StemCell Therapy

"So actually when we exercise and we don't eat, these genes come on and act as traffic lights - and they are traffic cops that direct the body to repair itself and protect itself from diseases and aging."

Peter Dearden, a professor of biochemistry at the University of Otago, says although we're starting to understand how longevity and aging works in humans, we're really "a long way away" from putting that into a pill.

"You can improve longevity in mice, but no one has shown we can do that in humans yet," he tells The Project on Tuesday.

Kiwi aging expert Greg Macpherson says we should adopt better lifestyle choices as well as add in a few extra supplements.

"We can get some lessons from places called the 'blue zones' and blue zones are places around the world where people have lived and get to a hundred much more than the rest of us," he told The Project.

"And these people do these things like they have a plant-based diet, they exercise a bunch and we can take lessons from that and add in a few extra supplements that are available to us now that weren't available to previous generations.

"And these things are going to see us be healthier for a lot longer and that's going to have some effect on the amount of time we're around."

Macpherson's book Harnessing the Nine Hallmarks of Aging addresses the science of aging.

More:
Could a simple pill improve longevity and slow the aging process? - Newshub

In the U.K. it is customary toreceive a personalized message from the queenon your 100th birthdaysuch is the relative rarity of reaching the milestone.

Prince Philip was just a couple months off,dying at the age of 99 years and 10 monthson April 9, 2021. The last notable royal death before his was that of thequeen mother in 2002. She was 101 years old.

Reaching such a ripe old age isnt uncommon among the British ruling familyin fact, my analysis shows that on average they live an additional 30 years compared with their subjects.

I looked at the duration of life of the last six British monarchs, along with the longevity of their spouses and childrenin total 27 royals. What it reveals is a fascinating and familiar story for those of us who study aging and longevity for a living.

Being born into or living in poverty has been shown to be one of the most important factors that shortens lifespanand it is here that perhaps the royals have the greatest advantage.

As aprofessor of epidemiology and biostatistics, I had previouslyobserved the exact same phenomenon among U.S. presidentsthey also tend to live decades longer than the general population they serve.

The ruling U.K. monarchs from Queen Victoria onward have lived an average of 75 years. And this will continue to rise with each day that Queen Elizabeth IIcurrently age 95lives. Their spouses survived even longer, reaching an average age of 83.5 years. If Victorias husband Prince Albert, whodied of suspected typhoid feverat age 42 in 1861, is removed from the equation, the average duration of the life of the spouses of the monarchs was an astonishing 91.7 years.

By contrast, the average life duration of the wider U.K. population for the years the monarchs were born throughout this period was only 46 years, according to figures from theHuman Mortality Database.

For example, the typical life expectancy at birth for a female in the U.K. in 1819 was just under 41 years. Queen Victoria, also born in 1819, was 81 when she died. By the time Elizabeth II was born in 1926, life expectancy at birth for females in the U.K. had risen to 62the queen has already surpassed that by some 33 years.

Such differences in lifespanwith some members of the royal family living to an age double that expected of the general populationare considered in aging circles to be extremely large, but not uncommon.

Lifespan differences of this magnitude are the result of a combination ofgenetic as well as social and behavioral influences.

No one can live long without first having won the genetic lottery at birth. To maximize the chances of achieving exceptional longevityupward of 85 years oldyou must begin by beinglucky enough to have long-lived parents. But even for those blessed with the gift at birth of the potential for a long life, this is no guarantee youll outlive your contemporaries.

The next challenge is to avoid behaviors that shorten life. That list is longit is a lot easier to shorten life than extend itbut among the most well known aresmoking, eating in excess and lack of exercise.

And then there is the influence of poverty and privilege. Beingborn into or living in povertyhas been shown to be one of the most important factors that shortens lifespanand it is here that perhaps the royals have the greatest advantage.

Further evidence of privilege being a crucial ingredient in the recipe for exceptional longevity can be seen in the fact that the children of the last six U.K. monarchs that died from natural causes lived an average of 69.7 years. This is some 23 years more than the average age of British subjects over that period.

Put simply, British monarchs and their families live so much longer than their subjects for the same reason other subgroups of the population across the globe live longer than contemporaries born in the same year: privilege over poverty. A famousstudy conducted in Manchester, England, in 2017demonstrated vast differences in life expectancy depending on the conditions of where people lived. Access to higher education and economic status was directly correlated with longer life, while lower education, lower income, and poverty were linked to shorter lives.

In the U.S., similarstudies of life expectancy by county,census tractand ZIP Code demonstrated the same phenomenon. In fact, there are multiple instances of dramatic differences in longevity among people living as close as across the street from each othercaused by differences in poverty and privilege.

Differences in duration of life are first defined by genetics, but it is then heavily mediated by education, income, health care, clean water, food, indoor living and working environments, and the overall effects of high or low socioeconomic status.

The long life of Prince Philip is a cause for celebrating the progress of medical science in being able to keep people alive for longer. But it is in part the result of a privilege denied to many and a reminder that humanity has a long way to go to equalize the chances of living a long life.

S. Jay Olshanskyis a professor of epidemiology and biostatistics in the School of Public Health at the University of Illinois at Chicago. He is a research associate at the Center on Aging at the University of Chicago and at the London School of Hygiene and Tropical Medicine, and is chief scientist at Lapetus Solutions, Inc.

This commentary was originally published by The ConversationLong live the monarchy! British royals tend to survive a full three decades longer than theirsubjects.

More:
How Prince Philip and Queen Elizabeth outlived the average British subject by three decades - MarketWatch

SEOUL, April 13 (Korea Bizwire) The value of life annuity benefits has decreased sharply over the past twenty years as the average lifespan increased.

The age with a mortality rate of higher than 5 percent rose to 80 for men and 84 for women in 2019 from 73 and 78 in 2000, according to the latest report by the Korea Insurance Research Institute.

The extension of the average lifespan has led to an increase in the number of life annuity benefit receivers, resulting in a decline in the amount of per-capita life annuity benefits.

The report said that for a life annuity product that pays a benefit every month to male beneficiaries until their death if they make a lump-sum payment of 100 million won (US$88,920) at the age of 60, those who subscribed to the product in 2000 could receive 482,000 won per month.

However, the amount of monthly benefit dropped by 23.8 percent to 367,000 won for those who subscribed to the product in 2019.

The amount of monthly benefit for female beneficiaries also decreased by 19.9 percent from 380,000 won to 304,000 won.

Image Credit: Yonhap / photonews@koreabizwire.com

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Monthly Life Annuity Benefits Decrease in the Longevity Era - The Korea Bizwire

NBIS Celebrates 25 Years of Service to the SC&RA

ATLANTA (PRWEB) April 12, 2021

SC&RAs Longevity Awards are presented to member companies for their longtime support and dedication to the Association and its mission. NBIS was recognized with the 25 Years Award.

Throughout its membership, NBIS has been the endorsed provider of property casualty insurance to the members of the SC&RA. NBIS serves SC&RA members and the industry with unparalleled Risk Solutions developed alongside SC&RA members to be right sized for the industry. Every policyholder has access to our Risk Management Support System (RMSS) and able to take advantage of resources and partnerships developed to support the safety culture, manage & reduce claims and increase compliance with industry regulations & standards.

We are proud of our partnership and endorsement with the SC&RA and its members commented Bill Tepe, President & CFO of NBIS. Adding, Together, NBIS and the Association worked to improve the risk profile of the member companies and the industry as a whole.

As a leading provider of Risk Management & Insurance Solutions, NBIS specializes in providing insurance solutions for the Crane & Rigging, Concrete Pumping and Specialized Transportation/Heavy Haul Industries.

Want to learn more about NBIS Coverages and the Risk Management Support System? Contact us today at 870.866.RMSS

To learn more about NBIS insurance & risk solutions, visit us on the web: http://www.NBIS.com

Media Contact for NBIS: Lisa McAbee, Marketing Director (770) 257-1707 lmcabee@nbis.com

About NBISNBIS is the Premiere provider of Insurance & Risk Management Solutions to the heavy construction industry and the exclusively endorsed provider for the Specialized Carriers & Rigging Association (SC&RA). Providing coverage and Risk Management Services that works for you to prevent losses and give your company the best fighting chance in the event of a claim. For more information about NBIS, please visit: http://www.NBIS.com.

About SC&RAThe Specialized Carriers & Rigging Association (SC&RA) is an international trade association of more than 1,400 members from 46 nations. Our members are involved in specialized transportation, crane and rigging operations, machinery moving and erecting, industrial maintenance, millwrighting, manufacturing, concrete pumping, and rental services. SC&RA helps members run more efficient and safer businesses by monitoring and affecting pending legislation and regulatory policies at the state and national levels and researching and reporting on safety concerns and best business practices. For more information, visit scranet.org.

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NationsBuilders Insurance Services, Inc. (NBIS) Awarded Longevity Award by SC&RA for 25 Years of Service - PR Web

AS HE watched Eccleshill lift the West Riding County Cup at Valley Parade in 2014, Conor Sellars could not have imagined that he would be back one day in the home dug-out.

And it might have also been stretching it to think that Harrogate, beaten by a last-minute penalty that night, would now be on an equal footing with City in League Two.

They were in the National League North when Sellars spent a season playing at Wetherby Road.

But there were some experienced names in the line-up, including former City midfielder Adam Bolder and Scotland international and current Portsmouth goalkeeper Craig McGillivray.

Ive played a few reserve games at Valley Parade but I do remember that night, recalled Citys joint boss. It was nice to be playing there but it was a tough one to take losing 1-0 (to a last-minute penalty).

We had players who had played in the Championship or maybe the Premier League and obviously Craig went on to the Football League and is having a good career.

There were a lot of players from different backgrounds who had played at different levels.

I think Harrogate have always attracted good players along the way, although maybe not myself.

Simon Weaver was his manager at the time and will still be there on the sidelines for Citys Saturday lunchtime visit as he approaches his 12th anniversary next month at the Harrogate helm.

It is a remarkable achievement, even more so in the hire em, fire em environment of the modern game and something that new managers like Sellars and Mark Trueman can aspire to.

Sellars added: Its brilliant. Mark and I obviously know Simon and how long hes been there.

I had some good discussions with him while I was a player there and enjoyed working with him.

I used to really like his desire and how committed he was.

We were part-time at the time in Conference North but he lived and breathed it. His intensity in his work was great to see.

Success is maybe not just an immediate thing. Its something built over years of hard work and putting your identity and stamp on it.

We have to get results, we have to show intent and improve. We know that.

But we also want to build something long term at this club and hopefully were given the chance to do so.

Could they still be in the job after a dozen seasons like Weaver?

Why not? he said. But thats why it is such a good story seeing Harrogate go up the leagues.

This year was a massive test for them but I think theyve shown everybody that they deserve to be in this division.

Its been fantastic to see the development. When I was there, they always spoke about moving forward and trying to get into the National League and then into the EFL and theyve done that.

The midweek hiccup against Crawley has left City four points adrift of the play-offs. But Sellars insists they are still in the mix going into a six-game shoot-out.

Its hard to predict and I wouldnt want to do that. It can go in lots of different directions.

We just hope it can go in the most positive one.

We have confidence that we can do that but were also realistic to know that everything is not going to be a smooth as wed like.

From the day that we took over until now, we feel were in a good position. Its a bonus that were trying to get into the play-offs.

But again, I think it shows the hard work of everybody involved.

Continued here:
Bradford City duo inspired by Weaver longevity at Harrogate - Bradford Telegraph and Argus

What counts as flavonoids?

Flavonoids are mainly found in fruits, vegetables and other plant-based foods but also crop up in red wine and dark chocolate.

"The general rule is that the more colourful a fruit or vegetable is, the higher the level of flavonoids it contains," explains Holland and Barrett.

As the health body explains, there are five main types of flavonoids that contain various benefits, each of which are found in different foods.

These are:

Flavanols

They are commonly found in kale, peaches, tomatoes, onions, lettuce, tea, grapes, red wine, blueberries, and other fruit.

Flavan-3-ols

Nutrient-rich flavan-3-ols can be found in lots of foods. These include white, green, and black tea, as well as apples, grapes, strawberries, blueberries and even cocoa products, such as dark chocolate.

Flavones

Like all flavonoids, flavones are praised for their antioxidant properties. Citrus fruits like lemons, grapefruit, limes and oranges are familiar sources of flavones as are celery, parsley, and hot peppers.

Isoflavones

More research is needed around isoflavones, but experts believe this type of flavonoid can help with the bodys hormone balance. Isoflavones are richest in soy products along with peanuts, pistachios, and fava beans.

Anthocyanins

The last flavonoid on our list, anthocyanins. Youll commonly find these flavonoids in the outer skin of various berries, including red and purple grapes, blackberries, strawberries, blueberries, cranberries and even red wine.

Continued here:
How to live longer: A diet rich in flavonoids linked to a lower risk of cancer - study - Express

Tim Graham/Getty

In the U.K. it is customary to receive a personalized message from the queen on your 100th birthdaysuch is the relative rarity of reaching the milestone.

Prince Philip was just a couple months off, dying at the age of 99 years and 10 months on April 9, 2021. The last notable royal death before his was that of the queen mother in 2002. She was 101 years old.

Reaching such a ripe old age isnt uncommon among the British ruling familyin fact, my analysis shows that on average they live an additional 30 years compared with their subjects.

I looked at the duration of life of the last six British monarchs, along with the longevity of their spouses and childrenin total 27 royals. What it reveals is a fascinating and familiar story for those of us who study aging and longevity for a living. As a professor of epidemiology and biostatistics, I had previously observed the exact same phenomenon among U.S. presidentsthey also tend to live decades longer than the general population they serve.

If you love The Daily Beasts royal coverage, then we hope youll enjoy The Royalist, a members-only series for Beast Inside. Become a member to get it in your inbox on Sunday.

The ruling U.K. monarchs from Queen Victoria onward lived an average of 75 years. And this longevity will continue to rise with each day that Queen Elizabeth IIcurrently age 95lives. Their spouses survived even longer, reaching an average age of 83.5 years. If Victorias husband Prince Albert, who died of suspected typhoid fever at age 42 in 1861, is removed from the equation, the average duration of the life of the spouses of the monarchs was an astonishing 91.7 years.

By contrast, the average life duration of the wider U.K. population for the years the monarchs were born throughout this period was only 46 years, according to figures from the Human Mortality Database. For example, the typical life expectancy at birth for a female in the U.K. in 1819 was just under 41 years. Queen Victoria, also born in 1819, was 81 when she died. By the time Elizabeth II was born in 1926, life expectancy at birth for females in the U.K. had risen to 62the queen has already surpassed that by some 33 years.

Story continues

Such differences in lifespanwith some members of the royal family living to an age double that expected of the general populationare considered in aging circles to be extremely large, but not uncommon.

Lifespan differences of this magnitude are the result of a combination of genetic as well as social and behavioral influences.

No one can live long without first having won the genetic lottery at birth. To maximize the chances of achieving exceptional longevityupward of 85 years oldyou must begin by being lucky enough to have long-lived parents. But even for those blessed with the gift at birth of the potential for a long life, this is no guarantee youll outlive your contemporaries.

The next challenge is to avoid behaviors that shorten life. That list is longit is a lot easier to shorten life than extend itbut among the most well known are smoking, eating in excess and lack of exercise.

And then there is the influence of poverty and privilege. Being born into or living in poverty has been shown to be one of the most important factors that shortens lifespanand it is here that perhaps the royals have the greatest advantage.

Further evidence of privilege being a crucial ingredient in the recipe for exceptional longevity can be seen in the fact that the children of the last six U.K. monarchs that died from natural causes lived an average of 69.7 years. This is some 23 years more than the average age of British subjects over that period.

Put simply, British monarchs and their families live so much longer than their subjects for the same reason other subgroups of the population across the globe live longer than contemporaries born in the same year: privilege over poverty. A famous study conducted in Manchester, England, in 2017 demonstrated vast differences in life expectancy depending on the conditions of where people lived. Access to higher education and economic status was directly correlated with longer life, while lower education, income and poverty were linked to shorter lives.

In the U.S., similar studies of life expectancy by county, census tract and zip code demonstrated the same phenomenon. In fact, there are multiple instances of dramatic differences in longevity among people living as close as across the street from each othercaused by differences in poverty and privilege.

Differences in duration of life are first defined by genetics, but it is then heavily mediated by education, income, health care, clean water, food, indoor living and working environments, and the overall effects of high or low socioeconomic status.

The long life of Prince Philip is a cause for celebrating the progress of medical science in being able to keep people alive for longer. But it is in part the result of a privilege denied to many and a reminder that humanity has a long way to go to equalize the chances of living a long life.

S. Jay Olshansky is a professor of epidemiology and biostatistics at the University of Illinois at Chicago

Read more at The Daily Beast.

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British Royals Survive 30 Years Longer Than Their Subjects - Yahoo News

Feeding the organic compound spermidine to mice and fruit flies boosted mitochondrial activity in the animals brains and, with it, their cognitive ability, according to a paper in Cell Reportspublished April 13. The study also intimates a similar spermidine-linked cognition boost applies to humans.

Overall, I think that spermidine is probably one of the most promising molecules for aging research in general . . . and here they focus on cognition, says gerontologist Valter Longo of the University of Southern California who was not involved in the work. The most convincing data are from flies and mice, he says, because the human data are only correlative. But, he adds, the good news is that if you have a spermidine-rich diet, it seems to be a good one. Its certainly not bad for you in terms of cognition.

Spermidine is a natural compound present in a wide range of foods, such as wheat germ and aged cheese, though it was originally identified in semen. The compound promotes autophagya sort of cellular self-cleaning processand levels of both spermidine and autophagy appear to diminish in the bodys cells as animals, including humans, age.

Prior studies on lab animals have shown all manner of benefits from spermidine, from an increase in longevity to fortification of heart and immune cells to preservation of memory in old age.

Other groups have investigated the effects of spermidine injections . . . on behavioural and cognitive phenotypes, but we wanted to increase translatability for future applications and therefore concentrated on a dietary approach, study coauthors Frank Madeo and Stephan Sigrist write in an email to The Scientist. Both Madeo, who studies aging at the University of Graz in Austria, and Sigrist, a neuroscientist at Freie University in Germany, have equity stakes in The Longevity Labs, a company that sells spermidine supplements.

Madeo and Sigrist have already been involved in a pilot clinical study in which dietary spermidine was given daily to 14 older individuals for three months. The results of that placebo-controlled trial indicated a slight improvement in memory in the group taking spermidine. The researchers new work lends support to those preliminary trial results and dives into the physiological as well as cognitive effects of the compound.

For example, in addition to showing that old mice given spermidine in their drinking water for six months performed better than control mice did in learning and memory tests (associating a light stimulus with access to a reward, and remembering the location of a platform submerged in water), the team observed that the compound crosses the blood-brain barrier and steadily accumulates in the brain over a period of weeks. In the animals hippocampia brain region associated with learning and memorythe team found that the compound boosted cellular respiration, essentially increasing the brain cells energy levels, and promoted the modification of a protein called eIF5A, a translation factor that drives the production of a master autophagy regulator.

Compared with controls, spermidine-fed flies similarly displayed improved memory and higher brain cell respiration, both of which were dependent on autophagy, the team showed. And the treated insects exhibited the eIF5A modification, which Madeo and Sigrists team describe in detail in a second Cell Reports paper, also published this week. The modification, known as hypusination, involves the addition of hypusine, an uncommon amino acidso uncommon, in fact, that eIF5A is the only known protein to contain it.

Its quite convincing that they can show the same thing in mice and flies, says immunologist Katja Simon of the University of Oxford who was not involved in the study. As for the hypusination of eIF5A, which Simons team had previously reported drives immune cell rejuvenation in spermidine-fed mice, she adds, It was pleasing to see that they could see that in the brain [too]. Simon is a paid consultant for Oxford Healthspan, a company that sells a spermidine dietary supplement, but has no financial stake in the company.

In addition to the mouse and fly studies, the team also examined human epidemiological data. They examined cognitive test scores and dietary records of more than 800 older adults, calculating the participants spermidine intake from diet questionnaires. After five years from the studys baseline (1990), estimated spermidine intake positively correlated with cognitive test scores, with higher intakes also reducing the chance of developing cognitive impairment.

Altogether, the work indicates that dietary spermidine may support improved cognition later in life and, says Longo, points to a need for larger-scale clinical studies to investigate spermidines effects on cognitive decline.

Although decisive clinical proof for spermidines cognitive benefits are lacking, Oxford Healthspan and The Longevity Labs sell spermidine supplements for around $100 for a months supply. High levels of this molecule can also be acquired rather more cheaply by eating wheat germ, mature cheddar, soybeans, mushrooms, and other foods in which it is abundant.

S. Schroeder et al., Dietary spermidine improves cognitive function,Cell Rep, doi:10.1016/j.celrep.2021.108985, 2021.

YT. Liang et al., eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction,Cell Rep, doi:10.1016/j.celrep.2021.108941, 2021.

Visit link:
Dietary Spermidine Boosts Cognition in Insects and Rodents - The Scientist

CeCile happy with rise of female talent - Says once they produce timeless music, longevity is a must | Entertainment | Jamaica Star

Skip to main content

April 16, 2021

Entertainer Ce'Cile, who is celebrating two decades in the entertainment business, says that not only is she satisfied with the quantity of women rearing their heads in today's musical landscape, but also the quality these 'alpha females' possess.

"I am just so happy with what our women have been bringing to the table. There are so many of them that are doing well that it makes me proud to watch. The girls have been showing up and showing out and because of that the industry is a lot more balanced today than it was several years ago," she told THE WEEKEND STAR. "You have so many of these young ladies who are doing their thing not just in reggae but dancehall. And not only are they showing up in numbers but their work is impressive."

Ce'Cile, who just dropped her latest EP Sophisticated, said the only advice she would give to the current crop of young female artistes is to do music that will last through generations.

"I have tried from the beginning of my career to make sure that every song I put out there is one that will outlive me. I would be washed up already if I wasn't doing music that stood the test of time but I always thought about longevity," she said. "It's not by accident that I have lasted so long and why I seem fresh to a lot of people. I wrote some classic tracks. I can go anywhere and people a bawl fi hear I'm Waiting. That is what I want for these women in the business."

"That is why I love and idolise people like Beres Hammond. My mom listened to Beres Hammond, I grew up listening to Beres Hammond, and Nana [her daughter] is now listening to him and she loves his songs. His songs connect with every generation," she continued. "As an artiste, it is great when you can produce work that will outlive you and last for generations. I really believe the women I see doing their thing in music today can have that. They just have to be deliberate about the business and serious about their craft."

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Ce'Cile happy with rise of female talent - Says once they produce timeless music, longevity is a must - Jamaica Star Online

The Longevity and Anti-senescence Therapy market research report identifies all the factors positively and negatively impacting the growth of this vertical, to direct stakeholders in making right decisions. Besides, it includes statistics coverage of the past and current business scenario to validate the forecast figures presented in the document. Moreover, the report elaborates the various industry segments and unveils the lucrative prospects that will assure high profits for the forthcoming years.

As per industry experts, Longevity and Anti-senescence Therapy market is predicted to accumulate notable profits during 20XX-20XX, recording a CAGR of XX% throughout.

Apart from these factors, the document illustrates the impression of COVID-19 on this domain, emphasizing on the challenges like variations in supply-demand, cost management, and digitizing operations faced by businesses. In this context, it suggests solutions that will ensure an upward growth trajectory in the ensuing years.

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Importantpointers from Longevity and Anti-senescence Therapy market report:

Longevity and Anti-senescence Therapy market segments covered in the report:

Regional bifurcation: North America, Europe, Asia-Pacific, South America, Middle East & Africa, South East Asia

Product types: Hemolytic Drug Therapy , Gene Therapy , Immunotherapy and Other Stem Cell Therapies

Application spectrum: Hospital , Medical Service Institution and Drug and Device Sales

Competitive dashboard: CohBar , AgeX Therapeutics?Inc , TA Sciences , Unity Biotechnology and PowerVision Inc

Highlights of the Report:

The scope of the Report:

The report offers a complete company profiling of leading players competing in the global Longevity and Anti-senescence Therapy marketwith a high focus on the share, gross margin, net profit, sales, product portfolio, new applications, recent developments, and several other factors. It also throws light on the vendor landscape to help players become aware of future competitive changes in the global Longevity and Anti-senescence Therapy market.

Reasons to Buy the Report:

Major Points Covered in Table of Contents:

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Longevity and Anti-senescence Therapy Market Analysis, Status and Global Outloo - Business-newsupdate.com

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A 2020 study by the National Association of Home Builders (NAHB) examined who decides what building materials to use in new home construction. Not surprisingly, builders and contractors exert the greatest influence over primary construction materials, such as windows and doors, siding and house wrap, lumber and plywood.

But this applies more to home builders in planned developments. If you're lucky enough to be custom-building a new home or vacation getaway, or remodeling an existing one, you'll probably have a much larger role in deciding what materials go into the build. And if you're taking on a DIY building or renovation project, then it's all on you to make sure the materials meet the demands of your location, climate and budget.

Here are seven questions to ask when choosing building materials:

Unless you have a limitless building budget, choose materials priced within your means without compromising too much on quality. Natural stone siding is the most expensive residential exterior building material, but it's also one of the most durable. When properly installed, stone siding can last more than 100 years. Make sure the materials you choose strike the right balance between price and longevity.

You may love the look of a certain material, but that doesn't mean it's right for your climate or region. Wood siding looks authentic and natural, but if you put it on a house in South Florida, the long rainy seasons can do lots of damage. So can termites, who also like the warm climates of the Southeast. Before you commit to a material, make sure it's hardy enough for the climate challenges of your specific region.

You loved those hand-painted tiles you saw on your trip to Portugal, and you absolutely want them in your new kitchen. But how long are you willing to wait for them?

The more unique or rare the material, the harder it may be to find, and the longer it may take to be delivered. You probably have a timeline in mind for your project, so make sure to choose materials that fit the timeline. If those hand-painted tiles direct from Lisbon take three months to arrive, it may not be worth it.

You want to build green, and a modular home on your wooded lot seems like the right solution. But will you need to cut down trees to position that home where you want it? Consider whether your materials can be delivered with relative ease. Keep in mind things like driveway width, overhead utility lines and if you're building in a remote area the size, condition and grade of access roads.

If building with sustainable materials is a priority, make sure you choose the right materials for your climate and setting. Solar panels, for example, might not power you through a long Midwestern winter.

Also keep transport costs in mind. If those sustainable materials must be hauled halfway across the country to your job site, the carbon emissions of transport might negate any eco-benefits.

A traditional log cabin looks great in the woods of Vermont. On a beach in Florida, not so much.

When choosing materials, especially wood, stone, stucco or other kinds of exterior siding, consider regional aesthetics. If you're building in a developed area, especially in deed-restricted communities, pay attention to local building codes, zoning ordinances and Homeowners Association (HOA) rules. These may dictate everything from what materials you can use to what color your house can be.

Concrete, steel, wood and vinyl are among the most common exterior materials because they are readily available and long-lasting. If you're deciding between these or building materials that are more sustainable, more aesthetically pleasing or new to the market, do your homework and think long-term.

Talk with homeowners or designers who've worked with the materials you're considering. Think about how long you plan to own the home you're building or renovating, and how much maintenance you're willing to do over the next five, 10 or 20 years. Let that guide your decisions, especially if you're building a vacation getaway. You don't want to spend all your time there on upkeep!

Continue reading here:
What to Consider When Choosing Construction and Building Materials - MSN Money

Longevity and Anti-senescence Therapy Market 2021-2027:

The Global Longevity and Anti-senescence Therapy market exhibits comprehensive information that is a valuable source of insightful data for business strategists during the decade 2015-2027. On the basis of historical data, Longevity and Anti-senescence Therapy market report provides key segments and their sub-segments, revenue and demand & supply data. Considering technological breakthroughs of the market Longevity and Anti-senescence Therapy industry is likely to appear as a commendable platform for emerging Longevity and Anti-senescence Therapy market investors.

The complete value chain and downstream and upstream essentials are scrutinized in this report. Essential trends like globalization, growth progress boost fragmentation regulation & ecological concerns. This Market report covers technical data, manufacturing plants analysis, and raw material sources analysis of Longevity and Anti-senescence Therapy Industry as well as explains which product has the highest penetration, their profit margins, and R & D status. The report makes future projections based on the analysis of the subdivision of the market which includes the global market size by product category, end-user application, and various regions.

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This Longevity and Anti-senescence Therapy Market Report covers the manufacturers data, including shipment, price, revenue, gross profit, interview record, business distribution, etc., these data help the consumer know about the competitors better.

Topmost Leading Manufacturer Covered in this report:

CohBar, TA Sciences, Unity Biotechnology, AgeX Therapeutics?Inc, PowerVision Inc.

Product Segment Analysis:

Hemolytic Drug Therapy Gene Therapy Immunotherapy Other Stem Cell Therapies

Application Segment Analysis:

Hospital Medical Service Institution Drug and Device Sales

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Regional Analysis For Longevity and Anti-senescence TherapyMarket

North America(the United States, Canada, and Mexico)

Europe(Germany, France, UK, Russia, and Italy)

Asia-Pacific(China, Japan, Korea, India, and Southeast Asia)

South America(Brazil, Argentina, Colombia, etc.)

The Middle East and Africa(Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

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To analyze and forecast the market size of Longevity and Anti-senescence TherapyIndustry in theglobal market.

To study the global key players, SWOT analysis, value and global market share for leading players.

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To analyze the market potential and advantage, opportunity and challenge, restraints and risks of global key regions.

To find out significant trends and factors driving or restraining the market growth.

To analyze the opportunities in the market for stakeholders by identifying the high growth segments.

To critically analyze each submarket in terms of individual growth trend and their contribution to the market.

To understand competitive developments such as agreements, expansions, new product launches, and possessions in the market.

To strategically outline the key players and comprehensively analyze their growth strategies.

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At last, the study gives out details about the major challenges that are going to impact market growth. They also report provides comprehensive details about the business opportunities to key stakeholders to grow their business and raise revenues in the precise verticals. The report will aid the companys existing or intend to join in this market to analyze the various aspects of this domain before investing or expanding their business in the Longevity and Anti-senescence Therapy markets.

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Longevity and Anti-senescence Therapy Market 2021: Current and Future Market Potential NeighborWebSJ - NeighborWebSJ

The long sought-after fountain of youth may have been hidden in plain sight all along. Three new studies suggest strawberries may be associated with slowing down aging of the brain, cardiovascular system, and gut microbiome.Courtesy Riss Design on Unsplash

As a person ages, the brain can experience changes that result in impairments in learning, memory, gait, and balance. Sometimes these changes lead to early cognitive decline, disability, or falls among older adults.

In a recent study by Dr. Barbara Shukitt-Hale and her team at the USDA Human Nutrition Research Center on Aging at Tufts University, 37 healthy older adults participated in a two-arm trial in which they consumed either freeze-dried strawberry powder beverages (24g/day, equivalent to two cups of fresh strawberries) or a calorie-matched control powder for 90 days. Participants completed a battery of balance, gait, and cognitive tests at baseline, midpoint, and conclusion of the trial.

Participants in the strawberry group performed better on spatial memory tasks and word recognition tests relative to those in the control group. These findings show that the addition of strawberry to the diets of healthy, older adults can improve some aspects of cognition, although more studies are needed to confirm this finding.

This research comes on the heels of recent publications that indicate diets higher in long-term flavonoid intake, from foods such as strawberries, could contribute to reducing the risk of Alzheimers Disease and related dementias.CourtesyAnastasia Zhenina on Unsplash

Endothelium is a thin layer of cells that lines every blood vessel in the body. Its responsible for the relaxation and constriction of veins and arteries, playing a major role in blood flow, blood pressure regulation, blood clotting, and wound healing. High total cholesterol and LDL (the bad cholesterol) can impair the function of the endothelium, clog arteries, and lead to heart disease, particularly in later years of life.

A new study from Dr. Britt Burton Freemans team of researchers at Illinois Institute of Technology asked middle-aged adults with moderately-high LDL cholesterol to drink beverages two times a day made from freeze-dried strawberry powder (25g in each) or a control powder for four weeks. After completing their first assigned beverage, they switched to the other one (strawberry/control) for an additional four weeks.

The health of the endothelium, measured by flow-mediated dilation, improved in the strawberry group one hour after drinking the beverage. Systolic blood pressure decreased two hours after drinking the strawberry beverage compared to the control, and this was more pronounced four weeks after the strawberry intervention.

The findings suggest that strawberries may improve endothelial function and be considered a specific food to include in a heart-healthy diet for aging adults with moderately-high cholesterol.CourtesyVanesa Conunaese on Unsplash

Strawberries act as prebiotics and may increase gut bacteria associated with lean body weight, health, and longevity, according to a new study out of University of California, Los Angeles (UCLA).

The pilot study led by Dr. Zhaoping Li and her team at the Center for Human Nutrition considered whether strawberries would alter the gut microbiota.

Fourteen adults were asked to follow a beige diet low in fiber and polyphenols for 8 weeks. Two weeks in, a 13g strawberry powder drink was introduced to the diet twice a day, for four weeks. Then the participants returned to a beige-only diet for the two final weeks without strawberries.

Drinking strawberry powder beverages twice a day for four weeks was associated with an increase of 24 operational taxonomic units (OTUs), or gut microorganisms. Once the participants returned to a beige-only diet, several of the OTUs reversed back to their pre-strawberry status, suggesting strawberrys role in influencing the gut bacteria.

Something as simple as making strawberries a regular part of the diet may be the key to delaying aging of both the mind and the body.

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Can strawberries slow down the aging process? - The Packer

Feb 15, 2021

Emily KaplanESPN

When the Chicago Blackhawks publicly admitted to a rebuild this past offseason, there was plenty of speculation about whether Chicago's veteran core would want to see it through.

Perhaps we weren't asking the right questions. One month into the 2021 season, the Blackhawks are far more competitive than expected; at 7-5-4, Chicago is in lockstep with the Columbus Blue Jackets for the fourth Central Division playoff spot. And while the youth movement has been a driving force, we should have been asking: Is the veteran core going to expedite this rebuild?

Captain Jonathan Toews remains away from the team with a medical absence, while Brent Seabrook has not played this season, still recovering from a back injury.

However, the two top performers on the Blackhawks -- besides rookie goaltender Kevin Lankinen -- are Stanley Cup stalwarts Patrick Kane, who is third in the league in points with 22 through 16 games, and Duncan Keith, who leads the team in minutes played by a decent margin while still playing elite-level defense. Neither appears to be slowing down anytime soon.

"I feel like my energy levels have never been better, really," Keith said Sunday evening.

2 Related

A quick reminder that Keith is 37 years old. But across sports, we're starting to recalibrate athletic longevity. Though there is still an obsession with youth, especially in hockey, we've been inundated with more and more examples of athletes defying Father Time.

When the Patriots parted with Tom Brady they might have figured he would decline in his 40s -- because quarterbacks typically have -- but that didn't happen. Brady credits his off-field work, the TB12 method, for a lot of his success. Meanwhile, in a season when many expected LeBron James to take it easy thanks to an unprecedented 71-day offseason, the 36-year-old is top 10 in the NBA in minutes played, building a legitimate MVP case. A few years ago, James' business partner, Maverick Carter, said the Lakers star spends about $1.5 million on his body per year.

A few years ago, Keith said he planned to play until he's 45. The defenseman admits he spoke a little capriciously. "I kind of just said that because I was sick of the media asking," he said. "It started a few years ago when I was 34 or 35. For me, I felt like I was young, I didn't know why I was being asked these questions. At 37 now, I look around and I'm the oldest guy on the team and there's not a whole lot of guys my age [in the league] anymore."

Asked if he could play to 50, Keith laughed. "I don't know if I'll go that far," he said. "But I feel really good right now."

Ask anyone who has played with Keith and they'll tell you he's obsessive about his off-ice regimen. Many young players try to absorb the lessons, while others are just in awe.

"My first year, I was really impressed to learn how much work [Keith] does off the ice, especially when it comes to recovery," Kirby Dach told me last year. "He puts so much work in you don't see behind closed doors."

In 2019, The New York Times wrote an article about Keith's routine in which he called himself a "biohacker and part-time hockey player." Keith said he lies on a mat with electric currents for eight minutes every morning, and routinely spends time in front of Joovv lights, which are designed to help with recovery.

"I've always been diligent about my training," Keith says, now. "But now I feel like I put it all together. I've learned a lot over the years of what my body specifically needs."

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Since Keith debuted in 2005-06, only Ryan Suter has played more minutes than his 28,839. Perhaps most impressive is Keith's consistency. As a rookie he led the Blackhawks in ice time with over 23 minutes per game. Sixteen years later, he's still leading the team, averaging over 24 minutes per contest.

Keith said the aspect of his routine that has changed the most as a pro is his nutrition. "I always thought my eating habits were pretty good," he said. "But now I'm at a point where I'm really dialed in, and I know how to get my energy levels up if they were down through healthy, nutritious foods I put in my body, knowing what my body responds well to."

And for Keith, the answer is not always complicated. "I eat a lot of steak, a lot of meat, and potatoes," he said.

Beyond nutrition, he's constantly thinking about his energy levels.

"I think in general, I've had more awareness to what takes energy away from myself," Keith said. "Whether that's staying up late, staring at my phone, looking at the screen on a TV or computer. I don't think it's necessarily one little gadget that helps me. They've got Normatec boots that help with lymphatic drainage, which is good. There's lots of those types of little things out there you can do and spend money on, but I feel it's always really important to master the basics, which nobody really can -- or anyone that I've met has. That's your sleep, your food, your hydration and your breathing. So I focus on those and it branches out after that."

Of course, we've heard countless athletes talk about sleep, nutrition and hydration, but breathing is discussed far less often.

"It's very underrated," Keith said. "There should be more talk about that. Breathing, and the power of the brain, are two things in hockey or sports, that don't get enough attention. I don't know why that is. The muscles and aesthetics get mentioned -- everyone wants to look good -- and that's important, for sure. There's meditation breathing to bring your nervous system down to more of a parasympathetic state, where you're relaxing, and you're able to recover and rest. But for me, I work on my breathing and the mechanics of it a lot. I actually really started getting into proper breathing eight years ago, and have taken it to the next level in the last year especially. So that's something I'll continue working on."

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Entering the 2021 season, Keith wasn't quite as daunted by the team's approach as some Blackhawks fans might have been. "My mindset didn't really change, because it feels like this has been going on for a while now," Keith said. "As a player, going through the ups and downs of the season each day, wins and losses, the rebuild isn't just starting this season. I just think the organization is trying to be a little more transparent with people. Some of these young guys that come in are excited to play NHL hockey and be in the NHL, and it's invigorating to be part of that type of energy."

This gives Keith an opportunity to be transparent about his own situation. Because he's still contributing at an elite level, and playing on a bargain of a contract for his services -- he's on the tail end of a 13-year contract, which pays him $5,538,462 annually through 2022-23 -- many have assumed Keith might waive his no-trade clause to play for a contender. But Keith emphatically says he has no intention of doing that.

"Why would I go anywhere?" Keith said. "Where is it better than Chicago? It's a great city, I've been fortunate to play here my whole career, great ownership, and I just love it. My goal is to win another Stanley Cup in Chicago. That's what I want."

Jump ahead:Three stars of the weekWhat we liked this weekWhat we didn't likeBest games on tapSocial post of the week

1. A group of 27 student-athletes, coaches and administrators announced the formation of a group called College Hockey for Diversity, Equity & Inclusion this week.

"It's a group of people that wanted to get together and actually make a change in hockey," says University of Alabama Huntsville freshman Ayodele Adeniye, who is part of the coalition. "Our saying is, 'One shift at a time.' Because it might not be the biggest change at a time, but we're just trying to enact change in some way at all times."

Adeniye himself has an interesting story. He was born in 1999 in Ohio, one year before the Blue Jackets debuted, so he grew up amid the area's participation spike, fostered by the Blue Jackets. Adeniye began playing through the NHL's local Hockey Is For Everyone program, the Columbus Ice Hockey Club. "Up until I was around 6 or 7, I was playing with a majority of Black kids," he said. "But as I started going from lower-level hockey and working my way up to higher levels, I started to be the only one."

Who will be the top pick this summer? Early top-32 prospect rankings How COVID-19 will impact evaluations

College hockey, Adeniye explains, is not extremely diverse. "I have one teammate [Peyton Francis] who is African-Jamaican-Canadian," Adeniye says. "But other than him, I have not seen another Black kid in our league. I saw one other player of color this year, when we played [Robert Morris University]. I'm actually in a group on Instagram of all the Black kids playing in NCAA hockey, and I think there are 15 or 16 of us total."

Adeniye chose UAH in part because his parents moved to Alabama when he was 16. UAH is the only Division I program in a southern state. "My mom hasn't really been able to see me play a lot since I was 16," he said. "So I knew I would be closer to her, and the fam."

When he heard about the formation of the College Hockey for Diversity, Equity & Inclusion group, it piqued his interest. Adeniye reached out to a reporter he knew who had a phone number for Jennifer Flowers, the WCHA women's league commissioner who was organizing the group. "I reached out to her, then told my coach I wanted to be a part of it, and they accepted me," he said.

The group meets on Sundays, via Zoom, and so far is focusing on its "first shift." Members have been sending each other resources they find online focusing on systemic racism. Their first goal is to put together an instructional video that can be played in every college hockey locker room ahead of next season. Adeniye has his own ideas, too.

"There isn't a whole lot of grassroots hockey in Alabama," Adeniye says. "There's not a lot of hockey programs down there, and we definitely don't have any diversity programs or anything like that down here. So once COVID is over, I'm hoping to get into the inner city, and places where there hasn't traditionally been hockey here, and spread the game. I already have a couple teammates that want to support me. I'm going to call it African Floor Hockey Fanatics, and we'll go to Boys & Girls Clubs around here and teach them how to play ball hockey, give them tickets to games, and spread hockey all over Huntsville and the South, which will make it a more inclusive game."

2. It's been a while since the best women's players in the world -- Marie-Philip Poulin, Shannon Szabados, Hilary Knight, Kendall Coyne-Schofield, Brianna Decker -- have had a stage to perform. We'll start to see them showcased in PWHPA games, beginning Feb. 27 at Madison Square Garden, but the event everyone is circling is April's IIHF Women's World Championship in Nova Scotia (which gets a second chance at hosting after the 2020 tournament was canceled).

Players I've talked to are cautiously optimistic the world championships will go on this year -- especially since the IIHF and Hockey Canada were able to stage a world junior championships in December, in a bubble in Edmonton. However, we haven't heard much about the women's senior tournament, at all. I heard that Hockey Canada asked the IIHF to move the tournament back until May, and the sides might push it back as far as August. I asked Hockey Canada for an update last week. In a statement, the organization said it is in constant communication with IIHF as well as the province of Nova Scotia.

"At present time, hosting the 2021 IIHF Women's World Championship in Halifax and Truro, N.S., on behalf of the International Ice Hockey Federation (IIHF) remains a priority for Hockey Canada," the statement said. "All our hockey, venue and event partners remain committed to finding a solution to host a successful world championship."

So, stay tuned ...

1. Cam Atkinson, RW, Columbus Blue Jackets

After a down 2019-20, Atkinson looks to have rediscovered his scoring touch. The Blue Jackets veteran had three goals and four assists in three games this week. Atkinson now has three short-handed goals on the season, and 15 shorties for his career, which is now the most in Columbus franchise history (passing Rick Nash's 14).

2. Mike Smith, G, Edmonton Oilers

He missed the first month of the season on long-term injured reserve, and some fans weren't pleased that the Oilers decided to bring back the 38-year-old (instead of finding an upgrade this offseason). But Smith was a stabilizing force for Edmonton this week, stopping 65 of 66 shots over two appearances (.985 save percentage), including a shutout against Montreal.

3. Marc-Andre Fleury, G, Vegas Golden Knights

The Golden Knights are 8-1-1 at home this season, and Fleury has been a big part of that success. A 30-save shutout on Sunday (the 63rd of his career) meant he stopped 100 of 106 shots over four games this week (.943 save percentage), three of which were wins.

1. Boston Bruins goalie Tuukka Rask is one of the best personalities in the game. He doesn't take himself too seriously. He has human moments, and is happy to talk about them. And that's exactly what happened Wednesday night when Rask left the Bruins' net with one minute remaining in a tied game.

"I honestly thought we were down 2-1," Rask admitted afterward. "That's it. I thought we were down 2-1. I was waiting for [coach Bruce Cassidy] to wave me over there. I'm like why the heck is he not? ... Then I think Chucky [Charlie McAvoy] told me, 'Buddy it's 2-2.' So ..."

Luckily the Bruins made it out of the jam unscathed, and won thanks to Brad Marchand's overtime winner.

"It's an entertainment industry I guess," Rask said. "That's what we're trying to provide, entertainment for the fans. I'm sure people were shocked at first, but hopefully they got a good laugh out of that. I sure did."

2. Speaking of Fleury, here's the best save I've seen this year:

3. The Los Angeles Kings recognized Black History Month on Tuesday with all players wearing warm-up jerseys featuring either Willie O'Ree's or Blake Bolden's name. This is exactly what allyship looks like, and it was cool to see how moving the gesture was for the 29-year-old Bolden, who works for the Kings and is the NHL's first Black female scout.

1. While I know new Pittsburgh president of hockey ops Brian Burke and GM Ron Hextall are well-known hockey men with experience running NHL teams -- something the Pittsburgh Penguins coveted, given their urgency to maximize the end of the Sidney Crosby era -- you have to ask yourself: Are there really only 40 people qualified for these types of jobs, and at what point do we stop cycling through them? Again, not a total slight to the Penguins here, what they did is just emblematic of hockey's hiring practices.

Last year, NHL coaching agent Neil Glasberg -- a champion for diversifying front offices, including the consideration of more European candidates -- called this the NHL's groupthink problem. We've talked about it in relation to coaches, but it's just as bad with management positions.

"The easiest way to frame it is an unwillingness to consider -- let alone listen -- to anybody who isn't widely known by the hiring manager, whether it's the GM, the [assistant] GM, owner, or whoever is running the search," Glasberg said. "Which I think is selling themselves short. Why wouldn't you want to talk to as many qualified people as possible? Instead, most NHL teams have this 'hire-a-friend' mentality. I hear this from my guys all the time: 'It's not the best candidate that gets hired. It's the candidate with the best network or who is the best known.' That's not how you build success. No company would ever be successful if they were just hiring people they knew."

2. Greg Wyshynski and I will have much more on the NHL's plans to finish the season later this week, but it's of note that we're only a month in, and the NHL has already had to adjust its safety protocols twice -- clamping down on player movements each time. In the latest edict, sent to teams this week, it is "strongly recommended" that members of players' households limit their activities as much as possible. Players, meanwhile, will be required to remain at home unless they are attending practices and games, exercising outdoors, performing essential activities (such as going to the doctor), or dealing with family or other emergencies.

There's still optimism that the season can be completed in its current format, and sources on both the NHL and NHLPA sides stressed that they're willing to tweak protocols as many times as needed to adapt. There haven't been any meaningful conversations about returning to a bubble -- and we know how players feel about the bubble, so it would be a hard sell -- but it's alarming that we're in a situation where some teams (like the Vancouver Canucks, who have competed in 18 games) have played double the amount as other teams (the New Jersey Devils have completed just nine games).

That's why everyone you talk to around the NHL stresses one thing: Pay attention to points percentage. All teams might not get to 56 games, but it will be essential for every division to hit approximately the same number of games.

Note: All times Eastern.

Monday, Feb. 15: St. Louis Blues vs Arizona Coyotes, 4 p.m.

It all comes down to this: In an unprecedented seven straight games featuring the same opponents, Monday marks the pivotal Game 7. The Yotes came out strong, but the banged-up Blues won the past two. Aggregate goals are 20-19, St. Louis. Both teams are looking forward to a break from each other after this.

Friday, Feb. 19: Edmonton Oilers at Calgary Flames, 9 p.m. (ESPN+)

Despite this being an entire season built around rivalry games, every contest in the Battle of Alberta feels like appointment viewing. Both teams are still trying to find their stride, with Edmonton putting veteran James Neal on waivers over the weekend (to be put on the taxi squad for cap flexibility).

Saturday, Feb. 20: Vegas Golden Knights at Colorado Avalanche, 3 p.m.

The NHL's first of a two-game set in Lake Tahoe will feature these two Western powers. Get excited for a stunning backdrop -- the rink was built on a golf course next to the lake -- plenty of panoramic views and some playoff-level intensity (it will be the third time these teams play this week). Luckily for Colorado, star Nathan MacKinnon is back after being sidelined three weeks with a lower-body injury.

Chirping doesn't stop once you hang up the skates. Classic troll job from Kevin Bieksa here:

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The NHL's best and worst this week - The secrets to Chicago Blackhawks defenseman Duncan Keith's longevity - ESPN

Beans play a big part in sustaining a healthier and lengthier life. Dubbed the worlds easiest beans by Blue Zones founder Dan Buettner, youll only need a handful of ingredients for his latest recipe to promote longevity. Its delightfully simple, especially at a time when so many of us are over it when it comes to cooking.

According to Buettner, incorporating beans into your everyday diet is very much a good idea. The longevity all-star food is beans, he says. If youre eating about a cup of beans a day, its probably worth an extra four years of life expectancy.

Chickpeas, in particular, are high in fiber and help regulate your blood sugar. Theyre also high in protein, delivering 39 grams per cup. The worlds easiest chickpea recipe below packs 78 grams of protein and 22 grams of fiber for the day.

Chickpeas are a fun and versatile legume, says Tracey Lockwood Beckerman, RD. The combo of fiber and protein helps slow carb absorption and maintain healthy blood sugar levels. The high fiber content also supports a healthy heart.

One of the best things about Buettners chickpea recipe is that its so easy to modify. Try adding some fresh pressed garlic, a pinch of red pepper flakes, or a minced shallotwhatever your heart desires.

Ingredients2 cups chickpeas2 Tbsp olive oilLemonSaltPepper

1. Place chickpeas, olive oil, salt and pepper, with a squeeze of lemon in a bowl.2. Mix all ingredients together.3. You can serve it at room temperature or warm it up on the stovetop.

The health benefits of chickpeas, according to a registered dietitian:

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This Worlds Easiest Beans Recipe for Longevity Only Requires a Handful of Simple Ingredients - Well+Good

HONG KONG, Feb. 16, 2021 /PRNewswire/ -- Regent Pacific Group Limited ("Regent Pacific" or the "Company" and together with its subsidiaries, the "Group"; SEHK: 0575.HK)'s Deep Longevity, Inc, a company acquired on 14 December 2020 which develops artificial intelligence to track human aging and extend productive longevity, today announced the publication of an article in Lancet Healthy Aging titled "The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19".

While the pandemic continues to unfold, targeted therapeutic solutions for COVID-19 are still not established. The extremely rapid development of various vaccines as a preventative approach provides reassurance, but at the same time faces a number of majour challenges: insufficient protection against mutated variants, production line limitations, anti-vaccination sceptics etc. At the same time, COVID-19 still disproportionately affects older and comorbid individuals, who mostly suffer from more severe courses of illness, complications and lethal outcomes. Most frequently, advanced age goes hand in hand with comorbidities, which potentiates the adverse effect of the virus drastically.

Vaccines are still far from arriving at a complete protection. Unfortunately, the population least likely to benefit from such solutions are also those at the highest risk: the elderly and individuals with pre-existing age-related conditions. "It is a double-edged sword: the immune system of elderly and multimorbid (any age) patients is compromised. Those individuals are thus more prone to get infected and to develop a more severe disease. On the other hand, their response to a vaccine -- which acts on and with the immune system - might be insufficient. We also see reinfections occurring in elderly patients, which then take an even more aggressive course, leading to fatalities," said associate prof. Evelyne Bischof, Harvard, Columbia and Basel trained MD, practicing physician, one of the authors of the paper in Lancet Healthy Longevity today -- a joined work of the world-renowned biogerontologists and longevity specialists prof. Alex Zhavoronkov, prof.Matt Kaeberlein, and prof. Richard Siow. 'It is a major problem not only because of the predominantly aged demographics, increased danger in care homes for elderly, but especially because most elderly patients are also comorbid -- due to the aging processes causing age-related, mostly chronic diseases," prof. Evelyne Bischof continues. Such patients are at a significantly enhanced high risk of infection and death if they need to be hospitalized for non-COVID-19 reasons.

Story continues

While most trials exclusively target the infectious component of the disease, the authors outline the rationale behind a double approach: targeting COVID in the biologically aged for better prevention, vaccination efficacy and improved outcomes. The reasoning is complex and interrelated: old age is related with immunosenescence (immune system aging and thus worse function), with age-related diseases that are related with more severe COVID-19 course, e.g. diabetes, hypertension, cancer etc., with frailty and vulnerability (more exposure, e.g. due to homecare or institutionalization). Therefore, in order to efficiently intervene, geroprotective and senoremediative interventions towards mounting the immune response to vaccines are of uttermost importance, both from the medical, as well as the global economic aspect.

AI-based strategies were harnessed for repurposing known geroprotectors such as rapamycin, for the prevention of SARS-CoV-2 infection. Pre-clinical simulation analysis and previous evidence showing paradoxical immunopotentiation effects of rapamycin urge to propose additional clinical trials for these molecules in the broad elderly population.

In addition, in contrast to current studies, the authors propose to use an objective measurement of the biological rather than the chronological age. In the absence of reliable predictive and prognostic COVID19-biomarkers, minimally-invasive deep aging clocks are suggested as surrogate markers of biological age to track the efficacy of these preventative geroprotective interventions and to stratify the patients by predicted severity of the disease. Moreover, it will allow validation of markers of biological age in the context of viral infections and identification mechanisms by which geroprotectors enhance resilience against infections and reduce the severity of symptoms. This AI based approach in precision medicine was just recently illustrated in Nature Aging.

The Lancet Healthy Aging paper outlined the available evidence and a clinical translation of the geroprotector rapamycin for further research in a clinical trial setting, paving a new perspective: longevity medicine in pandemics. Longevity medicine as AI-based precision medicine aims to assure a healthy lifespan, mitigating and eliminating the risks and development of age-related diseases. Different from the reactive medicine, it uses the latest anticipatory technologies and muti-omics technologies to delay, attenuate or reverse senescence on all levels (cellular, tissue, system, organism, society). The benefits of such an approach in this and future pandemics is obvious, while the publication pioneers the scientific base for a longevity medicine RCT using geroprotective interventions.

About Deep Longevity

Originally incubated by Insilico Medicine, Deep Longevity was acquired on 14 December 2020 by Regent Pacific Group Limited (SEHK:0575.HK), a specialist healthcare, wellness and life sciences investment group whose shares are listed on the HK Stock Exchange. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS) solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other experts AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers.

longevity.ai/

About Regent Pacific (SEHK: 0575.HK)

Regent Pacific is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness and life sciences sectors whose shares are listed on the HK Stock Exchange. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering.

regentpac.com

SOURCE Regent Pacific Group Limited

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Deep Longevity Publishes Article About Preventing COVID-19 and Aging - Yahoo Finance

NORTH PALM BEACH, Fla., Feb. 15, 2021 /PRNewswire/ --West Palm Beach-based R3 Health, a provider of individualized services that address the health, medical, beauty, lifestyle, and aging concerns of patients, is set to introduce its innovative whole-body approach to wellness to North Palm Beach with the opening of a brand new location in March. This is the second location that the company has established, and it will be based at 772 US-1 Suite 101, North Palm Beach, FL 33408.

"At R3 Health, we believe that personalized healthcare is the key to optimal and balanced wellness. In turn, it helps prevent chronic disease and manages the aging process. We've seen how well a more individualized form of healthcare can enhance the overall wellness of our patients in West Palm Beach, so we're delighted to now have the chance to help the people of North Palm Beach experience the same improvements in their quality of life," said Joseph Radich, Founder and Clinical Director of R3 Health. "We're thrilled to be opening our second location in North Palm Beach this March and look forward to helping those in the community achieve and maintain optimal health."

R3 Health offers three areas of service in their all-encompassing approach: medical, beauty, and regenerative. For its medical services, rather than using a synthetic drug to mask the developed result of an imbalance, R3 Health's approach to patient care focuses on utilizing naturally occurring substances to help better balance the natural homeostasis of our bodies. The company's beauty solutions utilize cutting-edge techniques, like OxyGeneo and stem cell facials, customized and formulated to give skin the highest level of treatment and care. Finally, for its regenerative service, R3 Health provides advanced, minimally invasive, and regenerative therapies individualized for patients who simply want to improve their longevity and quality of life. R3 health not only provides world renowned individualized regenerative treatment plans for its patients, but also has a full physician training program, so not only are you getting the best services but you're also receiving them from a group that has trained over 500 physicians from all over the world.

During this year, R3 Health will also be refreshing its flagship West Palm Beach location to include a brand new, never-before-seen, and state-of-the-art regenerative medicine membership facility. Additionally, the company plans to launch a telemedicine and video medicine service with a dedicated app later this year, allowing them to serve patients all over the world, including countries like United Kingdom, Israel, Turkey, Greece, Italy, and Canada.

Widely known for offering a safe and trusted VIP healthcare experience, R3 Health treats household name celebrities, athletes, and CEOs of major brands.

As well as performing the most cutting-edge wellness, anti-aging, beauty, and regenerative services, R3 Health has an online supplement store at R3HealthEssentials.com that offers top notch physician grade only nutraceuticals. The company also offers a full practitioner training program and has trained over 500 doctors in more than 30 states.

About R3 Health

Headquartered in West Palm Beach, Florida, R3 Health provides a safe and trusted VIP experience designed for patients to address all their health, medical, beauty, regenerative, and lifestyle concerns. By applying the latest technology, individualized wellness programs, and cutting-edge treatments, R3 Health treats every patient with a whole-body approach. For more information, please visit R3Health.co.

Media Contact

Alejandro Narvaez[emailprotected](561) 331-2983

SOURCE R3 Health

http://R3Health.co

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R3 Health to Bring Whole-Body, Individualized Healthcare Longevity Services to North Palm Beach with New Location Opening - PRNewswire

The roaring 90s were a heyday for the music biz especially for bands in the college and alt-rock sectors. Record deals were given out like candy to any group falling under that newly burgeoning musical umbrella. A worthy beneficiary of the craze for quirk and cool was Local H. They first got together in 1987 while in high school officially forming Local H in the first year of the 90s, setting themselves apart by usually performing as a duo.

Led by singer/guitarist Scott Lucas (the only regular member), the Illinois-based band ended up with an unlikely hit on alt-rock and modern rock radio with 1996s Bound for the Floor, which propelled Local H from the underground to the mainstream adjacent. The angst-driven song was perfect for the time (and would never get on mainstream radio today) and ended up charting at No. 5 on the Billboard Modern Rock Tracks chart and No. 10 on the Mainstream Rock Tracks chart. Theyd also have another pair of hits with Eddie Vedder (which includes the classic line, If I was Eddie Vedder/would you like me any better?) and Fritzs Corner landing on the Billboard Mainstream and Alternative Charts. They also had a stint opening up for Stone Temple Pilots on their 1996 fall tour.

Record biz politics ultimately derailed Local Hs chance at further widespread fame, but Lucas carried on. Over 30 years into the bands career, Local H endures. They continue to release music, like last years strong LIFERS album that featured fellow alt-rock luminary Juliana Hatfield and was produced by Steve Albini and Andy Gerber.

We caught up with Lucas, who reflected on the bands biggest hit, LIFERS and who would replace Eddie Vedder today as the title name in that eponymous song.

SPIN: LIFERS is a concept album, but also seems like an apropos title for an album about a duo of guys who, somehow, continue to soldier on in the music biz. Was that the double intent?Scott Lucas: That kind of IS the concept. We wanted this record to feel like a concept record without actually being a concept record at least in any technical sense. Kind of like The White Album. Thats not really a concept album, but in the way it feels plugged into the general mood of its time it certainly comes off like a concept record. But it isnt, even though in my mind, it feels more like a concept record than Sgt. Peppers. So I was very sure to make lyrical references to things that were going on in this country, but without mentioning any names so to speak. You want your record to be just as timeless as it is timely, so making something where youre screaming Fuck Trump for 11 tracks might not have the staying power or resonance that youd hope for. But once we had Juliana singing on the record, that made us think about the people we were surrounding ourselves with not just with this record, but in everything we try to do with our, um, career. These people that we look up to. That inspires us. Suddenly this idea of lifers became very interesting to us. And knowing that even that word itself has a double edge is it somebody who refuses to give up? or is it somebody whos just a loser? That became the concept.

What was it like working with Juliana Hatfield, John McCauley of Deer Tick and Steve Albini?Great! The thing with Juliana and John is, theyre friends. So it was just a matter of asking them to do something on the record while hoping that they wouldnt say no. It was the same thing with John Haggerty. But with Albini, I didnt know him at all. And I was kind of afraid of him. I mean, Id read his interviews. I knew he didnt suffer any bullshit. But Haggerty, who knows him very well, just laughed at me when I told him I was intimidated by Steve. He was like, Fuck that. You should work together. And he was right, of course.

Was this done prior to the pandemic?Yup. This was all in 2019. The idea was to take a year off from touring, make the record, and then tour the shit out of the record in 2020. Our timing. Impeccable as always.

What was the inspiration for Winter Western?I dont remember. Ha! I remember theres a line about raids before the dawn, and I know that had something to do with one of Trumps cronies. But I just love the imagery of Western movies that take place in winter. Like McCabe And Mrs. Miller. I do know that the song was just okay until we had the idea to ask Juliana to sing on it. After that, the song just clicked. I seriously got chills the first time I listened to her vocal. She sounds so cool on darker, heavier songs. Especially tunes that are in F#minor. Not to get too far in the weeds, but it is the saddest of all keys.

If you were to rerecord Eddie Vedder now, who would be the person highlighted in the song title?Shit. Taylor Swift?

Ha! Whats it like to hear Bound for the Floor on rock radio or satellite radio all these years later?Awesome. I remember a few years ago hearing Bound played on the Loop, here in Chicago. A great classic rock station that is now, sadly, no longer with us. We were sandwiched between Boston and Tom Petty. I thought that was pretty fucking cool.

Looking back, does it seem like more of a miracle that you were able to make a second album with a major label?There was some stuff going on behind the scenes that I wasnt really aware of at the time. But we were really rushed into making our second record by our A&R guy. I now know that was because we were a C-hair away from being dropped. I remember being told that we needed to sell 100,000 copies of our second record or else wed be dropped. That was the only time in my life that I counted sales. Once we got past 100,000 I said Fuck it. Lets make record number three.

Over 30 years in, are you surprised that not only youre still making music, but continue to do so in front of enthusiastic fans?Sometimes I feel like George Bailey in Its A Wonderful Life. I get the sense that people are constantly trying to frame our career as some kind of tragedy. But it just isnt so. We were never really cut out for the big leagues. Its just not us. There may not be a whole lot of people that dig us, but the ones that do holy shit! Ill never make a record good enough to deserve those people.

What are your thoughts on the current civil rights movement?Well. I certainly dont get why Black Lives Matter is supposed to be a controversial statement. I dont even understand why were discussing it. I was watching Blazing Saddles the other day and it struck me how beautiful that movie is. There was this moment in the 70s where it seemed like we could have some open and honest and even hilarious conversations about race in this country. But in America we cant have nice things, so the 80s came up and strangled the fuck out of that idea. I guess we have a lot of unfinished business in this country when it comes to race. Its fucked up.

Did you march or protest?I did not. I was driving across the country when that happened here in Chicago. But I had this idea for a noise rock jam called 8:46. And I remember thinking Whats the point? Surely, someone else will come up with the same idea and do it better. But that didnt happen. So I sat on it for a second. And that was a mistake, but I was like, who needs to hear this shit from us? Then I watched that Dave Chappelle special while I was driving through Kentucky and it devastated me. I realized that it didnt matter if somebody else had the same idea. In fact, it would be pretty cool if everybody on the planet released someTHING called 8:46. We went in and recorded our version the next week.

Local H's Scott Lucas performs in Los Angeles, 2018 CREDIT: Scott Dudelson/Getty Images

Are you optimistic about the state of the country?No. Are you? I dont know what to tell you.

Not really, no. On a lighter note, whats been your favorite pandemic discovery?My dog.

Is there a future for guitar rock anymore?Is Annie Clark (St. Vincent) not guitar rock? Is Phoebe Bridgers not guitar rock? The future of guitar rock is happening right now, guys like me are just too stupid to see it.

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Local Hs Scott Lucas on the Bands Longevity and Copacetic Career - SPIN

It's common knowledge that fruits and vegetables are extremely healthy for you. Certain fruits are in fact known as superfoods due to their numerous health benefits including helping to boost your longevity.

In one study, fruit flies were shown to live 10 percent longer when fed a regular diet containing blueberry extract.

Not only did the fruit flies live longer but they also showed improved levels of physical activity.

These enhancements arise both from increased tolerance of oxidant stress and from beneficial changes in the way certain important genes are expressed.

It was also shown that after supplementation with blueberry extract, these organisms lived an average of 28 percent longer, and the maximum life span increased by 14 percent.

The supplemented animals showed a 20 percent reduction in an age-related protein that impairs function, and vastly improved tolerance of stress in their environment.

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In addition to extending the life span of whole organisms, blueberries and their extracts slow ageing in individual tissues, providing wide physiological benefits, said Lifespan.

The health site added: Along with increasing all around longevity, blueberries can specifically decrease the risk of various degenerative diseases that reduce the human life spans.

Blueberry extracts have many positive effects that may help you lose weight and keep it off.

Studies show that animals fed blueberry extracts while on a high-fat diet had lower overall weight gain, and smaller accumulations of body fat, than control animals.

Importantly, the loss of body fat is especially prominent in the abdominal areas and the liver; fat in those areas poses the greatest risk of cardiovascular disease and other life-shortening complications of obesity.

Blueberry extracts promote sugar uptake into muscle cells, where it can be used as energy, rather than being stored as fat.

Berries are not only superstars for brain longevity, they also help with keeping the memory sharp.

Studies have found that a group of healthy elderly people performed better on cognitive tests when ingesting a daily dose of wild blueberry juice.

Blueberries are packed with polyphenols, a group of compounds which includes anthocyanins, the nutrient that gives blueberries their colour.

Anthocyanins are powerful medicine for the brain as they reduce inflammation, help neurons communicate, and regulate how the brain utilizes glucose for energy.

Along with other antioxidant-rich fruits and vegetables, eating blueberries can increase your total antioxidant intake to help reduce premature ageing.

Blueberries are high in antioxidants which help protect the skin from damage and promotes skin healing.

Meaning blueberries help with keeping both your inside and outside glowing with good health.

From improving brain health, helping with weight loss, improve the ageing process and boosting longevity; its a no brainer that blueberries should be included in your daily diet.

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How to live longer: Blueberries may reduce age-related diseases to boost longevity - Express

Why does it seem like every "wellness influencer" on Earth wants me to eat nothing but kale and drink nothing but water when it seems like everyone who lives a long and happy life does so while sipping on booze and eating sausages and French fries? I, for one, will be taking my cues from Sister Andr, Europe's oldest living person who turned 117 last week.

Sister Andr, a nun, currently resides in a nursing home in Toulon in France and recently became the oldest known person to survive a COVID-19 infection, according to The New York Times. The outbreak in her nursing home sickened 81 people and killed 11. Though she was infected, she is thought to have been largely asymptomatic during that time. Sister Andr and most of the other nursing home residents were allowed out of isolation last week, just in time for her birthday.

NICOLAS TUCATGetty Images

Sister Andr didnt feel the disease, so she wondered a lot why we were talking about the coronavirus every day, why she couldnt receive visits from us at the nursing home, or from relatives or fellow residents, David Tavella, the spokesman at the Ste. Catherine Labour nursing home told the Times.

During her birthday lunch on Thursday she was expected to celebrate with port wine, foie gras with hot figs, as well "roasted capon with mushrooms and sweet potatoes as a main course, followed by a two-cheese platterRoquefort, and goat cheeseand maybe a few glasses of red wine," the latter of which Tavella told the Associated Press was "one of her secrets of longevity."

As for a birthday cake, Tavella joked that putting candles on top for Sister Andr, believed to be the second-oldest living person in the world, hasn't always worked out so well: We stopped trying a long time ago. Even if we made big cakes, Im not sure that she would have enough breath to blow them all out. You would need a fire extinguisher.

The lunch was expected to be topped off with raspberry and peach flavored Baked Alaska and a glass of Champagne, of course. All of this made her "very, very, very, very happy," as she told the AP.

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The World's Second-Oldest Person Turned 117 And Said Red Wine Is One Of Her Longevity Secrets - Delish