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Archive for the ‘Longevity’ Category

Crew – Issues of longevity and proficiency – Superyacht News – The Superyacht Report

Wednesday, October 30th, 2019

In the run up to The Superyacht Forum 2019, SuperyachtNews spoke to John Wyborn, training director at BlueWater, to discuss the next generation of operations, considering who operate, maintain and manage the everchanging superyacht fleet in the future. During The Superyacht Forum, Wyborn will take centre stage with a panel of experts in a session called The Next Generation to discuss the future of operations.

What needs to change is the way people are recruited into the sector, starts Wyborn. There are some changes afoot and the industry is starting to develop a pipeline of people coming in that were requiring to have certain skills.

For example, UKSA in Cowes has started an apprenticeship where 16-18-year olds can learn necessary skills, he continues. Our plan then, when they graduate next Spring, is to try and place them in roles with the hope that they will remain in those jobs for longer periods of time than some current crew. The current issue is that the industry is placing too many graduates or lifestyle tourists in junior crew roles. However, the UK is waking up to this and there is a lot of potential government funding to provide training to young people in our sector.

Management companies need to take control. You cant change owners, you can simply manage expectation"

Ensuring the future quality of the workforce is vitally important to ensuring the prosperity of the market itself. How many times have we heard owners complaining about the quality or attitude of their crew? Too often. But, who bears the responsibility for working towards a proliferation of quality junior crew.

Management companies need to take control. You cant change owners, you can simply manage expectation, explains Wyborn, management companies need to lead this and [accept that] they have quite a responsibility. There needs to be a culture of learning on board, thats what they need to focus on.

Wyborn also believes that there needs to general change in crew members approach to safety on board. There is too much focus on tick box compliance and not enough on reality. There are many initiatives to try and improve that, such as the programme implemented by the Merchant Navy training board, which will make life easier for management companies and Im hoping to push that. This would provide training and exposure to potential risk which is a vital lesson for any crew member he says.

As we look towards a new generation hoping to enter the superyacht industry, either as a deck hand or in a management role, steps need to be made to ensure that issues relating to the proficiency and longevity of crew are dealt with. At The Superyacht Forum we look forward to a dynamic discussion in which a number of the markets foremost operational experts will explore the future of operations and discuss actionable market improvements.

The Superyacht Forum will take place from 18-20 November in Amsterdam alongside METSRADE. To register your place at the forum, click the button below.

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Cristiano Ronaldo reveals the key to his longevity and the importance of meditation – The Independent

Wednesday, October 30th, 2019

Cristiano Ronaldo has revealed his obsession to stay young as he continues to maintain his standards at 34 years of age while at Juventus.

The Portuguese recently scored his 700th career goal.

And Ronaldo believes his longevity comes down to his obsession to look beyond the training pitch to remain on top, including his love of meditation.

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My goal is to stay young as you get older, so competitive. Give me a player of my age who performs as much as I do at age, in a team like Juventus? Its very difficult, you know, Ronaldo told France Football.

They say that I have an athletes body, but its not just the physical or the training.

This week, The Independent is counting down the 100 greatest players of the 21st century. We will be revealing 20 players per day, today revealing the players who placed 100-21.

A brilliant midfielder who had everything: skill, tenacity, power, goals, energy. His defensive capabilities brought him to the fore at Barcelona before his attacking prowess made him such a weapon for Manchester City. He won two Ligas, three Premier Leagues, one Champions League, captained Ivory Coast to the Africa Cup of Nations and was African Player of the Year four times. LO

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His raw statistics are simply phenomenal. 130 Premier League goals for Tottenham Hotspur, in just 186 appearances. 27 in 42 for England. Twice a Premier League Golden Boot winner. A World Cup Golden Boot winner. Tottenhams talisman. Englands captain. And still just 26 years old. In 10 years time, expect to see Kane in the top 20 of a similar list. LB

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A ferociously competitive and combative midfield hard man, who made over 600 appearances for his beloved Roma and over 100 for his national team. A complete midfielder, who could in one passage of play win the ball, race forward and either release a team-mate with a pinpoint pass or score himself. And do not be fooled by his combustible reputation: in 2016, he placed his treasured World Cup winner's medal in the coffin of Pietro Lombardi, Italys kit man at the tournament. LB

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The meticulous German orchestrated Bayern Munich's midfield to eight Bundesliga titles and a Champions League, making over 500 appearances for the club. He was also one of the leaders in Germany's 2014 World Cup-winning campaign and carried an aura in the centre of the pitch few players can claim to have replicated. TK

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Its difficult to define his importance to both Manchester City and Belgium but its safe to say he was one of the most important players of a generation. There may well be a handful of technically better centre-backs but his intangibles were vital to the culture at club and country where there was not a legacy of winning previously. JR

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One of the few strikers on this list who can truly claim to be the complete forward, able to play wide or central, deep linking play or on the shoulder of the last defender, with the ability to sniff out scrappy goals and score beauties too. His medal haul speaks for itself, and he is approaching 300 career goals. But for his strained relationship with the French national team, he would have scored even more. LO

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The heartbeat of Arsenal's defence in the Invincibles season, a double-winner in 2002 and a mainstay of the England team for almost a decade, Campbell is one of the defining defensive figures of the Premier League era. TK

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One of the great villains of the game but a nasty, hard centre-back that would be very high on any great strikers list of defenders he least wanted to play against. While his grit and determination stand out, nobody lasts a decade at the Bernabeu without possessing exceptional quality, with three La Liga titles (which has eluded the club since his departure) and as many Champions Leagues, Zinedine Zidane would be wise to acquire a similar player now. JR

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The four-time Premier League winner made over 300 appearances in England and made an enduring habit of thriving under pressure, winning the man-of-the-match award in Manchester United's Champions League final victory in 2008. TK

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Only the finest players in the world enjoy long and fruitful stints at clubs such as Juventus, Bayern Munich and Barcelona. Il Guerriero has matured into a splendid holding midfielder, aggressive and dominant in the middle of the pitch but equally as effective arriving late into the box to complete attacks. A hero in his native Chile, for his role in the 2015 Copa Amrica victory. LB

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A key player in the glorious Real Madrid side that won La Liga in 2011/12 and the Champions League two seasons later. Widely considered a flop when he left Manchester United after only one miserable season, but the Argentine completely reinvented himself at Paris Saint-Germain, the starring attraction in one of the most expensive squads ever assembled, containing the likes of Neymar, Kylian Mbapp and Edinson Cavani. LB

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A figure of fun in his early Premier League days at Manchester United, Forlan went on to have the last laugh with a stellar career both internationally with Uruguay and in Spain, where he racked up goals for Villarreal and Atletico Madrid, twice winning the European Golden Shoe. LO

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In his pomp Falcao was probably the best striker on the planet. In a prolific four-year spell playing for Porto and Atletico Madrid he scored 142 goals in 178 games, and had injuries not hindered his career there is little doubt that Colombia's record scorer would be much higher up this list. LO

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Has excelled in a thoroughly mediocre Arsenal side for two seasons now, scoring at a rate better than a goal every other game in a side that has struggled since the departure of Arsne Wenger. But it is primarily for his achievements at Borussia Dortmund that he makes this list. He scored close to 150 Bundesliga goals for that wonderfully attacking team including 31 in one season winning the Bundesliga Player of the Year and Top Goalscorer awards. There have been few strikers as rapid or as decisive in front of goal in the last two decades. LB

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One of the best left foots in Premier League history graced two of its most revered clubs, becoming a star at both Arsenal and Manchester United. The Dutchman had a penchant for the spectacular but suffered with injuries, and it is a sign of what could have been that in the two Premier League seasons he played more than 30 games, he won the Golden Boot in both. LO

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A real pest of a striker who thrived in the hottest atmospheres and regularly overcame adversity. He scored plenty too, 116 league goals in eight seasons with United, City and Juventus (who probably all enjoyed prime Tevez), but it was the way he would trigger his teammates by forcing the first mistake or sparking counterattacks that really made him such an invaluable player. JR

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The midfield maestro could control games and decide them too, and was at the heart of the brilliant Valencia team which reached back-to-back Champions League finals in 2000 and 2001. He became one of the most expensive players of all time when he switched to Lazio, but he would never again reach the heights that made him a legend at the Mestalla. LO

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The defensive talisman cast a spell of leadership over Liverpool's 2019 Champions League-winning side and went the entire campaign without being dribbled past. Few defenders have carried such an overarching influence on any side in recent memory. TK

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One of the finest finishers of a generation but perhaps his best quality was his movement; particularly in the box, where nobody was more lethal at finding a yard of space and punishing opponents. Strong and an aerial threat, he was perhaps unfortunate to follow Gabriel Batistuta with Argentina, otherwise he would have been appreciated even more. Certainly as talented as Sergio Aguero and with perhaps more composure in the biggest occasions - an underrated player. JR

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A gem of a centre-back, who was perhaps ahead of his time, right now he would be even more valuable due to his versatility to thrive under any manager, no matter the philosophy or style of play. Became a real winner and leader at United and formed one of the greatest partnerships in international football history alongside John Terry with England - who should have obviously achieved much more with such an outstanding foundation to their team. JR

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A metronome in the middle, one of the finer passers in the world of football and the beating heart of a number of very successful sides, not least the World Cup winning Germany side of 2014. Four Champions League crowns as a key cog for Bayern Munich and Real Madrid underline his quality, but if you are to criticise it is that there have always seemed to be others doing more around him. HLC

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A traditional No 10 who was unhelpfully branded the new Maradona when he began setting the Primeira Division alight with Boca Juniors. His 10m move to Barcelona in 2002 did not exactly go as planned with another talented Argentine poised to write himself into club folklore instead but Riquelme made a success of himself in Spain with Villarreal under Manuel Pellegrini. A true artist who shone in an advanced playmaker role, before dropping deeper into midfield as his ageing legs lost their pace. LB

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Muller has popped up with important goals for Bayern Munich and Germany throughout his career. The gangly forward has scored nearly 250 goals combined for club and country, which has helped Bayern to eight Bundesliga titles and a single Champions League and Club World Cup. Muller will not be the last player to excel with Bayern and Germany, but he may well be the last sort of his type of player, placing the importance of timing and occupying space above all else in the game. KV

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The Egyptian king has turned into one of the most feared forwards in world football since joining Liverpool from Roma in 2017. After a torrid time at Chelsea, Salahs second spell in England brought about a Premier League history as he netted a record 32 goals in 36 league games. The outright Premier League top scorer in 2018 and the joint winner last season, no longer is anyone laughing at the 35m Liverpool paid for him over two years ago. KV

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The kind of defender every one wants on their team and no one wants to come up against. Godin is tough, utterly committed and completely fearless, and at the peak of his powers when Atletico Madrid won La Liga he was probably the best defender around. LO

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A midfield maestro capable of playing the game at his pace; speeding up and slowing down while painting a picture amid the frantic action in Premier League games. Silva has never been flustered and can always be relied upon to stand up in the most opportune moments, a cornerstone of the Manchester City era and a candidate for their best ever player, despite the money lavished on various other superstars. JR

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Such quality in tight spaces and an almost unrivalled ability to dribble at pace, Hazard is capable of true magic, with his best Premier League seasons propelling Chelsea to two titles, and earning . There have been more fallow years, of course, but at his best Hazard has been magnificent, including in helping Lille to Ligue 1 glory in 2010-11. HLC

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The fulcrum of Arsene Wengers side following Arsenals move to the Emirates Stadium, Fabregas combined vision with genuine goalscoring ability to establish himself as one of the worlds most well-rounded and exciting midfielders. Trophies commensurate to the playmakers ability to precisely pick out forwards runs more often that not did not come in north London, but two Premier League titles with Chelsea after his dream move to Barcelona failed to live up to expectation were just rewards for the midfielder. Nevertheless, he still won La Liga and the Copa del Rey while in Spain, and was part of the squads that won the 2008 and 2012 Euros as well as the 2010 World Cup. KV

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A player at home in any era who blossomed under Jose Mourinho not once but twice. At home at No 10 Deco effortlessly controlled games for Porto and latterly Chelsea as a key cog in two of the Special One's greatest sides. BB

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Enjoyed the best years of his storied career right at the very start of the 21st century, after he moved from Parma to Juventus in a double transfer, along with Gianluigi Buffon. Went on to form a formidable defensive partnership with Igor Tudor as well as Fabio Cannavaro, before a late career swansong at Barcelona. He also won the European Championship with France in 2000. An imperious defender, who now works tirelessly fighting against racism in football and society. LB

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Warrior. Tough as any Premier League centre-half, totemic at times and a pillar of consistency for Manchester United. Indomitable in the air, his partnership with Rio Ferdinand is perhaps the best English football has seen this century, contrasting in styles but with an innate understanding of each others abilities. Superb leader to boot. HLC

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The Brazilian is well renowned as one of the best attacking fullbacks in world football, and has been one of Real Madrids most consistent performers for a number of years. Arriving at the Santiago Bernabeu as a nervous 19-year-old, Marcelo has lived up to his reputation as Roberto Carlos successor at both club and international level, as likely to whip a cross in as he is to audaciously hammer one in from outside the penalty area. Often sporting a smile off the field, Marcelos trophy record makes for pleasant reading having experienced four consecutive Champions League victories as well as four La Liga and Club World Cup titles. KV

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While it can be argued his most captivating moments came before the turn of the millennium, Giggs longevity was remarkable, never truly fading from the first team at Old Trafford as the brighter sparks came and went. Evolved as football evolved, from teenage tearaway to cultured crosser as the legs slowed. Seven post-2000 Premier League titles, a PFA Player of the Year award and the 2009 Sports Personality of the Year. HLC

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A very modern forward, adept anywhere across the offensive line and a true team player, always ready to defend from the front. But it is ultimately for his ability in front of goal that he secures his place on this list. A revelation at Atltico Madrid and as equally important to the world champions: Griezmann was the top goal scorer as France finished as runners-up at Eurp 2016 before playing a starring role in their triumph two years later in Moscow. LB

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Seedorf enjoyed great longevity throughout his career divided into two decades. The latter of which, spent in Italy, easily earns his place here after gliding across the pitch for AC Milan, shining bright in Carlo Ancelotti's diamond to collect two Champions League titles - clinching four in total and becoming the only player to win the competition with three different sides. JR

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Sneijder won league titles in Spain, Italy, Turkey and his native Netherlands, as well as the Champions League with Jose Mourinho's Inter Milan, and built a stellar international career to become the most capped Dutch player of all time. But the lasting memory is simply of his natural grace on the pitch, gliding over the field before bursting into life to change any game in an instant. LO

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A great goalscorer and a scorer of great goals, Batistuta is one of the best strikers ever to have graced Italian football. He remains Fiorentina's top Serie A goalscorer, having spent the majority of his career in Florence before moving to Roma where he finally clinched the title. He is the only footballer ever to have scored a hat-trick at two separate World Cups. LO

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A captain of Atletico at 18 El Nino was destined for greatness ever since his formative years. While he may never have hit those heights for long enough his Liverpool career where he tortured the very best, notably Nemanja Vidic at Old Trafford, saw him comfortably become the most feared No 9 on the planet. Add in a world crown and two European titles and you have a player who more than earns his place here. BB

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Perhaps the most natural poacher in the countdown, Van Nistelrooy ended his career with better than a goal every two games and churned out far more through his peak years with PSV, Manchester United and Real Madrid. Most notable was his brilliance at the highest level, three times finishing a season as the Champions League's top scorer. Disputes with Dutch managers hindered an international career that might have propelled him higher up this list. LO

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Few on this list can say they redefined their position but the little French magician did just that. The Makelele role will go down in the annals for any player with any defensive nous whatsoever, but few since have boasted the football intelligence and positional discipline of the man who coined its name. A player far beyond his era. BB

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An unbroken streak of relentless goalscoring, spurring Manchester City to four Premier League titles, adapting his game to suit Pep Guardiola's style and resisting the challenges of a fleet of world-class temporaries, the Argentine may yet end his career as the greatest striker in English history. TK

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Well over a decade on from his retirement anyone even close to resembling a serviceable right-back is still known as the English, Scottish or Welsh Cafu, a testament to a glittering career where he redefined what was expected from his position. A dynamic, attack-minded full-back he was also an esteemed leader and captained his country to the World Cup with typical class in 2002. Anyone remembered as one of Brazils greatest players is more than worthy of this list. BB

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Only Marta has scored more goals in World Cups than Klose and his supreme record at international level with Germany is what sees him earn his place here. The archetypal target man famously rarely scored from anywhere other than inside the box, but he made the 18-yard area his own in a storied career that saw him score more goals for Germany than anyone before or since. BB

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A maestro and marshal at the heart of Manchester City's midfield, the Belgian is one of the most inventive, tactically astute and well-rounded players to grace the Premier League. He has won back-to-back league titles, an FA Cup and a raft of individual awards and only injuries have prevented him from casting his influence further. TK

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The Swede scored pots of goals for his home town club, Helsingborg, in his early years, and never really stopped until he retired back at his boyhood team. In between he ventured away to write history with Celtic, win the Champions League with Barcelona and even make a memorable cameo at Manchester United. His pinnacle was the season after he broke his leg, when he returned so determined to make up for lost time that he won the European Golden Shoe. LO

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If Roger Federer was a footballer he might have been something like Xabi Alonso: majestic, composed and precise, playing with a wand while barely breaking a sweat. Liverpool fans still adore him and so does everyone else. He was understated, bar those halfway line goals, and that was part of his charm, redefining what a holding role player could be, and he won it all: Champions League, La Liga, Bundesliga, European Championships and the World Cup. LO

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The player who brought the Premier League to the height of technical grace and artistry, the Dutchman was synonymous with moments of unthinkable ingenuity and other-worldly touches as he pulled the attacking strings in both Arsenal's 2002 double-winning campaign and the Invincibles season. TK

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Utah bison roundup ensures health and longevity of one of nations largest and oldest herds – ABC 4

Wednesday, October 30th, 2019

Posted: Oct 26, 2019 / 11:19 AM GMT-0600 / Updated: Oct 26, 2019 / 11:46 AM GMT-0600

Courtesy: Utah Department of Natural Resources

Antelope Island (ABC4 News) It looks like a scene from the wild west. Hundreds of volunteers on horseback are rounding up one of the nations oldest and largest herds of wild bison in hopes of ensuring the health of more than 700 animals.

In its 33rd year, wildlife officials say the Utah Bison Round-Up moves the herd from all parts of Antelope Island into one central location where the animals will receive health screenings, vaccinations, and a small external computer chip.

Once the bison are checked, officials say most of the herd is once again released to roam on the island.

Each year about 100 to 200 calves are born into the herd and Utah wildlife officials say the herd needs to be reduced in order to have enough food for herd as well as other animals on the island.

Some of the bison are sold at an auction. The money from the sale goes to help fund the Wildlife and Habitat Management Program, according to Wildlife officials.

Wildlife officials say the round-up happens in two phases: Saturday the bison are rounded up into corrals where they can relax, making them more cooperative for the exams and tests. Phase two takes place next week when the animals are checked one by one and given their vaccinations, before being released.

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What 71,000 Americans Did To Help Them Live Longer – Forbes

Wednesday, October 30th, 2019

Look on the bright side. For real. Scientists at Boston University School of Medicine and Harvard University say just being optimistic can help you live longer. Specifically, their research showed both men and women who had higher levels of optimism had longer life spans, and that both sexes had a greater chance of living past age 85.

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Optimism is a psychological attribute characterized as the general expectation that good things will happen, or the belief that the future will be favorable because one can control important outcomes, wrote lead author Lewina O. Lee, of the National Center for Posttraumatic Stress Disorder and the Boston University School of Medicine. Previous studies reported that more optimistic individuals are less likely to suffer from chronic diseases and die prematurely. Our results further suggest that optimism is specifically related to an 11% to 15% longer life span, on average, and to greater odds of achieving exceptional longevity, that is, living to the age of 85 or beyond.

The associations held irregardless of socioeconomic status, health conditions, depression, social integration and health behaviors like smoking, diet and alcohol use, the authors wrote. Overall, findings suggest optimism may be an important psychosocial resource for extending life span in older adults.

Were talking about exceptional longevity. which some define as over 85 and others over 100 years of age.

In January, Robert J. Pignolo, M.D., Ph.D., of the Division of Geriatric Medicine and Gerontology at the Mayo Clinic in Rochester, Minnesota, published a review of literature on exceptional longevity in the clinical journal, Mayo Clinic Proceedings. In it he held that the basis for exceptional longevity is multifactorial and involves disparate combinations of genes, environment, resiliency and chance, all of which are influenced by culture and geography. Pignolo examined how studying the oldest old may give credence to the biological and environmental characteristics of those who seem to defy the odds.

Pignolo said centenarians stave off age-related diseases. And theyre somehow resistant to otherwise lethal illnesses occurring earlier in life. But even so, even the oldest of the old vary in the characteristics they possess that seem to allow them to live so long. Associations between specific clinical or genetic biomarkers exist, but there is unlikely to be a single biomarker predictive of long life, he wrote. He added that while careful observations in the oldest old offer some strategies that favor increased health span and life span, there is unlikely to be a one-size-fits-all prescription for longer life. Exceptional longevity represents an extreme phenotype, he wrote.

Scientists studying longevity have largely investigated the biological and medical factors associated with survival, but the Massachusetts scientists recent work in Proceedings of the National Academy of Sciences, suggests nonbiological factors could also have huge implications to aging.

We tested whether higher optimism was associated with longer life span and greater likelihood of exceptional longevity, the authors wrote. Researchers used a good amount of data to come to their conclusions, though some limitations of their study could limit whether their findings apply to a wide range of people, including that participants were largely white and had higher socioeconomic status than the general population.

The Boston researchers studied about 70,000 women from the Nurses Health Study (NHS) and about 1,400 men from the Veterans Affairs Normative Aging Study (NAS), with follow-ups of 10 years (2004 to 2014) and 30 years (1986 to 2016), respectively.

In both groups, higher levels of optimism were associated with extended lifespan and higher odds of achieving exceptional longevity. The associations persisted even after researchers adjusted for demographics and various health conditions like cancer, heart disease, high cholesterol and stroke, as well as habits like smoking, primary care visits and alcohol use. And the associations still remained after scientists adjusted for whether or not a person suffered from depression.

While prior studies have reported that optimism may reduce risk of premature death in mid- and later life, the current findings suggest that optimism promotes substantially longer life span, the authors wrote. As longer life span appears to accompany longer health span, our findings have implications for understanding psychosocial factors that promote healthy and resilient aging.

In other words, a person who practices optimism over the course of their life is more likely to live long and live healthily while they do it, Inverse.com reported. This study joins others that have explored the health benefits of optimism, including a 2009 study from the University of Pittsburgh showing that women who are optimistic are 14% less likely to die from any causes than pessimists.

Though researchers admit the exact benefits of optimism are hard to pinpoint, they say their new findings indicate that optimism could serve as a valuable target for interventions that promote health.

One explanation is that more optimistic individuals may experience less extreme emotional reactivity, which helps them recover more quickly from stressors, Inverse reported. Still, Lee says that scientists do not fully understand the pathways from optimism to health and longevity.

Even so, it does appear evident that psychological assets can promote good health, and the likelihood of long life cant be limited to genetic factors, Inverse reported.

The Massachusetts researchers defined exceptional longevity as survival to age 85 or older. Optimism was assessed using the Life Orientation Test-Revised in NHSa standard psychological self-help instrument that indicates the level of optimism in a person and gives insight into how one can replace harmful thought patterns with more constructive onesand the Revised Optimism-Pessimism Scale from the Minnesota Multiphasic Personality Inventory-2 in NASa scale measuring the psychological attribute that provides insight into how people explain to themselves why they experience a particular event, either positive or negative. Given work indicating optimism is modifiable, these findings suggest optimism may provide a valuable target to test for strategies to promote longevity, the authors wrote.

The study, according to Inverse, puts the focus on the state of our mindsand finds that exceptional longevity is intimately linked to optimism.

So why might optimism affect longevity? asked David R. Topor, Ph.D., in an article for Harvard Health Publishing. Topor is a clinical psychologist and the associate director for Healthcare Professional Education at the VA Boston Healthcare System. He is also an assistant professor in the Department of Psychiatry at Harvard Medical School. The study wasnt designed to explain this, but the researchers had several thoughts. While one component of optimism appears to be heritablethat is, tied to our genesour environment and learning also shape a significant portion. One takeaway is that we can all learn ways to be more optimistic.

Whether youre naturally optimistic or not, you can take certain steps in that direction, said Topor. He offered the following suggestions on how anyone can become more optimistic:

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Sex and longevity at the Trottier Public Science Symposium – McGill Tribune

Wednesday, October 30th, 2019

The 2019 Trottier Public Science Symposium, hosted by the Office for Science and Society from Oct. 22 23, addressed the unavoidable process of aging in a presentation titled Longing for Longevity. The second night featured keynote speakers Joe Schwarcz, director of the office, and psychosexual therapist and author Ruth Westheimer.

In his opening remarks, Tomlinson Professor of Chemistry Bruce Lennox shared the symposiums mandate.

The Trottier Symposium [] has proven to be a key element in the promotion of science and science communication [] to the public [.] This is the 20th year [for] the office for Science and Society, something thats really quite a landmark in public science outreach in the world, Lennox said. The office, of course, has a national and international presence in its mission [] to separate sense from nonsense on the scientific stage.

According to Schwarcz, there is a long history of nonsensical claims in scientific research about longevity. From believing that urine is a source of longevity to encouraging the so-called rejuvenating practice of lying with young women, there is no shortage of ridiculous methods in history.

This sort of silly science now has hard roots to it, but it goes beyond that, Schwarcz said. Today, researchers are looking at telomeres, [] the end of the chromosomes, [] and every time a cell divides, there is a disturbance of the end of the chromosome, and the belief is that if somehow you could prevent that you could slow down aging [.] In 2009, a nobel prize was awarded for this kind of research [done by] Jack Szostak, [] a McGill graduate.

In his presentation, Schwarcz acknowledged that the cure for aging remains unknown.

No, were not going to cheat death [.] You dont get out of life alive, but the idea is to put off death to the very last minute, Schwarcz said.

Schwarcz also noted the connection between sexuality and mortality by referring to a recent British study that showed sex can slow aging.

Beyond her experience as a sex therapist, Westheimer has lived around the world. She was born in Germany and escaped to Switzerland during the Holocaust, where she continued to live for 10 years.

If you would have told me, the child of orthodox Jewish parents, that I would talk about orgasms at McGill University, I would have said you must be crazy, Westheimer said. The one thing I knew [] is that I had to do something to [justify] that I am alive while one [and a half] million [] Jewish children were killed.

Westheimer emphasized the importance of proper and well-rounded sexual education.

In todays world, we dont have the luxury not to be sex educated, Westheimer said. We have to do sex education. Girls [and] women menstruate at an earlier and earlier age [.] We do have to tell girls and boys about menstruation [.] We do have to talk about nocturnal emission, [and] about wet dreams.

Dr. Ruth believes the roots of sexual illiteracy come from psychologist Sigmund Freuds influence in academia.

Sigmund Freud shouldve taken a course with me, Westhiemer said. He did us women a tremendous disservice, because he said as if sex was only for [] men and that there was nothing in it for women.

The celebration and de-stigmatization of female sexuality is a central theme in Westheimers work. She also advocates for the education of sex beyond traditional methods and the acceptance of diverse types of sexual relationships.

The whole issue of sexual satisfaction [] doesnt have to be a penis inside a vagina [.] It doesnt have to be the way it used to be when they were younger, so people should adjust to that [.] If there is a problem, Im all for going for a few sessions to a sex therapist.

Westheimer left a piece of advice to young and old people in the audience alike.

Make sure that you are sexually literate, that you know what is changing [in the world], and that you do know to go for help if there is a question, Westheimer said.

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Canine pals could be the secret to longevity – Cosmos

Friday, October 11th, 2019

As most dog owners will attest, four-legged canine companions generate boundless love and joy through their playful antics and tail-wagging devotion.

Accordingly, much research finds they can improve mental health - and now, evidence for their tangible physical health benefits is growing.

A Swedish study and separate meta-analysis, published in the journal Circulation, found that dog owners live longer and do better after having a heart attack or stroke.

First, the Swedes compared the health outcomes of 182,000 people with and without dogs after a heart attack and 155,000 people after a stroke, using health data recorded by the Swedish National Patient Register between 2001 and 2012.

The largest differences between dog owners and non-owners were seen in single households.

After adjusting for demographic and socioeconomic factors, they found that dog owners who lived alone had 33% lower risk of death after a heart attack and 27% less chance of death after a stroke. The effect was not quite as pronounced for people living with a partner or child, with 15% and 12% lower risk, respectively.

Although the mechanisms cant be confirmed with the observational study design, senior author Tove Fall from Uppsala University in Sweden says he was surprised at the large differences in the outcomes, and thinks its likely that exercise and companionship factor in.

We know that dogs can be a good motivator for physical activity, he says. We also know that physical activity and social support are important for optimal recovery after a major cardiovascular event.

Meanwhile, clinician and research scientist Caroline Kramer, from Mt Sinai Hospital in Toronto, Canada, was curious about research showing the benefits of dog ownership in her pursuit of lifestyle changes that can promote peoples health.

What really sparked it, she admits, was her dog a miniature Schnauzer called Romeo.

Since I adopted him, she says, I got more active, and the daily routine with a dog companion is a joy. So when I saw a research report on that I was curious and decided to research further.

The result was a systematic review and meta-analysis of the association between dog ownership and death from all causes or heart disease.

The composite analysis included 10 studies with data from 3.8 million patients and follow-ups ranging from one to 22 years. Overall, having a dog prolonged survival, reducing risk of death by 24%.

When it came to heart attacks and other heart-related issues, dog owners had a 65% and 31% lower risk of death, respectively.

The research builds upon prior findings and conclusions of the American Heart Association (AHA)s scientific statement that dog ownership is associated with lower risk factors for heart disease, such as high blood pressure and blood lipid levels, says Glenn Levine, chair of the statements writing group.

Further, these two studies provide good, quality data indicating dog ownership is associated with reduced cardiac and all-cause mortality, he adds.

While these non-randomised controlled studies cannot prove that adopting or owning a dog directly leads to reduced mortality, those robust findings are certainly at least suggestive of this.

In a related editorial, Who is rescuing whom?, Dhruv Kazi, from Harvard Medical School, Boston, notes that pet owners tend to have other heart-health promoting features. These include being younger, better educated, wealthier and more likely to be married. Its also possible that healthier people are more able to adopt a dog.

However, he remarks that its plausible they improve peoples health, given that dog ownership prompts more time being active outdoors. He also notes evidence that the rich variety of germs they bring into the home can positively alter peoples gut microbiome.

He agrees with the AHA, though, that medical reasons alone should not the driving motivator to get a dog, as its a much larger undertaking than embarking on a new medical therapy, involving significant commitment and lifestyle changes.

Quoting Pulitzer-Prize winning poet Mary Oliver, he concludes that the real reward of dog ownership is that there can hardly be a sweeter arrangement than the unconditional love of a loyal friend.

The health benefits of dog ownership are a welcome and possibly substantial bonus.

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Decoding the Genetic Mechanisms of Aging – Technology Networks

Friday, October 11th, 2019

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could be developed to extend healthy human lifespan. But as is often the case in science, the genetic regulation of aging is more complicated than it first appeared.

The nature of this complexity is illuminated in a new paper byMDI Biological LaboratoryscientistsJarod Rollins, Ph.D., andAric Rogers, Ph.D., co-corresponding authors, which describes the mechanisms by which longevity is regulated post-transcriptionally, or after a genetic blueprint has been transcribed from an organism's DNA. The identification of these mechanisms will serve as a road map for screening new, more specific drugs to prolong healthy lifespan.

The research was conducted inC. elegans, a tiny nematode worm that is a popular model in aging research because of its genetic similarity to humans and because of its short lifespan, which allows scientists to easily study lifespan-extending interventions.

"The MDI Biological Laboratory is deeply committed to translational research, or research that can be translated into therapies to improve human health in our focus areas of regeneration and aging," saidHermann Haller, M.D., president. "Because it identifies new potential drug targets in the form of the post-transcriptional mechanisms governing longevity, this research will be hugely important in screening for new therapies to extend healthy human lifespan."

The paper, "Dietary Restriction Induces Post-transcriptional Regulation of Longevity Genes," which was recently published in the journalLife Science Alliance, is the product of five years of research in the Rollins and Rogers laboratories at the MDI Biological Laboratory.

The scientists used bioinformatics, or data analysis, techniques to compare genes in worms fed normal diets with those whose diets were restricted.Dietary restriction, or DR, which refers to calorie restriction without malnutrition, is the most robust intervention known for extending lifespan, and has been demonstrated to increase lifespan and delay the onset of age-related degenerative disease in a wide range of species, from one-celled yeasts to primates.

The scientific evidence on the lifespan-prolonging effects of DR has ignited a quest to develop "DR mimetics," or drugs that mimic the effects of DR without the need to dramatically reduce calories. In addition to being difficult to adhere to, such a diet is associated with negative side effects including increased sensitivity to cold and loss of energy and libido. The identification of these new mechanisms opens up the possibility of developing new, more precise DR mimetics.

"Science already knows a lot about how longevity is regulated at the genetic level, but the picture isn't complete if we just look at transcription," Rollins said. "With this research, we are drilling down to additional layers of regulation, which brings us one step closer to extending healthy human lifespan without the need to dramatically restrict calories or to take drugs that, because they are less selectively targeted, are more likely to cause adverse reactions."

The goal of DR mimetics is to access the adaptive programs in the cell that are activated when an organism is exposed to an existential threat such as a scarcity of nutrients. In such a case, the cellular machinery shifts from an emphasis on growth and reproduction, which is costly in terms of cellular resources, to an emphasis on survival. In order to ensure that an organism survives to reproduce when conditions improve, nature seeks to ensure that its cells function at peak efficiency.

In addition to confirming existing theories about the adaptive response to DR, the paper highlights the importance of post-transcriptional regulation -- or regulation that occurs after a gene has been "read" or "transcribed" from the DNA in the nucleus of the cell. The identification of the mechanisms that govern post-transcriptional levels of gene expression charts a pathway for screening, or testing, drugs that may have pro-longevity effects.

"We found that hundreds of genes are being regulated almost solely at the post-transcriptional level," Rollins said. "These are genes that weren't previously known to have a role in longevity. This level of regulation can be missed if scientists are looking at the transcriptional level alone. The identification of these mechanisms gives us a better idea of how DR works and opens up a whole new area of potential investigation for the aging biology community."

Reference: Rollins et al. 2019.Dietary restriction induces posttranscriptional regulation of longevity genes. Life Science Alliance. DOI: 10.26508/lsa.201800281.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Lordi Envision Greater Longevity With ‘Killection’ Album – Loudwire

Friday, October 11th, 2019

The records state that Lordi formed in 1992 and released their first album in 2002, but what if they actually had been around much longer? That's a bit of the idea behind their latest album, Killection.

According to the press announcement for the new album, the group has envisioned the release as if they had actually been around making music since the early '70s, with this selection of songs spanning that entire era.

"Killection is a compilation album that simply says what if Lordi had been in existence since the early 70's. It contains all their imaginary hit singles from different periods done with painstaking attention to detail using authentic studios and vintage technology. This is how they would have sounded if Lordi would have made music back then and therefore would have had the hit material to release this compilation now," reads a description for the album.

Mr. Lordi himself adds, "Killection is a fictional compilation album. It contains songs that Lordi would have written between the early 70's through the mid-90's. The compilation contains one "brand new" song from 2019 as well, cause thats somehow always typical for compilations."

Killection is due Jan. 31 and you can check out the artwork and track listing below. At present, they have a one-off in Helsinki, Finland on Dec. 13, but will return to the road in earnest in February for a month-and-a-half long European tour. See all their dates here.

Lordi, Killection Artwork + Track Listing

01 Radio SCG 1002 Horror for Hire03 Shake the Baby Silent04 Like a Bee to the Honey05 Apollyon06 SCG10 the Last Hour07 Blow My Fuse08 I Dug a Hole in the Yard For You09 Zombimbo10 Up To No Good11 SCG10 Demonic Semitones12 Cutterfly13 Evil14 Scream Demon15 SCG10 I Am Here

10 Best Masked Rock + Metal Acts

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The longevity of ‘Little Women’ – WCVB Boston

Friday, October 11th, 2019

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

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ANTHONY: A GRAND CELEBRATION CALLS FOR A FRESH COAT OF PAINT AT THIS ORCHARD HOUSE IN CONCORD. 2018 MARKED THE SESQUICENTENNIAL OF THE PUBLISHING -- PUBLICATION OF LITTLE WOMEN. >> I AM REREADING IT WITH MY BEST FRIEND. IT WAS NEAT BEING ABLE TO COME AND SEE THE HOUSE. ANTHONY: WRITTEN HERE 150 YEARS AGO, NEVER OUT-OF-PRINT, TRANSLATED INTO 50 LANGUAGES. HOLLYWOOD HAS MADE ANOTHER MOVIE OF THE CLASSIC. THIS ONE DIRECTED BY OSCAR NOMINATED GRETA GERWIG. >> GRETA GERWIG AND THE ACTRESSES HAVE COME THROUGH MULTIPLE TIMES ASKING QUESTIONS, WANTING TO ABSORB THE HOUSE. THEY WANTED THE EXACT RANGE COLOR. THEY HAVE BEEN PASSIONATE ABOUT GETTING IT RIGHT. ANTHONY: THERE IS NO SHORTAGE OF PASSION FOR ORCHARD HOUSE, SAYS EXECUTIVE DIRECTOR JAN TURNQUIST . VISITORS FROM AROUND THE WORLD FIND THEIR WAY HERE. >> IT SEEMS TO SPEAK TO THE HEART OF SO MANY READERS, THE MATTER WHAT THEIR CULTURE. THE FACT YOU CAN COME INTO THE ROOMS AND FEEL AS IF THE FAMILY HAS JUST LEFT A MOMENT AGO, IT IS AS CLOSE AS THEY CAN COME TO MEETING THE AUTHOR. ANTHONY: MOST NOTABLE IS LOUISAS WRITING DESK. >> BRONSON AND ABIGAIL GOT -- THEY FELT THEIR DAUGHTERS SHOULD FILL THEIR OWN DESTINY. A DESK OF HER OWN IN ANOTHER EMILY WOULD HAVE BEEN CONSIDERED FOR BITTEN. PHYSICIANS HAD PROVED SUPPOSEDLY BRAINWORK LIKE WRITING WOULD DESTROY A WOMANS HEALTH. THEY THOUGHT IT WAS RIDICULOUS. BRONSON BUILT LOUISA THE DESK AND MRS. ELLICOTT GAVE HER A PEN. THE MAVIS PENN USED TO INSPIRE WHEN WRAPPED IN -- [INDISCERNIBLE] ANTHONY: THE EDUCATOR FOUNDED THE CONCORD SCHOOL OF PHILOSOPHY AND LITERATURE IN HIS STUDY. HE BUILT A LECTURE HALL OUTSIDE. THE SCHOOL IS SLATED FOR ITS HOLLYWOOD DEBUT. >> THE MAKERS OF THIS MOVIE WANTED SO MUCH TO DO SOME OF THE FILMING HERE AT THE SCHOOL. THEY THOUGHT IT WOULD WORK FOR THE SCENE WHEN AMY MARCH BRINGS PICKLE BLINDS TO SCHOOL. ANTHONY: 150 YEARS AND STILL GOING STRONG. WHAT WOULD LOUISA MAKE OF ALL THE FUSS. >> SHE WOULD COMPLETELY ASTONISHED IT COULD CONTINUE LONG AFTER THE PUBLICATION OF HER BOOK. 150 YEARS. SHE WOULD BE AMUSED, PLEASED AND MOSTLY AMAZED. ANTHONY: ALL OF THE ABOVE. LITTLE WOMEN CHRISTMAS DAY. SHAYNA: THAT IS CHRONICLE FOR TODAY. THANK YOU FOR JOINING US. I AM SHAYNA SEYMOUR. ANTH

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

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The Alife Guys Talk About Longevity and New Collabs – Highsnobiety

Friday, October 11th, 2019

On this weeks episode of The Dropcast, hosts Jian DeLeon and Noah Thomas are joined by Treis Hill and Rob Cristofaro, partners-in-crime at Alife, who are on to celebrate the 20th anniversary of the New York City-based lifestyle, street, and skatewear brand.

The quick hits start off with Kiths co-branded apparel capsule in collaboration with Nobu and their dinner event which took place at the worlds most recognized Japanese restaurant (2:48). While Noah was filling up on sushi as a Nobu regular (shout out to Uncle Woody), Jian was knee-deep in work at the office. Treis notes the merging of food with fashion as the cast expresses their mutual love for authentic restaurant merch (4:30). Somehow, discussion of the Snow Peak x New Balance sneakers brings us back to food again more specifically, food utensils, including the worlds most luxurious spork (8:06).

Talk of Burberrys Nova Check fleece jacket drop leads to Rob and Treis sharing the lack of high fashion pieces in their closets and Alifes history of collabs (11:10). Rather, the duo emphasizes the importance of finding relevance in co-branding as seen through their work with Foot Lockers Project Greenhouse (16:13). The initiative focuses on sustainable product design and empowering youth culture through collaboration with mentors.

Alifes multifaceted identity, which includes being a museum, extends their storytelling beyond pure products as seen with their recent partnerships with Brooklyn Museum and The Bronx Museum of the Arts. When the latter held an exhibit for street art photographer Henry Chalfant who produced a body of work referred to as the Bible of graffiti (22:53), Alife injected their contemporary DNA into the collaboration by creating a pop-up retail space selling a capsule featuring Chalfants work.

In light of their 20th anniversary, Alife is collaborating with Lee Jeans who are also celebrating 130 years in the making (26:00). This leads up to the Question of the Week (QOTW): Whats your favorite Alife collab? (29:08) with the hosts giving their takes.

The cast wraps up the episode by making the rounds in Whatd You Cop? Rob got his hands on the iPhone 11 Pro while Treis got a pair of red Chuck 70s.

Check up on our next QOTW out Monday on Highsnobietys Instagram, and make sure to leave us a voicemail on The Dropcast hotline at 833-HIGHSNOB (833-444-4766) for a chance to be featured in a future episode.

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The longest-living people in the world have these 9 things in common – Well+Good

Friday, October 11th, 2019

In the US, the average life expectancy is 78 years. But there are a few places in the worldspecifically Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; and Icaria, Greecewhere living to be over 100 isnt uncommon at all. In these regions, known as Blue Zones, the life expectancy isnt just higher; centenarians are generally also healthy, their minds and bodies still working well.

National Geographic journalist Dan Buettner spent years studying each culture, pinpointing the exact reasons why they thrived before publishing his findings in the best selling book, The Blue Zones: Lessons for Living Longer From the People Whove Lived the Longest.Buettner found that despite the geographical differences, people living in the Blue Zones all had nine key lifestyle habits in common, which he named the Power 9. Here, each pillar is explained, with input from doctors about why its so crucially connected to health and longevity. Keep reading for the complete intel, including how to apply the pillars to your own life.

Buettner found that in all the Blue Zones communities, movement was a regular part of daily life for the residents. The Longevity Plan author John Day, MD saw this first-hand as well when he spent a year living in remote China. Even in their advanced age, he saw centenarians working in the fields and throughout the village.

Of course, here in the States, our jobs are a lot more sedentary. But Dr. Day still says we can work this pillar into everyday life. Unfortunately, our modern lifestyles have been engineered in a way to take movement out of our lives, so it is up to us to get in as much as we can during the day, he says. For example, you could take a vow to never use an elevator or escalator again unless the stairs are restricted. Other options include an evening walk or doing everything possible to avoid having to use a car. Even vacations can be scheduled in a way that are physically active, like a vacation centered around skiing, hiking, or cycling.

Richard Honaker, MD, who works with Your Doctors Online, echoes this saying, The more exercise you can fit into your day, the better. Even walking is good for your health. His recommendation is to aim for a minimum of 30 minutes of exercise three times a week. This is the bare minimum amount of exercise to do that will benefit your health, he says.

Having a clear sense of why you wake up in the morning is connected to living a long, healthy life. Purpose is related to happiness, and happiness is associated with better health than sadness or indifference, Dr. Honaker says.

Dr. Day adds that the connection between the mind, health, and a sense of purpose is powerful. Whether your goal is to beat cardiovascular disease or cancer, or even to live a long and healthy life, study after study has found an association of purpose in life with all kinds of better health outcomesan effect that stands regardless of age, sex, education or race, he says. You have to have a reason to get out of bed every morning. Something that pushes and motivates you. For without purpose it is next to impossible to maintain the healthy behaviors and lifestyle that is conducive to a long and healthy life.

PSA: Chronic stress is terrible for your health, which is why stress management is one of the pillars for living a long, healthy life. We all have stress. The key is how you perceive your stress, Dr. Day says. If you view stress as something that is making you stronger or refining you then it can be a good thing. If you view stress as something destructive then it probably is.

During his time in China, he saw that simple lifestyle habits such as eating nourishing foods, being physically active, getting good sleep, and socializing with family and neighbors all helped negate the stress the townspeople experienced, showing that the pillars are intertwined and connected to each other.

Here in the States, generous, oversized portions of food are valued greatly. But in Blue Zones, Buettner found that people stopped eating when they were mostly full, not when they finished everything on their plate or were too stuffed to eat another bite. He also observed that the biggest meal of the day occurred in late afternoon or early evening, not right close to bedtime. Scientific research has shown that eating late at night is linked to unhealthy weight gain, which isnt exactly great for lifespan.

Speaking of Blue Zones, heres what to know about the expert-loved Mediterranean diet:

While were on the subject of food, people in Blue Zones tend to eat a diet thats primarily plant-based, consuming meat only a few times a month on special occasions. Processed foods and added sugar have never shown to have a health benefit. Cutting them out is 90 percent of a a healthy diet right there, Dr. Day says. [In Chinas longevity village], they picked their own produce and ate it the same day. And since they were essentially cut off from the rest of the world, they didnt have any access to sugar or processed foods. He also adds that they ate fish about twice a week, which of course brings to mind the Mediterranean diet, a long-beloved eating plan by doctors and dietitians.

Across Blue Zones, Buettner observed that alcohol was consumed, but moderately, at one to two glasses a day, with friends or food. This makes sense, as light to moderate drinking (particularly of wine) has been associated with a longer lifespan. According to a 2017 333,000-person, eight-year analysis, those who enjoyed an occasional drinkseven or less per week, to be exactwere 20 percent less likely to die of any cause and 25 percent to 30 percent less likely to die of cardiovascular disease than those who were completely sober. The key, of course, is to be mindful.

A sense of family and community is important in all Blue Zones communities, which Dr. Honaker says has been directly linked to health. Many studies have shown lower rates of hypertension, obesity, diabetes, and possibly even cancer for people with lots of friends and loving relationships in their lives, he says.

Dr. Day observed first-hand how belonging affected the health of the people in Chinas longevity village. Our research showed that as long as people stayed in the village and adopted the village lifestyle, they were healthy and aging was slowed, he says. However, if they left for employment in one of the big cities in China then their health suffered.

Similarly, in Blue Zones, families tend to be close, both geographically and emotionally. Younger generations value and help care for older ones. Dr. Day says that healthy aging requires a close network of friends and family who share their health goals and values, not something people can do on their own. This may too be related to a sense of belonging. This may be in part to the healthy lifestyles happy people adopt along with other factors we cannot measure, Dr. Honaker says.

People in Blue Zones areas not only have supportive families and communities, they actively participate in them. For some, faith may be the cornerstone of their social life, which Dr. Honaker says can provide both comfort and camaraderie through a shared beliefs system. As with purpose, study after study suggests that having a faith may increase longevity, Dr. Days says of this connection, adding that faith often involves frequent social gatherings. Another study published in 2016 emphasizes the importance of even casual social relationships when it comes to longevity.

Heres more intel on exactly how relationships impact your health. Plus, why chili peppers are linked to longevity.

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The longest-living people in the world have these 9 things in common - Well+Good

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What you might have missed – Cosmos

Friday, October 11th, 2019

Here's a snapshot of a few stories we particularly enjoyed. Click on the links to read them in full. You can also see all the week's yarns here.

Nature giveth, and humans taketh away

Nature has been supporting life on Earth for millennia. But human exploitation of her generous resources is wearing thin, and an interactive global map created by a large team of scientists from the US, Canada and Europe models where and how.

Read the full story here.

Rumbles, screams and dinks and donks: the sounds of Mars

Scientists listening to recordings made by NASA's Mars InSight lander have discovered a rich haul although many of the sounds captured turn out to made by the machine itself.

Read the full story here.

Canine pals could be key to longevity

As most dog owners will attest, four-legged canine companions generate boundless love and joy through their playful antics and tail-wagging devotion.

Accordingly, much research finds they can improve mental health - and now, evidence for their tangible physical health benefits is growing.

Read the full story here.

Would you like some chemicals with that?

If anyone needs another good reason for choosing home-cooked food over restaurants or take-out, here it is: a study has found it lowers exposure to fluorinated chemicals commonly lurking in food packaging.

Read the full story here.

Traffic-light system can predict repeat earthquakes

Earthquake researchers believe they have found a traffic-light style warning system that can determine if a big earthquake is a prelude to an even larger event, or is itself the main shock.

Read the full story here.

More fuel for early Anthropocene

New research from the nation of Belize, Central America, has revealed that ancient Maya culture responded to population and environmental pressures by creating massive agricultural features in wetlands, potentially increasing atmospheric CO2 and methane through burning forests and farming.

Read the full story here.

And here's our image of the week

European Southern Observatory

The rather uninspired name of this jellyfish galaxy, ESO 137-001, belies this breathtaking image, created by composite data from several telescopes.

To view all this week's featured images, click here.

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What you might have missed - Cosmos

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This Social Security Change in 2020 Will Happen for Only the 10th Time in 85 Years – The Motley Fool

Friday, October 11th, 2019

This has been a big week for Social Security beneficiaries. Yesterday, nearly 64 million monthly benefit recipients found out exactly how much of a "raise" they'll be getting in 2020. And while it's nowhere near as robust as the cost-of-living adjustment (COLA) that was passed along this year, it's far and away better than the 0% COLA passed along in 2010, 2011, and 2016, or the minuscule 0.3% COLA in 2017.

However, Social Security's COLA reveal also means it's time to look forward to a host of changes in the program for the following year. For example, the rich will have to hand over a bit more in payroll tax in 2020 than they did in 2019, and the long-term disabled (along with the blind) will be able to earn more each month before their disability checks would be stopped.

Image source: Getty Images.

But the most notable change of all might just be the increase in the full retirement age by another two months to 66 years and eight months for those born in 1958. The full retirement age (also known as "normal retirement age" by the Social Security Administration) is the age at which you become eligible to receive 100% of your monthly benefit, as determined by your birth year.

When Social Security was signed into law back in August 1935, the full retirement age was set at 65. It would remain at this level through the year 1999. Mind you, the system didn't work back then as it does today. This is to say that beneficiaries didn't have the option of choosing to claim earlier than age 65. The early claiming option that allowed workers to begin taking a reduced payout as early as age 62 was signed into law in 1961 by President John F. Kennedy. Thus, up until 1961, workers had no choice but to wait until age 65 to receive their payout.

Since 2000, the full retirement age has increased nine times, as part of the Reagan administration overhaul passed in 1983. Each of these increases to the full retirement age has been in two-month increments. Between 2000 and 2005, the full retirement age for persons between 1938 and 1943 increased by two months annually, ultimately rising from 65 to 66. Then, after a more-than-one-decade lull when the full retirement age stood at 66, it began increasing again in 2017. It'll peak at age 67 in 2022 for those born in 1960 and later.

Next year, when the program's full retirement age climbs to 66 years and eight months, it'll mark just the 10th time in 85 years that it's increased.

Image source: Getty Images.

This may not seem like a big deal, but the full retirement age is arguably one of the biggest problems with the Social Security program.

Back in 1940, when the very first benefit checks were doled out to eligible workers, the average life expectancy for a baby born in the U.S. was 60.8 years for men and 65.2 years for women. As of 2017, it had risen to 78.6 years for the average baby. Put another way, in the time it's taken for Social Security's full retirement age to rise by less than two years, the average life expectancy has increased by approximately 15 years. There are some pretty major implications for this disparity.

When the program was signed into law, it was designed with the idea that it would provide a financial foundation for those workers who could no longer provide for themselves. But the expectation is that these payouts would continue for years, not decades. Today, the Social Security Administration finds that the average 65-year-old will live another 20 years. That's potentially two or more decades of payouts, and it's clearly becoming a burden on the program.

Rising income inequality has also led to the exploitation of this disparity between the full retirement age and longevity. Since the well-to-do have little or no financial constraints when it comes to receiving preventative care, medical care, or prescription medicine, they're living substantially longer than the low-income workers that Social Security was truly designed to protect. Not only does this mean that wealthier individuals are, on average, receiving a Social Security payout for decades at a time, but this payout is considerably higher than the average monthly benefit paid to retired workers.

Image source: Getty Images.

So, why hasn't the full retirement age been increased to reflect rising longevity and ease some of the burden on the Social Security program? The issue is that increasing the full retirement age is akin to cutting benefits, and that's a big no-no for a lot of politicians on Capitol Hill.

Since your full retirement age represents the point at which you become eligible to receive 100% of your monthly payout, gradually raising it over a period of years or decades means reducing the lifetime earning potential of future generations of workers.

For example, one of the core solutions to Social Security's imminent cash shortfall offered by Republicans is the idea of gradually increasing the full retirement age from 67 to as high as 70. While sparing current and near-term retirees, such a move would likely require millennials and generation Z to either wait longer to collect their full payout or to accept an even steeper reduction by taking their benefit early. Thus, future generations of retired workers would have fewer years to collect if they wait, or would receive even less each month if claiming early. No matter their choice, the amount paid out by the program would be less than under the current model. It's a cut to long-term benefits.

Democrats in Washington, D.C. simply won't support any legislation that reduces benefits, either on an up-front or long-term basis. This is why legislation that increases the full retirement age, or even offers to index it to longevity, is unlikely to be addressed anytime soon.

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Sustainability and Longevity: New Trends in the Global Automotive ACC ECU Market 2020-2029 – Motor Expo

Friday, October 11th, 2019

Reports Predict Growth in Global Automotive ACC ECUMarket research report highlights 2020 projection of business, market supercharge growth and challenges, new strategic technology and progressive approach innovations, future roadmap and forecast to 2029.

Acumulative analysis on Automotive ACC ECU Markethas included a report by Market.us, offers an exhaustive study based on current trends influencing this vertical throughout assorted geographies. Key data regarding different market size, world new comparative market share, statistics, growing application, and revenue are compiled in the research to develop an ensemble prediction. Additionally, this research provides an in-depth competitive analysis concentrating on business prognosis highlighting expansion plans accepted by marketplace volatility.

The portrays information of the report starts with the inclusion of basicdata as well as an overview of the market profile. It assembles information about key manufacturing technology and applications that informs about the growth of the automotive acc ecumarket. Based on the entire market overview, the market has been segmented into various segments, which also includes the maximum market share during the forecast period by 2029. The in-depth summary of the automotive acc ecu marketis also provided based on highly competitive scale, key players, and their market revenue in the particular year. Apart from this, the players from global, regional, and country-specific, who are making the automotive acc ecu market highly fragmented are also included.

Dont miss out on business opportunities inAutomotive ACC ECU Market | Get PDF Sample For Technological Breakthroughs:https://market.us/report/automotive-acc-ecu-market-request-sample/

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Competitive Analysis:

The global automotive acc ecu market 2020, research study putt a lot of stress on regulative problems, macro-economic influencing factors, key market trends and growth drivers that are changing the industry dynamics of the market. The study incorporates industry esteem chain, powerful business strategies, cost, structure, creation limit, conveyance, market range and limits usage rate. The Research study evaluating the region-wise market status, highlighting opportunities, risk analysis, and leveraged with strategic decision-making support bytop manufacturers-Bosch, Denso, Fujitsu, Continental, Autoliv, Delphi, ZF, Valeo, Hella.

Abstract:

1. New 2020 report covers the forecast and analysis for the Automotive ACC ECU Market on a global and regional level.

2. The technological advancements expected to boost revenue generated by thetop industry players has been analyzed in the report.

3. The market numbers have been calculated using top-down and bottom-up approaches.

4. The Automotive ACC ECU Market has been analyzed using Porters Five Forces Analysis.

5. The report includes trends, strategy and growth factor, SWOT analysis and detailed company profiles of the prominent market players.

The Goal Of The Report:

The main goal of this research study is to provide a clear picture and a better understanding of the market for the research report to the manufacturers, suppliers, and the distributors operational in it. The readers can gain a deep insight into this market from this piece of information that can enable them to formulate and develop critical strategies for the further expansion of their businesses.

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Segment Snapshot:

By Type Coverage (Volume and Value from 2020 to 2029)

OEMAftermarket

By End-Use Application Coverage (Volume and Value from 2020 to 2029)

Passenger VehicleCommercial Vehicle

Promising Regional Description:

The most substantial areas covered from the accounts of global automotive acc ecu market areEurope, Asia-Pacific, North America, Latin America and the Middle East and Africa.

Factors that can be investigated through Global Automotive ACC ECU Market research include:

Market information:

* Prices of different commodities in the market

* Supply and demand situation.

Market Trends:Market trends are the upward or downward movement of a market, during a period of time.

SWOT Analysis:SWOT is a written analysis of the Strengths, Weaknesses, Opportunities and Threats to a business entity

Some of the Major Highlights of TOC Covers:

Chapter 1.Industry Overview

Chapter 2.Executive Summary

Chapter 3.Methodology and Scope

Chapter 4.Market Insights

Chapter 5.Market Dynamics, PESTLE Analysis, Opportunity Map Analysis, PORTERS Five Forces Analysis, Market Competition Scenario Analysis

Chapter 6.Company Profiles

Chapter 7.Appendix

Chapter 8.Research Conclusion

Reasons to Investment this Report:

1. Statistical Information Of Automotive ACC ECU Market Risk Factors, Challenges And Scope.

2. Qualitative and quantitative analysis of the market based on the segmentation.

3. Provision of market value (USD Million) data.

4. Diagnosis by geography emphasizing the ingestion of this product/service.

5. Competitive landscape which incorporates the market ranking.

6. The current as well as the future market outlook of the industry.

7. Top-Vendor Landscape of Automotive ACC ECU Market.

Highlights from the Automotive ACC ECU Market Report

An embellished scenario of the parent market

Transformations in the market dynamics

comprehensive segmentation of the target market

Historical, current and forecast market size based on value and volume

Latest industry forthcoming developments and investments forecast

Competition landscape

Strategies adopted by the market top key players and product developments made

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‘Groomed for success’ | Local kennel discusses the secret to their longevity – 11Alive.com WXIA

Friday, October 11th, 2019

EAST POINT, Ga. When Ricky Bevins started working part-time at Dandie Scottie Kennel nearly ten years ago, he never dreamed that one-day, taking care of pets would become his full-time career. However, in the fall of 2016, he became the third owner of one of the oldest kennels in the Tri-Cities.

Tucked alongside the rows of non-descript buildings that line the industrial corridor of Central Ave, the modest pea soup green one-story barely registers a glance in the shadow of the massive SA Recycling scrap yard. Chances are that many a Tri-Cities resident has driven past it as they trek from East Point to Hapeville or vice-versa.

Dandie Scottie originally began as a dog breeder for Scottish Terriers but Bevins tells My East Point news that by the time he took over the reins, that practice had fallen by the wayside. Although, he is proud to admit that the last dog breed at the kennel is still kicking and still gets groomed at Dandie Scottie.

While he may not have been the original owner of the kennel for its sixty-plus year history, Bevins attributes the longevity of the business to 3 things: customer service, knowing your product and refusal to quit.

Anyone that does business in East Point, lives in East Point, comes through East Point. Its their responsibility to try to lift East Point up, said Bevins.

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The 10 new cars owners keep the longest are mostly sports cars, SUVs – INSIDER

Friday, October 11th, 2019

The new cars that owners keep the longest before reselling are mostly sports cars and SUVs, according to a study by car search engine iSeeCars.com.

Most owners keep their new cars for an average of 8.4 years, but the ten vehicles on the list averaged 9.7 to 11.4 years.

Almost all the sports cars on the list with the exception of the Porsche 911 in the coupe body style are the convertible versions. iSeeCars CEO Phong Ly claims this is because convertibles are the least-driven type of car and typically amass 60% fewer miles than the average car.

Read more: The 10 cars owners ditch after less than a year more than any other, according to data

"Sports cars typically aren't daily drivers and don't accrue high mileage as a result, so it takes them longer to show signs of wear and tear," Ly said in a prepared statement. "Because sports cars aren't typically used as primary vehicles, owners likely aren't as concerned with having the latest and greatest technology and safety features."

iSeeCars.com analyzed over 5 million cars to identify which models were kept the longest before being sold by their original owners between January 1, 2014 and December 31, 2018. Cars owned for less than five years were excluded from the data set.

Check out the new cars owners keep the longest:

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Push-ups? Here’s what can really help you live to a ripe old age – The Australian Financial Review

Friday, October 11th, 2019

The problem with any of these approaches is that you would just be training for a particular test, which misses the point. It's not the push-up itself that makes you live longer; it's that you are still strong and nimble enough to execute one.

What these tests have in common is they're good shorthand of things that matter for longevity: overall health, fitness and muscle strength. A fit person walks faster than someone out of shape, and getting up off the floor is tricky for people with weak bones and muscles.

"Frailty is a really bad thing starting in middle age, and even worse as you get older," says Michael Joyner, a physician and human physiology researcher at the Mayo Clinic.

One way to think of longevity is "not as some magic property of a body, but as the lucky state of not having a fatal disease", says Steve Cole, professor of medicine and psychiatry and bio-behaviouralsciences at the UCLA School of Medicine. "By and large, people don't die of being old; they die of disease." Therefore, the study of longevity is a way of looking at disease risk or the rate of disease development, he says.

Over the years, various drugs and nutritional supplements have been studied for their potential to help us live longer, but nothing has been shown to work in humans to the extent that would be required for the Food and Drug Administration's approval, says Gordon Lithgow, chief academic officer at the California-based Buck Institute for Research on Aging.

While researchers continue searching for a pill to extend life, you'll have to try these verified methods.

The most powerful way to promote longevity and improve your long-term health is also simple and, depending on how you do it, free.

"There's no question that exercise is the biggest anti-ageing medicine there's ever going to be - it's really huge," Lithgow says.

"Hands down, nothing compares to exercise," says Laura Carstensen, founding director of the Stanford Center on Longevity. "The great thing is that most people can do it, and you don't need 10,000 steps per day to get the benefits." It takes remarkably little exercise to get longevity benefits.

Even 10 to 15 minutes a day provides measurable rewards, says Michael Joyner, a physician and human physiology researcher at the Mayo Clinic. Going from sedentary to even just a bit of exercise is where you get the biggest payoffs. The health benefits - such as reducing your risk of heart disease and diabetes - increase with greater amounts of exercise, until you get to about an hour of exercise per day. After that, the rewards start to level off.

"Almost anyone doing more than that is doing it for things other than health," Joyner says.

Go ahead and train for that Ironman if that's what you want, but if you're exercising for health and longevity, you don't need to run a marathon. Work by Iowa State University epidemiologist Duck-Chul Lee suggests that even running a little less than 10 minutes a day could decrease your mortality risk by about 30 per cent.

But you don't have to run. Walking or other moderate activities are just as good if you're looking for a longevity boost.

Some of the early evidence for the heart benefits of moderate exercise came from studies in the 1950s by British epidemiologist Jeremy Morris showing that conductors on double-decker buses, who spent their shifts walking up and down, had lower rates of coronary heart disease and thus lived longer than bus drivers who spent their workday sitting. Since then, studies showing the cardiovascular benefits of exercise have been "incredibly consistent", Joyner says.

But there's more. Physical activity also reduces the risk of diabetes, which one study found shaved six years off life expectancy.

And it keeps your brain healthy, too. "Exercise has better effects on cognitive performance than sitting around playing brain games," Carstensen says. A 2006 study in Neuroscience found that exercise spurs the brain to release growth factors that promote new connections between neurons, keeping the brain healthy. There's even research suggesting that strength training can reverse some age-related changes in your muscles.

There seems to be something about keeping an active lifestyle, too.

When you look at centenarians as a group, they might not be Arnold Schwarzeneggers, but they typically maintain a high level of physical function, says author Bill Gifford, who interviewed quite a few of them while writing his book, Spring Chicken: Stay Young Forever (Or Die Trying). "They can go up and down stairs, probably because they never stopped going up and down stairs," Gifford says.

His research for the book spurred him to make sure he was exercising at least a little bit every day.

Extend your life span while you sleep. It sounds like a bad infomercial, but it turns out that sleeping well is a good way to keep your body healthy for the long haul. Sleep is a time when your brain gets caught up on maintenance. In 2013, a team led by Maiken Nedergaard at the University of Rochester Medical Center published a study in Science concluding that sleep helps the brain clear out metabolic waste that accumulated during waking hours, providing a kind of restorative maintenance.

Skimp on sleep, and you hinder this important work.

If you've ever missed a night of slumber, you know that sleep deprivation hampers your mood and makes it hard to think clearly, but it can have severe consequences for your metabolic health, as well. Take someone who needs seven hours of sleep a night and restrict them to only five hours of shut-eye for five nights and they experience metabolic changes that look a lot like diabetes, says Satchidananda Panda, who studies circadian biology at the Salk Institute for Biological Studies.

Indeed, numerous studies have shown that sleep deprivation can decrease insulin sensitivity - a measure of how well your body regulates blood sugar - and increase your risk of diabetes. A 2015 meta-analysis found that Type 2 diabetes risk was higher in people who sleep less than seven hours or more than nine hours, compared with people who got seven to eight hours a night.

So why is sleeping more than nine hours associated with greater mortality? "People who sleep 14 hours per day are probably not healthy," Carstensen says, but it's hard to say right now whether it's possible to get too much sleep. Most people are on the other end of the spectrum.

Regularly sleeping too long may indicate a health problem

The consensus among sleep researchers is that seven to eight hours of sleep is ideal, but that's just a best guess based on the current data, Carstensen says.

"The biggest problem is that most of the data is self-reported and people are really bad at that," Carstensen says.

The advent of sleep trackers can help with the measurements, but they aren't always accurate, so avoid fixating too much on the exact numbers or you may end up in a cycle of anxiety that prevents you from sleeping. The problem is common enough that researchers have coined a term for it - orthosomnia.

Don't make a habit of skimping on sleep during the week with the idea that you'll catch up on the weekends. It doesn't take many nights of short sleep to reduce insulin sensitivity, and a small study published this year in Current Biology found that recouping on sleep over the weekend didn't entirely make up for the metabolic problems that developed during sleep deprivation. Furthermore, when volunteers in the study were given the opportunity to catch up on sleep over the weekend, they ended up shifting their body clocks so that it became harder to get up on Monday morning.

(Getting enough sleep every night might also improve your work life. In the throes of writing his book, Gifford made a decision to start prioritising sleep over work. His deadline was fast approaching, and he'd been getting up early and staying up late. Allowing his body to sleep as long as it needed to led to a "radical transformation in my ability to write", Gifford says. "I'd been trying to work 14 hours per day, and then suddenly I was getting twice as much done in six or seven hours.")

Forget all those headlines you've seen about "anti-ageing diets" and anti-aging "superfoods".

"These notions are generally not supported by science," Lithgow says. That's not to say diet isn't important, only that "nutrition is just a very difficult science", he says.

Severely restricting calories in lab animals makes them live longer, but "it's not clear that it works in humans", Lithgow says. Although there's plenty of evidence that it's not good to overeat, he says, whether drastically limiting food intake can extend life in people remains an open question. The joke, of course, is that calorie restriction will surely make your life seem longer.

It might be possible to get some of the benefits of calorie restriction without giving up so much food. Intriguing work by Panda suggests that restricting the timing of when you eat, rather than the amount, might provoke some of the healthy metabolic changes that reduce the risk of diabetes. Most of these studies have been done in mice, however, and Panda acknowledges that the human studies are small.

Although Panda is confident enough in the results to have written a book, The Circadian Code, which includes instructions on how to try it, some scepticism is warranted, Joyner says.

"Time-restricted eating has shown some interesting results in small studies," Joyner says, but "will it be sustainable over time in the real world? This is important because most dietary strategies work only if they are adhered to."

He says he wonders whether the metabolic benefits that Panda has found with time-restricted eating is really about the timing or simply related to people eating less when their dining hours are restricted. One thing shown repeatedly in anti-ageing studies is that things that initially look like magic bullets never live up to their initial hype, Joyner says.

What does seem clear, however, is that metabolic health is important for long-term health, because it keeps diabetes in check and that insulin sensitivity in particular appears crucial.

Given what we know right now, a Mediterranean diet - with its heart-healthy emphasis on fish, vegetables, fruits, nuts, healthy fats like olive oil, whole grains and limited consumption of red meat - "is probably the best approach for improving longevity", Carstensen says.

But the benefits are pretty modest. If you hate eating that way, then the payoff probably won't feel worth it to you, she says. At least try to eat a diet rich in fruits and vegetables.

The idea of red wine as a health elixir became popular in the 1980s with the observation that rates of coronary heart disease were low in France, despite the predominance of a diet relatively high in fat and cholesterol. The French penchant for a glass of red wine with dinner was proposed as an explanation for this "French Paradox", popularisingthe notion of red wine as heart helper.

Subsequent studies have indeed found that moderate alcohol consumption may reduce the risk of coronary heart disease, and a two-year randomisedclinical trial in Israel showed that people with Type 2 diabetes who were assigned to drink a glass of red wine with dinner every night experienced some improvements in blood markers associated with cardiovascular disease risk.

But other studies suggest that alcohol may raise the risk of many cancers, and a report published last year in the journal Lancet concluded that there's no amount of alcohol that improves health. What gives?

"Alcohol studies are very much like nutrition studies - based almost exclusively on self-reports, and we know that people are really bad at self-reporting," Carstensen says. "Most people, when they say they're drinking two drinks per day, are probably consuming more. We don't know the amounts that people are consuming nor do we know what else they do."

There's some evidence that people who abstain from alcohol are sicker or less healthy than those who imbibe a little.

"That probably reflects not a lack of alcohol in their system, but something about their world - that they're sick or isolated or don't have friends to meet at the pub," Carstensen says. "I've never seen a study that's really controlled for all of those factors." Which means that the studies calculating the health consequences of alcohol consumption depend on consumption figures that are inherently unreliable and may fail to account for other factors that could be at play.

Drinking to excess - more than one or two drinks a day - is unhealthy, and will take a toll on your longevity - no doubt about it. But taking the published studies together, "I don't think we have a lot of evidence that moderate alcohol is bad for you," Carstensen says. At the same time, she'd "be very hesitant to recommend that people who don't drink should start".

In today's world, it's easy to live in a state of chronic stress, and the problem isn't just that stress feels lousy. It also makes you more susceptible to diseases that could shorten your life.

Researchers are now learning that many conditions associated with older age - such as cancer, heart attacks and Alzheimer's disease - share a common ingredient: inflammation.

Under normal conditions, inflammation is simply the body's response to injury - it's how the body heals cuts and wounds and other insults, Cole says. "Inflammation by itself is not inherently evil." But when we're feeling chronically threatened or under siege, our bodies amp up their inflammatory machinery to ready our biological response to injury, and that inadvertently fuels the development of an array of age-related diseases, where inflammation is a common fertiliser, Cole says.

Research has identified chronic stresses that can provoke harmful biological changes, including living in poverty, caregiving for a dying spouse, losing a loved one, suffering post-traumatic stress disorder, and experiencing prejudice.

"Any way of feeling threatened or insecure seems to be enough to activate the body to produce more inflammation," Cole says. "This is one of the best defined connections between the world as we experience it and how we end up generating a body that's a fertile ground for the development of these diseases."

Your chance of developing chronic inflammation also rises with the passing years. "Inflammation seems to be a general sign of aging, where our inflammatory processes are being turned on or accumulated," Lithgow says. "Age-related inflammation is very much like inflammation from an injury, but now it's coming on without a source of infection."

What's the antidote? "Obviously we should all just be happy," Cole says with a laugh, as if it were that easy. He knows that it's not and says you probably can't eliminate stress from your life, but you can find ways to manage it. Identify the recurring stressors in your life, and work on a plan to diffuse them.

Wellness strategies such as yoga, tai chi and meditation can reliably help diffuse stress, Cole says, although he acknowledges that they often don't make a huge difference.

Forging connections with other people has been found to be a powerful way to manage stress and improve your overall wellbeing.

"People who report having stronger relationships live longer than people who are socially isolated," Carstensen says. A meta-analysis published in 2015 calculated that loneliness and social isolation were associated with 29 per cent and 26 per cent increases in mortality risk, respectively, and living alone was linked to a 32 per cent increase risk of dying.

What's clear is that people who have a strong sense of purpose and meaning in their lives have a markedly lower risk of death than those who don't.

"How we can bottle that and make it useful is more of a challenge," says Cole, who has studied loneliness and longevity.

Telling a lonely person to stop being lonely doesn't work, Cole says, "but if you can go to the lonely person and say, 'Hey, we really need your help. Is there anything you can do to help others?' - that is incredibly powerful. The mechanism here seems to be turning attention away from yourself and your own suffering and toward a community or cause greater than yourself."

Centenarians tend to have a sense of purpose in their lives.

"It's really important that people who are entering the later phases of life have a clear purpose, something to get up for every day," Lithgow says. That thing can be anything from looking after a grandchild or working or tending a garden.

Many centenarians continued working into their 80s, 90s and beyond, Lithgow says, and usually these jobs are in environments where they interact with younger people.

Interacting with other generations can keep older people engaged, and some retirement communities and nursing facilities are now taking steps to give their residents opportunities to connect with kids - for instance, placing kindergarten classrooms in nursing homes.

Most of the proven tips for living a long, healthy life are not products that you buy, but good lifestyle habits that you adopt (or bad ones, such as smoking, that you either quit or never take up and are clearly associated with diminished longevity).

Even something as simple as always wearing a seat belt can reduce your chances of dying early. Most of the things that make up a longevity lifestyle are simple - exercise, eat (and drink) healthily, sleep adequately, stay engaged - if only people would do them.

"To me, the bottom line is: Live a reasonably moderate life and you'll be OK," Carstensen says.

Washington Post

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Insilico Medicine Becomes the Face of AI Drug Discovery – Nanalyze

Friday, October 11th, 2019

In many industries, theres usually one or two companies that become nearly synonymous with their particular market. One of the most obvious examples is Coca Cola (KO). Think about it: We still refer to a soda as a coke, even though the soft drink manufacturer allegedly abandoned using cocaine in its formulation long ago. In emerging technologies like artificial intelligence, its more difficult to pinpoint a clear leader in many cases. Nvidia (NVDA) is still the obvious choice for AI chips. After that, there are very few household names that represent anything close to a pure play in AI technology. However, one name has emerged in the last few years that has become the face of AI drug discovery: Insilico Medicine.

Regular readers will certainly recognize the startup as a key player in the longevity industry. Weve profiled the company on several lists here and here related to drug discovery, as part of our ongoing coverage of life extension science. September was a particularly good month for the Rockville, Maryland startup. At the beginning of the month, it published a paper in Nature Biotechnology that detailed its efforts to design and validate a drug candidate for treating fibrosis and other diseases in just 46 days, shaving off months if not years from the discovery process, not to mention saving millions of dollars. A week later, the five-year-old startup completed a $37 million Series B, bringing its total disclosed funding to $51.3 million.

Insilico Medicine co-founder and CEO Alex Zhavoronkov

We recently caught up with Insilico Medicine co-founder and CEO Alex Zhavoronkov, who is on a crusade to prove that automation will be a big part of the future of healthcare. We talked about the companys recent achievement in accelerating the drug discovery process; its open challenge to big pharma; Insilicos numerous partnerships and joint ventures; the difficulties in getting funding for longevity therapy research and development; and the AI hype surrounding healthcare in general.

We wont spend too much time dissecting Insilicos latest achievement, as thats already gotten plenty of press. You can find a good deep dive into the paper and its significance by Margaretta Colangelo, a managing partner at Deep Knowledge Ventures, which made some of the first investments in the company about five years ago. It wasnt just the fact that Insilico Medicines new AI platform, called Generative Tensorial Reinforcement Learning (GENTRL), accomplished the feat of designing and validating a drug in such a short timeframe. It was also the first time anyone had combined two AI techniques known as generative adversarial networks (GANs) and generative reinforcement learning for drug discovery. Both Colangelo and Zhavoronkov refer to the achievement as pharmas AlphaGo moment, referring to Google DeepMinds defeat of a professional Go player.

Insilico Medicines AI platform, called Generative Tensorial Reinforcement Learning (GENTRL), combines two AI techniques known as generative adversarial networks and generative reinforcement learning for drug discovery. Credit: Insilico Medicine

Zhavoronkov first presented the paper at a conference in Basal, Switzerland, hometown to two of big pharmas biggest players Roche and Novartis. The choice of venue was obviously intentional, as Insilico has actively sought the spotlight since it was founded in 2014 in order to prove the value of AI to improve human health and quality of life. In 2015, for example, a group of Zhavoronkovsstudents and colleagues founded, Youth Laboratories, listing him as an adviser. It was a machine vision company that focused on aging and skin health which made headlines in 2016 for hosting an online beauty contest, Beauty.AI, that was judged solely by machines and attracted a bit of controversy for picking mostlyfair-skinned people. That led to yet another project, Diversity.AI, an effort to use machine learning to make sure we all have an equal opportunity to be spied on marketed to. Last year, the company was named to CB Insights prestigious AI 100 list.

But back to Insilicos primary focus: defeating age-related disease. Zhavoronkov believes his companys AI platform has advanced to the point where it could automate drug pipeline development from end to end and produce a marketable drug within 24 months or less with the right kind of backing. So while its efforts have focused on pre-clinical activities like identifying drug targets and developing therapeutic molecules around those specific disease targets, Insilicos AI also boasts predictive powers.

Insilico Medicine applies artificial intelligence throughout the drug development pipeline. Credit: Insilico Medicine

We also work with some of our pharma partners on predicting clinical trial outcomes; we also analyze clinical trials data, said Zhavoronkov, who is looking to partner with a major pharmaceutical company on an XPRIZE-type challenge where Insilico races against the clock to develop the first drug fully developed using artificial intelligence and one that targets a rare disease. If no contenders emerge, Zhavoronkov said he still believes it will be possible to develop a viable drug using AI within four or five years.

He noted that investment banks are also interested in Insilicos AI predictive analytics around clinical outcomes. The reason for the attention is obvious: If investors can leverage a tool that can better predict the chance of success or failure of a particular drug, that would surely influence how much money if any they are willing to put into a particular project or company. Weve noted previously that venture capitalists are increasingly turning toward AI to guide their investments into the hottest startups.

While Insilico awaits to see what big pharma company will emerge to take up its challenge, it has plenty of other partnerships and ventures to juggle. In fact, the company just announced today a new collaboration worth up to $200 million with one of Chinas biggest pharmaceutical companies, Jiangsu Chia Tai Fenghai Pharmaceutical Co. The goal of the collaboration is to accelerate drug discovery for triple-negative breast cancer using artificial intelligence.

We actually started making those kind of advanced partnerships where we would plan to take products into [clinical trials] only recently, Zhavoronkov said, for about the last year or so.

He noted that his company has about 16 ongoing collaborations, including several with one of the key players in the longevity industry Juvenescence. One of the more advanced joint ventures with Juvenescence is with a company called Generait Pharmaceuticals that is targeting senescent cells, which are cells that have stopped dividing but continue to secrete inflammatory molecules that damage nearby cells and tissues, leading to disease and an earlier death. Generait has already identified several disease targets but Zhavoronkov could not go into details at this time.

A sampling of some of the deals and partnerships brokered by Insilico Medicine. Credit: Insilico Medicine

Another joint venture between Juvenescence and Insilico, which also includes the nonprofit Buck Institute for Research on Aging, is Napa Therapeutics. Insilico has already done its part and Napa is now working on several potential drug molecules that could help boost the levels of an oxidized compound called nicotinamide adenine dinucleotide (NAD+), which is involved in getting the power plant of the cell called the mitochondria revved up again. So far, the molecules look very good, Zhavoronkov said.

Many [partnerships] are with smaller companies, you know, where we do get less money up front, but we do get the data, he noted. We need their pre-clinical data so we can train [our algorithms].

While Zhavoronkov is obviously pleased to have just pocketed $37 million from investors like Chinese AI tech giant Baidu and a pharmaceutical firm like Eli Lilly and Company, he feels that respect for the longevity industry is still lacking. For example, few of Insilicos major investors backed the company because they are specifically interested in life extension science, according to Zhavoronkov.

They invested not because of longevity. I actually need to divest of some of my longevity-focused programs, he explained. They invested because of the generative chemistry. It works; they know it works. Thats a major disruption. So thats why they invested. They didnt consider longevity; longevity is not being perceived as credible in financial circles yet.

Legitimacy is also difficult to build when there is so much hype around artificial intelligence.

There are lots and lots of scientific charlatans very often re-positioning very old technology as AI, he said. Suddenly, every statistician within big pharma became an AI scientist.

In terms of direct competitors, Zhavoronkov noted that he deeply respects the work being done by San Francisco-based Atomwise, but the technology from others is mostly smoke and mirrors. Thats why Insilico is focused on publishing its work in peer-reviewed journals in order to back up its claims. The company has published about 60 papers in the last five years.

Thats because Zhavoronkov believes that there is nothing more important than longevity, whether youre talking about the big-picture economics of healthcare or living more productive, healthier years in the twilight of life.

The goal is to create the longevity economy, he said. So, in the next couple years, as we ingest a little bit more data and develop more advanced algorithms, we will be able to go after more complex problems.

If the longevity industry does live up to its lofty goals of becoming the biggest industry in human history, Insilico Medicine will likely play a major role in that success. Even if we dont all end up living as old as Moses, the potential to cure some of humanitys most debilitating diseases is too good to ignore. And, right now, no one is ignoring Insilico Medicine.

We thinkthis AI-powered weight loss app could be a multi-billion dollar business - not because it's backed by the world's most sophisticated investors- but because it works. If you want to lose weight and keep it off for good, check out Noom. People who use Noom lose weight and keep it off for good.

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‘NCIS’: How the Cast Feels About Not Receiving an Emmy – Showbiz Cheat Sheet

Friday, October 11th, 2019

Most would agree NCIS is a great show. It has a huge fan base and is one of the most-watched television dramas. However, the shows following hasnt translated into an Emmy award (at least not yet). Heres how the NCIS cast feels about the series being passed over for an Emmy after all these years.

Mark Harmon told Entertainment Tonight host Kevin Frazier he knows how fortunate he is to be part of NCIS. Harmon said he tells actors who decide to leave the show that theyre leaving a special place with a lot of support. He also reminds them theyre leaving one of the top shows in the world:

And if we can talk about awards or talk about whatever, the longevity of this show, I tell young actors all the time. I say, Hey, are you gonna leave? Thats great. Good luck. And I said, But you come here, and you have a chance to work every day with friends who are going to support you. You work with a tremendous safety net underneath you here that nobodys going to let you fail. And I said, And theyre paying you. And, oh yeah, by the way, its the number one show in the world.

Harmon told Frazier the people who are part of NCIS genuinely enjoy being there. He says its a family environment where everyone comes together to just chat and talk about whats going on in their personal lives. I think its great that people love it, and people enjoy it. And we all sit here and laugh and talk about our day and how we approach it. But theres a bunch of professionals here who know what theyre doing. And I dont know that this kind of thing in network television is going to happen again, Harmon said.

Frazier asked the cast how they feel about doing such great work but never receiving an Emmy. This show has done Emmy-caliber work, but youve never won an Emmy. When you think about that, does it bother you? he asked. Rocky Carroll, who plays NCIS Director Leon Vance, says he isnt bothered about the lack of an Emmy when he thinks about the fate of shows that have one multiple Emmy awards. I think of all the shows that have won multiple Emmys that are not on the air, that have run their course. And, you know, I say that jokingly, but there are a lot of shows that have stood on the podium and accepted Emmys, but theyre in the Where are They Now? file now. And were still here, Carroll said.

Brian Dietzen (Jimmy Palmer) says not receiving an Emmy doesnttake away from the fact that theyre a talented cast:

I do think that 16 years, longevity doesnt preclude it from having some pretty awesome performances. I mean, whether its guest stars or some of the people in these chairs. There have been some amazing performances this year. The fact that we dont get recognized for awards season, its a bummer. I think wed all love to see that happen and whatnot, but that doesnt mean that the good work isnt happening right here. The fact that the people who do watch this show, see that and appreciate it, I think thats kind of what we hang our hat on.

Read more: InsideCote de Pablo and Mark Harmons Sweet Relationship

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How long do timing belts last? | HowStuffWorks

Sunday, September 29th, 2019

Your car's timing belt is responsible for maintaining the precision that's crucial to your engine's functions. Essentially, it coordinates the rotations of the camshaft and crankshaft so the engine's valves and pistons move in sync. The expected lifespan of your timing belt is specific to your car and engine configuration, usually between 60,000 and 100,000 miles. (You can check your owner's manual or look online for your car's service schedule.)

The manufacturer's recommended intervals are a safe guideline; you probably won't need to replace your belt any earlier [source: Allen]. However, if you're approaching your service interval and have doubts about the belt's condition, you might as well get it replaced a little early. It'll be less expensive than waiting until after the belt breaks.

Why is it important to replace the timing belt on such a strict schedule? The belt is a synthetic rubber strap that contains fiber strands for strength. It has teeth to prevent slipping, which fit into the grooves on the end of the camshaft and crankshaft. It's a simple part for such an important function, and when it snaps, things get a lot more complicated. Unlike many car parts that gradually lose function as they wear out, a timing belt simply fails. Whether the belt breaks or a couple of teeth strip, the end result is the same. One minute, your car will be running perfectly; the next minute, it won't. You're in trouble if your car has an "interference engine," in which the valves are in the path of the pistons. If the camshaft or crankshaft moves independently in an interference engine, there will be at least one valve/piston collision. The fragile valves will bend, and you'll be faced with a costly repair.

It's easy to check the belt for signs of premature wear -- just locate it in the engine bay (usually under a plastic or metal shield that should be easy to remove) and check it for drying, fraying and discoloration.

The belt itself is inexpensive, probably costing less than $20 at an auto parts store. Your mechanic will probably charge several hundred dollars (or more) for a belt replacement service, though. Those hours spent dismantling and reassembling the engine bay add up quickly.

You can replace the timing belt yourself if you have access to the necessary equipment. In some cars, it's a straightforward procedure -- remove the engine covers and shrouds, line up the camshaft and crankshaft, slip off the old belt, and slip on the new one. Sometimes, though, it's a lot more complicated. For example, the timing belt might loop through a motor mount, in which case the mount would need to be removed to access the belt. You'd need an engine hoist or stand to safely remove and replace the mount [source: Juran].

Keep in mind that an error in this job, such as improperly turning the engine by hand or failing to coordinate the shafts, will cause the same damage as a snapped belt. Make sure you understand the procedure before getting started.

Need more help with the do-it-yourself approach? The next section will point you in the right direction.

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