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Oralair pill that retrains the immune system to reduce risk of thunderstorm asthma – 7NEWS

October 7th, 2022 1:44 am

A daily pill can change immune cell memory and reduce allergic reactions such as hay fever and thunderstorm asthma, new research shows.

A study led by Monash University researchers found Victorians who took the prescribed medication Oralair for four months in the lead up to allergy season for three consecutive years had retrained immune cells, providing long-term protection against allergic reactions.

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In 2019, researchers studied 27 Victorians allergic to ryegrass pollen; half of them took the daily tablet consisting of grass pollen under the tongue and the others received antihistamines.

Its probably about 75 per cent effective in terms of symptom improvement, such as nasal congestion, the runny nose, sneezing and itching, allergy specialist Dr Joy Lee said.

The pill exposed sufferers to five different types of grass pollen and works by retraining the immune system and can reduce the risk of thunderstorm asthma.

This is very good news... we compared the samples before and after for any changes in immune memory and what we found is the bases treated with the tablet - their immune cells that responded to ryegrass pollen had changed, Monash Universitys Central Clinical School lead researcher Menno van Zelm said.

The cells in the patients that were not treated with the medication had not changed.

More than 4.6 million Australians suffer from hay fever, which is often triggered by an allergic reaction to outdoor or indoor allergens such as pollen and dust mites, according to the Australian Institute of Health and Welfare.

In 2016, Melbourne had the worlds largest epidemic thunderstorm asthma event, with thousands of people developing breathing difficulties and at least nine deaths.

Oralair does not work for everyone and asthma sufferers should first check with their general practitioner.

- With AAP

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Oralair pill that retrains the immune system to reduce risk of thunderstorm asthma - 7NEWS

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