistic Approach to Health and Fitness - Medriva
Get interventions to market and to people faster and cheaper Longevity.Technology
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Get interventions to market and to people faster and cheaper - Longevity.Technology
The Rocky Mountain States, for example, have a lower prevalence of cancer death compared to the Gulf States, says Chrysohoou yet the background radiation in Idaho, Colorado and New Mexico is around three times as high as the natural background radiation in Louisiana, Mississippi and Alabama. A few animal studies have also found that a very low dose of radiation can induce an anti-inflammatory response and DNA repair possibly in the same way that the small but beneficial stress of caloric restriction can trigger protective mechanisms within cells.
For the time being, the finding remains a curiosity. Many more studies would have to confirm that these patterns cannot be explained by other factors and their potential mechanisms; Chrysohoou certainly isnt suggesting that radioactive drinks might be the elusive elixir of youth. It is rather dangerous to expect that radioactivity is good for your health, she admits.
The moderation principle
Clearly, exceptional longevity of the Blue Zones cant be restricted to a single magic ingredient, but is the combination of many factors some of which are shared between the regions, and some of which are unique to each individual place. While that may not be as enticing as the discovery of a miraculous anti-ageing elixir or superfood, there are nevertheless many ways we could learn from these discoveries.
Eating moderately with plenty of fruit and vegetables, exercising plenty, drinking coffee and tea, and finding space for spiritual solace (whether thats church or a long mountain walk) these are things that we can all build into our daily lives.
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* David Robson is the author of The Intelligence Trap, which examines why smart people act foolishly and the ways we can all make wiser decisions. He is @d_a_robson on Twitter.
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The chorus of the theme song for the movie Fame, performed by actress Irene Cara, includes the line Im gonna live forever. Cara was, of course, singing about the posthumous longevity that fame can confer. But a literal expression of this hubris resonates in some corners of the worldespecially in the technology industry. In Silicon Valley, immortality is sometimes elevated to the status of a corporeal goal. Plenty of big names in big tech have sunk funding into ventures to solve the problem of death as if it were just an upgrade to your smartphones operating system.
Yet what if death simply cannot be hacked and longevity will always have a ceiling, no matter what we do? Researchers have now taken on the question of how long we can live if, by some combination of serendipity and genetics, we do not die from cancer, heart disease or getting hit by a bus. They report that when omitting things that usually kill us, our bodys capacity to restore equilibrium to its myriad structural and metabolic systems after disruptions still fades with time. And even if we make it through life with few stressors, this incremental decline sets the maximum life span for humans at somewhere between 120 and 150 years. In the end, if the obvious hazards do not take our lives, this fundamental loss of resilience will do so, the researchers conclude in findings published in May 2021 in Nature Communications.
They are asking the question of Whats the longest life that could be lived by a human complex system if everything else went really well, and its in a stressor-free environment? says Heather Whitson, director of the Duke University Center for the Study of Aging and Human Development, who was not involved in the paper. The teams results point to an underlying pace of aging that sets the limits on life span, she says.
For the study, Timothy Pyrkov, a researcher at a Singapore-based company called Gero, and his colleagues looked at this pace of aging in three large cohorts in the U.S., the U.K. and Russia. To evaluate deviations from stable health, they assessed changes in blood cell counts and the daily number of steps taken and analyzed them by age groups.
For both blood cell and step counts, the pattern was the same: as age increased, some factor beyond disease drove a predictable and incremental decline in the bodys ability to return blood cells or gait to a stable level after a disruption. When Pyrkov and his colleagues in Moscow and Buffalo, N.Y., used this predictable pace of decline to determine when resilience would disappear entirely, leading to death, they found a range of 120 to 150 years. (In 1997 Jeanne Calment, the oldest person on record to have ever lived, died in France at the age of 122.)
The researchers also found that with age, the bodys response to insults could increasingly range far from a stable normal, requiring more time for recovery. Whitson says that this result makes sense: A healthy young person can produce a rapid physiological response to adjust to fluctuations and restore a personal norm. But in an older person, she says, everything is just a little bit dampened, a little slower to respond, and you can get overshoots, such as when an illness brings on big swings in blood pressure.
Measurements such as blood pressure and blood cell counts have a known healthy range, however, Whitson points out, whereas step counts are highly personal. The fact that Pyrkov and his colleagues chose a variable that is so different from blood counts and still discovered the same decline over time may suggest a real pace-of-aging factor in play across different domains.
Study co-author Peter Fedichev, who trained as a physicist and co-founded Gero, says that although most biologists would view blood cell counts and step counts as pretty different, the fact that both sources paint exactly the same future suggests that this pace-of-aging component is real.
The authors pointed to social factors that reflect the findings. We observed a steep turn at about the age of 35 to 40 years that was quite surprising, Pyrkov says. For example, he notes, this period is often a time when an athletes sports career ends, an indication that something in physiology may really be changing at this age.
The desire to unlock the secrets of immortality has likely been around as long as humans awareness of death. But a long life span is not the same as a long health span, says S. Jay Olshansky, a professor of epidemiology and biostatistics at the University of Illinois at Chicago, who was not involved in the work. The focus shouldnt be on living longer but on living healthier longer, he says.
Death is not the only thing that matters, Whitson says. Other things, like quality of life, start mattering more and more as people experience the loss of them. The death modeled in this study, she says, is the ultimate lingering death. And the question is: Can we extend life without also extending the proportion of time that people go through a frail state?
The researchers final conclusion is interesting to see, Olshansky says. He characterizes it as Hey, guess what? Treating diseases in the long run is not going to have the effect that you might want it to have. These fundamental biological processes of aging are going to continue.
The idea of slowing down the aging process has drawn attention, not just from Silicon Valley types who dream about uploading their memories to computers but also from a cadre of researchers who view such interventions as a means to compress morbidityto diminish illness and infirmity at the end of life to extend health span. The question of whether this will have any impact on the fundamental upper limits identified in the Nature Communications paper remains highly speculative. But some studies are being launchedtesting the diabetes drug metformin, for examplewith the goal of attenuating hallmark indicators of aging.
In this same vein, Fedichev and his team are not discouraged by their estimates of maximum human life span. His view is that their research marks the beginning of a longer journey. Measuring something is the first step before producing an intervention, Fedichev says. As he puts it, the next steps, now that the team has measured this independent pace of aging, will be to find ways to intercept the loss of resilience.
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Humans Could Live up to 150 Years, New Research Suggests
Life expectancy is the statistical measure of the average time a person is expected to live. According to the World Health Organization (WHO), the global life expectancy as of 2016 was 72.0 years, 74.2 for females and 69.8 years for men. The average life expectancy at birth for the U.S. varies depending on the source. The latest figures are: 78.5 years, according to the OECD; 78.6 years, according to the CDC; 80.0 years, according to the CIA.
In general, life expectancy is based on two major factors: genetics and lifestyle choices. These include, but are not limited to: gender, access to quality health care, hygine, obesity, diet and nutrition, exercise, and crime rates. Overall, you can expect to see the highest life expectancies in the healthiest states. Additionally, women tend to live longer than men. American men expect to live an average of 76.1 years, while women expect to live an average of 81.1 years, a five-year difference.
Because the above factors vary greatly by state, so do life expectancies. On average, Hawaii residents live longer than residents in any other state, about 81.5 years, while Mississippi residents live the shortest lives at 74.6 years. This is a difference of 6.9 years. In general, the South has lower life expectancies than other parts of the country.
The ten states with the longest life expectancies, in order, are: Hawaii (81.5), California (80.8), Minnesota (80.8), New York (80.7), Connecticut (80.6), New Jersey (80.4), Colorado (80.0), Washington (80.0), Massachusetts (79.0), and Vermont (79.0). Hawaii has the longest life expectancy in the United States at 81.5 years. Women in Hawaii are the longest-living Americans at 84.3 years. If Hawaii were a country, it would have the 21st-highest longevity globally. Physical activity is high in the state, and its 25% obesity rate is the third-lowest nationwide. Low obesity rates are common in this list, with eight of the ten states having obesity rates at 28.3% or lower. Colorado has the lowest at 23.8%.
The ten states with the lowest life expectancies, in order, are: Mississippi (74.6), West Virginia (74.9), Alabama (74.9), Kentucky (75.1), Arkansas (75.4), Oklahoma (75.5), Louisiana (75.5), Tennessee (76.1), South Carolina (76.2), and Ohio (76.6). Mississippi's longevity is the lowest in the United States at 74.6 years. Mississippi men live the shortest lives on average of 71.4 years. Mississippi is the most obese state, with 40.8% of adults being obese. Unsurprisingly, nine of the ten most obese states are also on the list of the ten states with the shortest life spans. In general, Louisiana, Mississippi, Alabama, Oklahoma, and Arkansas are considered the least-healthy states, with high rates of obesity, excessive drinking, cancer, and heart disease, and low-quality health care.
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Life Expectancy by State 2023 - World Population Review
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With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Note that the numbers in parentheses (1, 2, etc.) are clickable links to these studies.
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By Joe Boland
July 6, 2021
Most people tend to look at the cycle of life as inevitable, and while its true that none of us can outrun Father Time, there are natural life extenders that can activate longevity pathways to slow the aging process.
Genes are not your destiny, says Dr. David Sinclair, Ph.D., A.O., on the Dr. Axe show podcast. You can change that rate of aging by doing the right things.
What are those things? Sinclair, a professor in the Department of Genetics, co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and founder of the Sinclair Lab at Harvards Blavatnik Institute, which specializes in genetics and longevity, says that a healthy lifestyle is the key, emphasizing these five things the most:
These things can extend your life span by 14 years or more just by doing the basics, he says. And it turns out an estimated 80% of your health and longevity is not genetic. It depends on how you live your life.
Sinclair says four important factors in longevity are:
By looking at these factors and others, Sinclairs team has been able to determine peoples biological age how old they are based on their bodies and health, not necessarily how long since they were born and his researchers have discovered a group of longevity genes called sirtuins.
They control how fast we age, Sinclair says of sirtuins. There are molecules in foods we eat that activate these defenses in our body, these genes. These molecules are the same that are in food types that people in Blue Zones eat: resveratrol and oleic acid found in things like olive oil, avocado and nuts.
It turns out, these genes are not predetermined. They can be fostered to help extend longevity and support a healthier overall lifestyle.
Weve got the wrong conception about what aging is. We tend to think that its just a natural process that we can do nothing about, but weve learned that thats not true 80% of the rate of our aging is in our own hands. Its actually controlled by how we live and what we eat, Sinclair says.
I am proposing a new theory about why we age: the loss of information in our body and how to preserve that information over time. The analogy would be if we had a DVD of information on ourselves, over time the it gets scratched, so the cell cannot read the original genetic information easily. What weve discovered is we can now polish that DVD and get the cell to read the useful information again. And in that way, were actually showing that we can reverse the aging process.
Theres a lot of evidence that fasting turns on these longevity pathways, Sinclair says. Dont eat three large meals a day and snack in between. I think the old idea of always having food around and never being hungry has to be revised.
Dont sit in a chair all day. Get a standing desk if you can. Go for walks, and even better do HIIT if you can. Work out. Keep your muscles from declining, says Sinclair.
Maybe its also finding a new sport that you want to play again and again, with friends such as golf, tennis or pickleball.
Sleep affects all aspects of health and has huge effects on aging. Its vital. Aim for at least seven hours a night.
Part of that is having a goal in life. The other is to have a partner or friends and family that are caring and loving around you. That will definitely reduce your amount of stress. Itll help you sleep, and itll make every day much more enjoyable as well, he says.
Chronic stress is a real problem for aging, he adds. It can rapidly shorten the ends of chromosome, the telomeres. We also know mainly from studies in the lab with mice is that if you manipulate the brain of the mouse to have more inflammation, it will age prematurely and vice versa if you lower the inflammation in the brain it can live longer.
We also know that if you turn gene No. 1 on in the mouses brain, itll be healthier and live longer. That tells me probably how our brains are functioning, how worried we are, how depressed we are can have major impacts on the aging of the rest of the body.
Remove the bad from the diet, and focus on nutritious foods:
I stopped eating dessert at age 40, though I still steal tastes, Sinclair says. Try to focus on fresh food if you can, and also I think plant-based mainly is the way to go for ultimate longevity based on a lot of data over the last few thousand years. We know that thats what you need to do.
I try to skip breakfast or have a very small breakfast, Sinclair says.
He has a few spoonfuls of homemade yogurt mixed with resveratrol if he does eat breakfast, then doesnt eat again until having a late lunch or even dinner on busy days. When he does eat lunch, he typically eats light, such as a salad without much dressing and possibly some fruit. He also consumes plenty of hot drinks that are low in caffeine to support immunity.
Then for dinner I eat mostly a plant-based diet, Sinclair says. Ill eat a little meat since I lift weights to help body recover but not a big red meat, steak guy. I dont think in the long run thats super healthy. Carnivore diets are OK short run, but I focus on eating plants that are picked freshly.
Sinclair describes these as activities that trick the body into feeling like its under threat, under adverse conditions, and it fights back. Thats hormesis. The definition of hormesis is to be uncomfortable, and that pays dividends in the long run.
For people who are in the second half of their life, its important to maintain flexibility and muscle strength. Lift some weights. Especially if youre in the first half of your life and all the way up to 80, you want to do high-intensity interval training, get your heart rate up to a safe level. It doesnt have to be for a half hour it can be as little as 10 minutes every few days. That alone has been shown to have remarkable protection against diseases of aging, says Sinclair.
Related: Can Reduced Brain Activity Boost Longevity?
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Longevity: The Keys to Slow the Aging Process - Dr. Axe
"I got a 20-year contract. Giannis is going to play for 20 more years" - Mike Budenholzer on the longevity of Giannis Antetokounmpo and the Milwaukee Bucks Basketball Network
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"I got a 20-year contract. Giannis is going to play for 20 more years" - Mike Budenholzer on the longevity of Giannis Antetokounmpo and the...
"I think Nadal has been doing a great job of that in the last four or five years": McEnroe believes Murray needs to shorten points for longevity TennisUpToDate.com
Jon Voight is 'blessed' to have had such a long Hollywood career Yakima Herald-Republic
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Jon Voight is 'blessed' to have had such a long Hollywood career - Yakima Herald-Republic
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USD Index to sink to 103 by end-2023 amid greater certainty and longevity of Dollar downtrend Westpac - FXStreet
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